Curriculum vitae
PERSONAL INFORMATION
Carolina Scagnolari
WORK EXPERIENCE
November 2001–November 2005
Phd Student
SAPIENZA University of Rome, (Italy)
Research activities in basic and clinical virology
November 2001–December 2001
Visiting reserach scientist
Retrovirus Centre and Virology Section, Department of Experimental Pathology, University of Pisa,
(Italy)
Research activities in Real Time PCR assay (HIV)
May 2003–September 2003
Visiting reserach scientist
Viral Pathogens and Biosafety Unit, Vita-Salute San Raffaele University, School of Medicine, (Italy)
Research activities in respiratory viral infection (Sars coronavirus)
January 2010–December 2010
Postdoctoral Fellow
ANLAIDS ONLUS -Associazione Nazionale per la Lotta contro l'AIDS, (Italy)
Research activities in respiratory viruses, HIV and HCV infections
January 2005–December 2005
Postdoctoral Fellow
ANLAIDS ONLUS -Associazione Nazionale per la Lotta contro l'AIDS, (Italy)
Research activities in respiratory viruses, HIV and HCV infections
May 2005–June 2005
Visiting reserach scientist
Joan and Sanford I. Weill Medical College, Cornell University, New York City, (United States)
Research activities in emerging infectious diseases
January 2007–December 2007
Postdoctoral Fellow
Policlinico Universitario Agostino Gemelli-Università Cattolica del Sacro Cuore), (Italy)
Research activities in clinical virology
January 2009–October 2009
Postdoctoral Fellow
SAPIENZA University of Rome, (Italy)
Research activities in clinical virology
January 2011–Present
Vice-chairman of the Bachelor in Nursing- Sapienza University of Rome , Region
Molise-Pentria/Isernia
SAPIENZA University of Rome, (Italy)
November 2010–Present
Assistant Professor of Virology
SAPIENZA University of Rome, (Italy)
Main activities and responsibilities:
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Curriculum vitae
Carolina Scagnolari
Head of numerous research projects in basic virology and clinical virology.
Member of Editorial Board of Open Journal of Medical Microbiology from 2011 until now
Head of the Research Unit: Antiviral Innate Immunity (Department of Molecular Medicine-Sapienza
University of Rome (http://dmm.uniroma1.it/node/5581/laboratori/laboratorio-di-virologia/immunitinnata-antivirale)
Member of Advisory Board of Archives of Virology from 2012 until now
Reviewer for the following journals: Journal of interferon and citokines research; Journal of BMC
infectious diseases; Journal of Clinical Microbiology and Infection; New Microbiologica; Plos one.
Professor of Virology (integrated course of Microbiology) (SSD: MED/07), Degree in Medicine and
Surgery, Faculty of Pharmacy and Medicine, "Sapienza" University of Rome (Latina)
Professor of General Microbiology, Degree in Nursing, Faculty of Pharmacy and Medicine ,
"Sapienza" University of Rome (Isernia)
Professor of General Microbiology, Degree in Dental Hygiene, Faculty of Pharmacy and Medicine ,
"Sapienza" University of Rome (Isernia)
Professor at the Postgraduate School of Microbiology and Virology, Faculty of Pharmacy and
Medicine, "Sapienza" University of Rome
Professor and secretary of the Master's Degree in Molecular Virology, Sapienza University of Rome.
