Italian contribution to research Publications in international scientific reviews – Monitoring period: from October 7th to December 22nd 2010 – The monitoring of international scientific reviews is a new initiative of the National Interest Project: the objective is to highlight Italian contributions to scientific research worldwide. The monitoring includes publications by Italian researchers or by teams mainly composed of Italians. Nature • Nature Neuroscience Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP 7th November 2010 By Michela Di Salvio (CEINGE Biotecnologie Avanzate, Naples, Italy), Luca Giovanni Di Giovannantonio (CEINGE Biotecnologie Avanzate, Naples, Italy), Dario Acampora (CEINGE Biotecnologie Avanzate, Naples, Italy, SEMM European School of Molecular Medicine, Naples site, Naples, Italy, Institute of Genetics and Biophysics “A. Buzzati-Traverso,” CNR, Naples, Italy), Raffaele Prosperi (Dipartimento di Matematica e Statistica, Università degli Studi del Sannio, Benevento, Italy), Daniela Omodei (CEINGE Biotecnologie Avanzate, Naples, Italy), Nilima Prakash, Wolfgang Wurst and Antonio Simeone (CEINGE Biotecnologie Avanzate, Naples, Italy, SEMM European School of Molecular Medicine, Naples site, Naples, Italy, Institute of Genetics and Biophysics “A. BuzzatiTraverso,” CNR, Naples, Italy). The entire article and the abstract can be found at: http://www.nature.com/neuro/journal/v13/n12/full/nn.2661.html Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease 12th December 2010 By Marcello D'Amelio (Dulbecco Telethon Institute at the Laboratory of Molecular Neuroembryology, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy, Laboratory of Molecular Neuroscience, University Campus-Biomedico, Rome, Italy), Virve Cavallucci (Dulbecco Telethon Institute at the Laboratory of Molecular Neuroembryology, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy), Silvia Middei (Consiglio Nazionale delle Ricerche (CNR) Institute of Neuroscience, IRCCS Fondazione Santa Lucia, Rome, Italy.), Cristina Marchetti (Laboratory of Molecular Mechanisms of Synaptic Plasticity, European Brain Research Institute, Rome, Italy), Simone Pacioni (Laboratory of Cellular Physiology of Cortical Microcircuits, European Brain Research Institute, Rome, Italy), Alberto Ferri (CNR Institute of Neuroscience, Department of Psychobiology and Psychopharmacology, Rome, Italy), Adamo Diamantini (Laboratory of Neuroimmunology, IRCCS Fondazione Santa Lucia, Rome, Italy), Daniela De Zio (Department of Biology, University of Rome 'Tor Vergata', Rome, Italy), Paolo Carrara (Department of Biology-Interdepartmental Laboratory of Electron Microscopy (LIME), University Roma Tre, Rome, Italy), Luca Battistini (Laboratory of Neuroimmunology, IRCCS Fondazione Santa Lucia, Rome, Italy), Sandra Moreno (Department of Biology-Interdepartmental Laboratory of Electron Microscopy (LIME), University Roma Tre, Rome, Italy), Alberto Bacci (Laboratory of Cellular Physiology of Cortical Microcircuits, European Brain Research Institute, Rome, Italy), Martine Ammassari-Teule, Hélène Marie and Francesco Cecconi (Dulbecco Telethon Institute at the Laboratory of Molecular Neuroembryology, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy, Department of Biology, University of Rome 'Tor Vergata', Rome, Italy) The entire article and the abstract can be found at: http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.2709.html • Oncogene Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors 8th November 2010 By P. Pittoni (Molecular Immunology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy), S. Piconese (Molecular Immunology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy), C. Tripodo (Molecular Immunology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy) and M. P. Colombo (Molecular Immunology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2010494a.html