Pubblicazioni XXIII ciclo 1. Amelio I, Melino G, Knight RA. Cell death pathology: cross-talk with autophagyand its clinical implications. Biochem Biophys Res Commun. 2011 Oct 22;414(2):277-81. Epub 2011 Sep 22. Review. PubMed PMID: 21963447. 2. Rufini S, Lena AM, Cadot B, Mele S, Amelio I, Terrinoni A, Desideri A, Melino G, Candi E. The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles. Biochem Pharmacol. 2011 Nov 15;82(10):1262-8. Epub 2011 Jul 27. PubMed PMID: 21820419. 3. Lena AM, Cipollone R, Amelio I, Catani MV, Ramadan S, Browne G, Melino G, Candi E. Skn1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression. Biochem Biophys Res Commun. 2010 Oct 29;401(4):568-73. Epub 2010 Oct 1. PubMed PMID: 20888799. 4. Insabato L, Amelio I, Quarto M, Zannetti A, Tolino F, de Mauro G, Cerchia L, Riccio P, Baumhoer D, Condorelli G, Terracciano L, de Franciscis V. Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors. Oncology. 2009;77(6):378-84. Epub 2010 Jan 18. PubMed PMID:20090381. 5. 5: D'Alessio A, Cerchia L, Amelio I,, Incoronato M, Condorelli G, de Franciscis V. Shp2 in PC12 cells: NGF versus EGF signalling. Cell Signal. 2007 Jun;19(6):1193-200. Epub 2007 Jan 10. PubMed PMID: 17287109. 6. Bongiorno-Borbone L, De Cola A, Vernole P, Finos L, Barcaroli D, Knight RA, Melino G, De Laurenzi V. FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy. Cell Cycle. 2008 Aug;7(15):2357-67. Epub 2008 May 21. 7. De Cola A, Bongiorno-Borbone L, Bianchi E, Barcaroli D, Carletti E, Knight RA, Di Ilio C, Melino G, Sette C, De Laurenzi V. FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription. Oncogene. 2012 Feb 2;31(5):573-82. doi: 10.1038/onc.2011.274. Epub 2011 Jul 4. 8. Bongiorno-Borbone L, De Cola A, Barcaroli D, Knight RA, Di Ilio C, Melino G, De Laurenzi V. FLASH degradation in response to UV-C results in histone locus bodies disruption and cell-cycle arrest. Oncogene. 2010 Feb 11;29(6):802-10. Epub 2009 Nov 16. PubMed PMID: 19915611. 9. Falconi M., Chillemi G., Di Marino D., D'Annessa I., Morozzo della Rocca B., Palmieri L., Desideri A. (2006). Structural dynamics of the mitochondrial ADP/ATP carrier revealed by molecular dynamics simulation studies. Proteins. 65(3): 681-91. 10. Chillemi G., Fiorani P., Bruselles A., Castelli S., Campagna A., Sarra O., Tesauro C., Fiorentini M., Vassallo O., D'Annessa I., Santoleri S., Desideri A. (2007). Role of flexibility and long range communication on the function of human topoisomerase I. Ital J Biochem. 56(2): 110-4. Review. 11. Losasso C, Cretaio E, Fiorani P, D'Annessa I, Chillemi G, Benedetti P. A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance. Nucleic Acids Res. 2008 Oct;36(17):5635-44. 12. Chillemi G, D'Annessa I, Fiorani P, Losasso C, Benedetti P, Desideri A. Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations. Nucleic Acids Res. 2008 Oct;36(17):5645-51. 13. D’Annessa I, Chillemi G, Desideri A. (2009). Structural-dynamical properties of the Deinococcus radiodurans topoisomerase IB in absence of DNA: correlation with the human enzyme. J Biomol Struct Dyn. 27(3): 307-18. 14. Fiorani P, Tesauro C, Mancini G, Chillemi G, D'Annessa I, Graziani G, Tentori L, Muzi A, Desideri A. (2009). Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant. Nucleic Acids Res. 37(20): 6849-58. 