we have consistently found an improvement in angina
class and objective evidence of enhanced perfusion
(see Figure below). In our preclinical studies we have
worked on animal models of acute MI and heart failure
secondary to MI. Other laboratories worldwide are
working on the use of cell therapy to treat non-ischemic
cardiomyopathy, cardiac arrhythmias and pulmonary
hypertension.
The economic hurdle. The development of any
therapeutic intervention requires enormous financial
investments and, in the case of drugs and medical
devices, the industry supports the research activities,
from basic studies to clinical trials. In regenerative
medicine the only interest for the industry is in drug
therapy and in the development of cell products for
allogenic use, as it is presently being done for bone
marrow-derived mesenchymal cells. Autologous cell
therapy falls in a different category; the financial
support comes from taxpayers money and directly
from institutions which aim at developing a “service” to
offer their patients, somewhat similar to bone marrow
transplant. Therefore, finding the financial resources
to support autologous cell therapy studies is a major
obstacle that has to be overcome in order to bring cell
therapy to clinical practice.
Publications, Clinical Research Projects,
Seminars, Conferences and Courses
Conclusions. The studies performed so far have shown
the great potential of cardiovascular regenerative
medicine. However, many issues have still to be
addressed in order to establish regenerative medicine
full potential. The ongoing worldwide effort in this field
may ultimately lead to cell therapy interventions which
best suit each patient’s need.
Improvement of myocardial perfusion at stress (see arrows) 6-months after intramyocardial injection
of bone-marrow-derived CD133+ cells in a patient with refractory untreatable angina.
226
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CCM — Scientific Report 2011 — Ongoing research 2012
227
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Quantitative Analysis of Mitral Valve
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152
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Clinical Research Projects in Progress during 2011
0,712
Title
Principal Investigator
RESEARCH LABORATORIES
40
272
2,397
Erythrocyte NO metabolic pathway in patients with microvascular angina
Cavalca
Effect of acute hyperglycemia on the synthesis pathway of nitrogen monoxide (NO) in erythrocytes
Cavalca
Effect of aspirin chronic treatment on platelet function in coronary patients with type II diabetes
Cavalca
In vivo evaluation of the effect of treatment with folic acid on the metabolic pathway of nitric oxide synthesis
Cavalca
N-acetylcysteine as
​​ a treatment in the iperomocysteinuric patient not responding to folic acid therapy
Cavalca
Transcriptome analysis in blood leukocytes of patients with coronary artery disease
Colombo
Association between the BDNF Val66Met polymorphism and coronary artery disease
Colombo
Circulating microRNAs in atrial fibrillation
D'Alessandra
Analysis of circulating microRNAs in patients with coronary artery disease
D'Alessandra
Indices of systemic and cellular activation, modulation of oxidative stress in aortic valve replacement
Nava
Prevention of atherothrombotic risk
Parolari
Assessment of the carotid intima-media thickness contribution to the cardiovascular risk. Comparison among different
European populations at high and low risk.
Tedesco
Transcriptomics of antiplatelet resistance
Tremoli
Antiplatelet effect of aspirin at low doses every 12 hours in patients undergoing coronary artery bypass graft and / or aortic
valve replacement using bioprosthesis
Tremoli
Impact of the measurement of carotid intima-media thickness on cardiovascular risk classification in patients in primary
prevention
Veglia
Evaluation of the flow-mediated dilatation (FMD) of the brachial artery using the lumen area in place of the diameter
Veglia
Calculation of the minimum amount of measurements needed to correctly estimate the progression of subclinical atherosclerosis
Veglia
Nutrient-drug interaction: green tea and simvastatin
Werba
Oral niacin flush. Predictive value of skin tests using methylnicotinate
Werba
CRITICAL CARDIOLOGY
238
CCM — Scientific Report 2011 — Ongoing research 2012
Influence of ACE genotype on lung diffusion (DLCO) at rest and after intravenous water load in patients with chronic heart
failure (CHF) receiving ACE inhibitors
Agostoni
Treatment of severe heart failure by ultrafiltration
Agostoni
