Curriculum vitae
PERSONAL INFORMATION
Gianfranco Delle Fave
WORK EXPERIENCE
January 1975–Present
Full Professor of Gastroenterology/Head of the dept. of Digestive and Liver
Diseases/Director of Post Graduate training Program on Dig Diseases /
Coordinator of the PhD Program in Dg.Oncology
Gianfranco Delle Fave, (Italy)
Specialty: Internal Medicine, Digestive Diseases, Specialist
Università degli Studi di Roma “La Sapienza” , School of Medicine
Specialty: Digestive Diseases
Università degli Studi di Roma “La Sapienza” , School of Medicine
EDUCATION AND TRAINING
1977–Present
Full Professor of Gastroenterology/Head of the dept. of Digestive
and Liver Diseases/Director of Post Graduate training Program on
Dig Diseases / Coordinator of the PhD Program in Dg.Oncology
University of Roma La Sapienza / Sant'Andrea Hospital, (Italy)
Specialty: Internal Medicine, Digestive Diseases, Specialist
Università degli Studi di Roma “La Sapienza” , School of Medicine
Specialty: Digestive Diseases
Università degli Studi di Roma “La Sapienza” , School of Medicine
–
FULL PROFESSOR - HEAD OF THE DEPARTMENT OF
DIGESTIVE AND LIVER DISEASE
SAPIENZA UNIVERSITY OF ROMA, (Italy)
ADDITIONAL INFORMATION
Expertise
WORK EXPERIENCE
1975-1980
Università degli Studi di Roma “La Sapienza” , School of Medicine
Post-Doc, Basic and Clinical Research, Clinical, (Chief of Lab.)
1980-2001
Università degli Studi di Roma “La Sapienza” , School of Medicine
Senior Investigator, Basic and Clinical Research, Clinical (Vice Chairman)
2001- Current Position
Università degli Studi di Roma “La Sapienza” , School of Medicine / Sant’Andrea Hospital
-Full Professor of Gastroenterology/
-Head of Department of Digestive and Liver Diseases Chair,
-Coordinator Digestive Oncology
1981-1984
National Institute of Health Digestive Diseases Branch, Cell biology,
Visiting Scientist
1982-1993
Saint Bartolomew College (London) School of Medicine, Dept. of Gastroenterology,
Visiting Professor, Teaching
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Curriculum vitae
Gianfranco Delle Fave
1994
University of Saint Louis (MO, USA), Dept. Internal Medicine, School of Medicine, Cell biology,
Visiting Professor, Teaching and Lab.
1995
University of California Los Angeles (UCLA), Dept. of Surgery, Cell biology
Visiting Professor, Teaching and lab.
1997-2007
National Institutes of Health, Digestive Diseases Branch, Clinical and lab, GI Oncology
Consultant
2009
Temple University (Philadelphia,Pennsylvenia, USA, Cell biology and GI Oncology
Faculty
2013 UCLA (University of California, Los Angeles), Professor of GI, Faculty
Publications
1: Buscarini E, Conte D, Cannizzaro R, Bazzoli F, De Boni M, Delle Fave G,
Farinati F, Ravelli P, Testoni PA, Lisiero M, Spolaore P; Italian Association of
Hospital Gastroenterologists and Endoscopists (AIGO), Italian Society of
Endoscopy (SIED), Italian Society of Gastroenterology (SIGE). White Paper of
Italian Gastroenterology: Delivery of services for digestive diseases in Italy:
Weaknesses and strengths. Dig Liver Dis. 2014 Jul;46(7):579-89. doi:
10.1016/j.dld.2014.02.019. Epub 2014 Jun 7. PubMed PMID: 24913902.
2: Anania G, Gigante E, Piciucchi M, Pilozzi E, Pucci E, Pellicelli AM, Capotondi
C, Rossi M, Baccini F, Antonelli G, Begini P, Delle Fave G, Marignani M. Liver
biopsy: Analysis of results of two specialist teams. World J Gastrointest
Pathophysiol. 2014 May 15;5(2):114-9. doi: 10.4291/wjgp.v5.i2.114. PubMed PMID:
24891983; PubMed Central PMCID: PMC4025071.
3: Pagnini C, Menasci F, Festa S, Rizzatti G, Delle Fave G. "Mucosal healing" in
ulcerative colitis: Between clinical evidence and market suggestion. World J
Gastrointest Pathophysiol. 2014 May 15;5(2):54-62. doi: 10.4291/wjgp.v5.i2.54.
Review. PubMed PMID: 24891976; PubMed Central PMCID: PMC4025073.
4: Panzuto F, Merola E, Rinzivillo M, Partelli S, Campana D, Iannicelli E,
Pilozzi E, Mercantini P, Rossi M, Capurso G, Scarpa A, Cascinu S, Tomassetti P,
Falconi M, Delle Fave G. Advanced digestive neuroendocrine tumors: metastatic
pattern is an independent factor affecting clinical outcome. Pancreas. 2014
Mar;43(2):212-8. doi: 10.1097/MPA.0000000000000032. PubMed PMID: 24518498.
5: Marignani M, Marzano A, Begini P, Vitolo U, Luminari S, Levis A, Deli I,
Gigante E, De Santis E, Delle Fave G, Monarca B, Cox MC. Perception of hepatitis
B virus infection reactivation-related issues among specialists managing
hematologic malignancies: result of an Italian survey. Leuk Lymphoma. 2014 Mar 7.
[Epub ahead of print] PubMed PMID: 24471911.
6: Pezzilli R, Andriulli A, Bassi C, Balzano G, Cantore M, Delle Fave G, Falconi
M; Exocrine Pancreatic Insufficiency collaborative (EPIc) Group. Exocrine
pancreatic insufficiency in adults: a shared position statement of the Italian
Association for the Study of the Pancreas. World J Gastroenterol. 2013 Nov
28;19(44):7930-46. doi: 10.3748/wjg.v19.i44.7930. Review. PubMed PMID: 24307787;
PubMed Central PMCID: PMC3848141.