EDUCATION AND TRAINING
September 2005–September
2008
Postgraduate MD specialization course in Microbiology and Virology
Sapienza University of Rome, (Italy)
Respiratory viruses and interferons
November 2001–November 2005
PhD in Experimental Medicine (XVII cycles)
Sapienza University of Rome, (Italy)
Sars coronavirus and interferons
Innate immunity in HCV infections
drug viral resistance (HIV and HCV)
September 1995–June 2000
Degree in Biological Sciences (110/110 with honours)
Sapienza University of Rome, (Italy)
INTERFERON AND SCLEROSIS MULTIPLE
PHARMACODYMIC OF IFN IN HCV INFECTIONS
ADDITIONAL INFORMATION
Expertise
Principal areas of expertise:
Role of interferon in acute and chronic viral infections and in multiple sclerosis;
Interferon and their therapeutic applications in CHC
Viral and cellular resistance to antiviral drugs
Immunopathogenesis of HIV, HCV and HPV
Diagnosis, pathogenesis and therapy of respiratory viruses
Natural history of flavivirus infections
Publications
1: Nenna R, Ferrara M, Nicolai A, Pierangeli A, Scagnolari C, Papoff P, Antonelli G, Moretti C, Midulla
F. Viral Load in Infants Hospitalized for Respiratory Syncytial Virus Bronchiolitis Correlates with
Recurrent Wheezing at 36 Months
Follow-Up. Pediatr Infect Dis J. 2015
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Curriculum vitae
Carolina Scagnolari
2: Giacomini E, Severa M, Cruciani M, Etna MP, Rizzo F, Pardini M, Scagnolari C, Garaci E, Coccia
EM. Dual effect of Thymosin α 1 on human monocyte-derived dendritic cell in vitro stimulated with viral
and bacterial toll-like receptor
agonists. Expert Opin Biol Ther. 2015
3: Monteleone K, Selvaggi C, Cacciotti G, Falasca F, Mezzaroma I, D'Ettorre G, Turriziani O, Vullo V,
Antonelli G, Scagnolari C. MicroRNA-29 family expression and its relation to antiviral immune
response and viro-immunological markers inHIV-1-infected patients. BMC Infect Dis. 2015 Feb
12;15:51.
4: Maggi F, Mazzetti P, Focosi D, Macera L, Scagnolari C, Manzin A, Antonelli G, Nelli LC. Lack of
usutu virus RNA in cerebrospinal fluid of patients withencephalitis of unknown etiology, Tuscany, Italy.
J Med Virol. 2015
5: Antonelli G, Scagnolari C, Moschella F, Proietti E. Twenty-five years of type I interferon-based
treatment: a critical analysis of its therapeutic use.Cytokine Growth Factor Rev. 2015 Apr;26(2):12131.
6: Cannella F, Pierangeli A, Scagnolari C, Cacciotti G, Tranquilli G, Stentella P, Recine N, Antonelli G.
TLR9 is expressed in human papillomavirus-positive cervical cells and is overexpressed in persistent
infections. Immunobiology. 2015
7: Cuomo L, Cirone M, Di Gregorio AO, Vitillo M, Cattivelli M, Magliocca V, Maiorano S, Meledandri M,
Scagnolari C, La Rocca S, Trivedi P. Elevated antinuclear antibodies and altered anti-Epstein-Barr
virus immune responses.
Virus Res. 2015 Jan 2;195:95-9.
8: Riva E, Scagnolari C, Turriziani O, Antonelli G. Hepatitis C virus and interferon type III (interferonλ3/interleukin-28B and interferon-λ4): genetic basis of susceptibility to infection and response to
antiviral treatment. Clin Microbiol Infect. 2014 Dec;20(12):1237-45.
9: Pierangeli A, Trotta D, Scagnolari C, Ferreri ML, Nicolai A, Midulla F, Marinelli K, Antonelli G,
Bagnarelli P. Rapid spread of the novel respiratory syncytial virus A ON1 genotype, central Italy, 2011
to 2013. Euro Surveill. 2014
Jul 3;19(26).
10: Meager A, Heath A, Dilger P, Zoon K, Wadhwa M; Participants of the Collaborative Study.
Standardization of human IL-29 (IFN-λ1): establishment of a World Health Organization international
reference reagent for IL-29 (IFN-λ1). J
Interferon Cytokine Res. 2014;34(11):876-84.
11: Midulla F, Nicolai A, Ferrara M, Gentile F, Pierangeli A, Bonci E, Scagnolari C, Moretti C, Antonelli
G, Papoff P. Recurrent wheezing 36 months after bronchiolitis is associated with rhinovirus infections
and blood eosinophilia.
Acta Paediatr. 2014 Oct;103(10):1094-9.
12: Scagnolari C, Selvaggi C, Di Biase E, Fraulo M, Dangond F, Antonelli G. In vitro assessment of
the biologic activity of interferon beta formulations used for the treatment of relapsing multiple
sclerosis. J Immunoassay Immunochem.
2014;35(3):288-99.