A multicenter, randomized, double-blind, parallel group, active-controlled study to evaluate the efficacy and safety of both
aliskiren monotherapy and aliskiren/enalapril combination therapy compared to enalapril monotherapy, on morbidity and
mortality in patients with chronic heart failure (ALISKIREN - CSPP100F2301 - ATMOSPHERE)
Agostoni
Evaluation of the effects of 4 oral dosages of S 44121 vs placebo on cardiac function and NT-proBPN in patients with chronic
heart failure and left ventricular dysfunction not treated with a beta-blocker (CL2 4412-003)
Agostoni
Evaluation of the effects of 4 oral dosages of S 44121 vs placebo on cardiac function and NT-proBPN in patients with chronic
heart failure and left ventricular dysfunction not treated with a beta-blocker (CL2 4412-004)
Agostoni
CCM — Scientific Report 2011 — Ongoing research 2012
239
240
International registry on cardioversion of atrial fibrillation (RHYTHM-AF)
Agostoni
INTERVENTIONAL CARDIOLOGY
"Sleep and Heart" Italian Multicenter Project (PROMISES)
Agostoni
Percutaneous mitral repair using Evalve MitralClip
Bartorelli
Effects of beta 2-receptor blocking on pulmonary function in a human model of acute fluid overload
Agostoni
Agostoni
Clinical evaluation of a new procedure for percutaneous denervation of the renal sympathetic nervous system in patients with
hypertension refractory to drug treatment
Bartorelli
Evaluation of the dead space in patients with chronic heart failure
Evaluation of the effects of beta-blocker therapy on exercise tolerance in uncomplicated hypertension
Alimento
A continuation in the clinical evaluation of the BVS everolimus eluting coronary stent system in the treatment of patients with
de novo native coronary artery lesions (ABSORB EXTEND)
Bartorelli
Reference values ​​of cardiac output during exercise in healthy subjects.
Cattadori
Bartorelli
Psychological assessment and dyastolic dysfunction in hypertension (Paddy study)
Fiorentini
A randomized comparison of the NEVOTM Sirolimus-eluting coronary stent system using a bioresorbable polymer vs the
Everolimus-eluting coronary stent system (XIENCE V/ XIENCE PRIME/PROMUS) using a durable polymer in coronary artery
lesions (NEVO II)
Clinical and prognostic significance of vitamin D plasma levels in patients with acute coronary syndrome
Marenzi
Bartorelli
Prognostic significance of acute renal failure in course of acute coronary syndrome
Marenzi
A phase IV pilot study to evaluate kidney measured by neutrophil gelatinase-associated lipocalin (NGAL) as a new bio-marker
in patients with normal GFR undergoing percutaneous coronary intervention with IOPAMIDOL injection 370 or IODIXANOL
320 (IOP 116)
Prevention of contrast nephropathy in patients affected by renal failure in diuretic therapy and controlled hydration (Renal
Guard)
Marenzi
Bartorelli
Impact of different therapeutic approaches in patients with cardiorenal syndrome in course of acute congestive heart failure
Marenzi
A multicenter, double-blind, randomized trial to determine the clinical benefit and safety of vytorin versus simvastatin
monotherapy in high-risk patients with acute coronary syndrome (IMPROVE-IT)
Marenzi
A prospective, single blind, randomized controlled study to evaluate the safety and effectiveness of the tryton side branch
stent™ used in conjunction with a drug-eluting stent compared to side branch balloon angioplasty in conjunction with a
drug-eluting stent in the treatment of de novo bifurcation lesions involving the main branch and side branch within the native
coronary circulation (TRYTON)
Evaluating Xience V in Multi Vessel Disease (EXECUTIVE registry)
Bartorelli
A multicenter, randomized, double blind, placebo controlled study to evaluate the safety and efficacy of SCH530348 in
addition to standard of care in subjects with a history of atherosclerosis disease: thrombin receptor antagonist in secondary
prevention of atherothrombotic ischemic events (TRA2P TIMI 50)
Marenzi
Randomized evaluation of intracoronary nitroprusside vs adenosine after thrombus aspiration during primary PErcutaneous
coronary intervention for the prevention of No reflow in Acute Myocardial Infarction (REOPEN-AMI )
Fabbiocchi
Marenzi
Multicenter registry of the treatment of acute myocardial infarction according to the currently available best practice
(OPTIMA)
Fabbiocchi
Long-term follow-up of management models of antithrombotic therapies in patients with acute coronary syndrome (EPICOR)
Safety and efficacy evaluation of short-term treatment with A-2002 in patients with acute coronary syndromes (VISTA 16)
Marenzi
PROMUSTM ElementTM Everolimus-eluting coronary stent system European post-approval surveillance study . A prospective,