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7: Iannicelli E, Di Pietropaolo M, Marignani M, Briani C, Federici GF, Delle Fave
G, David V. Gadoxetic acid-enhanced MRI for hepatocellular carcinoma and
hypointense nodule observed in the hepatobiliary phase. Radiol Med. 2014
Jun;119(6):367-76. doi: 10.1007/s11547-013-0364-x. Epub 2013 Dec 3. PubMed PMID:
24297598.
8: Margagnoni G, Pagnini C, Menasci F, Festa S, Delle Fave G. Critical review of
the evidence on 5-aminosalicilate for chemoprevention of colorectal cancer in
ulcerative colitis: a methodological question. Curr Clin Pharmacol. 2014
Feb;9(1):84-90. PubMed PMID: 24218994.
9: Campana D, Delle Fave G, Falconi M, Tommassetti P. Radiolabelled somatostatin
analogue treatment in gastroenteropancreatic neuroendocrine tumours: factors
associated with response and suggestions for therapeutic sequence: response to
comments by Ezziddin et al. Eur J Nucl Med Mol Imaging. 2014 Jan;41(1):176-7.
doi: 10.1007/s00259-013-2603-8. PubMed PMID: 24193364.
10: Maraví-Poma E, Patchen Dellinger E, Forsmark CE, Layer P, Lévy P, Shimosegawa
T, Siriwardena AK, Uomo G, Whitcomb DC, Windsor JA, Petrov MS; Pancreatitis
Across Nations Clinical Research and Education Alliance (PANCREA). [International
multidisciplinary classification of acute pancreatitis severity: the 2013 Spanish
edition]. Med Intensiva. 2014 May;38(4):211-7. doi: 10.1016/j.medin.2013.03.013.
Epub 2013 Jun 7. Spanish. PubMed PMID: 23747189.
11: Layer P, Dellinger EP, Forsmark CE, Lévy P, Maraví-Poma E, Shimosegawa T,
Siriwardena AK, Uomo G, Whitcomb DC, Windsor JA, Petrov MS; Pancreatitis Across
Nations Clinical Research and Education Alliance (PANCREA). [Determinant-based
classification of acute pancreatitis severity. International multidisciplinary
classification of acute pancreatitis severity: the 2013 German edition]. Z
Gastroenterol. 2013 Jun;51(6):544-50. doi: 10.1055/s-0033-1335526. Epub 2013 Jun
5. Review. German. PubMed PMID: 23740353.
12: Attili F, Capurso G, Vanella G, Fuccio L, Delle Fave G, Costamagna G, Larghi
A. Diagnostic and therapeutic role of endoscopy in gastroenteropancreatic
neuroendocrine neoplasms. Dig Liver Dis. 2014 Jan;46(1):9-17. doi:
10.1016/j.dld.2013.04.007. Epub 2013 May 31. PubMed PMID: 23731843.
13: Larghi A, Panic N, Capurso G, Leoncini E, Arzani D, Salvia R, Del Chiaro M,
Frulloni L, Arcidiacono PG, Zerbi A, Manta R, Fabbri C, Ventrucci M, Tarantino I,
Piciucchi M, Carnuccio A, Boggi U, Costamagna G, Delle Fave G, Pezzilli R, Bassi
C, Bulajic M, Ricciardi W, Boccia S. Prevalence and risk factors of
extrapancreatic malignancies in a large cohort of patients with intraductal
papillary mucinous neoplasm (IPMN) of the pancreas. Ann Oncol. 2013
Jul;24(7):1907-11. doi: 10.1093/annonc/mdt184. Epub 2013 May 14. PubMed PMID:
23676419.
14: Campana D, Capurso G, Partelli S, Nori F, Panzuto F, Tamburrino D, Cacciari
G, Delle Fave G, Falconi M, Tomassetti P. Radiolabelled somatostatin analogue
treatment in gastroenteropancreatic neuroendocrine tumours: factors associated
with response and suggestions for therapeutic sequence. Eur J Nucl Med Mol
Imaging. 2013 Aug;40(8):1197-205. doi: 10.1007/s00259-013-2402-2. Epub 2013 Apr
26. PubMed PMID: 23619938.
15: Petrone G, Ricci R, Familiari P, Inzani F, Matsuoka M, Mutignani M, Delle
Fave G, Costamagna G, Rindi G. Endoscopic snare papillectomy: a possible radical
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treatment for a subgroup of T1 ampullary adenocarcinomas. Endoscopy.
2013;45(5):401-4. doi: 10.1055/s-0032-1326213. Epub 2013 Apr 24. PubMed PMID:
23616129.
16: O'Toole D, Delle Fave G, Jensen RT. Gastric and duodenal neuroendocrine
tumours. Best Pract Res Clin Gastroenterol. 2012 Dec;26(6):719-35. doi:
10.1016/j.bpg.2013.01.002. Review. PubMed PMID: 23582915.
17: Valente R, Antonelli M, Piciucchi M, Federici GF, Signoretti M, Iannicelli E,
Capurso G, Delle Fave G. Celiac disease and CFTR mutations in patients with
chronic asymptomatic pancreatic hyperenzymemia. Am J Gastroenterol. 2013
Apr;108(4):618. doi: 10.1038/ajg.2013.13. PubMed PMID: 23552311.
18: Zerbi A, Capitanio V, Boninsegna L, Delle Fave G, Pasquali C, Rindi G,
Campana D, Falconi M; AISP-Network Study Group. Treatment of malignant pancreatic
neuroendocrine neoplasms: middle-term (2-year) outcomes of a prospective
observational multicentre study. HPB (Oxford). 2013 Dec;15(12):935-43. doi:
10.1111/hpb.12065. Epub 2013 Mar 8. PubMed PMID: 23472667; PubMed Central PMCID:
PMC3843611.
19: Oberg K, Casanovas O, Castaño JP, Chung D, Delle Fave G, Denèfle P, Harris P,
Khan MS, Kulke MH, Scarpa A, Tang LH, Wiedenmann B. Molecular pathogenesis of
neuroendocrine tumors: implications for current and future therapeutic
approaches. Clin Cancer Res. 2013 Jun 1;19(11):2842-9. doi:
10.1158/1078-0432.CCR-12-3458. Epub 2013 Mar 4. Review. PubMed PMID: 23459719.