13: Monteleone K, Di Maio P, Cacciotti G, Falasca F, Fraulo M, Falciano M, Mezzaroma I, D'Ettorre G,
Turriziani O, Scagnolari C. Interleukin-32 isoforms: expression, interaction with interferon-regulated
genes and clinical significance
in chronically HIV-1-infected patients. Med Microbiol Immunol. 2014
14: Cannella F, Scagnolari C, Selvaggi C, Stentella P, Recine N, Antonelli G, Pierangeli A. Interferon
lambda 1 expression in cervical cells differs between low-risk and high-risk human papillomaviruspositive women. Med Microbiol
Immunol. 2014;203(3):177-84.
15: Selvaggi C, Pierangeli A, Fabiani M, Spano L, Nicolai A, Papoff P, Moretti C, Midulla F, Antonelli G,
Scagnolari C. Interferon lambda 1-3 expression in infants hospitalized for RSV or HRV associated
bronchiolitis. J Infect. 2014
May;68(5):467-77.
15: Nicolai A, Nenna R, Stefanelli P, Carannante A, Schiavariello C, Pierangeli A, Scagnolari C,
Moretti C, Papoff P, Bonci E, Ferrara M, Papasso S, Midulla F. Bordetella pertussis in infants
hospitalized for acute respiratory symptoms remains a concern. BMC Infect Dis. 2013
16: Pierangeli A, Ciccozzi M, Chiavelli S, Concato C, Giovanetti M, Cella E, Spano L, Scagnolari C,
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Moretti C, Papoff P, Muraca M, Midulla F, Antonelli G. Molecular epidemiology and genetic diversity of
human rhinovirus affecting hospitalized children in Rome. Med Microbiol Immunol. 2013
17: Scagnolari C, Antonelli G. Antiviral activity of the interferon α family: biological and
pharmacological aspects of the treatment of chronic hepatitis C. Expert Opin Biol Ther. 2013
18: Scagnolari C, Caputo B, Trombetti S, Cacciotti G, Soldà A, Spano L, Villari P, della Torre A,
Nowotny N, Antonelli G. Usutu virus growth in human cell lines: induction of and sensitivity to type I
and III interferons. J Gen Virol. 2013
19: Riva E, Scagnolari C, Monteleone K, Selvaggi C, Picardi A, Mazzarelli C, Pizzigallo E, Vincenzi B,
Carducci A, Antonaci S, Giannelli G, Antonelli G. Interleukin-28B (IL-28B) single-nucleotide
polymorphisms and interferon plus ribavirin treatment outcome in Italian chronically HCV-infected
patients. J Viral Hepat. 2012
20: Pierangeli A, Scagnolari C, Selvaggi C, Cannella F, Riva E, Impagnatiello A, Bernardi G, Ciardi A,
Moschella CM, Antonelli G, Indinnimeo M. High detection rate of human papillomavirus in anal
brushings from women attending a proctology clinic. J Infect. 2012
21: Scagnolari C, Midulla F, Selvaggi C, Monteleone K, Bonci E, Papoff P, Cangiano G, Di Marco P,
Moretti C, Pierangeli A, Antonelli G. Evaluation of viral load in infants hospitalized with bronchiolitis
caused by respiratory syncytial virus. Med Microbiol Immunol. 2012
22: Visentini M, Conti V, Cagliuso M, Siciliano G, Scagnolari C, Casato M, Fiorilli M. Persistence of a
large population of exhausted monoclonal B cells in mixed cryoglobuliemia after the eradication of
hepatitis C virus infection. J Clin Immunol. 2012
23: Scagnolari C, Midulla F, Riva E, Monteleone K, Solimini A, Bonci E, Cangiano G, Papoff P, Moretti
C, Pierangeli A, Antonelli G. Evaluation of interleukin 28B single nucleotide polymorphisms in infants
suffering from bronchiolitis. Virus Res. 2012
24: Scagnolari C, Trombetti S, Soldà A, Milella M, Gaeta GB, Angarano G, Scotto G, Caporaso N,
Morisco F, Cozzolongo R, Giannelli G, Fasano M, Santantonio T, Antonelli G. Development and
specificities of anti-interferon neutralizing antibodies in patients with chronic hepatitis C treated with
pegylated interferon-α. Clin Microbiol Infect. 2012
25: Nenna R, Papoff P, Moretti C, Pierangeli A, Sabatino G, Costantino F, Soscia F, Cangiano G,
Ferro V, Mennini M, Salvadei S, Scagnolari C, Antonelli G, Midulla F. Detection of respiratory viruses
in the 2009 winter season in Rome: 2009 influenza A (H1N1) complications in children and
concomitant type 1 diabetes onset. Int J Immunopathol Pharmacol. 2011
26: Pierangeli A, Scagnolari C, Selvaggi C, Monteleone K, Verzaro S, Nenna R, Cangiano G, Moretti
C, Papoff P, Antonelli G, Midulla F. Virological and clinical characterization of respiratory infections in
children attending an emergency department during the first autumn-winter circulation of pandemic A
(H1N1) 2009 influenza virus. Clin Microbiol Infect. 2012
27: Pierangeli A, Scagnolari C, Selvaggi C, Verzaro S, Spina MT, Bresciani E, Antonelli G, Bertazzoni