open-label, multicenter, observational study with all-comers enrollment (PE-PROVE)
Fabbiocchi
A randomized, double-blind, placebo controlled, parallel group, multinational trial, to assess the prevention of thrombotic
events with ticagrelor compared to placebo on a background of acetyl salicylic acid (ASA) therapy in patients with history
of myocardial infarction (PEGASUS-TIMI 54)
Marenzi
Cangrelor versus standard therapy to achieve optimal management of platetel inhibition (PHOENIX-TMC CAN 10-01)
Galli S
Marenzi
AnGiox in elderly subjects with myocardial infarction (with or without ST-segment elevation) undergoing percutaneous
coronary intervention (PCI) in Lombardy, Lombardy AGE-MI Registry. Coordinated by the Regional Registry Study Group
LombardIMA - Hippocrates Research
Galli S
Randomized, double-blind, triple-dummy trial to compare the efficacy of otamixaban with Unfractionated Heparin +
eptifibatide, in patients with Unstable angina/Non ST segment Elevation Myocardial infarction scheduled to undergo an early
invasive strategy (SEPIA 2 -EFC6204 TAO)
Marenzi
Myocardial contrast-echocardiography role in the assessment of acute and chronic outcome in PCI and CTO. Comparison with
MR angiography by dipyridamole stress
Grancini
A phase II, randomized, double-blind, parallel-arm, placebo-controlled, with variation of the dose study to evaluate the safety
and efficacy of apixaban in patients with recent-onset of acute coronary syndrome (APPRAISE-APIXABAN)
Short-term clinical outcome in patients with percutaneous or surgical coronary revascularization combined with valve surgery
Lualdi
Project to implement adherence to guidelines in the management of acute coronary syndromes during intra-and posthospitalization (BLITZ 4)
Marenzi
Assessment of myocardial functional recovery after percutaneous reopening of a chronic total occlusion in patients with
monovascular coronary artery disease. Role of MR angiography
Lualdi
Evaluation of early cessation or reduction of cigarette smoking through the use of electronic cigarette used as an adjunct to
standard counseling activities (SMOKING)
Marenzi
Tolerability and safety of the proximal cerebral protection during carotid stenting in patients with intracranial variants of
the Willis circle
Montorsi
Identification of proteomic / proinflammatory and immune biomarkers in patients with acute coronary syndromes at high risk
to develop clinical events: genomic and proteomic approaches
Marenzi
Evaluation of carotid stenosis by CT angiography. Comparison with intravascular carotid assessment by IVUS
Montorsi
Long-term follow-up of management models of antithrombotic therapies in patients with acute coronary syndrome (EPICOR)
Palermo
Endovascular treatment of carotid "near-occlusion"
Montorsi
Using the biomarker copeptin for the early exclusion of a serious condition in patients presenting with symptoms of "acute
chest pain."
Salvioni
A phase III, double blind, randomized, placebo controlled study to evaluate the effects of R04607381 on cardiovascular risk
in stable CHD patients with a documented recent acute coronary syndrome (EFFETTI RO 4607381)
Salvioni
A multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of SCH 530348 in
addition to standard of care in subjects with acute coronary syndrome: thrombin receptor antagonist for clinical event
reduction in acute coronary syndrome (TRACER )
Salvioni
Study of cardiovascular events to evaluate the potential of aleglitazar in reducing cardiovascular risk in patients with Type-2
diabetes mellitus (T2D) and recent episode of acute coronary syndrome (ALECARDIO)
Salvioni
Steroids In cardiac surgery (SIRS)
Parolari
Phase III, multicenter, randomized, double-blind, placebo-controlled trial to evaluate the effect of saxagliptin on cardiovascular
death , myocardial infarction or ischemic stroke incidence in patients with type 2 diabetes (SAVOR)
Salvioni
Compassionate therapy with intramyocardial injection of autologous marrow cells in patients with refractory myocardial
ischemia
Pompilio
RE-LY registry on atrial fibrillation (AF): risk factors, treatments and outcomes of patients with atrial fibrillation admitted to
the emergency department in multiple regions of the world (RE-LY )
Salvioni
Pompilio
Randomized, placebo-controlled trial to assess cardiovascular outcomes after treatment with sitagliptin in patients with type
2 diabetes mellitus and inadequate glycemic control (TECOS)
Salvioni
A double-blind, randomized, placebo-controlled, parallel group study to evaluate the efficacy and safety of four 4 mg doses