20: Capurso G, Boccia S, Salvia R, Del Chiaro M, Frulloni L, Arcidiacono PG,
Zerbi A, Manta R, Fabbri C, Ventrucci M, Tarantino I, Piciucchi M, Carnuccio A,
Boggi U, Leoncini E, Costamagna G, Delle Fave G, Pezzilli R, Bassi C, Larghi A;
Italian Association for Study of Pancreas (AISP); Intraductal Papillary Mucinous
Neoplasm (IPMN) Study Group. Risk factors for intraductal papillary mucinous
neoplasm (IPMN) of the pancreas: a multicentre case-control study. Am J
Gastroenterol. 2013 Jun;108(6):1003-9. doi: 10.1038/ajg.2013.42. Epub 2013 Mar 5.
PubMed PMID: 23458848.
21: Piciucchi M, Crippa S, Del Chiaro M, Valente R, Pezzilli R, Falconi M, Delle
Fave G, Capurso G. Outcomes of intraductal papillary mucinous neoplasm with
"Sendai-positive" criteria for resection undergoing non-operative management. Dig
Liver Dis. 2013 Jul;45(7):584-8. doi: 10.1016/j.dld.2013.01.016. Epub 2013 Feb
27. PubMed PMID: 23453065.
22: Del Chiaro M, Verbeke C, Salvia R, Klöppel G, Werner J, McKay C, Friess H,
Manfredi R, Van Cutsem E, Löhr M, Segersvärd R; European Study Group on Cystic
Tumours of the Pancreas. European experts consensus statement on cystic tumours
of the pancreas. Dig Liver Dis. 2013 Sep;45(9):703-11. doi:
10.1016/j.dld.2013.01.010. Epub 2013 Feb 14. PubMed PMID: 23415799.
23: Capurso G, Fendrich V, Rinzivillo M, Panzuto F, Bartsch DK, Delle Fave G.
Novel molecular targets for the treatment of gastroenteropancreatic endocrine
tumors: answers and unsolved problems. Int J Mol Sci. 2012 Dec 20;14(1):30-45.
doi: 10.3390/ijms14010030. PubMed PMID: 23344019; PubMed Central PMCID:
PMC3565249.
24: Campa D, Rizzato C, Bauer AS, Werner J, Capurso G, Costello E,
Talar-Wojnarowska R, Jamroziak K, Pezzilli R, Gazouli M, Khaw KT, Key TJ, Bambi
F, Mohelnikova-Duchonova B, Heller A, Landi S, Vodickova L, Theodoropoulos G,
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Bugert P, Vodicka P, Hoheisel JD, Delle Fave G, Neoptolemos JP, Soucek P, Büchler
MW, Giese N, Canzian F. Lack of replication of seven pancreatic cancer
susceptibility loci identified in two Asian populations. Cancer Epidemiol
Biomarkers Prev. 2013 Feb;22(2):320-3. doi: 10.1158/1055-9965.EPI-12-1182. Epub
2012 Dec 18. PubMed PMID: 23250936.
25: Corleto VD, Pagnini C, Cattaruzza MS, Zykaj E, Di Giulio E, Margagnoni G,
Pilozzi E, D'Ambra G, Lamazza A, Fiori E, Ferri M, Masoni L, Ziparo V, Annibale
B, Delle Fave G. Is proliferative colonic disease presentation changing? World J
Gastroenterol. 2012 Dec 7;18(45):6614-9. doi: 10.3748/wjg.v18.i45.6614. PubMed
PMID: 23236236; PubMed Central PMCID: PMC3516210.
26: Di Florio A, Sancho V, Moreno P, Delle Fave G, Jensen RT. Gastrointestinal
hormones stimulate growth of Foregut Neuroendocrine Tumors by transactivating the
EGF receptor. Biochim Biophys Acta. 2013 Mar;1833(3):573-82. doi:
10.1016/j.bbamcr.2012.11.021. Epub 2012 Dec 4. PubMed PMID: 23220008; PubMed
Central PMCID: PMC3556220.
27: Campa D, Rizzato C, Capurso G, Giese N, Funel N, Greenhalf W, Soucek P,
Gazouli M, Pezzilli R, Pasquali C, Talar-Wojnarowska R, Cantore M, Andriulli A,
Scarpa A, Jamroziak K, Delle Fave G, Costello E, Khaw KT, Heller A, Key TJ,
Theodoropoulos G, Malecka-Panas E, Mambrini A, Bambi F, Landi S, Pedrazzoli S,
Bassi C, Pacetti P, Piepoli A, Tavano F, di Sebastiano P, Vodickova L, Basso D,
Plebani M, Fogar P, Büchler MW, Bugert P, Vodicka P, Boggi U, Neoptolemos JP,
Werner J, Canzian F. Genetic susceptibility to pancreatic cancer and its
functional characterisation: the PANcreatic Disease ReseArch (PANDoRA)
consortium. Dig Liver Dis. 2013 Feb;45(2):95-9. doi: 10.1016/j.dld.2012.09.014.
Epub 2012 Dec 1. PubMed PMID: 23206934.
28: Capurso G, Rinzivillo M, Bettini R, Boninsegna L, Delle Fave G, Falconi M.
Systematic review of resection of primary midgut carcinoid tumour in patients
with unresectable liver metastases. Br J Surg. 2012 Nov;99(11):1480-6. doi:
10.1002/bjs.8842. Epub 2012 Sep 13. Review. PubMed PMID: 22972490.
29: Capurso G, Zerboni G, Signoretti M, Valente R, Stigliano S, Piciucchi M,
Delle Fave G. Role of the gut barrier in acute pancreatitis. J Clin
Gastroenterol. 2012 Oct;46 Suppl:S46-51. doi: 10.1097/MCG.0b013e3182652096.
PubMed PMID: 22955357.
