Istituto Superiore di Sanità Spedizione in abbonamento postale 70% - Filiale di ISSN 0021–2571 Coden: AISSAW 39 (N. 4) 457-610 (2003) President Enrico Garaci Director-General Sergio Licheri Volume 39, N. 4, 2003 ISTITUTO SUPERIORE DI SANITA’ – VIALE REGINA ELENA, 299 – ROMA Istituto Superiore di Sanità Viale Regina Elena, 299 00161 Rome, Italy Istituto Superiore di Sanità Tel. +39-064990 1 Fax +39-064938 7118 The Istituto Superiore di Sanità is the leading technical and scientific body of the Italian National Health Service. Its activities include research, trials, control and training in public health. E-mail: [email protected] www.iss.it (Italian National Institute of Health) Edited by Publishing Activities Istituto Superiore di Sanità July 2004 The peer-reviewed science journal of the Istituto Superiore di Sanità www.iss.it Broncopneumopatia cronica ostruttiva: fisiopatologia, diagnosi e terapia ANNALI dell’Istituto Superiore di Sanità Responsible Director The journal Issues published in 2003-2004 Enrico Garaci Editor-in-chief Enrico Alleva Direction and Editorial Office Settore Attività Editoriali Istituto Superiore di Sanità Viale Regina Elena, 299 00161 Rome, Italy Director of Publishing Activities Giuseppe Vitiello Editorial Secretary Federica Napolitani Cheyne E-mail: [email protected] Tel. +39-064990 2945 Fax +39-064990 2253 E-mail: [email protected] Website: www.iss.it/annali Subscription information Istituto Poligrafico e Zecca dello Stato Funzione Editoria - Settore abbonamenti Piazza G. Verdi, 10 00198 Rome, Italy Tel. +39-068508 2207 Fax +39-068508 4117 E-mail: [email protected] / Website: www.ipzs.it Subscription terms - Year 2004 Annual: Italy € 57,00; other countries € 67,00 Each quarterly issue: Italy € 18,00; other countries € 21,00 The journal can be exchanged with periodicals of interest to the Istituto Superiore di Sanità. Requests of exchange agreements should be addressed to the Editorial Office. Annali dell’Istituto Superiore di Sanità was first published in 1965 (from 1938 as Rendiconti dell’Istituto di Sanità Pubblica). It is a quarterly science journal which publishes in the different fields of public health: • original articles • reviews • monographic issues • brief and technical notes “Instructions to authors” are printed in each issue and available from www.iss.it/annali. Papers, presented for publication, in Italian or English, must be original and are submitted for review to qualified referees. 39 (1) Qualità dell’ambiente marino-costiero e rischio sanitario Edited by Irene Di Girolamo and Enzo Funari 39 (2) Le complicanze macrovascolari nel diabete di tipo 2 Edited by Roberto Raschetti and Marina Maggini Research and Methodology 39 (3) Il materiale particellare aerodisperso: proprietà, misure, norme ed effetti sulla salute Edited by Achille Marconi and Giorgio Cattani Research and Methodology 39 (4) Broncopneumopatia cronica ostruttiva: fisiopatologia, diagnosi e terapia Edited by Paolo Montuschi 40 (1) La donna e l’alcol: aspetti clinici, epidemiologici e di prevenzione Edited by Comitato Pari Opportunità of the Istituto Superiore di Sanità New biological and diagnostic features of Toxoplasma Gondii infection Edited by Maria Cristina Angelici and Simona Cherchi Research and Methodology Annali is edited by the Publishing Activities of Istituto Superiore di Sanità and is printed by Istituto Poligrafico e Zecca dello Stato. Annali is available in full text at www.iss.it/annali, as from 2001. Links to full text are also available from PubMed, as from 2003. In press 40 (2) Biostatistical and ethological approaches for the promotion of welfare of laboratory animals and quality of experimental data Edited by Maria Puopolo, Augusto Vitale and Giovanni Laviola Research and Methodology 40 (3) Riflessione etica e ricerca scientifica: produzione e diffusione di risorse informative Edited by Maurella della Seta, Adriana Dracos and Elisabetta Poltronieri 40 (4) Research and Methodology Annali is indexed by: • MEDLINE • EMBASE/Excerpta Medica • CHEMABS • PASCAL