of XRP0038/NV1FGF at intervals of 2 weeks on the events of amputation or death from any cause in patients with critical
ischemia of lower limbs and skin lesions (TAMARIS)
Salvioni
A prospective, randomized, multicenter, international drug vs placebo to assess the impact of clonidine and acetylsalicylic
acid (ASA) in patients undergoing noncardiac surgery at risk for cardiovascular events in the perioperative (POISE 2)
Salvi
Randomized, placebo-controlled trial to assess cardiovascular outcomes after treatment with exenatide once weekly in
patients with diabetes mellitus type 2 ( EXSCEL )
N-acetylcysteine in
​​ the prevention of contrast nephropathy in transcatheter aortic prosthesis implantation
Sisillo
A comparison between prasugrel and clopidogrel in acute coronary syndrome (ACS) subjects with UA/NSTEMI who are
medically managed (TRILOGY ACS Study)
Salvioni
CCM — Scientific Report 2011 — Ongoing research 2012
Correlation among clinical, angiographic and intra-hospital outcomes in myocardial infarction with ST-segment elevation
Italian AvantgarDE Dual AntiplateLet Therapy Registry (IDEAL)
Ravagnani
Trabattoni D
CARDIOVASCULAR SURGERY
SOURCE Registry: Edwards Sapien Aortic Bioprosthesis European Outcome registry
Fusari
SOURCE XT Registry: Edwards SAPIEN XT Aortic Bioprothesis Multi-Region Outcome Registry
Fusari
Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation (OPERA)
Parolari
TM
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Relationship between lipoprotein profile, plasma thiol level of inflammatory markers and carotid atherosclerosis. Identification
of plasma biomarkers of cardiovascular disease
Spirito
Expression of molecules involved in athero-thrombotic and aneurysmal process in infrarenal aortic perivascular adipose
tissue
Spirito
Endovascular treatment of steno-occlusions in the SFA by Zilver PTX stent
Trabattoni P
Acute type A dissection: emergency surgical treatment combined with E-XL Aortic Stent
Trabattoni P
Hybrid treatment of aortic arch aneurysms
Trabattoni P
Modification of peri-and postoperative right ventricular function in mitral valve plastic: influence of the surgical approach
and the mode of myocardial protection
Zanobini
Electrophysiology
Coronary atherosclerosis in outlier subjects: protective and individual risk factor evaluation (GISSI Outliers CAPIRE )
Andreini
Pathophysiological determinants of mitral annulus tissue Doppler systolic velocity obtained by high resolution echocardiography
Barbier
Accurate real-time 3D echocardiography in the localization of trans esophageal mitral valve prolapse: comparison between
visual method and with dedicated software
Pepi
Quantitative intraoperative evaluation of mitral valve apparatus pre-and post- annuloplasty intervention
Pepi
New techniques of morphofunctional evaluation of the tricuspid ring and valve and right ventricle by reconstruction from
MRI and 3D echocardiographic images
Pepi
Role of multidetector CT (MDCT) in evaluation of patients undergoing percutaneous aortic valve implantation (TAVI)
Pontone
Feasibility and diagnostic accuracy of ultra low dose'''' multidetector CT in the evaluation of coronary artery disease
Pontone
New anatomical parameters of the left atrium as predictors of atrial fibrillation
Pontone
Role of low-dose MDCT in the preoperative evaluation of patients with mitral valve prolapse
Pontone
Clinical study on the use of a electrophysiology low flow irrigation electrocatheter for the ablation of ventricular tachycardia
Carbucicchio
Pacemapping techniques for identification of the ablation site in patients with ventricular arrhythmias: validation and utility
of a new system of mathematical analysis (PAcing SOftware).
Carbucicchio
Comparison between 64-slice cardiac CT and stress echo in the diagnosis of significant coronary artery disease
Pontone
Endomyocardial biopsy via transeptal puncture in patients undergoing atrial fibrillation ablation. Searching for new biomarkers
using analysis of tissue microRNAs
Casella
Role of Magnetic Resonance Imaging (MRI) in assessing aortic annulus in patients undergoing percutaneous aortic valve
implantation (TAVI).
Pontone
Mapping and ablation of ventricular extrasystoles: usefulness of the automatic algorithm "Paso" implemented in the mapping
system CARTO (MAE-Paso)
Casella
3D transesophageal assessment of right ventricular size and function in the operating room
Tamborini
Near zerO fluoroscopic exPosure during catheter ablAtion of supRavenTricular arrhYthmias (NO-PARTY)
Casella
3D assessment of left atrial size and function pre-and post-plastic mitral surgery.