30: Larghi A, Capurso G, Carnuccio A, Ricci R, Alfieri S, Galasso D, Lugli F,
Bianchi A, Panzuto F, De Marinis L, Falconi M, Delle Fave G, Doglietto GB,
Costamagna G, Rindi G. Ki-67 grading of nonfunctioning pancreatic neuroendocrine
tumors on histologic samples obtained by EUS-guided fine-needle tissue
acquisition: a prospective study. Gastrointest Endosc. 2012 Sep;76(3):570-7. doi:
10.1016/j.gie.2012.04.477. Erratum in: Gastrointest Endosc. 2012 Nov;76(5):1085.
PubMed PMID: 22898415.
31: Adesso L, Calabretta S, Barbagallo F, Capurso G, Pilozzi E, Geremia R, Delle
Fave G, Sette C. Gemcitabine triggers a pro-survival response in pancreatic
cancer cells through activation of the MNK2/eIF4E pathway. Oncogene. 2013 Jun
6;32(23):2848-57. doi: 10.1038/onc.2012.306. Epub 2012 Jul 16. PubMed PMID:
22797067.
32: Dellinger EP, Forsmark CE, Layer P, Lévy P, Maraví-Poma E, Petrov MS,
Shimosegawa T, Siriwardena AK, Uomo G, Whitcomb DC, Windsor JA; Pancreatitis
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Across Nations Clinical Research and Education Alliance (PANCREA).
Determinant-based classification of acute pancreatitis severity: an international
multidisciplinary consultation. Ann Surg. 2012 Dec;256(6):875-80. doi:
10.1097/SLA.0b013e318256f778. PubMed PMID: 22735715.
33: Lahner E, Sbrozzi-Vanni A, Vannella L, Corleto VD, Di Giulio E, Delle Fave G,
Annibale B. No higher risk for colorectal cancer in atrophic gastritis-related
hypergastrinemia. Dig Liver Dis. 2012 Sep;44(9):793-7. doi:
10.1016/j.dld.2012.04.012. Epub 2012 May 15. PubMed PMID: 22595617.
34: Capurso G, Festa S, Valente R, Piciucchi M, Panzuto F, Jensen RT, Delle Fave
G. Molecular pathology and genetics of pancreatic endocrine tumours. J Mol
Endocrinol. 2012 Jun 26;49(1):R37-50. doi: 10.1530/JME-12-0069. Print 2012 Aug.
Review. PubMed PMID: 22586144.
35: Marignani M, Fonzo Md, Begini P, Gigante E, Deli I, Pellicelli AM, Gallina S,
de Santis E, Delle Fave G, Cox MC. 'Les liaisons dangereuses': Hepatitis C,
Rituximab and B-cell non-Hodgkin's lymphomas. World J Gastrointest Pharmacol
Ther. 2012 Apr 6;3(2):21-8. doi: 10.4292/wjgpt.v3.i2.21. PubMed PMID: 22577616;
PubMed Central PMCID: PMC3348959.
36: Guagnozzi D, Pagnini C, Delle Fave G, Corleto VD. CARD15 and Toll-like
receptor 4 mutations in Italian patients with inflammatory bowel disease. Dig
Liver Dis. 2012 Sep;44(9):800-1. doi: 10.1016/j.dld.2012.03.024. Epub 2012 May 7.
PubMed PMID: 22571967.
37: Fanelli G, Gensini G, Canonico PL, Delle Fave G, Lora Aprile P, Mandelli A,
Nicolosi G. [Pain in Italy. Background examination. Operative proposals]. Recenti
Prog Med. 2012 Apr;103(4):133-41. doi: 10.1701/1068.11703. Italian. PubMed PMID:
22561992.
38: Rindi G, Falconi M, Klersy C, Albarello L, Boninsegna L, Buchler MW, Capella
C, Caplin M, Couvelard A, Doglioni C, Delle Fave G, Fischer L, Fusai G, de Herder
WW, Jann H, Komminoth P, de Krijger RR, La Rosa S, Luong TV, Pape U, Perren A,
Ruszniewski P, Scarpa A, Schmitt A, Solcia E, Wiedenmann B. TNM staging of
neoplasms of the endocrine pancreas: results from a large international cohort
study. J Natl Cancer Inst. 2012 May 16;104(10):764-77. doi: 10.1093/jnci/djs208.
Epub 2012 Apr 23. PubMed PMID: 22525418.
39: Capurso G, Cocomello L, Benedetto U, Cammà C, Delle Fave G. Meta-analysis:
the placebo rate of abdominal pain remission in clinical trials of chronic
pancreatitis. Pancreas. 2012 Oct;41(7):1125-31. doi:
10.1097/MPA.0b013e318249ce93. PubMed PMID: 22513290.
40: Cox MC, Aloe-Spiriti MA, Cavalieri E, Alma E, Gigante E, Begini P, Rebecchini
C, Delle Fave G, Marignani M. HCV infection, B-cell non-Hodgkin's lymphoma and
immunochemotherapy: Evidence and open questions. World J Gastrointest Oncol. 2012
Mar 15;4(3):46-53. doi: 10.4251/wjgo.v4.i3.46. PubMed PMID: 22468183; PubMed
Central PMCID: PMC3312928.
41: Marignani M, Gigante E, Begini P, Marzano A, di Fonzo M, Deli I, Gallina S,
Cox MC, Delle Fave G. Patients with hematological malignancies and serological
signs of prior resolved hepatitis B. World J Gastrointest Oncol. 2012 Mar
15;4(3):37-45. doi: 10.4251/wjgo.v4.i3.37. PubMed PMID: 22468182; PubMed Central
PMCID: PMC3312927.
42: Capurso G, Di Florio A, Sette C, Delle Fave G. Signalling pathways passing
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Src in pancreatic endocrine tumours: relevance for possible combined targeted
therapies. Neuroendocrinology. 2013;97(1):67-73. doi: 10.1159/000336093. Epub
2012 Mar 21. Review. PubMed PMID: 22441103.
43: Valente R, Capurso G, Pierantognetti P, Iannicelli E, Piciucchi M, Romiti A,
Mercantini P, Larghi A, Federici GF, Barucca V, Osti MF, Di Giulio E, Ziparo V,
Delle Fave G. Simultaneous intraductal papillary neoplasms of the bile duct and
pancreas treated with chemoradiotherapy. World J Gastrointest Oncol. 2012 Feb
15;4(2):22-5. doi: 10.4251/wjgo.v4.i2.22. PubMed PMID: 22403738; PubMed Central
PMCID: PMC3296805.
