PRODUCT PROFILE
PRODUCT PROFILE
Description
Soothing, hydrating and protective gel
For external use only
Regulatory status Cosmetic
Dosage 1 application per day
Principle ingredients
Zinc Gluconate and Taurine (natural substances present in
an healthy body characterized by important activities.
They work together and are able to reduce vaginal
inflammation, restore the mucosa integrity preventing ulcers
and infection and reduce bacterial colonization)
Indication In combination therapy with pharmacological
treatment or during the menstrual period to
reduce skin irritation due to the use of sanitary
napkin or tampon
Suggested Public Price
€ 12,00.
MARKET NEEDS
Including drugs and medical devices, the
Italian market of Vaginal gel is
about 4,8 million units.
Vaginal dryness can be often the origin of vulvo-vaginal
irritation or phogosis and the consequence could be a local
infection
Most common cases are gynecological explorations,
contraceptive prosthesis applications, difficulty in
sexual relationships due to various physiological
causes , skin irritation due to the use of vaginal
tampons during the menstruation period
The use of specific products, especially in form of gel could
be the solution. The gel formulation is a specific market
requirement, highly recommended by the physicians
The major needs are: soothing and refreshing action, itch
reduction, natural ingredients based products
VAGINAL GEL MARKET
REFERENCE MARKET: ITALY
Sell-out UN
MAT/7/2009
(Absolute)
12D9 ALTRE PREP.GINECOLOGICHE
COMBE ITALIA VAGISIL CREMA 2% 20G
PROGINE FARMACEUT.
COLPOFIX
GEL VAG. 10 20ML
GEL+EROG
DIFESAN
CPR.VAG+APPL 7
CORMAN
LADY P. ACTIGEL
GEL BIOADES 50ML
SANDOZ
CLOMIREX T
GEL VAG 20G
MIPHIL
GEL 20G
85D4 LUBRIFICANTI INTIMI
ROTTAPHARM
SAUGELLA
IDROCREMA 30ML
GEL DI ATTIV 30ML
SAUGELLA GEL IG.
TUBO 30ML
INTILAC PLUS
GEL VAG. MON 7 5ML
SAUGELLA GEL M/DOS
MONODOSE 6 5ML
INTILAC
C/APPLICAT. TUBO 7
RECKITT BENCKIS.HC
DUREX MASSAGE
DUREX TOP GEL
DUREX O
GEL 15ML
GANASSINI
VIDERMINA INTIMO
Sell-out UN
MAT/7/2010
(Absolute)
3.823.117
827.510
54.533
38.102
30.555
7.547
13.008
13.008
79.090
79.090
79.090
50.233
23.909
23.909
24.411
24.411
1.890.386
366.549
227.381
191.245
36.135
110.919
110.919
17.646
17.646
10.541
10.541
63
63
367.371
160.466
102.705
104.200
104.200
327.785
141.643
Sell-out UN
MAT/7/2011
(Absolute)
4.508.664,3
766.534,7
75.194,5
39.689,3
30.750,7
8.938,6
13.155,1
13.155,1
86.209,5
86.209,5
86.209,5
55.194,3
33.411,9
33.411,9
21.651,3
21.651,3
2.115.651,5
366.742,8
238.705,7
201.194,4
37.511,3
104.816,5
104.816,5
13.485,1
13.485,1
9.681,2
9.681,2
54,2
54,2
413.442,5
164.366,8
115.801,4
78.244,1
78.244,1
331.289,7
138.852,5
4.840.650
759.570
99.649
44.702
33.619
11.082
20.857
20.857
93.251
93.251
93.251
61.365
41.321
41.321
10.507
10.507
2.279.789
353.192
237.737
201.487
36.250
94.959
94.959
11.007
11.007
9.480
9.480
9
9
411.641
207.800
114.330
39.924
39.924
320.655
131.591
VAGINAL GEL MARKET
REFERENCE MARKET: ITALY
12D9 ALTRE PREP.GINECOLOGICHE
COMBE ITALIA
VAGISIL CREMA 2% 20G
SAGINIL
GEL C/DISP. 30ML
MONODOSE 6 4.5ML
SAGINIL IN
MONODOSE 10 4.5ML
PROGINE FARMACEUT.
COLPOFIX
GEL VAG. 10 20ML
GEL+EROG
DIFESAN
CPR.VAG+APPL 7
CORMAN
LADY P. ACTIGEL
GEL BIOADES 50ML
SANDOZ
CLOMIREX T
GEL VAG 20G
MIPHIL
GEL 20G
85D4 LUBRIFICANTI INTIMI
ROTTAPHARM
SAUGELLA
IDROCREMA 30ML
GEL DI ATTIV 30ML
SAUGELLA GEL IG.