Liprin-α1 regulates breast cancer cell invasion by affecting cell motility, invadopodia and extracellular matrix degradation 13th December 2010 By V. Astro (Cell Adhesion Unit, Division of Neurosciences, San Raffaele Scientific Institute and San Raffaele University, Milano, Italy), C. Asperti (Cell Adhesion Unit, Division of Neurosciences, San Raffaele Scientific Institute and San Raffaele University, Milano, Italy), G. Cangi (Cell Adhesion Unit, Division of Neurosciences, San Raffaele Scientific Institute and San Raffaele University, Milano, Italy), C. Doglioni (Cell Adhesion Unit, Division of Neurosciences, San Raffaele Scientific Institute and San Raffaele University, Milano, Italy) and I. de Curtis (Cell Adhesion Unit, Division of Neurosciences, San Raffaele Scientific Institute and San Raffaele University, Milano, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2010562a.html • British Journal of Cancer An immunohistochemically positive E-cadherin status is not always predictive for a good prognosis in human breast cancer 9th November 2010 By P. Querzoli (Section of Anatomic Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, 44100 Ferrara, Italy), D. Coradini (Biostatistics for Bioinformatics and Clinical Translational Research, Institute of Medical Statistics and Biometry, University of Milano, 20133 Milano, Italy), M. Pedriali (Section of Anatomic Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, 44100 Ferrara, Italy), P. Boracchi (Biostatistics for Bioinformatics and Clinical Translational Research, Institute of Medical Statistics and Biometry, University of Milano, 20133 Milano, Italy), F. Ambrogi (Biostatistics for Bioinformatics and Clinical Translational Research, Institute of Medical Statistics and Biometry, University of Milano, 20133 Milano, Italy), E. Raimondi (Biostatistics for Bioinformatics and Clinical Translational Research, Institute of Medical Statistics and Biometry, University of Milano, 20133 Milano, Italy), R. La Sorda (Unit of Cancer Pathology, Department of Oncology and Neurosciences and CeSI, Fondazione ‘G. D' Annunzio’, University of Chieti, 66100 Chieti, Italy), R. Lattanzio (Unit of Cancer Pathology, Department of Oncology and Neurosciences and CeSI, Fondazione ‘G. D' Annunzio’, University of Chieti, 66100 Chieti, Italy), R. Rinaldi (Section of Anatomic Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, 44100 Ferrara, Italy), M. Lunardi (Section of Anatomic Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, 44100 Ferrara, Italy), C. Frasson (Section of Anatomic Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, 44100 Ferrara, Italy), F. Modesti (Section of Anatomic Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, 44100 Ferrara, Italy), S. Ferretti (Section of Anatomic Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, 44100 Ferrara, Italy), M. Piantelli (Unit of Cancer Pathology, Department of Oncology and Neurosciences and CeSI, Fondazione ‘G. D' Annunzio’, University of Chieti, 66100 Chieti, Italy), S. Iacobelli (Unit of Medical Oncology, Department of Oncology and Neurosciences and CeSI, Fondazione ‘G. D' Annunzio’, University of Chieti, 66100 Chieti, Italy), E. Biganzoli (Biostatistics for Bioinformatics and Clinical Translational Research, Institute of Medical Statistics and Biometry, University of Milano, 20133 Milano, Italy, Fondazione IRCCS, Istituto Nazionale tumori, 20133 Milano, Italy), I. Nenci (Section of Anatomic Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, 44100 Ferrara, Italy) and S. Alberti (Unit of Cancer Pathology, Department of Oncology and Neurosciences and CeSI, Fondazione ‘G. D' Annunzio’, University of Chieti, 66100 Chieti, Italy, Department of Basic and Applied Medical Sciences, University of Chieti, 66100 Chieti, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/bjc/journal/v103/n12/full/6605991a.html • Nature