Tamborini
Percutaneous implantation of aortic valve prosthesis: 3D transesophageal echocardiography usefulness
Tamborini
Impact of percutaneous aortic valve replacement (TAVI) on left ventricular systolic and diastolic function : echocardiographic
long-term follow-up
Tamborini
Morphological and electrophysiological characteristics of myocardial substrate associated with increased arrhythmic risk in
patients with dilated cardiomyopathy (EMOSIDD)
Dello Russo
Usefulness of cardiac MRI in the identification of intraventricular desynchronization area in patients undergoing ventricular
resynchronization therapy
Dello Russo
Substrate in Heart failure And effectiveness of Resynchronization Therapy by EnSite Array system (SHARE-M)
Dello Russo
Evaluation of cardiac output by cardiopulmonary exercise testing with non-invasive measurement in patients with chronic
atrial fibrillation undergoing catheter ablation
Fassini
Monitoring after catheter ablation of atrial fibrillation by implantation of implantable recorder (loop recorder)
Moltrasio Massimo
Interference between the modern implantable cardiac devices and instrumentation used in the dental setting. An in vivo study
Moltrasio Massimo
Atrial fibrillation ablation registry
Moltrasio Massimo
Monitoring resynchronization in cardiac patients (MORE CARE)
Moltrasio Massimo
Genetic polymorphism and incidence of intra-atrial thrombosis in patients with permanent AF / chronic despite adequate oral
anticoagulation
Riva
Assessing the usefulness of the delayed-enhancement MRI in determining the degree of atrial fibrosis and its prognostic
correlation with the medium / long term efficacy of chronic AF transcatheter ablation
Riva
Identification of the levels of autonomy of patients undergoing implantation of mono and bicameral pacemaker
Tondo
Role of endomyocardial biopsy guided by electroanatomic mapping in the definition of the arrhythmic substrate in patients
with ventricular arrhythmias without apparent organic heart disease or uncertain diagnostic tests
Tondo
Endoscopic Guided Ablation and Voyage mapping (IRIS)
Tondo
A prospective, randomized, milticenter, interventional study designed to evaluate the safety and efficacy of percutaneous
ablation catheter TactiCath for the treatment of symptomatic paroxysmal atrial fibrillation using an irrigated catheter for
radiofrequency ablation with full recognition of the contact force (ToccaStar)
Tondo
Clinical WoRkflow Study for the EValuation Of the Multi-ELectrode PUlmonary Vein Isolation System for the Treatment of
Paroxysmal AtrIal FibrillatiON (REVOLUTION)
Tondo
Post-market clinical study of the CardioFocus endoscopic ablation system-adaptive contact (CF-EAS-AC)
Tondo-Dello Russo
CARDIOVASCULAR IMAGING
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Additional clinical role of 64 slice cardiac MDCT in the visualization of anatomical variants and of coronary anomalies
Andreini
Feasibility and diagnostic accuracy of MDCT in the evaluation of coronary circulation in diabetic patients with suspected
coronary artery disease
Andreini
Feasibility and diagnostic accuracy of multidetector low-dose CT in the evaluation of coronary stents patency
Andreini
Prognostic role of multidetector CT in patients undergoing coronary artery bypass graft
Andreini
Comparison between nuclear magnetic resonance (NMR) and two-dimensional echocardiography in the quantification of
mitral regurgitation in mitral valve prolapse
Andreini
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243
Ongoing Grants in 2011
Age.na.s
•Training of pharmacists: estimation of cardiovascular risk and approach to critical situations
European Commission
•IMPROVE
•Role of cyclophilin A in bone marrow vascular progenitor cell mobilization and recruitment in the angiogenic response to
ischemia - CAPI
•Nucleolar-dependent secretion of microRNA in a model of doxorubicin and trastuzumab cardiomyopathy - NUMIRDT
Fondazione Monzino
•Development of engineered cardiac valves
•Laboratory of experimental surgery: cardiovascular regenerative therapy
•New pathogenetic mechanisms of acute coronary syndromes
•Study of the pathogenic mechanisms of heart failure during emotional stress
Fondazione Veronesi
•The circulating transcriptome in coronary artery disease: a next generation sequencing approach
Ministero della Salute
Ricerca Corrente
•Absorption of the glycosaminoglycans (GAGs) into saphenous vein wall after their oral administration
•Analysis of the functional role of pentraxin 3 in endothelial cells through an integrated approach of proteomics and gene
silencing
•Analysis of the functional role of tissue factor in cardiomyocytes through an integrated approach of proteomics and gene
silencing
•Analysis of transcriptional profiles associated to brain damage in spontaneously hypertensive stroke prone (SHRSP) rats
•Aortic valve with minimally-invasive implantation
•Assessing oxidative stress in patients with carotid stenosis underwent surgical treatment and / or carotid stenting
•Assessment of the effectiveness of a medium / long term complex multistep strategy in the transcatheter ablation of
chronic AF
•Brachial artery diameter: a new marker of atherosclerosis?