G. Rhinovirus frequently detected in elderly adults attending an emergency department. J Med Virol.
2012
28: Midulla F, Pierangeli A, Cangiano G, Bonci E, Salvadei S, Scagnolari C, Moretti C, Antonelli G,
Ferro V, Papoff P. Rhinovirus bronchiolitis and recurrent wheezing: 1-year follow-up. Eur Respir J.
2012
29: Pierangeli A, Degener AM, Ferreri ML, Riva E, Rizzo B, Turriziani O, Luciani S, Scagnolari C,
Antonelli G. Interferon-induced gene expression in cervical mucosa during human papillomavirus
infection. Int J Immunopathol Pharmacol. 2011
30: Scagnolari C, Trombetti S, Selvaggi C, Carbone T, Monteleone K, Spano L, Di Marco P, Pierangeli
A, Maggi F, Riva E, Antonelli G. In vitro sensitivity of human metapneumovirus to type I interferons.
Viral Immunol. 2011
31: Papoff P, Moretti C, Cangiano G, Bonci E, Roggini M, Pierangeli A, Scagnolari C, Antonelli G,
Midulla F. Incidence and predisposing factors for severe disease in previously healthy term infants
experiencing their first episode of bronchiolitis. Acta Paediatr. 2011
32: Scagnolari C, Trombetti S, Soldà A, Selvaggi C, Monteleone K, Spano L, Pierangeli A, Clementi
M, Turriziani O, Antonelli G. Pandemic 2009 H1N1 influenza virus is resistant to the antiviral activity of
several interferon alpha subtypes. J Interferon Cytokine Res. 2011
33: De Rossi A, Zanchetta M, Vitone F, Antonelli G, Bagnarelli P, Buonaguro L, Capobianchi MR,
Clementi M, Abbate I, Canducci F, Monachetti A, Riva E, Rozera G, Scagnolari C, Tagliamonte M, Re
MC; SIVIM (Italian Society of Medical Virology) Group. Quantitative HIV-1 proviral DNA detection: a
multicentre analysis. New Microbiol. 2010
34: Scagnolari C, Zingariello P, Vecchiet J, Selvaggi C, Racciatti D, Taliani G, Riva E, Pizzigallo E,
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Antonelli G. Differential expression of interferon-induced microRNAs in patients with chronic hepatitis
C virus infection treated with pegylated interferon alpha. Virol J. 2010
35: Pierangeli A, Scagnolari C, Gentile M, Spina MT, Iudicello A, Bertazzoni G, Antonelli G. Virological
diagnosis of respiratory virus infection in patients attending an emergency department during the
influenza season. Clin Microbiol Infect. 2010
36: Midulla F, Scagnolari C, Bonci E, Pierangeli A, Antonelli G, De Angelis D, Berardi R, Moretti C.
Respiratory syncytial virus, human bocavirus and rinovirus bronchiolitis in infants. Arch Dis Child. 2010
37: Pierangeli A, Scagnolari C, Trombetti S, Grossi R, Battaglia M, Moretti C, Midulla F, Antonelli G.
