Europaisches Patentamt
J
0
00 Publication number:
European Patent Office
PATENT
APPLICATION
© int. a * C07D
A61K
© Application number: 88115001.5
@ Date of filing: 14.09.88
©
8 7 9
A3
Office europeen des brevets
EUROPEAN
307
311/86, C07C 1 4 3 / 8 0 ,
31/35, A61K 3 1 / 1 8
1-56100 Pisa(IT)
Priority: 16.09.87 IT 2193087
@ Date of publication of application:
22.03.89 Bulletin 89/12
©
Designated Contracting States:
AT BE CH DE FR GB LI LU NL SE
©
Date of deferred publication of the search report:
04.07.90 Bulletin 90/27
© Inventor: Caccia, Giulio
Via Gabriele d'Annunzio 13
I-55049 Viareggio (Lucca)(IT)
Inventor: Baldacci, Massimo
Via delle Piagge 9
1-56100 Pisa(IT)
© Representative: Dragotti, Gianfranco et al
SAIC BREVETTI s.r.l. Viale Bianca Maria, 15
1-20122 Milano(IT)
© Applicant: LABORATORI BALDACCI Spa
Via San Michele degli Scalzi, 73
© Sulfonamido derivatives inhibiting the aldose reductase enzyme system and pharmaceutical
compositions containing them.
© The xantosulfonamido and benzensulfonamido derivatives corresponding to the formula:
SO -N-CH -COOH
(I)
CO
<
O)
00
o
wherein X represents an alkyl-alkoxy halogen, Y represents an alkyl-alkoxy-halogen and Z represents the
group
-so
j»3
--N-CH2-C00H(
n-c;
or Y and Z taken together form the group:
LU
Xerox Copy Centre
EP 0 307 879 A3
(II)
wherein Ri in turn is a group selected among electron attracting groups, halogens and the group:
?H3
-SO -N-CH -C0OH i t s e l f ,
possess activity in inhibiting the aldose-reductase enzyme system and are thus useful in the treatment of
the complications , at the eye and peripheral neuropathy levels, as induced by diabetes.
J
European Patent
Office
)
Application Number
E U R O P E A N SEARCH R E P O R T
EP
88 11 5001
D O C U M E N T S C O N S I D E R E D TO BE R E L E V A N T
/-„*„„„..„
Category
Citation of document with indication, where appropriate,
of relevant passages
A
US-A-4 232 040
(L.D. WATERBURY)
* Column 1, line 64 - column 2, line
34; column 6, l i n e s 7-17; column 9,
example 1; column 12-13, t a b l e I; claim
1,2,812
A
FR-A-1 485 648
* Page 1; claim
1,3,812
A
JOURNAL OF PHARMACEUTICAL SCIENCES,
vol. 76, no. 2, February 1987, p a g e s
149-152, Washington D.C., US; J. DE
RUITER, et a l . : "In v i t r o a l d o s e
reductase inhibitory a c t i v i t y of
substituted N-benzenesulfonylglycine
derivatives
* Page 150, t a b l e 1, compound 7; page
151, t a b l e 11, compound 7; p a g e s
151-152, general method *
1,8,12
A
ARZNEIMITTEL-FORSCHUNG, vol. 17, no. 6,
June 1967, paqes 653-659, A u l e n d o r f ,
DE; H. HORSTMANN et al . : " C h e m i s c h e
S t r u k t u r und d i u r e t i s c h e Wirkung in der
Reihe der
4-Chlor-3-Sulfonamido-Benzolsulfonamide"
* Page 655, t a b l e B, compound 9 *
1,3
(C.
*
RIVIERE)
The present search report has been drawn up for all claims
Date of completion of the search
Place of search
06-04-1990
THE HAGUE
CATEGORY OF CITED DOCUMENTS
X : particularly relevant if taken alone
Y : particularly relevant if combined with another
document of the same category
A : technological background
_
O : non-written disclosure
P : intermediate document
Relevant
to claim
CLASSIFICATION OF THE
APPLICATION (Int. C1.4)
.
iJJ/Qn
r «7 r
j"
J Ji/Sc
? ?T 5 J i / S
technical fields
searched o*. o a )
C 07 D 3 1 1 / 0 0
C 07 C 1 4 3 / 0 0
Examiner
ENGLISH R.F.
T : theory or principle underlying the invention
E : earlier patent document, but published on, or
after the filing date
D : document cited in the application
L : document cited for other reasons
& • member of the same patent family, corresponding
document