Europaisches Patentamt
19
European Patent Office
Office europeen des brevets
EUROPEAN
© Publication number : 0 4 6 2
948
A3
PATENT A P P L I C A T I O N
<&) Int. CI.5: A61K 3 1 / 5 5
© Application number: 91830275.3
(22) Date of filing : 20.06.91
(30) Priority : 21.06.90 IT 4808690
(43) Date of publication of application :
27.12.91 Bulletin 91/52
@ Designated Contracting States :
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
(88) Date of deferred publication of search report :
04.03.92 Bulletin 92/10
(n) Applicant : Sigma-Tau Industrie
Farmaceutiche Riunite S.p.A.
47, Viale Shakespeare
1-00144 Rome (IT)
Inventor : Cozzolino, Roberto
2, Piazza Santa Maria alle Fornaci
1-00165 Rome (IT)
Inventor : Giannessi, Fabio
16, Via Abbadia San Salvatore
1-00189 Rome (IT)
Inventor : Misiti, Domenico
3, Via Bacchiglione
1-00199 Rome (IT)
Inventor : Tinti, Maria Ornella
81, Via Ernesto Basile
1-00182 Rome (IT)
Inventor : Scolastico, Carlo
13/b, Via Vallisneri
1-20133 Milan (IT)
(74) Representative
c/o Sigma-Tau
Riunite S.p.A.,
1-00144 Rome
(72) Inventor : Ghirardi, Orlando
69, Via Filippo de Grenet
1-00182 Rome (IT)
: Fassi, Aldo
Industrie Farmaceutiche
Viale Shakespeare 47
(IT)
(54) Pharmaceutical compositions comprising 3-amino-epsilon-caprolactames for enhancing learning
and memory.
(57)
Pharmaceutical compositions for enhancing
the process of learning and memory are disclosed, that contain as active principle a 3amino-s-caprolactam of formula (1)
(1)
CO
<
00
o>
CM
CO
Wherein R is selected from the group consisting
of hydrogen, formyl and acetyl.
Orally or parenterally administrable pharmaceutical compositions in unit dosage form
comprise from about 100 to about 500 mg of a
compound of formula (1).
LU
Jouve, 18, rue Saint-Denis, 75001 PARIS
European rateni
Office
Application Number
EUROPEAN SEARCH REPORT
EP
U U L U M O i> CONSIDERED TO BE RELEVANT
v-uuuuD oi Document mm indication, wnere appropnate,
Relevant
of relevant passages
to claim
NtunuiLi. L t n . , supplement no. 39,
1-3
1990, page S62, ABSTRACTS OF THE FOURTH
MEETING OF THE ITALIAN SOCIETY OF
^EUROSCIENCE, Palermo, 4th - 7th
December 1990; R. C0ZZ0LIN0 et a l . :
"Amnesia-reversal a c t i v i t y of new
3-am1 no-eps1 1on-caprol actam
derivatives"
* The a b s t r a c t *
:HEMICAL ABSTRACTS, vol. 110, no. 23,
5th June 1989, page 594, a b s t r a c t no.
210983p, Columbls, Ohio, US; & JP-A-63
283 591 (TORAY INDUSTRIES, INC.)
21-11-1988 (Cat. D)
* The a b s t r a c t *
L-3
h AM. CHEM. SOC, vol. Ill, no. 2,
1989, pages 647-654, American Chemical
society; M. ADAMCZESKI et al . : "Novel
sponge-derived amino a d d s . 5.
Structures, s t e r e o c h e m i s t r y , and
synthesis of several new h e t e r o c y c l e s "
* Page 649, compounds 26,27 *
L-3
'Martindale, The Extra Pharmacopoeia",
29th e d i t i o n , February 1989, edited by
J.E.F. Reynolds, The Pharmaceutical
5ress, London, GB
* Page 1602, monograph 13124-x,
'Plracetam" *
-3
toe present searcn report nas Seen drawn up for all claims
m
r Min iw^iwi—oi iae Km
fHE HAGUE
35-12-1991
; : particularly relevant if taken alone
! : particularly relevant if combined with another
document of the same category
i : technological background
) : non-written disclosure
' : intermediate document
91 83 0275
CLASSIFICATION OF THE
APPLICATION ant a. 5)
A 61 K 31/55
TECHNICAL FIELDS
SEARCHED (Int. CL5)
A 61 K
DRVIZ DIAZ P.
leory or principle underlying the invention
arller patent document, but published on, or
fter the filing date
locument cited in the application
ocument cited for other reasons
nenwer ot tne same patent tamuy, corresponding
ocument