15. Tesauro C, Fiorani P, D’Annessa I, Chillemi G, Turchi G, Desideri A. (2010). Erybraedin C, a natural compound from the plant Bituminaria bituminosa,inhibits both the cleavage and religation reactions of human topoisomerase I. Biochem J. 425(3): 531-9. 16. Mancini G, D'Annessa I, Coletta A, Sanna N, Chillemi G, Desideri A. (2010). Structural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I - DNA 17. Vassallo O, Castelli S, D'Annessa I, Della Rocca BM, Stella L, Knudsen BR, Desideri A. (2011). Evidences of a natively unfolded state for the human topoisomerase IB N-terminal domain. Amino Acids. 41(4): 945-53. 18. Sengupta S, Ganguly A, Roy A, Bosedasgupta S, D'Annessa I, Desideri A, Majumder HK. (2011). ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism. Nucleic Acids Res. 39(8): 3295-309. 19. Roy A, D’Annessa I, Tordrup D, Laursen RR, Knudsen BR, Desideri A, Andersen FF. (2011). Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum. Mol. Biol. Int. 2011: 854626. 20. Di Marino D, Oteri F, Morozzo Della Rocca B, D'Annessa I, Falconi M. (2011). Mapping multiple potential ATP binding sites on the matrix side of the bovine ADP/ATP carrier by the combined use of MD simulation and docking. J Mol Model. Epub ahead of print. 21. Roy A, Chowdhury S, Sengupta S, Mandal M, Jaisankar P, D'Annessa I, Desideri A, Majumder HK. (2011). Development of Derivatives of 3, 3'-Diindolylmethane as Potent Leishmania donovani Bi-Subunit Topoisomerase IB Poisons. PLoS One. 6(12): e28493. 22. D'Annessa I, Tesauro C, Fiorani P, Chillemi G, Castelli S, Vassallo O, Capranico G, Desideri A. (2012). Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin. Epub ahead of print. 23. 1: Gunes Z, Zucconi A, Cioce M, Meola A, Pezzanera M, Acali S, Zampaglione I, De Pratti V, Bova L, Talamo F, Demartis A, Monaci P, La Monica N, Ciliberto G, Vitelli A. Isolation of Fully Human Antagonistic RON Antibodies Showing Efficient Block of Downstream Signaling and Cell Migration. Transl Oncol. 2011 Feb 1;4(1):38-46. PubMed PMID: 21286376; PubMed Central PMCID: PMC3026407. 24. Santucci R, Sinibaldi F, Patriarca A, Santucci D, Fiorucci L. Misfolded proteins and neurodegeneration: role of non-native cytochrome c in cell death. Expert Rev Proteomics. 2010 Aug;7(4):507-17. Review. PubMed PMID: 20653507. 25. Patriarca A, Eliseo T, Sinibaldi F, Piro MC, Melis R, Paci M, Cicero DO, Polticelli F, Santucci R, Fiorucci L. ATP acts as a regulatory effector in modulating structural transitions of cytochrome c: implications for apoptotic activity. Biochemistry. 2009 Apr 21;48(15):3279-87. PubMed PMID: 19231839 26. F. Sinibaldi , L. Fiorucci, A. Patriarca, R. Lauceri, T. Ferri, M. Coletta, and R. Santucci (2008) Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength, Biochemestry 47, 6928-6935. 27. Dharmapuri S., Aurisicchio L., Biondo A., Welsh N., Ciliberto G., La Monica N. “Anti-apoptotic siRNA as potent adjuvant of DNA vaccination in a mouse mammary tumor model”. Hum. Gene Ther. 2009 Feb 17. 28. Aurisicchio L, Peruzzi D, Conforti A, Dharmapuri S, Biondo A, Giampaoli S, Fridman A, Bagchi A, Winkelmann CT, Gibson R, Kandimalla ER, Agrawal S, Ciliberto G, La Monica N. Treatment of Mammary Carcinomas in HER-2 Transgenic Mice through Combination of Genetic Vaccine and an Agonist of Toll-Like Receptor 9. Clin Cancer Res. 2009 Feb 24. 29. Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M. Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity. J Mol Biol. 2009 Feb 6;385(5):1556-67. Epub 2008 Nov 25. 