TUBO 30ML
INTILAC PLUS
GEL VAG. MON 7 5ML
SAUGELLA GEL M/DOS
MONODOSE 6 5ML
INTILAC
C/APPLICAT. TUBO 7
RECKITT BENCKIS.HC
DUREX MASSAGE
DUREX TOP GEL
DUREX O
GEL 15ML
GANASSINI
VIDERMINA INTIMO
Sell-out EUR/PUB
MAT/7/2009
(Absolute)
40.498.736,8
6.802.929,7
534.746,0
440.207,2
94.538,8
95.749,7
95.749,7
1.035.541,1
700.779,7
603.173,4
97.606,2
256.743,2
256.743,2
1.083.128,6
1.083.128,6
1.083.128,6
818.023,6
334.149,9
334.149,9
457.232,7
457.232,7
23.294.053,4
4.348.021,5
2.805.924,3
2.359.788,1
446.136,2
1.194.778,5
1.194.778,5
211.596,8
211.596,8
135.079,5
135.079,5
642,4
642,4
3.898.381,0
1.567.417,9
797.163,1
1.533.800,0
1.533.800,0
4.201.203,6
1.869.624,5
Sell-out EUR/PUB
MAT/7/2010
(Absolute)
48.115.086,6
6.540.131,9
507.304,3
500.807,1
6.497,2
257.478,3
257.478,3
1.493.100,5
724.565,5
609.504,2
115.061,2
259.881,7
259.881,7
1.201.202,6
1.201.202,6
1.201.202,6
874.294,2
467.441,6
467.441,6
405.018,5
405.018,5
25.969.580,4
4.457.749,5
3.021.515,8
2.546.483,4
475.032,4
1.139.195,6
1.139.195,6
171.476,1
171.476,1
124.992,7
124.992,7
569,3
569,3
4.574.650,4
1.575.763,8
919.965,8
1.148.497,0
1.148.497,0
4.289.037,9
1.834.970,2
Sell-out EUR/PUB
MAT/7/2011
(Absolute)
55.596.422
6.610.647
532.991
531.995
996
319.409
319.409
1.999.851
810.641
666.988
143.653
412.190
412.190
1.373.141
1.373.141
1.373.141
952.345
577.599
577.599
196.537
196.537
27.533.327
4.319.877
3.020.698
2.560.217
460.481
1.034.771
1.034.771
141.639
141.639
122.670
122.670
98
98
4.225.871
1.999.741
907.804
579.975
579.975
4.181.924
1.739.148
PRODUCT VS. MARKET NEEDS
Ginoxil Gel is, actually, the
perfect answer to the reference
markets
needs:
Soothing and refreshing Action
Inflammation reduction
Strictly based on Natural ingredients which
do not interfere with any drugs or specific treatment
Itch reduction
Gel presentation with high patients compliance
For external use only
MARKET POSITIONING
Ginoxil Gel , with its soothing ,
refreshing and anti- itching
activity is based on natural
ingredients and it is indicated
for sensitive and irritated
intimate areas
Zinc and Taurine ,natural
active ingredients, are well
known for their safety and
synergic action and
efficacy to reduce local
inflammation and risks for
microbial infection.
ARGUMENTS
Zinc is present in the healthy body and it is essential for the function of at least 70
enzymes and is involved in a variety of metabolic processes. Zinc is also a limiting
factor in zinc-dependent enzymes such as RNA and DNA polymerases, deoxythymidine
kinase, and reverse transcriptase, which are responsible for the regulation of RNA and
DNA metabolism. Zinc supplementation has been shown to markedly improve wound
healing. Zinc supplementation is recommended as a ROS scavenger and anti
inflammatory agent, as well as anti-aging. Moreover Zinc increase T helper lymphocyte
and Zinc salts are known to inhibit bacterial and viral growth.
It seems to have activity similar to insulin, antioxidant activity
protecting mucosal cells.
Taurine, or 2 aminoethanesulfonic acid, is an organic acid.
It is also a major constituent of bile and can be found in the
lower intestine and in small amounts in the tissues of many animals
and in humans as well.
The association between Zinc and Taurine has demonstrated
anti inflammatory action, protection and repairing the vaginal mucosa,
preventing local ulcers. Both substances has antimicrobial activity, and
they show a synergic action to get a significant reduction of microorganisms.
CLINICALS
GINOXIL WASH & GINOXIL GEL, starting October 2012
Purpose of the trial : evaluation of the efficacy of topical Zinc gluconate and
Taurine based products on vulvo-vaginal inflammation
Participants : 30 subjects, between 18 and 70 years
Methods: 10 subjects treated with Ginoxil gel for 10 days
20 subjects treated with Ginoxil gel for 10 days & Ginoxil wash every other day
Primary endpoint: evaluation of itch, dryness, pain and leuchorrea
Secondary endpoint: evaluation of the tolerability and acceptance of the products