Europaisches Patentamt J European Patent Office © Publication number: Office europeen des brevets EUROPEAN PATENT © Application number: 93118278.6 I278.6 © 0 598 337 A3 APPLICATION int. ci.<>: A61 K 9/14, A61 K 9 / 2 0 @ Date of filing: 11.11.93 ® © Applicant: VECTORPHARMA INTERNATIONAL S.p.A. Corso Italia, 31 1-34122 Trieste (IT) Priority: 13.11.92 IT MI922603 @ Date of publication of application: 25.05.94 Bulletin 94/21 © Designated Contracting States: AT BE CH DE ES FR GB GR IT LI LU NL PT © Date of deferred publication of the search report: 14.06.95 Bulletin 95/24 @ Inventor: Carli, Fabio Salita Cedassammare, 3/1 1-34136 Trieste (IT) Inventor: Lombardi, Daniela Via Ananian, 19 1-34142 Trieste (IT) Inventor: Esposito, Pierandrea Via Montona, 4 1-34145 Trieste (IT) Inventor: Dobetti, luca Via Mayer, 13 1-34100 Trieste (IT) Inventor: Boltri, Luigi Via Revoltella, 74 1-34139 Trieste (IT) © © CO ^ [•> O f 00 Oi m Representative: Gervasi, Gemma, Dr. NOTARBARTOLO & GERVASI Sri Viale Bianca Maria 33 1-20122 Milano (IT) Pharmaceutical compositions including a drug, a cross-linked polymeric substance, an oil, and a surface active agent. © The pharmaceutical compositions including a slightly soluble drug incorporated in a water-swellable, but water-insoluble cross-linked polymer, a surface active agent, and an oil show much improved dissolution and, consequently, bioavailability in respect of the drug as is or used with a polymeric carrier of said type. o Q_ LLI Rank Xerox (UK) Business Services (3. 10/3.09/3.3.4) J ) European Patent Office Application Number EP 93 11 8278 EUROPEAN SEARCH REPORT DOCUMENTS CONSIDERED TO BE RELEVANT Citation of document with indication, where appropriate, Relevant Category of relevant passages to claim D,A EP-A-0 078 430 (BAYER AG) * claims * 1-11 D,A EP-A-0 448 091 (THE GREEN CROSS CORPORATION) * claims * * examples 5-7 * 1-11 D,A GB-A-2 153 678 (FARMITALIA CARLO ERBA S.P.A.) * claims * 1-11 DE-A-32 24 619 (FREUND INDUSTRIAL CO., LTD.) * claims 1,2,10,11,13-18 * 1-11 CLASSIFICATION OF THE APPLICATION (Int.C1.5) A61K9/14 A61K9/20 TECHNICAL FIELDS SEARCHED (Im.CI.S) A61K The present search report has been drawn up for all claims Dateof completion ofthe March Piece ofMarch 21 April 1995 THE HAGUE CATEGORY OF CITED DOCUMENTS X: particularly relevant if taken alone Y: particularly relevant if combined with another document of the same category A: technological background O : non-written disclosure P : intermediate document Exanfaer Scarponi, U T : theory or principle underlying the invention E : earlier patent document, but published on, or after the filing date D : document cited in the application L : document cited for other reasons &: member of the same patent family, corresponding document