Reviews Urology Uterus preservation in pelvic organ prolapse surgery 9th November 2010 By Alessandro Zucchi (Department of Urology and Andrology of the University of Perugia, Italy), Massimo Lazzeri (Department of Urology and Andrology of the University of Perugia, Italy), Massimo Porena (Department of Urology and Andrology of the University of Perugia, Italy), Luigi Mearini (Department of Urology and Andrology of the University of Perugia, Italy) and Elisabetta Costantini (Chief of the Urogynaecological Section and Day Surgery, Department of Urology and Andrology of the University of Perugia, Italy). The entire article and the abstract can be found at: http://www.nature.com/nrurol/journal/v7/n11/full/nrurol.2010.164.html • Nature Reviews Neurology Epilepsy: Risk of suicidal behavior with antiepileptic drugs December 2010 By Maurizio Pompili (Department of Neuroscience, Mental Health and Sensory Functions, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035, Rome, Italy) and Ross J. Baldessarini (Department of Neuroscience, Mental Health and Sensory Functions, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035, Rome, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/nrneurol/journal/v6/n12/full/nrneurol.2010.165.html • Leukemia Multiple forms of PKR present in the nuclei of acute leukemia cells represent an active kinase that is responsive to stress 12th November 2010 By W.L. Blalock, A. Bavelloni (Cell Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy), M. Piazzi (Cell Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy), F. Tagliavini (Cell Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy), I. Faenza (Cell Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy), A.M. Martelli (Cell Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy), M.Y. Follo (Cell Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy) and L. Cocco (Cell Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/leu/journal/vaop/ncurrent/full/leu2010264a.html HOXB7 expression by myeloma cells regulates their pro-angiogenic properties in multiple myeloma patients 23rd November 2010 By P. Storti (Chair of Hematology and BMT Center, University of Parma, Parma, Italy), G. Donofrio (Sezione Malattie Infettive, Dipartimento di Salute Animale’, University of Parma, Parma, Italy), S. Colla (Chair of Hematology and BMT Center, University of Parma, Parma, Italy), I. Airoldi (AIRC Laboratory of Immunology and Tumors, G. Gaslini Institute, Genova, Italy), M. Bolzoni (Chair of Hematology and BMT Center, University of Parma, Parma, Italy), L. Agnelli (Department of Medical Sciences University of Milan, Hematology 1, Fondazione IRCCS Ca' Granda Ospedale Maggiore, Policlinico, Milano, Italy), M. Abeltino (Chair of Hematology and BMT Center, University of Parma, Parma, Italy), K. Todoerti (Department of Medical Sciences University of Milan, Hematology 1, Fondazione IRCCS Ca' Granda Ospedale Maggiore, Policlinico, Milano, Italy), M. Lazzaretti (Dip. Genetica, Biologia dei Microrganismi, Antropologia, Evoluzione’, University of Parma, Parma, Italy), C. Mancini (Pathology, ‘Azienda Ospedaliero-Universitaria di Parma’, Parma, Italy), D. Ribatti (Department of Human Anatomy, University of Bari, Italy), S. Bonomini (Chair of Hematology and BMT Center, University of Parma, Parma, Italy), V. Franceschi (Sezione Malattie Infettive, Dipartimento di Salute Animale’, University of Parma, Parma, Italy), V. Pistoia (Department of Experimental and Laboratory Medicine, G. Gaslini Institute, Genova, Italy), G. Lisignoli (Laboratorio di Immunologia e Genetica, Istituti Ortopedici Rizzoli, Bologna, Italy), A. Pedrazzini (U.O. ‘Patologia dell’Apparato Locomotore’, ‘Azienda Ospedaliero-Universitaria di Parma’, Parma, Italy), O. Cavicchi (ENT Department, S. Orsola-Malpighi Hospital, Bologna University, Bologna, Italy), A. Neri (Department of Medical Sciences