44: Capurso G, Sette C, Delle Fave G. The role of SRC family kinases in
neuroendocrine tumors. Gastroenterology. 2012 Apr;142(4):e19. doi:
10.1053/j.gastro.2012.01.036. Epub 2012 Feb 27. PubMed PMID: 22381375.
45: Pape UF, Perren A, Niederle B, Gross D, Gress T, Costa F, Arnold R, Denecke
T, Plöckinger U, Salazar R, Grossman A; Barcelona Consensus Conference
participants. ENETS Consensus Guidelines for the management of patients with
neuroendocrine neoplasms from the jejuno-ileum and the appendix including goblet
cell carcinomas. Neuroendocrinology. 2012;95(2):135-56. doi: 10.1159/000335629.
Epub 2012 Feb 15. PubMed PMID: 22262080.
46: Pavel M, Baudin E, Couvelard A, Krenning E, Öberg K, Steinmüller T, Anlauf M,
Wiedenmann B, Salazar R; Barcelona Consensus Conference participants. ENETS
Consensus Guidelines for the management of patients with liver and other distant
metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown
primary. Neuroendocrinology. 2012;95(2):157-76. doi: 10.1159/000335597. Epub 2012
Feb 15. PubMed PMID: 22262022.
47: Delle Fave G, Kwekkeboom DJ, Van Cutsem E, Rindi G, Kos-Kudla B, Knigge U,
Sasano H, Tomassetti P, Salazar R, Ruszniewski P; Barcelona Consensus Conference
participants. ENETS Consensus Guidelines for the management of patients with
gastroduodenal neoplasms. Neuroendocrinology. 2012;95(2):74-87. doi:
10.1159/000335595. Epub 2012 Feb 15. PubMed PMID: 22262004.
48: Caplin M, Sundin A, Nillson O, Baum RP, Klose KJ, Kelestimur F, Plöckinger U,
Papotti M, Salazar R, Pascher A; Barcelona Consensus Conference participants.
ENETS Consensus Guidelines for the management of patients with digestive
neuroendocrine neoplasms: colorectal neuroendocrine neoplasms.
Neuroendocrinology. 2012;95(2):88-97. doi: 10.1159/000335594. PubMed PMID:
22261972.
49: Jensen RT, Cadiot G, Brandi ML, de Herder WW, Kaltsas G, Komminoth P, Scoazec
JY, Salazar R, Sauvanet A, Kianmanesh R; Barcelona Consensus Conference
participants. ENETS Consensus Guidelines for the management of patients with
digestive neuroendocrine neoplasms: functional pancreatic endocrine tumor
syndromes. Neuroendocrinology. 2012;95(2):98-119. doi: 10.1159/000335591. Epub
2012 Feb 15. PubMed PMID: 22261919; PubMed Central PMCID: PMC3701449.
50: Falconi M, Bartsch DK, Eriksson B, Klöppel G, Lopes JM, O'Connor JM, Salazar
R, Taal BG, Vullierme MP, O'Toole D; Barcelona Consensus Conference participants.
ENETS Consensus Guidelines for the management of patients with digestive
neuroendocrine neoplasms of the digestive system: well-differentiated pancreatic
non-functioning tumors. Neuroendocrinology. 2012;95(2):120-34. doi:
10.1159/000335587. Epub 2012 Feb 15. PubMed PMID: 22261872.
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Gianfranco Delle Fave
51: Panzuto F, Campana D, Fazio N, Brizzi MP, Boninsegna L, Nori F, Di Meglio G,
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somatostatin-14 and some analogues on human natural killer cell activity.
Peptides. 1994;15(6):1033-6. PubMed PMID: 7991446.
263: Bordi C, Azzoni C, Pilato FP, Robutti F, D'Ambra G, Caruana P, Rindi G,
Corleto VD, Annibale B, Delle Fave G. Morphometry of gastric endocrine cells in
hypergastrinemic patients treated with the somatostatin analogue octreotide.
Regul Pept. 1993 Sep 22;47(3):307-18. PubMed PMID: 8234912.
264: Kohn A, Annibale B, Delle Fave G, Levenstein S. Maintenance treatment with
H2 receptor antagonists for duodenal ulcer disease: toward a rational use. Dig
Dis. 1993 Jul-Oct;11(4-5):228-38. Review. PubMed PMID: 7900939.
265: Corleto V, Annibale B, D'Ambra G, Saggioro A, Ferrua B, Cassetta MR, Delle
Fave G. Efficacy of long-term therapy with low doses of omeprazole in the control
of gastric acid secretion in Zollinger-Ellison syndrome patients. Aliment
Pharmacol Ther. 1993 Apr;7(2):167-73. PubMed PMID: 8485270.
266: Pallone F, Luzza F, Delle Fave G, Annibale B, Marcheggiano A, Biancone L,
Torsoli A, Capurso L. Lansoprazole and Helicobacter pylori infection. Clin Ther.
1993;15 Suppl B:49-57. PubMed PMID: 8205595.
267: Caruana P, Azzoni C, Bertelé A, Annibale B, Franzé A, Delle Fave G, Bordi C.
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Focal oxyntic gland atrophy with endocrine cell hyperplasia in Zollinger-Ellison
syndrome during omeprazole treatment. Histopathology. 1992 Oct;21(4):359-63.
PubMed PMID: 1398539.
268: Delle Fave G, Annibale B, Franceschi M, Quatrini M, Cassetta MR, Torsoli A.
Omeprazole versus famotidine in the short-term treatment of duodenal ulcer
disease. Aliment Pharmacol Ther. 1992 Aug;6(4):469-78. PubMed PMID: 1420739.