•CABG, genomics, perioperative changes in hemostasis and inflammation and clinical outcomes at follow-up.
•Carotid atherosclerotic plaque: characterization by imaging, biochemical and histopathological techniques
•Caveolin-rich membrane microdomains and Tissue Factor modulation by protease receptors (PARS): role of cholesterol
biosynthesis inhibitors
•Cell therapy of heart failure and ischemic heart injury
•Characterization by MRI techniques of heart ischemia in ApoE KO mice
•Characterization of cells derived from cardiac mesenchyme: epigenetic and functional studies, stem cell reprogramming
•Characterization of human carotid plaques by imaging techniques and histopathology
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•Characterization of the epigenetic role of nitric oxide in aging and cellular senescence
•Clinical evaluation of safety and efficacy of a new system of hemostasis (QuikClot® Interventional) after diagnostic
percutaneous coronary or interventional procedures
•Correlation between platelet and megakaryocyte trascriptome in CAD patients
​​
•Development of a procedure for “decellularisation” and cryo-preservation of human pericardial patches in order to
engineer cardiovascular tissue
•Development of innovative diagnostic systems for atherosclerotic disease: ANN-IDA study
•Development of methods based on mass spectrometry for the absolute quantitative analysis of proteins in biological samples
•Development of murine model of dilated cardiomyopathy induced by doxorubicin and trastuzumab
•Echocardiographic and histological study of the influence of aging on left atrial function in mice
•Effect of cigarette smoke in the modulation of endothelial dysfunction
•Effect of drugs in drug-eluting stents on endothelial function and oxidative stress
•Effectiveness of nitric oxide and Histone Deacetylases inhibitors in dystrophic cardiomyopathy: identification of common
targets using a proteomic approach
•Endothelial cell secretoma
•Endovascular exclusion of aneurysms of the thoraco-abdominal aorta by fenestrated endograft: advantages of the
radiology suite in elective and emergency implantation
•Engineered tissues: cryopreserved valves cellularized by autologous cells of the recipient.
•Epigenetic modifications and impaired endothelialization of circulating endothelial progenitor cells in normal subjects and
patients at risk
•Epigenetic role of chronic electrical stimulation in cardiac cells
•Evaluation of the platelet activation state following stent placement in the carotid and / or iliac-femoral artery.
Observational study
•Evaluation of the hemostatic system in the mouse COX-2 knockout
•Evaluation of the molecular mechanisms involved in the stabilization of platelet mRNA
•Functional adaptation of the stem cell population of the saphenous vein (SVPs) as a factor predisposing to the development
of restenosis in coronary artery bypass grafting
•Genomic and proteomic expression profile of diabetic patients affected by platelet coronary syndromes
•Glycosaminoglycan and proteoglycan determinations in human aortic valves in normal and pathological conditions.