University of Milan, Hematology 1, Fondazione IRCCS Ca' Granda Ospedale Maggiore, Policlinico, Milano, Italy), V. Rizzoli (Chair of Hematology and BMT Center, University of Parma, Parma, Italy) and N. Giuliani (Chair of Hematology and BMT Center, University of Parma, Parma, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/leu/journal/vaop/ncurrent/abs/leu2010270a.html Synergistic induction of PI-PLCβ1 signaling by azacitidine and valproic acid in highrisk myelodysplastic syndromes 26th November 2010 By M.Y. Follo (Department of Human Anatomical Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy), C. Finelli (Department of Human Anatomical Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy), S. Mongiorgi (Department of Human Anatomical Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy), C. Clissa (Department of Human Anatomical Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy), F. Chiarini (Department of Human Anatomical Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy), G. Ramazzotti (Department of Human Anatomical Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy), S. Paolini (Department of Human Anatomical Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy), G. Martinelli (Department of Human Anatomical Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy), A.M. Martelli (Department of Human Anatomical Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy) and L. Cocco (Department of Human Anatomical Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/leu/journal/vaop/ncurrent/full/leu2010266a.html • Nature structural & molecular biology Structural characterization of a misfolded intermediate populated during the folding process of a PDZ domain 14th November 2010 By Stefano Gianni (Istituto Pasteur–Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Università di Roma 'La Sapienza', Rome, Italy), Ylva Ivarsson, Alfonso De Simone (Department of Chemistry, University of Cambridge, Cambridge, UK), Carlo Travaglini-Allocatelli (Istituto Pasteur–Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Università di Roma 'La Sapienza', Rome, Italy), Maurizio Brunori (Istituto Pasteur– Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Università di Roma 'La Sapienza', Rome, Italy) and Michele Vendruscolo (Department of Chemistry, University of Cambridge, Cambridge, UK). The entire article (fee required) and the abstract can be found at: http://www.nature.com/nsmb/journal/v17/n12/full/nsmb.1956.html • Nature Photonics High-energy isolated attosecond pulses generated by above-saturation few-cycle fields 14th November 2010 By F. Ferrari (Politecnico di Milano, Department of Physics, Istituto di Fotonica e Nanotecnologie, CNR– IFN, Piazza L. da Vinci 32, 20133 Milano, Italy), F. Calegari (Politecnico di Milano, Department of Physics, Istituto di Fotonica e Nanotecnologie, CNR–IFN, Piazza L. da Vinci 32, 20133 Milano, Italy), M. Lucchini (Politecnico di Milano, Department of Physics, Istituto di Fotonica e Nanotecnologie, CNR– IFN, Piazza L. da Vinci 32, 20133 Milano, Italy), C. Vozzi (Politecnico di Milano, Department of Physics, Istituto di Fotonica e Nanotecnologie, CNR–IFN, Piazza L. da Vinci 32, 20133 Milano, Italy), S. Stagira (Politecnico di Milano, Department of Physics, Istituto di Fotonica e Nanotecnologie, CNR–IFN, Piazza L. da Vinci 32, 20133 Milano, Italy), G. Sansone (Politecnico di Milano, Department of Physics, Istituto di Fotonica e Nanotecnologie, CNR–IFN, Piazza L. da Vinci 32, 20133 Milano, Italy) and M. Nisoli (Politecnico di Milano, Department of Physics, Istituto di Fotonica e Nanotecnologie, CNR–IFN, Piazza L. da Vinci 32, 20133 Milano, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/nphoton/journal/v4/n12/full/nphoton.2010.250.html Scale-free optics and diffractionless waves in nanodisordered ferroelectrics 19th December 2010 By E. DelRe (Dipartimento di Ingegneria Elettrica