Human bocavirus infection in hospitalized children in Italy. Influenza Other Respir Viruses. 2008
38: Scagnolari C, Selvaggi C, Chiavuzzo L, Carbone T, Zaffiri L, d'Ettorre G, Girardi E, Turriziani O,
Vullo V, Antonelli G. Expression levels of TLRs involved in viral recognition in PBMCs from HIV-1infected patients failing antiretroviral therapy. Intervirology. 2009
39: Scagnolari C, Midulla F, Pierangeli A, Moretti C, Bonci E, Berardi R, De Angelis D, Selvaggi C, Di
Marco P, Girardi E, Antonelli G. Gene expression of nucleic acid-sensing pattern recognition receptors
in children hospitalized for respiratory syncytial virus-associated acute bronchiolitis. Clin Vaccine
Immunol. 2009
40: Bellomi F, Bramanti P, Trojano M, Scagnolari C, Muto A, Sessa E, La Volpe V, Russo P, Antonelli
G. Neutralizing and binding antibodies to interferon beta in patients with multiple sclerosis: a
comparison of assay results from three italian centres. J Immunoassay Immunochem. 2009
41: Pierangeli A, Scagnolari C, Degener AM, Bucci M, Ciardi A, Riva E, Indinnimeo M, Mancini G,
D'Ettorre G, Vullo V, Antonelli G. Type-specific human papillomavirus-DNA load in anal infection in
HIV-positive men. AIDS. 2008
42: Scagnolari C, Trombetti S, Cicetti S, Antonelli S, Selvaggi C, Perrone L, Visca M, Romano S,
Antonelli G. Severe acute respiratory syndrome coronavirus elicits a weak interferon response
compared to traditional interferon-inducingviruses. Intervirology. 2008
43: Riva E, Maggi F, Abbruzzese F, Bellomi F, Giannelli G, Picardi A, Scagnolari C, Folgori A, Spada
E, Piccolella E, Dianzani F, Antonelli G; Acute Hepatitis C Italian Study Group. Immune complexed
(IC) hepatitis C virus (HCV) in chronically and acutely HCV-infected patients. Med Microbiol Immunol.
2009
44: Scagnolari C, Midulla F, Trombetti S, Pierangeli A, Tromba V, Grossi R, Di Marco P, Dianzani C,
Girardi E, Antonelli G. Upregulation of interferon-induced genes in infants with virus-associated acute
bronchiolitis. Exp Biol Med (Maywood). 2007
45: Bruno R, Sacchi P, Scagnolari C, Torriani F, Maiocchi L, Patruno S, Bellomi F, Filice G, Antonelli G.
Pharmacodynamics of peginterferon alpha-2a and peginterferon alpha-2b in interferon-naïve patients
with chronic hepatitis C: a randomized, controlled study. Aliment Pharmacol Ther. 2007
46: Scagnolari C, Duda P, Bagnato F, De Vito G, Alberelli A, Lavolpe V, Girardi E, Durastanti V,
Trojano M, Kappos L, Antonelli G. Pharmacodynamics of interferon beta in multiple sclerosis patients
with or without serum neutralizing antibodies. J Neurol. 2007
47: Pierangeli A, Gentile M, Di Marco P, Pagnotti P, Scagnolari C, Trombetti S, Lo Russo L, Tromba V,
Moretti C, Midulla F, Antonelli G. Detection and typing by molecular techniques of respiratory viruses
in children hospitalized for acute respiratory infection in Rome, Italy. J Med Virol. 2007
48: Turriziani O, Bucci M, Stano A, Scagnolari C, Bellomi F, Fimiani C, Mezzaroma I, D'Ettorre G,
Brogi A, Vullo V, Antonelli G. Genotypic resistance of archived and circulating viral strains in the blood
of treated HIV-infected individuals. J Acquir Immune Defic Syndr. 2007
49: Scagnolari C, Bellomi F, Trombetti S, Casato M, Carlesimo M, Bagnato F, Lavolpe V, Bruno R,
Millefiorini E, Antonelli L, Girardi E, Turriziani O, Antonelli G. Expression of biomarkers of interferon
type I in patients suffering from chronic diseases. Clin Exp Immunol. 2007
