Europaisches Patentamt J European Patent Office 00 Publication number: Office europeen des brevets EUROPEAN PATENT 169 A3 APPLICATION © Intel.*: A61K © Application number: 90200951.3 0 396 31/415, A 6 1 K 4 7 / 1 8 ® Date of filing: 18.04.90 © Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. Viale Amelia, 70 1-00181 Roma(IT) ® Priority: 26.04.89 IT 2027589 @ Date of publication of application: 07.11.90 Bulletin 90/45 © Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE @ Date of deferred publication of the search report: 22.05.91 Bulletin 91/21 © Inventor: Silvestrini, Bruno Via Michelangelo Schipa, 15 1-00181 Roma(IT) © Representative: Marchi, Massimo et al c/o Marchi & Mittler s.r.l. Viale Lombardia 20 1-20131 Milano(IT) © Pharmaceutical composition for topical ophthalmic use having improved local tolerability. © The composition comprises from 0.1 to 3 moles of free lysine for each mole of an active ingredient selected from bendazac, 5-OH bendazac and the salts thereof with pharmaceutically acceptable organic and inorganic bases. CO < <J> CO CO M UJ Xerox Copy Centre European Patent Office J Application Number EUROPEAN SEARCH REPORT EP DOCUMENTS Category D,A CONSIDERED TO BE 90 20 0 9 5 1 RELEVANT Relevant to claim Citation of document with indication, where appropriate, of relevant passages EP-A-0 191 520 (AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO) * Page 3, lines 10-24; page 5, lines 7-22; page 617, examples 2,3,4 * 1-4 DE-A-3 202 561 (AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO) * Page 6, last paragraph - page 7, line 5; page 16, paragraph 2; page 18, examples E,F * 1-4 CLASSIFICATION OFTHE APPLICATION (Int. CI.5) A 61 K 31/415 A 61 K 47/1 8 TECHNICALFIELDS SEARCHED(Int. CI.5) A 61 K The present search report has been drawn up for all claims Place of search Date of completion of search Examiner The Hague 25 February 91 KRAUTBAUER B. CATEGORYOFCITED DOCUMENTS X: particularly relevant if taken alone Y: particularly relevant if combined with another document of the same catagory A: technological background O: non-written disclosure P: intermediate document T: theory or principle underlying the invention E: earlier patent document, but published on, or after the filing date D: document cited in the application L: document cited for other reasons &: member of the same patent family, corresponding document