e dell'Informazione, Universita' dell'Aquila, 67100 L'Aquila, Italy), E. Spinozzi (Dipartimento di Ingegneria Elettrica e dell'Informazione, Universita' dell'Aquila, 67100 L'Aquila, Italy), A. J. Agranat and C. Conti (Institute for Complex Systems (ISC-CNR), Dep. Physics University Sapienza, Piazzale Aldo Moro 2, 00185 Rome, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/nphoton/journal/v5/n1/full/nphoton.2010.285.html • Immunology and Cell Bology A multimeric immunogen for the induction of immune memory to beta-amyloid 23rd November 2010 By Francesca Mantile (Istituto di Genetica e Biofisica ABT, CNR, Naples, Italy), Carla Basile (Istituto di Genetica e Biofisica ABT, CNR, Naples, Italy), Valeria Cicatiello (Istituto di Genetica e Biofisica ABT, CNR, Naples, Italy), Diana De Falco (Istituto di Genetica e Biofisica ABT, CNR, Naples, Italy), Antonella Caivano (Istituto di Genetica e Biofisica ABT, CNR, Naples, Italy), Piergiuseppe De Berardinis (Istituto di Genetica e Biofisica ABT, CNR, Naples, Italy) and Antonella Prisco (Istituto di Genetica e Biofisica ABT, CNR, Naples, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/icb/journal/vaop/ncurrent/full/icb2010134a.html Stimulation of TLRs by LMW-HA induces self-defense mechanisms in vaginal epithelium 23rd November 2010 By Giuseppina F. Dusio (iMIL, italian Mucosal Immunity Laboratory, Dipartimento di Morfologia Umana e Scienze Biomediche 'Città Studi', Università degli Studi di Milano, Milano, Italy), Diego Cardani (iMIL, italian Mucosal Immunity Laboratory, Dipartimento di Morfologia Umana e Scienze Biomediche 'Città Studi', Università degli Studi di Milano, Milano, Italy), Laura Zanobbio (iMIL, italian Mucosal Immunity Laboratory, Dipartimento di Morfologia Umana e Scienze Biomediche 'Città Studi', Università degli Studi di Milano, Milano, Italy), Martina Mantovani (iMIL, italian Mucosal Immunity Laboratory, Dipartimento di Morfologia Umana e Scienze Biomediche 'Città Studi', Università degli Studi di Milano, Milano, Italy), Patrizia Luchini (iMIL, italian Mucosal Immunity Laboratory, Dipartimento di Morfologia Umana e Scienze Biomediche 'Città Studi', Università degli Studi di Milano, Milano, Italy), Lorenzo Battini (iMIL, italian Mucosal Immunity Laboratory, Dipartimento di Morfologia Umana e Scienze Biomediche 'Città Studi', Università degli Studi di Milano, Milano, Italy), Valentina Galli (iMIL, italian Mucosal Immunity Laboratory, Dipartimento di Morfologia Umana e Scienze Biomediche 'Città Studi', Università degli Studi di Milano, Milano, Italy), Angela Diana (iMIL, italian Mucosal Immunity Laboratory, Dipartimento di Morfologia Umana e Scienze Biomediche 'Città Studi', Università degli Studi di Milano, Milano, Italy), Andrea Balsari (iMIL, italian Mucosal Immunity Laboratory, Dipartimento di Morfologia Umana e Scienze Biomediche 'Città Studi', Università degli Studi di Milano, Milano, Italy) and Cristiano Rumio (iMIL, italian Mucosal Immunity Laboratory, Dipartimento di Morfologia Umana e Scienze Biomediche 'Città Studi', Università degli Studi di Milano, Milano, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/icb/journal/vaop/ncurrent/full/icb2010134a.html • European Journal of Human Genetics Family-based association study of ITGB3 in autism spectrum disorder and its endophenotypes 24th November 2010 By Valerio Napoleoni (Laboratory of Molecular Psychiatry and Neurogenetics, University 'Campus BioMedico', Rome, Italy, Laboratory of Molecular Psychiatry and Psychiatric Genetics, Department of Experimental Neurosciences, IRCCS 'Fondazione Santa Lucia', Rome, Italy), Federica Lombardi (Laboratory of Molecular Psychiatry and Neurogenetics, University 'Campus Bio-Medico', Rome, Italy, Laboratory of Molecular Psychiatry and Psychiatric Genetics, Department of Experimental Neurosciences, IRCCS 'Fondazione Santa Lucia', Rome, Italy), Roberto Sacco (Laboratory of Molecular Psychiatry and Neurogenetics, University 'Campus Bio-Medico', Rome, Italy, Laboratory of Molecular Psychiatry and Psychiatric Genetics, Department of Experimental Neurosciences, IRCCS 'Fondazione Santa Lucia', Rome, Italy), Paolo Curatolo (Laboratory of Molecular Psychiatry and Neurogenetics, University 'Campus Bio-Medico', Rome, Italy, Laboratory of Molecular Psychiatry and Psychiatric Genetics, Department of Experimental Neurosciences, IRCCS 'Fondazione Santa Lucia', Rome, Italy), Barbara Manzi (Laboratory of Molecular Psychiatry and Neurogenetics, University 'Campus BioMedico', Rome, Italy, Laboratory of Molecular Psychiatry and Psychiatric Genetics, Department of Experimental Neurosciences, IRCCS 'Fondazione Santa Lucia', Rome, Italy), Riccardo Alessandrelli (Laboratory of Molecular Psychiatry and Neurogenetics, University 'Campus Bio-Medico', Rome, Italy, Laboratory of Molecular Psychiatry and Psychiatric Genetics, Department of Experimental Neurosciences, IRCCS 'Fondazione Santa Lucia', Rome, Italy), Roberto Militerni (Laboratory of Molecular Psychiatry and Neurogenetics, University 'Campus Bio-Medico', Rome, Italy, Laboratory of Molecular Psychiatry and Psychiatric Genetics, Department of Experimental Neurosciences, IRCCS 'Fondazione Santa Lucia', Rome, Italy), Carmela Bravaccio (Laboratory of Molecular Psychiatry and Neurogenetics, University 'Campus Bio-Medico', Rome, Italy, Laboratory of Molecular Psychiatry and Psychiatric Genetics, Department of Experimental Neurosciences, IRCCS 'Fondazione Santa Lucia', Rome, Italy), Carlo Lenti (Laboratory of Molecular Psychiatry and Neurogenetics, University 'Campus Bio-Medico', Rome, Italy, Laboratory of Molecular Psychiatry and Psychiatric Genetics, Department of Experimental Neurosciences, IRCCS 'Fondazione Santa Lucia', Rome, Italy), Monica Saccani (Laboratory of Molecular Psychiatry and Neurogenetics, University 'Campus Bio-Medico', Rome, Italy, Laboratory of Molecular Psychiatry and Psychiatric Genetics, Department of Experimental Neurosciences, IRCCS 'Fondazione Santa Lucia', Rome, Italy), Cindy Schneider, Raun Melmed, Tiziana Pascucci (Laboratory of Molecular Psychiatry and Neurogenetics, University 'Campus Bio-Medico', Rome, Italy, Laboratory of Molecular Psychiatry and Psychiatric Genetics, Department of Experimental Neurosciences, IRCCS 'Fondazione Santa Lucia', Rome, Italy), Stefano Puglisi-Allegra (Laboratory of Molecular Psychiatry and Neurogenetics, University 'Campus Bio-Medico', Rome, Italy, Laboratory of Molecular Psychiatry and Psychiatric Genetics, Department of Experimental Neurosciences, IRCCS 'Fondazione Santa Lucia', Rome, Italy), Karl-Ludvig Reichelt, Francis Rousseau, Patricia Lewin and Antonio M. Persico (Laboratory of Molecular Psychiatry and Neurogenetics, University 'Campus Bio-Medico', Rome, Italy, Laboratory of Molecular Psychiatry and Psychiatric Genetics, Department of Experimental Neurosciences, IRCCS 'Fondazione Santa Lucia', Rome, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/ejhg/journal/vaop/ncurrent/full/ejhg2010180a.html • The Journal of Antibiotics The genus Actinoallomurus and some of its metabolites 1st December 2010 By Roberta Pozzi (KtedoGen Srl, Milano, Italy, NAICONS Scrl, Milano, Italy), Matteo Simone (KtedoGen Srl, Milano, Italy, NAICONS Scrl, Milano, Italy), Carlo Mazzetti (KtedoGen Srl, Milano, Italy, NAICONS Scrl, Milano, Italy), Sonia Maffioli (KtedoGen Srl, Milano, Italy, NAICONS Scrl, Milano, Italy), Paolo Monciardini (KtedoGen Srl, Milano, Italy, NAICONS Scrl, Milano, Italy), Linda Cavaletti (KtedoGen Srl, Milano, Italy, NAICONS Scrl, Milano, Italy), Ruggiero Bamonte (KtedoGen Srl, Milano, Italy, NAICONS Scrl, Milano, Italy), Margherita Sosio (KtedoGen Srl, Milano, Italy, NAICONS Scrl, Milano, Italy) and Stefano Donadio (KtedoGen Srl, Milano, Italy, NAICONS