Family name: Di Bari
First name:
Maria
PRESENT POSITION
Post-doc at the Department of Biology and Biotecnologies, University of Rome “Relazione tra
alterazione del sistema colinergico e infiammazione: studi in topi EAE e in pazienti in fase
Recidivante Remittente”
KEY QUALIFICATIONS
PhD in Cell and Development Biology, University “La Sapienza”, Rome, Italy.
EDUCATION
Master’s degree in Human Health (nutritionist address), University of Bari Aldo Moro (Bari)
graduated with honor. (29/04/10) Thesis in Biochemistry and Molecular Biology: “Apo(a) ricombinante agisce sulla risposta infiammatoria di cellule del SNC. Neutralizzazione del lipopolisaccaride mediante interferenza con componenti del siero e cellulari del suo signaling”.
B.Sc. in Human Health, University of Bari Aldo Moro (Bari) graduated with honor. Thesis in
Biochemistry and Molecular Biology: “r‐apo(a) inibisce la risposta infiammatoria indotta da LPS in astrociti umani” (2007)
General certificate of Education, Scientific studies High School "Ettore Majorana", Mola di Bari
(BA), mark: 100/100. (2004)
PROFESSIONAL EXPERIENCE Temporary employment at the Department of Biochemistry
and Molecular Biology, University of Bari, Aldo Moro
Ricerca bibliografica e bioinformatica volta all’individuazione dei domini strutturali dell’apolipoproteina(a) apo(a) coinvolti nella interazione con molecole del signaling di LPS e nella identificazione delle regioni di sCD14 e MD2 capaci di interagire con apolipoproteina(a). Post-graduate Internship at the Laboratory of Cellular and Molecular Biology-University of Bari
LANGUAGE SKILLS English
PARTICIPATION TO CONGRESS AND WORKSHOPS:
• Alessandrini F, Di Bari M., Zasso J., Conti L and Tata A.M. “M2 muscarinic receptor
activation impairs cell proliferation in human glioblastoma cancer stem cells” Rome SINS
4-6 October 2013
• M. Di Bari , V.Tombolillo, F.Alessandrini, C.Conte, F De Grassi, R. Ricordy, A.M.Tata
“Cytostatic and cytotoxic effects induced by M2 muscarinic receptor activation on human
glioblastoma cells.” XI European Meeting on Glial Cells in Health and Disease (Glia
2013). Berlin, Germany, July 3-6 2013
• Di Bari M, Talora C, Ponti D, Calogero A, and Tata AM “Cross interaction between M2
muscarinic receptor and Notch-1/Egfr in human glioblastoma cells” 54° Annual Meeting
of the Cancer Society, Bologna 1-4 October 2012 • M. Di Bari, C. Conte, V. Tombolillo, F. Alessandrini, F. Degrassi, R. Ricordy and A.M.
Tata “Cytotoxic/genotoxic effects of M2 agonist arecaidine on human glioblastoma cell
lines” 12th congress FISV, Rome, 24-27 September 2012
• M. Di Bari, C. Conte, M. Ferretti, R. Ricordy, M.Sciaccaluga, E. Castigli, C. Talora, A.
Calogero, A.M.Tata. “Cross Talk Between Notch-1/EGFR and M2 receptor pathways in
human glioblastoma cells: effects on cell proliferation and apoptosis”. 6th Meeting on
Molecular Mechanisms in Neuroscience Rome 3-4 October 2011.
• AM. Tata, C. Conte, R. Ricordy, M. Di Bari, M. Ferretti, G. Centofante, C. Fabbiano, D.
Ponte, M. Sciaccaluga, E. Castigli, C. Talora, A. Calogero. “M2 acetylcholine receptor
activation shows anti-proliferative and pro-apoptotic effects in human glioblastoma cells: a
new therapeutic perspective”. Third International Symposium on Non-neuronal
Acetylcholine. University of Groningen, Groningen, The Netherland, 24-26 August 2011.
• Mezzapesa, G. Chimienti, M. Di Bari, G. Pepe. “A new proposed role for apo(a) as LPS
neutralizing molecule in CNS cells”. 6th Seminar FRONTIERS IN MOLECULAR
BIOLOGY SIBBM Padua, 3-5 June 2010
• La terapia dei tumori e metastasi cerebrali: dalla ricerca di base alla pratica clinica
Associazione Italiana di Colture Cellulari, II Università di Napoli; Napoli 27-28 settembre
2011
• RNA day Roma 12-13 settembre 2013
POSTERS AND PRESENTATIONS
1. Alessandrini F, Di Bari M., Zasso J., Conti L and Tata A.M. “M2 muscarinic receptor
activation impairs cell proliferation in human glioblastoma cancer stem cells” Rome SINS
4-6 October 2013
2. M. Di Bari , V.Tombolillo, F.Alessandrini, C.Conte, F De Grassi, R. Ricordy, A.M.Tata
“Cytostatic and cytotoxic effects induced by M2 muscarinic receptor activation on human
glioblastoma cells.” XI European Meeting on Glial Cells in Health and Disease (Glia 2013).