30. Sbardella D, Fasciglione GF, Gioia M, Ciaccio C, Tundo GR, Marini S, Coletta M. Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes. Mol Aspects Med. 2012 Apr;33(2):119-208. Epub 2011 Nov 10. PubMed PMID: 22100792. 31. Cao Y, Nicoletti FP, De Sanctis G, Bocedi A, Ciaccio C, Gullotta F, Fanali G, Tundo GR, di Masi A, Fasano M, Smulevich G, Ascenzi P, Coletta M. Evidence for pH-dependent multiple conformers in iron(II) heme-human serum albumin: spectroscopic and kinetic investigation of carbon monoxide binding. J Biol Inorg Chem. 2012 Jan;17(1):133-47. Epub 2011 Sep 6. PubMed PMID: 21894504. 32. Ascenzi P, Cao Y, Tundo GR, Coletta M, Fanali G, Fasano M. Ibuprofen and warfarin modulate allosterically ferrous human serum heme-albumin nitrosylation. Biochem Biophys Res Commun. 2011 Jul 22;411(1):185-9. Epub 2011 Jun 24. PubMed PMID: 21726535. 33. Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E. Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease. Chemistry. 2011 Feb 25;17(9):275262. doi: 10.1002/chem.201002809. Epub 2011 Jan 27. PubMed PMID: 21274957. 34. Ascenzi P, Bolli A, di Masi A, Tundo GR, Fanali G, Coletta M, Fasano M. Isoniazid and rifampicin inhibit allosterically heme binding to albumin and peroxynitrite isomerization by heme-albumin. J Biol Inorg Chem. 2011 Jan;16(1):97-108. Epub 2010 Sep 25. PubMed PMID: 20865291. 35. Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M. The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B. J Mol Biol. 2009 Feb 20;386(2):419-34. Epub 2008 Dec 14. 36. Melino S, Nepravishta R, Bellomaria A, Di Marco S, Paci M. Nucleic acid binding of the RTN1-C C-terminal region: toward the functional role of a reticulon protein. Biochemistry. 2009 Jan 20;48(2):242-53. 37. Nepravishta R, Sabelli R, Iorio E, Micheli L, Paci M, Melino S. Oxidative species and Sglutathionyl conjugates in the apoptosis induction by allyl thiosulfate. FEBS J. 2012 Jan;279(1):154- 67. doi: 10.1111/j.1742-4658.2011.08407.x. Epub 2011 Nov 17. PubMed PMID: 22035263. 38. Nepravishta R, Bellomaria A, Polizio F, Paci M, Melino S. Reticulon RTN1-C(CT) peptide: a potential nuclease and inhibitor of histone deacetylase enzymes. Biochemistry. 2010 Jan 19;49(2):252-8. PubMed PMID: 20000484. 39. Astarita G, Piomelli D. Lipidomic analysis of endocannabinoid metabolism in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 14. [Epub ahead of print] 40. Astarita G, Ahmed F, Piomelli D. Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain. J Lipid Res. 2008 Jan;49(1):48-57. Epub 2007 Oct 23. 41. Potvin S, Kouassi E, Lipp O, Bouchard RH, Roy MA, Demers MF, Gendron A, Astarita G, Piomelli D, Stip E. Endogenous cannabinoids in patients with schizophrenia and substance use disorder during quetiapine therapy. J Psychopharmacol. 2008 May;22(3):262-9. 42. Fu J, Kim J, Oveisi F, Astarita G, Piomelli D. Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats. Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R45-50. Epub 2008 Apr 23. 43. Moise AM, Eisenstein SA, Astarita G, Piomelli D, Hohmann AG. An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters. Psychopharmacology (Berl). 2008 Oct;200(3):333-46. Epub 2008 Jun 11. 44. Schwartz GJ, Fu J, Astarita G, Li X, Gaetani S, Campolongo P, Cuomo V, Piomelli D. The lipid messenger OEA links dietary fat intake to satiety. Cell Metab. 2008 Oct;8(4):281-8. 