269: Plebani M, Di Mario F, Stanghellini V, Delle Fave G. Serological tests to
monitor treatment of Helicobacter pylori. Lancet. 1992 Jul 4;340(8810):51-2.
PubMed PMID: 1351624.
270: Sirianni MC, Annibale B, Tagliaferri F, Fais S, De Luca S, Pallone F, Delle
Fave G, Aiuti F. Modulation of human natural killer activity by vasoactive
intestinal peptide (VIP) family. VIP, glucagon and GHRF specifically inhibit NK
activity. Regul Pept. 1992 Mar 5;38(1):79-87. PubMed PMID: 1574603.
271: Procacciante F, Picozzi P, Fantini A, Pacifici M, Di Nardo A, Ribotta G,
Delle Fave G, Catani M, Ruggeri S, Romeo F, et al. [VIPoma: surgical treatment].
Minerva Chir. 1992 Feb;47(3-4):135-42. Italian. PubMed PMID: 1314346.
272: Annibale B, Bonamico M, Rindi G, Villani L, Ferrante E, Vania A, Solcia E,
Delle Fave G. Antral gastrin cell hyperfunction in children. A functional and
immunocytochemical report. Gastroenterology. 1991 Dec;101(6):1547-51. PubMed
PMID: 1683324.
273: Baron AD, Laakso M, Brechtel G, Edelman SV. Mechanism of insulin resistance
in insulin-dependent diabetes mellitus: a major role for reduced skeletal muscle
blood flow. J Clin Endocrinol Metab. 1991 Sep;73(3):637-43. PubMed PMID: 1874938.
274: Kohn A, Annibale B, Prantera C, Giglio L, Suriano G, Delle Fave G.
Reversible sustained increase of gastrin and gastric acid secretion in a subgroup
of duodenal ulcer patients on long-term treatment with H2 antagonists. J Clin
Gastroenterol. 1991 Jun;13(3):284-90. PubMed PMID: 1676714.
275: Severi C, Jensen RT, Erspamer V, D'Arpino L, Coy DH, Torsoli A, Delle Fave
G. Different receptors mediate the action of bombesin-related peptides on gastric
smooth muscle cells. Am J Physiol. 1991 May;260(5 Pt 1):G683-90. PubMed PMID:
1852115.
276: Baron AD, Laakso M, Brechtel G, Edelman SV. Reduced capacity and affinity of
skeletal muscle for insulin-mediated glucose uptake in noninsulin-dependent
diabetic subjects. Effects of insulin therapy. J Clin Invest. 1991
Apr;87(4):1186-94. PubMed PMID: 2010535; PubMed Central PMCID: PMC295132.
277: Fais S, Annibale B, Boirivant M, Santoro A, Pallone F, Delle Fave G. Effects
of somatostatin on human intestinal lamina propria lymphocytes. Modulation of
lymphocyte activation. J Neuroimmunol. 1991 Mar;31(3):211-9. PubMed PMID:
1671677.
278: Fiorucci S, Bosso R, Scionti L, DiSanto S, Annibale B, Delle Fave G, Morelli
A. Neurohumoral control of gallbladder motility in healthy subjects and diabetic
patients with or without autonomic neuropathy. Dig Dis Sci. 1990
Sep;35(9):1089-97. PubMed PMID: 2202570.
279: D'Adda T, Corleto V, Pilato FP, Baggi MT, Robutti F, Delle Fave G, Bordi C.
Quantitative ultrastructure of endocrine cells of oxyntic mucosa in
Zollinger-Ellison syndrome. Correspondence with light microscopic findings.
Gastroenterology. 1990 Jul;99(1):17-26. PubMed PMID: 2344924.
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280: Annibale B, Fais S, Boirivant M, Delle Fave G, Pallone F. Effects of high in
vivo levels of vasoactive intestinal polypeptide on function of circulating
lymphocytes in humans. Gastroenterology. 1990 Jun;98(6):1693-8. PubMed PMID:
1692554.
281: Delle Fave G, Annibale B, Puoti M, Giordano E, Corleto V, de Magistris L,
Torsoli A. Medical treatment of antral gastrin cell hyperfunction: role of
nonantisecretory therapy. Digestion. 1990;46(2):65-71. PubMed PMID: 2253824.
282: Delle Fave G, Annibale B, De Magistris L. Gastrin pathophysiology:
antisecretory drugs. Ital J Gastroenterol. 1990;22 Suppl 2:32-5. Review. PubMed
PMID: 1983415.
283: Severi C, Coy DH, Jensen RT, Boschero L, Anania MC, Delle Fave G.
Pharmacological characterization of [Leu-13-psi-CH2NH-Leu14]-bombesin as a
specific bombesin receptor antagonist on isolated smooth muscle cells. J
Pharmacol Exp Ther. 1989 Nov;251(2):713-7. PubMed PMID: 2478696.
284: Annibale B, Ribaldi S, Anania MC, Stagnitti F, Strom R, Corleto V, Delle
Fave G. Somatostatin infused during acute pancreatitis retains its biological
activity. Pancreas. 1989;4(6):674-9. PubMed PMID: 2573057.
285: Falconieri Erspamer G, Severini C, Erspamer V, Melchiorri P, Delle Fave G,
Nakajima T. Parallel bioassay of 27 bombesin-like peptides on 9 smooth muscle
preparations. Structure-activity relationships and bombesin receptor subtypes.
Regul Pept. 1988 May;21(1-2):1-11. PubMed PMID: 2839869.
286: Kohn A, Suriano G, Prantera C, Annibale B, delle Fave G. Hypergastrinaemia
after long-term H2-blocker treatment. Lancet. 1987 Dec 19;2(8573):1466-7. PubMed
PMID: 2892028.
287: Annibale B, Delle Fave G, Barbetti F, de Magistris L, Puoti M, Giordano E,
Leonetti F, Tamburrano G. Dose-response effect of somatostatin-14 on human basal
pancreatic hormones. Pancreas. 1987;2(5):551-6. PubMed PMID: 2890157.
288: Bou-Fayad J, Delle Fave G, Tamburano G, DeMagistris L, Mauceri M, Khon A.