Berlin, Germany, July 3-6 2013
3. Di Bari M, Talora C, Ponti D, Calogero A, and Tata AM “Cross interaction between M2
muscarinic receptor and Notch-1/Egfr in human glioblastoma cells” 54° Annual Meeting
of the Cancer Society, Bologna 1-4 October 2012 4. M. Di Bari, C. Conte, V. Tombolillo, F. Alessandrini, F. Degrassi, R. Ricordy and A.M.
Tata “Cytotoxic/genotoxic effects of M2 agonist arecaidine on human glioblastoma cell
lines” 12th congress FISV, Rome, 24-27 September 2012
5. M. Di Bari, C. Conte, M. Ferretti, R. Ricordy, M.Sciaccaluga, E. Castigli, C. Talora, A.
Calogero, A.M.Tata. “Cross Talk Between Notch-1/EGFR and M2 receptor pathways in
human glioblastoma cells: effects on cell proliferation and apoptosis”. 6th Meeting on
Molecular Mechanisms in Neuroscience Rome 3-4 October 2011.
6. AM. Tata, C. Conte, R. Ricordy, M. Di Bari, M. Ferretti, G. Centofante, C. Fabbiano, D.
Ponte, M. Sciaccaluga, E. Castigli, C. Talora, A. Calogero. “M2 acetylcholine receptor
activation shows anti-proliferative and pro-apoptotic effects in human glioblastoma cells: a
new therapeutic perspective”. Third International Symposium on Non-neuronal
Acetylcholine. University of Groningen, Groningen, The Netherland, 24-26 August 2011.
7. A. Mezzapesa, G. Chimienti, M. Di Bari, G. Pepe. “A new proposed role for apo(a) as LPS
neutralizing molecule in CNS cells”. 6th Seminar FRONTIERS IN MOLECULAR
BIOLOGY SIBBM Padua, 3-5 June 2010
8. M. Di Bari , V.Tombolillo, F.Alessandrini, C.Conte, F De Grassi, R. Ricordy, A.M.Tata
“Cytostatic and cytotoxic effects induced by M2 muscarinic receptor activation on human
glioblastoma cells.” GLIA 2013 Volume 61, Number S1, pag.214 July 2013 DOI:
10.1002/glia.22530
PUBLICATIONS ISI
M. Ferretti, C. Fabbiano, M. Di Bari, D. Ponti, A. Calogero, A. M. Tata M2 muscarinic receptor
inhibits cell proliferation in human glioblastoma cell lines.
Life Sciences (2012) 91:1134–37.
Ferretti M, Fabbiano C, Di Bari M, Conte C, Castigli E, Ponti D, Ruggeri P, Sciaccaluga M,
Ricordy R, Calogero A and Tata AM M2 receptor activation inhibits cell cycle progression and
survival in human glioblastoma cells
Journal of Cellular and Molecular Medicine (2013) 17: 552-66
TECHNICAL REPORTS Excellent knowledge of biochemical techniques and biomolecular:
preparation of human cell cultures, chromatographic purification techniques; purification and assay
of nucleic acids and proteins from cells and tissues; PCR; RT-PCR; real-time PCR; restriction
analysis; gene silencing; gel electrophoresis , Western blotting, densitometric analysis, statistical
analysis.
Computer programs: Word, Excel, Powerpoint, Photoshop, PUBMED, BLAST.
SUBMITTED & IN PREPARATION
Luca Pacini , Elena De Falco, Cinzia Fabbiano, Andrea Coccia, Camilla Siciliano, Donatella
Ponti, Maria Di Bari, Antonio Luigi Pastore, Vincenzo Petrozza, Antonio Carbone , Ada Maria
Tata and Antonella Calogero M2 muscarinic receptors inhibit cell proliferation and migration
in urothelial bladder cancer cells (submitted to Cancer Biology and Therapy) (2014)
Di Bari M, Tombolillo V, Conte C, Castigli E, Iorio E, Carpinelli G, Ricordy R, Fiore M, Degrassi
F and Tata AM (2014). Cytotoxic and genotoxic effects induced by M2 receptor activation in
human gliolastoma cells (manuscript submitted).