45. Piomelli D, Astarita G, Rapaka R. A neuroscientist's guide to lipidomics. Nat Rev Neurosci. 2007 Oct;8(10):743-54. Review. 46. Jung KM, Astarita G, Zhu C, Wallace M, Mackie K, Piomelli D. A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. Mol Pharmacol. 2007 Sep;72(3):612-21. Epub 2007 Jun 21. 47. Tarzia G, Antonietti F, Duranti A, Tontini A, Mor M, Rivara S, Traldi P, Astarita G, King A, Clapper JR, Piomelli D. Identification of a bioactive impurity in a commercial sample of 6-methyl2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754). Ann Chim. 2007 Sep;97(9):887-94. 48. King AR, Duranti A, Tontini A, Rivara S, Rosengarth A, Clapper JR, Astarita G, Geaga JA, Luecke H, Mor M, Tarzia G, Piomelli D. URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. Chem Biol. 2007 Dec;14(12):1357-65. 49. Sarra M, Caruso R, Cupi ML, Monteleone I, Stolfi C, Campione E, Diluvio L, Mazzotta A, Botti E, Chimenti S, Costanzo A, MacDonald TT, Pallone F, Monteleone G. IL-21 promotes skin recruitment of CD4(+) cells and drives IFN-γ-dependent epidermal hyperplasia. J Immunol. 2011 May 1;186(9):5435-42. Epub 2011 Mar 25. PubMed PMID: 21441456. 50. Zangrilli A, Campione E, Diluvio L, Paterno’ EJ, Orlandi A, Simone MD, Chimenti S. Treatment of disfiguring chronic graft versus host disease in a child with topical pimecrolimus. Pediatr Int. 2010 Jun;52(3):e161-3. PubMed PMID: 20723118. 51. Terrinoni A, Codispoti A, Serra V, Bruno E, Didona B, Paradisi M, Nistico’ S, Campione E, Napolitano B, Diluvio L, Melino G. Connexin 26 (GJB2) mutations as a cause of the KID syndrome with hearing loss. Biochem Biophys Res Commun. 2010 Apr 23;395(1):25-30. Epub 2010 Mar 20. PubMed PMID: 20307501. 52. Terrinoni A, Codispoti A, Serra V, Didona B, Bruno E, Nistico’ R, Giustizieri M, Alessandrini M, Campione E, Melino G. Connexin 26 (GJB2) mutations, causing KID Syndrome, are associated with cell death due to calcium gating deregulation. Biochem Biophys Res Commun. 2010 Apr 16;394(4):909-14. Epub 2010 Mar 15. PubMed PMID: 20230788. 53. Diluvio L, Romiti ML, Angelini F, Campione E, Rossi P, Prinz JC, Chimenti S, Lamioni A. Infliximab therapy induces increased polyclonality of CD4+CD25+ regulatory T cells in psoriasis. Br J Dermatol. 2010 Apr;162(4):895-7. Epub 2010 Feb 25. PubMed PMID: 20199542. 54. Campione E, Diluvio L, Paterno’ EJ, Chimenti S. Topical treatment of actinic keratoses with piroxicam 1% gel: a preliminary open-label study utilizing a new clinical score. Am J Clin Dermatol. 2010;11(1):45-50. 55. Campione E, Diluvio L, Paterno’ EJ, Di Marcantonio D, Francesconi A, Terrinoni A, Orlandi A, Chimenti S. Kaposi's sarcoma in a patient treated with imatinib mesylate for chronic myeloid leukemia. Clin Ther. 2009 Nov;31(11):2565-9. PubMed PMID: 20110001. 56. Caruso R, Botti E, Sarra M, Esposito M, Stolfi C, Diluvio L, Giustizieri ML, Pacciani V, Mazzotta A, Campione E, Macdonald TT, Chimenti S, Pallone F, Costanzo A, Monteleone G. Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. Nat Med. 2009 Sep;15(9):1013-5. Epub 2009 Aug 16. PubMed PMID:19684581. 57. Ambrogi V, Campione E, Mineo D, Paterno’ EJ, Pompeo E, Mineo TC. Bilateral thoracoscopic T2 to T3 sympathectomy versus botulinum injection in palmar hyperhidrosis. Ann Thorac Surg. 2009 Jul;88(1):238-45. PubMed PMID: 19559233. 