Bombesin and growth of digestive organs. Gastroenterology. 1986 Oct;91(4):1035-6.
PubMed PMID: 3743957.
289: Gambardella S, Felici MG, Annibale B, Delle Fave GF, Jacoangeli F, Spallone
V, Menzinger G. Pancreatic polypeptide response to a protein-rich meal in
diabetic patients with and without neuropathy. J Endocrinol Invest. 1986
Feb;9(1):1-4. PubMed PMID: 3700976.
290: Kohn A, Annibale B, Suriano G, Severi C, Spinella S, Delle Fave G. Gastric
acid and pancreatic polypeptide responses to modified sham feeding: indication of
an increased basal vagal tone in a subgroup of duodenal ulcer patients. Gut. 1985
Aug;26(8):776-82. PubMed PMID: 4018642; PubMed Central PMCID: PMC1432780.
291: Annibale B, Corleto V, Severi C, de Magistris L, De Toma G, Delle Fave G.
Evidence that bombesin releases extragastric gastrin in man. Regul Pept. 1985
May;11(1):43-9. PubMed PMID: 4011955.
292: Delle Fave G, Annibale B, de Magistris L, Severi C, Bruzzone R, Puoti M,
Melchiorri P, Torsoli A, Erspamer V. Bombesin effects on human GI functions.
Peptides. 1985;6 Suppl 3:113-6. PubMed PMID: 3913904.
293: de Magistris L, Annibale B, Delle Fave G, Salera M, Puoti M, Giordano E,
Forte A, Erspamer V. Peptides of the APUD system in amphibian skins. Peptides.
1985;6 Suppl 3:203-8. PubMed PMID: 2870472.
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294: Bruzzone R, Tamburrano G, Lala A, Mauceri M, Annibale B, Severi C, de
Magistris L, Leonetti F, Delle Fave G. Effect of bombesin on plasma insulin,
pancreatic glucagon, and gut glucagon in man. J Clin Endocrinol Metab. 1983
Apr;56(4):643-7. PubMed PMID: 6339534.
295: Delle Fave G, Kohn A, De Magistris L, Annibale B, Bruzzone R, Sparvoli C,
Severi C, Torsoli A. Effects of bombesin on gastrin and gastric acid secretion in
patients with duodenal ulcer. Gut. 1983 Mar;24(3):231-5. PubMed PMID: 6826108;
PubMed Central PMCID: PMC1419938.
296: Corazziari E, Delle Fave G, Pozzessere C, Kohn A, de Magistris L, Anzini F,
Torsoli A. Effect of bombesin on lower esophageal sphincter pressure in humans.
Gastroenterology. 1982 Jul;83(1 Pt 1):10-4. PubMed PMID: 7075935.
297: Fallucca F, Delle Fave G, Giangrande L, Del Balzo P, De Magistris L, Carratù
R. Effect of somatostatin on gastrin, insulin and glucagon secretion in two
patients with Zollinger-Ellison syndrome. J Endocrinol Invest. 1981
Oct-Dec;4(4):451-3. PubMed PMID: 6120969.
298: de Magistris L, Delle Fave G, Kohn A, Schwartz TW. Differential stimulation
of pancreatic-polypeptide and gastrin secretion by bombesin in man. Life Sci.
1981 Jun 8;28(23):2617-21. PubMed PMID: 7266241.
299: Delle Fave G, Bruzzone R, Annibale B, Severi C, De Toma G. Neurotensin and
the dumping syndrome. Lancet. 1981 May 30;1(8231):1209. PubMed PMID: 6112548.
300: Delle Fave G, Kohn A, de Magistris L, Mancuso M, Sparvoli C. Effect of
bombesin-stimulated gastrin on gastric acid secretion in man. Life Sci. 1980 Sep
15;27(11):993-9. PubMed PMID: 7432100.
301: Delle Fave G, de Magistris L, Kohn A. Gastrin and spaghetti: what is
physiological? Lancet. 1979 Dec 1;2(8153):1197-8. PubMed PMID: 91933.
302: Fallucca F, delle Fave GF, Gambardella S, Mirabella C, de Magistris L,
Carratu R. Glucagon secretion induced by bombesin in man. Adv Exp Med Biol.
1978;106:259-61. PubMed PMID: 362858.
303: Fallucca F, Delle Fave GF, Gambardella S, Mirabella C, De Magistris L,
Carratù R. Glucagon secretion induced by bombesin in man. Lancet. 1977 Sep
17;2(8038):609-10. PubMed PMID: 71425.
304: Delle Fave GF, Tamburrano G, De Magistris L, Natoli C, Santoro ML, Carratu
R, Torsoli A. Gynaecomastia with cimetidine. Lancet. 1977 Jun 18;1(8025):1319.
PubMed PMID: 68422.
305: Corazziari E, Habib FI, Delle Fave GF, Melchiorri P, Torsoli A, Carratu R.
Gastrointestinal and gallbladder motor effects of bombesin in man. Mater Med Pol.
1977 Apr-Jun;9(2):139-43. PubMed PMID: 895190.
306: Torsoli A, Delle Fave GF, Melchiorri P, Sopranzi N, Kohn A. Proceedings:
Neonatal hypergastrinaemia in man. Gut. 1975 Oct;16(10):834. PubMed PMID:
1205308.
Projects
Clinical and Pre-clinical Studies
"Studio osservazionale multicentrico italiano sui fattori che determinano la progressione dei tumori
endocrini metastatici del tratto digestivo"
WITH Università di Verona, Bologna, IEO Milano, Istituto Tumori Milano
"Studio osservazionale unicentrico sul rate di recidiva dei carcinoidi gastrici di Tipo 1, dopo trattamento
endoscopico"
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Curriculum vitae
Gianfranco Delle Fave
"Studio in vitro dei fattori molecolari associati alla resistenza alla gemcitabina nell’adenocarcinoma del
pancreas"
WITH Università di Tor Vergata, Roma
"Rilevanza della Patway di SRC come target terapeutico per tumori endocrini pancreatici"
WITH Università di Tor Vergata, Roma
"Fattibilità ed utilità della determinazione dell’indice proliferativo via ecoendoscopia in pazienti con
tumore endocrino pancreatico".