•GMP development of resident cardiac progenitors
•GPR17 purinergic receptor expression in stem cells residing in the heart
•Identification of human macrophage markers associated to the phenotype 5/1000
•Identification of the molecular targets of aspirin by a proteomic approach
•Identification of the role of the new purinergic receptor GPR17 in cardiomyocytes using a proteomic approach
•Impact of the BDNF Val66Met polymorphism on the hemostatic system: possible differences between the sexes
•Inflammation and cerebral ischemia
•Influence of dyslipidemia on left atrial size and compliance in subjects with isolated hypercholesterolemia
•Interactions between stem cells and biopolymers using’’ high throughput’’ systems, towards the engineering of artificial
stem cell niches for cardiovascular tissue bio-engineering
•Mecki score (Metabolic, Exercise, Cardiac, Kidney Index) for the identification of cardiovascular risk in patients with heart failure
•MicroRNAs and aging
•Minimally invasive aortic and mitral valve surgery
•Mitochondrial proteome of cardiac cells HL-1
•Mitral valve disease: genetic and phenotypic markers predictive of progression of the disease: systematic review of the
literature
•Modulation of endothelial prostanoids by cigarette smoke in association with IL-1 beta
•New markers of vascular imaging as predictors of vascular events in a European population of patients at high risk (new
projects based on the IMPROVE study)
•New model of left atrial function in mice
•Optimization of time / temperature in the decontamination of cardiovascular tissues with BASE.128
•Pharmacological control of cerebral ischaemia
•Plasma fatty acids and nutrition in patients with overt coronary artery disease
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•Platelet function in cardiac patients with chronic renal failure
•Possible role of brain-derived neurotrophic factor (BDNF) in the thrombosis
•Precursors of endothelial and smooth muscle cells in the abdominal aortic aneurysm: role of Cyclofillin A and microRNAs
modulated by aging
•Predictors of peri-operative renal injury after adult cardiac surgery: role of the pre-, intra-and postoperative variables and
of the extracorporeal circulation management
•Proteomics of atherosclerotic plaque
•Proteomics of C. elegans and effects of the silencing of the gene R53.1, the human ortholog of the gene FLAD1
•Proteomics of human heart valves
•Proteomics of plasma lipoproteins: identification of new associated molecules and clinical implications
•Proteomics of procoagulant microparticles
•Regeneration in adult zebrafish heart as a model for repair of cardiac ischemia
•Registry and Biobank of aortic valve disease
•Registry and Biobank of mitral valve disease
•Registry and Biobank of thoracic and abdominal aortic aneurysms and acute aortic syndromes
•Regulation of the alveolar capillary membrane function: is protein SP-B a useful marker?
•Regulation of the biosynthesis of Dickkopf-1 (Dkk-1) by statins in human endothelial cells
•Regulation of the pentraxin 3 biosynthesis by statins in human endothelial cells
•Relationship between platelet reactivity index and risk of adverse cardiovascular events in patients with acute coronary
syndrome treated with coronary angioplasty
•Role of cyclooxygenase-2 (COX-2) metabolites in the regulation of Tissue Factor (TF) induced by cigarette smoke
•Role of cyclooxygenase-2 in a mouse model of thrombosis
•Role of melanocortins in the restenosis and stent thrombosis prevention
•Study of the role of RAGE and HMGB1 in cardiovascular aging and development of cardiac fibrosis
•Surgical techniques to support electrophysiological procedures
•TF-dependent procoagulant contribution in leukocytes and platelets of patients with CAD
•The sum of early family aggregation for vascular disease in different districts and for risk factors as a novel risk factor for
atherosclerosis
•Thrombosis of drug-eluting stent
•Use of antithrombotics in atrial fibrillation (ATA - AF)
Ricerca Finalizzata
•Breathing disorders in heart failure: high altitude hypoxia as a model to define diagnostic tools, therapeutic strategies
•Identification of proteomic/proinflammatory and immune biomarkers in patients with acute coronary syndromes at high risk
to develop clinical events: genomic and proteomic approaches
•Insulin resistance and coronary disease: insights into inflammation, thrombosis and metabolic syndromes
•Role of longevity genes P66SH/SIR1 in insulin-resistance, diabetes and cardiovascular diseases
•Implementing brain repair in stroke via the exploiment of adult neurogenesis and gliogenesis: focus on the cross-talk
between microglial and endogenous precursor cells
•MicroRNA bioengeneering of human cardiac mesenchymal cells and heart regeneration
Progetti interni