50: Scagnolari C, Trombetti S, Alberelli A, Cicetti S, Bellarosa D, Longo R, Spanò A, Riva E, Clementi
M, Antonelli G. The synergistic interaction of interferon types I and II leads to marked reduction in
severe acute respiratory syndrome-associated coronavirus replication and increase in the expression
of mRNAs for interferon-induced proteins. Intervirology. 2007
51: Riva E, Serraino D, Pierangeli A, Bambacioni F, Zaniratti S, Minosse C, Selleri M, Bucci M,
Scagnolari C, Degener AM, Capobianchi MR, Antonelli G, Dianzani F; Roman Papillomavirus Study
Group*. Markers of human papillomavirus infection and their correlation with cervical dysplasia in
human immunodeficiency virus-positive women. Clin Microbiol Infect. 2007
52: Santantonio T, Milella M, Antonelli G, Scagnolari C. Neutralizing antibodies to interferon alpha in a
chronic hepatitis C patient non-responder to pegylated interferon. J Hepatol. 2006
53: Di Marco P, Pagnotti P, Bellomi F, De Vito G, Sessa E, Bagnato F, Scagnolari C, Bramanti P,
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Antonelli G. A novel assay to detect low-titred antibodies to interferon beta in multiple sclerosis
patients. New Microbiol. 2006
54: Scagnolari C, Vicenzi E, Bellomi F, Stillitano MG, Pinna D, Poli G, Clementi M, Dianzani F,
Antonelli G. Increased sensitivity of SARS-coronavirus to a combination of human type I and type II
interferons. Antivir Ther. 2004
55: Maffeo A, Bellomi F, Solimeo I, Bambacioni F, Scagnolari C, De Pisa F, Dupuis ML, Cianfriglia M,
Antonelli G, Turriziani O. P-glycoprotein expression affects the intracellular concentration and antiviral
activity of the protease inhibitor saquinavir in a T cell line. New Microbiol. 2004
56: Bagnato F, Clemenzi A, Scagnolari C, Strizzi L, Di Pasquale A, Bellomi F, Di Marco P, Antonelli G,
Antonini G. Neutralizing antibodies against endogenous interferon in myasthenia gravis patients. Eur
Cytokine Netw. 2004
57: Turriziani O, Scagnolari C, Bellomi F, Solimeo I, Focher F, Antonelli G. Cellular issues relating to
the resistance of HIV to antiretroviral agents. Scand J Infect Dis Suppl. 2003;106:45-8.
58: Casato M, Lilli D, Donato G, Granata M, Conti V, Del Giudice G, Rivanera D, Scagnolari C,
Antonelli G, Fiorilli M. Occult hepatitis C virus infection in type II mixed cryoglobulinaemia. J Viral
Hepat. 2003
59: Bellomi F, Scagnolari C, Tomassini V, Gasperini C, Paolillo A, Pozzilli C, Antonelli G. Fate of
neutralizing and binding antibodies to IFN beta in MS patients treated with IFN beta for 6 years. J
Neurol Sci. 2003
60: Antonelli G, Scagnolari C, Vicenzi E, Clementi M. Treatment of SARS with human interferons.
Lancet. 2003
61: Riva E, Antonelli G, Scagnolari C, Pistello M, Capobianchi MR, Monforte Ad, Pezzotti P, Dianzani
F; I.CO.N.A. Study Group. Human immunodeficiency virus (HIV) DNA load and level
immunosuppression in treatment-naive HIV-1-infected patients. J Infect Dis. 2003
62: Scagnolari C, Casato M, Bellomi F, De Pisa F, Turriziani O, Coviello R, Pirro MR, Dianzani F,
Antonelli G. Serum interferon (IFN)-neutralizing antibodies and bioactivities of IFNs in patients with
severe type II essential mixed cryoglobulinemia. Clin Diagn Lab Immunol. 2003
63: Turriziani O, Scagnolari C, Bambacioni F, Bellomi F, Focher F, Gentile M, Antonelli G. Selection of
a T-cell line resistant to stavudine and zidovudine by prolonged treatment with stavudine. Antivir Ther.