WITH Università Cattolica, Policlinico Gemelli, Roma
"Studio osservazionale, multicentrico su fattori associati alla recidiva di malattia dopo chirurgia curativa
in pazienti con tumore endocrino pancreatico"
WITH Università di Verona
"Studio dei meccanismi molecolari coinvolti nell’acquisizione della resistenza
al trattamento con gemcitabina in adenocarcinoma pancreatico (PDAC)"
WITH Università di Tor Vergata, Roma
"Studio multicentrico angiogenetico in pazienti con carcinoma neuroendocrino enteropancratico ben
differenziato metastatico al fegato trattati con RAD001 (Everolimus)"
WITH: Istituto Europeo di Oncologia, Milano (IEO)
"Studio multicentrico retrospettivo sull’utilizzo di RAD001 compassionevole (Everolimus) in pazienti
affetti da tumore endocrino gastroenteropancreatico"
WITH: Istituto Europeo di Oncologia, Milano (IEO); Policlinico di Modena, Oncologia Medica;
Ospedale Sant’Orsola Malpighi, Oncologia Medica, Bologna; Ospedale Civile di Genova, Oncologia
Medica, Genova; Fondazione Poliambulanza, Oncologia Medica, Brescia; Università degli Studi di
Napoli “Federico II”, Napoli; Ospedale Carreggi, Firenze; Azienda Ospedaliera Universitaria di
Ferrara, Endocrinologia, Ferrara; Ospedali Riuniti, Università degli Studi di Ancona, Oncologia
Medica, Ancona
-"Creazione Banca dati di pazienti affetti da tumore endocrino
gastroenteropancreatico, da malattie del pancreas e di controlli sani"
Clinical Trials:
"Studio Retrospettivo Osservazionale Multicentrico, Osservazionale, Italiano, non interventistico:
Pazienti con carcinoma endocrino avanzato in fase di progressione di malattia trattati con Everolimus
(RAD001) ad uso nominale". Centro Coordinatore (raccolta dati, analisti dati, comunicazione risultati)
"Studio Internazionale, Multicentrico, Trasversale, non interventistico, cross- sectional per valutare i
pazienti con tumore neuroendocrino (NET), attualmente in trattamento con IPSTYL, soluzione
iniettabile (LANREOTIDE AUTOGEL) per sindrome da carcinoide associata ad episodi di diarrea.
Centro satellite".
"Studio Multicentrico, Italiano, Interventistico “Screening dei familiari di 1° grado, fratelli e sorelle di
pazienti con cancro colorettale al momento della diagnosi del caso indice". Centro satellite
"Studio Multicentrico Italiano SOLE - Indagine epidemiologica IT-09-19 SOLE
sulla qualità di vita in pazienti affetti da Malattia di Crohn;"
"An International, Multi-Center Study Evaluating the Correlation of IL28B Genotypes with Chronic
Hepatitis C Disease Characteristics and Patient Demographics -ACRONYM gen-c; SPONSOR F.
Hoffmann-La Roche Ltd. STUDY PHASE Phase IV"
"Efficacy and Safety of BEZ235 Compared to Everolimus in Patients With Advanced Pancreatic
Neuroendocrine Tumors (CBEZ235Z2401)"
-"Everolimus Plus Best Supportive Care vs Placebo Plus Best Supportive Care in the Treatment of
Patients With Advanced Neuroendocrine Tumors (GI or Lung Origin) (RADIANT-4, CRAD001T2302)"
-"Pharmacogenomics study on IL28B genetic variants in Italian patients with HCV chronic infection
naïve to antiviral treatment".
-Telotristat Etiprate for Somatostatin Analogue Refractory Carcinoid Sindrome (TELESTAR, LEXICON
Study Lx1606.301)
PROJECT RESEARCH - UNIVERSITY OF ROMA "LA SAPIENZA"
PRIN 2007
"Digestive Endocrine Tumours: epidemiology, standardized clinical protocols and evaluation of new
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Curriculum vitae
Gianfranco Delle Fave
markers and therapeutic targets"
PRIN 2008-2012
Gastro-entero-pancreatic endocrine tumours: identification of specific clinico-pathological risk factors
and molecular markers
useful to define prognosis and related therapeutic strategies
-"Luminex. Ricerca:“Ruolo della predisposizione psicologica e della Positività sulla qualità di vita e
sulla sopravvivenza dei pazienti con carcinoma colo-rettale. Identificazione di determinanti
Immunologici, Endocrinologici e Genetici ed applicazioni translazionali"
Memberships
PUBLIC DUTIES AND FUNCTIONS
-Coordinator of the National Board of Directors: subspecialties “Gastroenterology” – Italian Ministry of
Education
-AIFA (Italian Agency for Medicine)
Section: Experimental Drug
-EMA: Expert Digestive Diseases
Governing Board-Scientific:
-ENETS (European Neuroendocrine Tumors Society), Foundator Member
-ESDO (European Society of Digestive Oncology)
-IAP
Affiliation:
-UEG (United European Gastroenterology)
-AGA (American Gastroenterological Association)
-APA (American Pancreatic Association)
-EPC (European Pancreatic Club)
-AISP Italian Association of the Study of Pancreas (Past President)
-SIGE Italian Society of Gastroenterology (Past President)
-ITANET Italian Association of Neuroendocrine Tumors (President)
-Digestive Diseases Foundation (President)
- American Association Cancer Research (AACR)
Other Relevant Information
FIleds of Interest:
-Pancreas: clinical and basic
Cancer : Esocrine and Endocrine
Chronic Inflammation: chronic pancreatitis
Pre-Cancerous Lesions: cystic, IPMN
-Stomach:
Carcinoid, Atrophic Gastritis, Micronutrient Malabsorption, HP infection,
-Small Bowel:
Celiac Diseases , Intestinal Microflora, Carcinoid
-Colon:
Pre-Cancerous Lesions- Cancer Screening, Carcinoids
-Esphagus:
GERD
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