•Cardiovascular Tissue Bank in Lombardia
•Clinical audit- Heart Surgery
•Clinical audit-Cardiology
•Patient analysis and tracking system data form
Regione Lombardia
•microRNA as new early markers of acute myocardial ischemia
•Echocardiographic imaging of the left atrium as a marker of cardiovascular events
•Setting up diagnostic and therapeutic pathways with the aid of telemedicine to identify mechanisms for the presentation
and development of atrial fibrillation. A prospective randomized multicenter study (PER.DI.FIA.TO)
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Seminars, conferences and courses 2011
Seminars
April 19 - Salvatore Cuzzocrea (Messina) “Strategies to
reduce I/R injury”
April 29 - Germano Ferrari (Milano) “Best practices in
technology transfer: from intellectual property protection
to market”
May 24 - Nicholas W. Shworak (Lebanon, NH, USA)
“A novel anti-inflammatory pathway of the blood vessel
wall”
May 31 - Giuseppe Gaipa (Monza) “Single cell phosphoflow analysis in haematological malignancies: methods
and applications”
June 07 - Silvia Soddu (Roma) “HIPK2: dall’attivazione di
p53 in risposta al danno al DNA alla citochinesi”
June 14 - Marco Bianchi (Milano) “HMGB1, inflammation
and tissue regeneration”
June 30 - Lina Badimon (Barcellona) “Atherosclerotic
plaque complications: plaque angiogenesis”
July 12 - Bianca Rocca (Roma) “Variability in the
responsiveness to low dose aspirin: pharmacological and
disease-related mechanisms”
September 20 - Massimiliano Gnecchi (Pavia) “Use of
mesenchymal stem cells to repair infarcted hearts”
September 27 - Andrea Urbani (Roma) “Clinical
proteomics strategies and investigations: a perspective”
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CCM — Scientific Report 2011 — Ongoing research 2012
October 11 - Elisabetta Cerbai (Firenze) “Alterazioni
elettrofisiologiche cellulari nell’ipertrofia e insufficienza
cardiaca umana: basi molecolari e prospettive
farmacologiche”
October 25 - Huei-Sheng Vincent Chen (La Jolla)
“Modeling inherited cardiac diseases with patientspecific iPScells”
November 22 - Angelo Scuteri (Roma) “L’ importanza
del fenotipo per valorizzare i risultati della ricerca di
base. Il modello della sindrome metabolica”
November 30 - Mauro Giacca (Trieste) “How can we
mend a broken heart” (Bee Gees, 1971): searching for
genes that induce myocardial protection or repair by in
vivo gene transfer using AAV vectors””
September 24 - Cesare Fiorentini, Elena Tremoli
“Giornata mondiale per il cuore 2011”
November 16 - Piergiuseppe Agostoni “Beta-bloccanti e
scompenso:come scegliere”
November 03-04 - Elena Tremoli “Aterotrombosi: dalla ricerca
di base alla clinica” V Convegno monotematico della SIF
November 21-22 - Claudio Tondo “Biopsia
endomiocardica per elettrofisiologi”
November 16 - Piero Montorsi “ 3° Audit Stenting
carotideo”
November 21-22 - Piero Montorsi “19° Carotiday” Corso
di stenting carotideo
December 14 - Rita Spirito “Il piede vascolare: percorso
diagnostico-terapeutico”
November 21-23 - Alessandro Lualdi “Corso teorico
applicativo di Cardiologia Interventistica”
Courses
March 21-22- Piero Montorsi “17° Carotiday” Corso di
stenting carotideo
Feb-Mar-Apr-May-Jun - Marco Agrifoglio “Corso di
perfezionamento in Ecocolordoppler Vascolare”
Jan-Feb-Apr-Jun-Oct-Nov - Claudio Tondo “Tecnica
della puntura transettale e trattamento della fibrillazione
atriale mediante crioablazione”
April 01 - Stefano Galli, Piero Montorsi, Paolo Ravagnani
“Focus IVUS Advanced”
May 9-10 - Piergiuseppe Agostoni: “Il test da sforzo
cardiopolmonare (CPET): basi fisiologiche, indicazioni e
interpretazione”
May 27 - Stefano Galli, Piero Montorsi, Paolo Ravagnani
“Focus IVUS Basic”
September 13-15 - Mauro Pepi, Paolo Barbier “Corso
base di ecocardiografia”
Conferences
March 03 - Elena Tremoli “Il cuore del Monzino per le
donne”
March 30 - Paolo Biglioli, Francesco Alamanni, Cesare
Fiorentini “Live Cardiac Surgery. Treatment of heart
failure”
September 26-28 - Claudio Tondo “Corso teoricopratico sulle diverse tecniche di puntura transettale per
elettrofisiologi”
October 24 - Paolo Barbier “Rigurgito mitralico: dalla
quantificazione ecodoppler all’analisi morfologica 3D
nella routine diagnostica”
May 09 - Paolo Biglioli. Cesare Fiorentini “ Audit Day
2011”
October 24-25 - Corrado Carbucicchio, Claudio Tondo
“Mappaggio e ablazione transcatetere di aritmie
ventricolari”
June 08 - Daniela Trabattoni “Forame Ovale Pervio:
quando, come, perché intervenire”
November 7-8 - Corrado Carbucicchio, Claudio Tondo
“Puntura pericardica e mappaggio epicardico”
June 10 - Paolo Ravagnani “La cardiopatia ischemica nel
terzo millennio: è tempo per una riflessione”
November 15-17 - Mauro Pepi, Paolo Barbier “Corso
avanzato di ecocardiografia”
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