2002
64: Monzani F, Meucci G, Caraccio N, Saviozzi M, Casolaro A, Moscato G, Lombardo F, Mosti S,
Scagnolari C, Bruschi F, Antonelli G, Ferrannini E, Murri L. Discordant effect of IFN-beta1a therapy on
anti-IFN antibodies and thyroid disease development in patients with multiple sclerosis. J Interferon
Cytokine Res. 2002
65: Giannelli G, De Marzo A, Scagnolari C, Bergamini C, Fransvea E, Bagnato F, Bellomi F, Millefiorini
E, Gasperini C, Antonaci S, Antonelli G. Proteolytic balance in patients with multiple sclerosis during
interferon treatment. J Interferon Cytokine Res. 2002
66: Turriziani O, Schuetz JD, Focher F, Scagnolari C, Sampath J, Adachi M, Bambacioni F, Riva E,
Antonelli G. Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a
mechanism of acquired resi stance independent of multidrug resistant protein 4 with a possible role for
ATP-binding cassette C11. Biochem J. 2002
67: Bagnato F, Pozzilli C, Scagnolari C, Bellomi F, Pasqualetti P, Gasperini C, Millefiorini E, Galgani S,
Spadaro M, Antonelli G. A one-year study on the pharmacodynamic profile of interferon-beta1a in MS.
Neurology. 2002
68: Scagnolari C, Bellomi F, Turriziani O, Bagnato F, Tomassini V, Lavolpe V, Ruggieri M, Bruschi F,
Meucci G, Dicuonzo G, Antonelli G. Neutralizing and binding antibodies to IFN-beta: relative
frequency in relapsing-remitting multiple sclerosis patients treated with different IFN-beta preparations.
J Interferon Cytokine Res. 2002
Projects
2013. Scientific Research - Funding Research Projects (Sapienza University of Rome). Title of the
research: In vitro and ex-vivo characterization of the role of type I and III interferon and inflammatory
immune response in the natural history of mosquito-borne USUTU virus infection. Duration 12
months. Role: PI (Principal Investigator)
2013. ACTIONS CONCERTEES INTERPASTEURIENNES (ACIP), Pilot Project proposal. Title of the
research: Mosquito borne USUTU virus infection: dissecting virus molecular epidemiology and in vitro
and ex-vivo characterization of innate immune responses. ACIP project A07-2013. Duration 2 years.
Role: PI (Principal Investigator)
2012. Institute Pasteur-Fondazione Cenci Bolognetti. Project "Under 40". Title of the research:
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Interleukin 32: molecular expression, epigenetic regulation , and biological activities in human
immunodeficiency virus 1-infection. Duration 3 years. Role: PI (Principal Investigator)
2012. Scientific Research - Funding Research Projects (Sapienza University of Rome) Title of the
research: Impact of Rhinovirus infections, antiviral innate immune response and environmental factors
on wheezing illnesses and asthma. Duration 12 months. Role: PI (Principal Investigator)
2010. Funding of research projects under 45 (Sapienza University of Rome). Title of research:
Environmental factors, immunologists and socio-economic risks associated with outbreaks of
Chikungunya virus transmitted by the Asian tiger mosquito in urban environments: an analysis at
different levels of biological organization. Duration 12 months PI: Dr. Angelo Solimini. Role:
component of research unit.
2009. Scientific Research - Funding Research Projects (Sapienza University of Rome) . Prot
C26F09TNE5. Title of the research: Optimizing therapy for chronic hepatitis C: in vitro study and
characterization of antiviral activity and therapeutic potential of the interferon system. Duration 24
months PI: Prof. G. Antonelli Role: component of research unit.
2008. Programmi di Ricerca Scientifica di Rilevante Interesse Nazionale (PRIN). Prot. N. 240
-18/12/2008 (200085JWPK3_001). Title of the research: Innovative therapeutic strategies for hepatitis
C virus infection: in vitro study and characterization of antiviral activity and therapeutic potential of the
interferon system. Duration 24 months PI: Prof. G. Antonelli. Role: component of research unit.
2007. National Institute of Health. Convention 28C5/3. Title of research: Viral infections in
immunocompromised patients. Duration 24 months. PI: Prof. G. Antonelli. Role: component of
research unit.