Scrl, Milano, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/ja/journal/vaop/ncurrent/full/ja2010149a.html • American Journal of Hypertension Diagnosis and Management of Left Ventricular Diastolic Dysfunction in the Hypertensive Patient December 2010 By Maurizio Galderisi (Cardioangiology Unit with CCU, Department of Clinical and Experimental Medicine, Federico II University Hospital, Naples, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/ajh/journal/vaop/ncurrent/full/ajh2010235a.html • Heredity Effects of human perturbation on the genetic make-up of an island population: the case of the Sardinian wild boar 22nd December 2010 By M Scandura (Dipartimento di Zoologia e Genetica Evoluzionistica, Università di Sassari, via Muroni 25, 07100 Sassari, Italy), L Iacolina (Dipartimento di Zoologia e Genetica Evoluzionistica, Università di Sassari, via Muroni 25, 07100 Sassari, Italy), A Cossu (Dipartimento di Zoologia e Genetica Evoluzionistica, Università di Sassari, via Muroni 25, 07100 Sassari, Italy) and M Apollonio (Dipartimento di Zoologia e Genetica Evoluzionistica, Università di Sassari, via Muroni 25, 07100 Sassari, Italy). The entire article (fee required) and the abstract can be found at: http://www.nature.com/hdy/journal/vaop/ncurrent/full/hdy2010155a.html The Lancet • The Lancet Treatment of older patients with acute myeloid leukaemia 4th December 2010 By F. Ferrara (Division of Haematology and Stem Cell Transplantation Unit, Cardarelli Hospital, 80128 Naples). The entire article (fee required) and the abstract can be found at: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)62104-6/fulltext Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study 10th December 2010 By M. Cavo , P. Tacchetti, L. Pantani, E. Zamagni (Istituto di Ematologia Seràgnoli, Università degli Studi di Bologna, Bologna, Italy), F. Patriarca, M. T. Petrucci (Cattedra di Ematologia, Università La Sapienza, Rome, Italy), M. Galli (Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy), F. Di Raimondo (Cattedra di Ematologia, Ospedale Ferrarotto, Catania, Italy), C. Crippa (Divisione di Ematologia, Spedali Civili, Brescia, Italy), A. Palumbo (Dipartimento di Ematologia, Azienda Ospedaliero-Universitaria San Giovanni Battista, Ospedale Molinette, Turin, Italy), M. Offidani, P. Corradini (Clinica di Ematologia, Ospedale Nuovo Torrette, Ancona, Italy), F. Narni (Clinica di Ematologia, Ospedale Nuovo Torrette, Ancona, Italy), A. Spadano (Divisione di Ematologia, Ospedale Civile dello Spirito Santo, Pescara, Italy), N. Pescosta (Divisione di Ematologia e Centro Trapianto Midollo Osseo, Ospedale Generale Regionale, Bolzano, Italy), G. Lambertenghi Deliliers (Unità Operativa di Ematologia 1, Centro Trapianti di Midollo Osseo, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore, Milan, Italy), A. Ledda (Ematologia e Centro Trapianti Midollo Osseo, Ospedale Binaghi, Cagliari, Italy), C. Cellini (Unità Operativa di Ematologia, Ospedale Santa Maria delle Croci, Ravenna, Italy), T. Caravita (Unità Operativa di Ematologia, Ospedale Santa Maria delle Croci, Ravenna, Italy), P. Tosi (Divisione di Ematologia, Ospedale Civile Infermi, Rimini, Italy), M. Baccarani (Dipartimento di Ematologia e Scienze Oncologiche Seràgnoli, Università degli Studi di Bologna, Bologna, Italy; Clinica Ematologica, Policlinico Universitario, Udine, Italy) The entire article (fee required) and the abstract can be found at: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)61424-9/fulltext Tired legs—a gut diagnosis 20th November 2010 By V. Di Lazzaro, F. Pilato, A. P. Batocchi, D. Restuccia, P. Profice (Department of Neurosciences, Università Cattolica, Rome, Italy), G. Cammarota (Department of Neurosciences, Università Cattolica, Rome, Italy). The entire article (fee required) and the abstract can be found at: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)61163-4/fulltext