58. Campione E, Mazzotta A, Paterno’ EJ, Diluvio L, Prinz JC, Chimenti S. Effect of calcipotriol on etanercept partial responder psoriasis vulgaris and psoriatic arthritis patients. Acta Derm Venereol. 2009;89(3):288-91. PubMed PMID: 19479128. 59. Codispoti A, Colombo E, Zocchi L, Serra V, Pertusi G, Leigheb G, Tiberio R, Bornacina G, Zuccoli R, Ramponi A, Campione E, Melino G, Terrinoni A. Knuckle pads, in an epidermal palmoplantar keratoderma patient with Keratin 9 R163W transgrediens expression. Eur J Dermatol. 2009 MarApr;19(2):114-8. Epub 2008 Dec 23. PubMed PMID: 19106041. 60. Rapanotti MC, Bianchi L, Ricozzi I, Campione E, Pierantozzi A, Orlandi A, Chimenti S, Federici G, Bernardini S. Melanoma-associated markers expression in blood: MUC-18 is associated with advanced stages in melanoma patients. Br J Dermatol. 2009 Feb;160(2):338-44. Epub 2008 Dec 5. 61. Orlandi A, Costantini S, Campione E, Ferlosio A, Amantea A, Bianchi L, Chimenti S, Spagnoli LG. Relation between animal-type melanoma and reduced nuclear expression of glutathione Stransferase pi. Arch Dermatol. 2009 Jan;145(1):55-62. 62. Campione E, Paternò EJ, Diluvio L, Orlandi A, Bianchi L, Chimenti S. Localized morphea treated with imiquimod 5% and dermoscopic assessment of effectiveness. J Dermatolog Treat. 2009;20(1):10-3. 63. Giunta A, Demin F, Campione E, Chimenti S, Bianchi L. Dermatitis artefacta in sporadic sclerodermoid hepatitis C virus-associated porphyria cutanea tarda. J Eur Acad Dermatol Venereol. 2008 Dec 22. [Epub ahead of print] 64. Zocchi L, Serra V, Pertusi G, Leigheb G, Tiberio R, Bornacina G, Zuccoli R, Ramponi A, Campione E, Melino G, Terrinoni A. Knuckle pads, in an epidermal palmoplantar keratoderma patient with Keratin 9 R163W transgrediens expression. Eur J Dermatol. 2008 Dec 23. [Epub ahead of print] 65. Carboni I, Costanzo A, Campione E, Paternò EJ, Chimenti S. [Ashy dermatosis: clinicopathological associations in two cases] Clin Ter. 2008 Sep-Oct;159(5):321-3. Italian. 66. Diluvio L, Campione E, Paterno EJ, Orlandi A, Terrinoni A, Chimenti S. Peculiar clinical and dermoscopic remission pattern following imiquimod therapy of basal cell carcinoma in seborrhoeic areas of the face. J Dermatolog Treat. 2008 Nov 7:1-5. [Epub ahead of print] 67. Paternò EJ, Campione E, Diluvio L, Orlandi A, Chimenti S. Imiquimod for restoring local immunity in a renal transplant patient with persistent keratoacanthoma. Dermatol Online J. 2008 Mar 15;14(3):8. 68. Diluvio L, Campione E, Paterno EJ, Hagman JH, Anemona L, Orlandi A, Chimenti S. Acute onset disseminated superficial porokeratosis heralding diffuse large B-cell lymphoma. Eur J Dermatol. 2008 May-Jun;18(3):349-50. Epub 2008 May 13. 69. Campione E, Paternò EJ, Diluvio L, Bianchi L, Giorgetti G, Chimenti S. Combination of lowdosage cyclosporine and topical pimecrolimus in severe atopic dermatitis with chronic hepatitis B. Acta Derm Venereol. 2008;88(1):74-5. No abstract available. 70. Campione E, Peris K, Paternò EJ, Chimenti S. Effectiveness of imiquimod on Molluscum contagiosum viral chemokines. J Cutan Med Surg. 2007 Jul-Aug;11(4):156-8. No abstract available. 71. Campione E, Terrinoni A, Orlandi A, Codispoti A, Melino G, Bianchi L, Mazzotta A, Garaci FG, Ludovici A, Chimenti S. Cerebral cavernomas in a family with multiple cutaneous and uterine leiomyomas associated with a new mutation in the fumarate hydratase gene. J Invest Dermatol. 2007 Sep;127(9):2271-3. Epub 2007 May 3.