2007. Ricerca Finalizzata. RF-FSR-2007-644129 convention IRCCS Fondazione Centro San
Raffaele del Monte Tabor & Ministero del Lavoro, della Salute e delle Politiche Sociali n. 88. Title of the
research: A prospective immunological, virological and genetic study of humoral and cellular immune
correlates of protection and crossprotection against influenza virus in health care workers and HIVpositive individuals. Duration 24 months PI: Prof. E. Vincenzi. Role: component of research unit.
2006. Projects in the field of Biomedical Research (Area 1: Etiology and pathogenesis of HIV-1).
Associazione Nazionale per la lotta contro l’AIDS-ANLAIDS ONLUS. Prot. Dc/455. Title of research:
Study on the pathogenic significance of the proviral and episomal HIV-1-DNA in the natural history of
HIV-1 infection. Duration 12 months. PI: Prof. G. Antonelli. Role: component of research unit
2005. Programmi di Ricerca cofinanziati. Ministry of University and Research. Prot. 2005060034_001.
Title of research: Study of cellular factors responsible for resistance to antiretrovirals. Duration 24
months PI: Prof. O. Turriziani. Role: component of research unit.
2005. Programmi di Ricerca cofinanziati. Ministry of University and Research. Prot. 2005062080_001.
Title of the research: Pre-clinical study of the efficacy of drugs and human neutralizing antibodies
against the hepatitis C virus (HCV). Duration 24 months. PI: Prof. G. Antonelli. Role: component of
research unit.
2004. Assegnazione finanziamento Ricerca Bando 2004- Italian Multiple Sclerosis Foundation. Prot.
249/05/F1. Title of research: Biological interferon induced markers and expression of viral sequences
in treated and untreated patients with multiple sclerosis. Duration 24 months PI: Prof. G. Antonelli
Role: component of research unit.
2004. Ricerca Finalizzata Ministeriale 2004. Prot. 20040021936. Title of research: Emerging viral
respiratory infections (influenza virus, coronavirus, metapneumovirus). Duration 24 months. PI: Prof. F.
Baldanti. Role: component of research unit.
2003. Ministry of Education, University and Research. Prot. 2003060214002. Title of research:
Qualitative and quantitative study on circulating immune complexes (antibody-virus) and on the
variability of chronic hepatitis C virus (HCV): their role in the pathogenesis of HCV infection and as a
marker of response to therapy with interferon alpha. Duration 24 months PI: Prof. M. Clementi. Role:
component of research unit.
2002. Ricerca Finalizzata. Prot. 1884. Research Title: Development and application of new microarray
technologies for diagnosing infectious diseases. Duration 24 months. PI: Prof. M. Piacentini. Role:
component of research unit.
Memberships
Member of Editorial Board of Open Journal of Medical Microbiology from 2011 ongoing
Member of Advisory Board of Archives of Virology from 2012 ongoing
Other Relevant Information
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Grants
© European Union, 2002-2015 | http://europass.cedefop.europa.eu
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Curriculum vitae
Carolina Scagnolari
“Sivim Award 2004” “Marcatori molecolari dell’infezione da HPV in donne HIV-negative e HIV-positive”
(3° FORUM SIVIM, “Virus e Tumori nell’uomo”, Roma, 18-19 novembre, 2004).
“ICAR-CROI Awards 2014” “Interleukin-32: Expression, Interaction
With IFN and Clinical Significance in HIV-1-infection" presentato al CROI Affiliated Event for Young
Investigators (CROI/2014, Boston).
“Special Jury Price 2014” from Guido Silvestri, Beatrice H Hahn and GS Deeks per il lavoro scientifico
dal titolo “Interleukin-32: Expression, Interaction With IFN and Clinical Significance in HIV-1-infection"
presentato al CROI Affiliated Event for Young Investigators. CROI/2014, Boston
“ICAR-CROI Awards 2015” “ Regulation of IL-32 expression by a promoter polymorphism and
microrna29b in HIV-1 infected patients” presentato al CROI Affiliated Event for Young Investigators
(CROI/2015, SEATTLE)
14/7/15
© European Union, 2002-2015 | http://europass.cedefop.europa.eu
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