Neurodegeneration and Neuroprotection NEUROCHEMISTRY AND NEUROANATOMY (Scientific Committee: FabbeneDe Bartolomeis) P01. CEREBELLAR NETWORK ACTIVITY RESOLVED BY TWO-PHOTON IMAGING OF MULTIPLE SINGLE NEURONS Tognolina M., Pozzi P., Gandolfi D., Mapelli L., Mapelli J., Chirico G., D’Angelo E. Unity of Neurophysiology, Dept of Brain and Behavioral Sciences, University of Pavia, Italy P02. CO-DISTRIBUTION OF GLT-1 AND SUBUNITS OF THE Na+/K+-ATPASE PUMP IN RAT CEREBRAL CORTEX Ciriachi C., Melone M., Conti F. Department of Experimental and Clinical Medicine, Section of Neuroscience and Cell Biology P03. NEUROCHEMICHAL ASPECTS OF THE POSTNATAL REELER CEREBELLUM Cocito C., Alasia S., Merighi A., Lossi L. Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095 Grugliasco (TO), Italy P04. CHARACTERIZATION OF CELLS EXPRESSING GAT-1, THE MOST IMPORTANT GABA TRANSPORTER, IN SUBCORTICAL WHITE MATTER OF THE RAT BRAIN Bassi S., Fattorini G., Melone M., Conti F. Department of Experimental and Clinical Medicine, Section of Neuroscience and Cell Biology NEUROPHARMACOLOGY (Scientific Committee: Bernardini-Secondo) P05. FLUOXETINE EFFECTS ON MOLECULAR, CELLULAR AND BEHAVIORAL ENDOPHENOTYPES OF DEPRESSION ARE DRIVEN BY THE LIVING ENVIRONMENT Milior G. Università Sapienza, Roma P06. BEHAVIORAL CHARACTERIZATION OF 5-HT1A/1B AGONIST, ELTOPRAZINE, IN EXPERIMENTAL PARKINSONISM Mineo D., Ghiglieri V., Vannelli A., Mancini M., Cacace F., Calabresi P., Picconi B. Fondazione Santa Lucia, IRCCS, Rome, Italy P07. PHARMACOLOGICAL CHARACTERIZATION OF A BINDING SITE FOR TLQP21, A VGF-DERIVED PEPTIDE Molteni L., Rizzi L., Bresciani E., Locatelli V., Torsello A. University of Milano-Bicocca, Monza Neurodegeneration and Neuroprotection P08. NANOPARTICLES RELATIONSHIP? IN THE BRAIN PARENCHYMA: A FRIENDLY Portioli C., Pedroni M., Speghini A., Bovi M., Monaco H.L., Benati D., Mazza M., Lozano Valdes N., Jasim D., Bussy C., Bentivoglio M., Kostarelos K. Dept. of Neurological and Movement Sciences, University of Verona, Verona, Italy; P09. EFFECT OF ADOLESCENT Δ9-THC PRETREATMENT IN DOSE–RESPONSE RELATIONSHIP DURING HEROIN SELF-ADMINISTRATION IN A GENETIC ANIMAL MODEL OF OPIATE VULNERABILITY. Scifo A., Lecca D., Pisanu A., Sil A., Cadoni C.2, Di Chiara G. University of Cagliari - Department of Biomedical Sciences, Cagliari, Italy P10. CORTICAL AND STRIATAL TOPOGRAPHY OF HOMER TRANSCRIPTSIS MODULATED BY MINOCYLINE OR MEMANTINEADD-ON TO HALOPERIDOL: IMPLICATIONS FOR TREATMENT RESISTANT PSYCHOSIS. Buonaguro E.F., Tomasetti C., Marmo F., Sarappa C.1, Eramo A., Iasevoli F., De Bartolomeis A. Dept Neurosci & Behavioral, Univ. Sch. Med. Federico II, Via Pansini 5, Italy P11. INVOLVEMENT OF CENTRAL HISTAMINERGIC SYSTEM IN THE OLEOYLETHANOLAMIDE-INDUCED ANTIDEPRESSANT-LIKE EFFECT IN THE MOUSE TAIL SUSPENSION TEST Costa A., Blandina P., Ghelardini C., Passani M.B., Provensi G. Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA) – Pharmacology and toxicology session. Universita‟ di Firenze. Viale Pieraccini 6 50139 Firenze P12. AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS AS AN ALTERNATIVE WAY IN THE TREATMENT OF GROWTH HORMONE (GH)SECRETING PITUITARY TUMORS: IN VITRO STUDIES. Faggi L., Giustina A., Tulipano G. Pharmacology unit, Department of Molecular and Translational Medicine, University of Brescia, Italy P13. PHARMACOLOGICAL MODULATION OF THE ENDOCANNABINOID SYSTEM IN A RODENT MODEL OF ANOREXIA NERVOSA Collu R., Scherma M., Satta V., Fattore L., Fadda P., Fratta W. Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology P14. M2 MUSCARINIC RECEPTOR ACTIVATION INHIBITS CELL SURVIVAL AND PROLIFERATION IN HUMAN GLIOBLASTOMA CANCER STEM CELLS Cristofaro I., Alessandrini F., Di Bari M., Spinello Z., Fiore M., Conti L., Tata A.M. Dept. Biology and Biotechnologies C. Darwin, Research Center of Neurobiology D. Bovet, Sapienza, University of Rome, Italy P15. MICRORNA-34B IS A POTENTIAL CANDIDATE NEUROBLASTOMA TUMOR SUPPRESSOR THROUGH DELTA-LIKE 1 REGULATION Neurodegeneration and Neuroprotection Bettinsoli P., Ferrari-Toninelli G., Bonini S. A., Prandelli C., Memo M. Department of Molecular and Translational Medicine, University of Brescia Medical School, Brescia, Italy P16. OPTOGENETIC REGULATION OF TRANSCRIPTION: MODULATION OF THE RE1-SILENCING TRANSCRIPTION FACTOR (REST) Criscuolo S., Paonessa F., Sacchetti S., Amoroso D., Scarongella H., Pruzzo G., Maragliano L.1, Cesca F., Benfenati F. Center for Synaptic Neuroscience, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy P17. MS-275 INHIBITS A1254-INDUCED SH-SY5Y NEURONAL CELL TOXICITY BY PREVENTING THE FORMATION OF THE HDAC3/REST COMPLEX ON THE SYNAPSIN-1 PROMOTER Laudati G., Formisano L., Guida N., Mascolo L., Di Renzo G., Canzoniero L.M.T. Division of Pharmacology, Department of Neuroscience, Federico II University of Naples, Naples, Italy P18. BIOINFORMATIC ANALYSIS OF DIFFERENT SPLICING VARIANTS OF KV7.2 NEURONAL POTASSIUM CHANNELS Medoro A., Soldovieri M.V., Vinciguerra I., Taglialatela M. Dept. of Medicine and Health Science, University of Molise, Campobasso, Italy PAIN (Scientific Committee: Fabbene-De Bartolomeis) P19. THE IMPACT OF MOUSE STRAIN IN THE ANALYSIS OF INFLAMMATORY AND NEUROPATHIC PAIN IN ANIMAL MODELS Fiori E., Marinelli S., Vacca V., Pavone F. EBRI, European Brain Research Institute, Rome, Italy P20. GPR35 AGONISTS MEDIATE ANALGESIC EFFECTS THROUGH THE MODULATION OF HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNELS. Resta F., Masi A., Sili M., Laurino A., Moroni F., Mannaioni G. Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy P21. LUMINANCE FUNCTION LEVEL RHYTHMICALLY MODULATES EARLY SENSORY Benedetto A., Cicchini G.M., Spinelli S., Burr D.C., Morrone M.C. Department of Neuroscience, Psychology, Pharmacology and Child Health, University of Florence, 50135 Florence, Italy. P22. MORPHOFUNCTIONAL ALTERATIONS IN NOCICEPTORS OF DIABETIC MICE Ciglieri E., Ferrini F., Salio C. Neurodegeneration and Neuroprotection Dipartimento di Scienze Veterinarie, Largo P. Braccini, 2, 10095 Grugliasco (TO) Italy PLASTICITY, MEMORY AND BEHAVIOUR (Scientific Committee: FattoreFormisano) P23. LONG TERM EFFECTS OF GENE / EARLY ENVIRONMENT INTERPLAY ON RESPONSE TO AVERSIVE AND REINFORCING STIMULI. Di Segni M., Andolina D., Pascucci T., D’Amato F., Babicola L., D’Apolito L.I., Luchetti A., Conversi D., Puglisi-Allegra S., Ventura R. Department of Psychology and Centre “Daniel Bovet”, “Sapienza” University of Rome, Rome, Italy P24. ROLE OF D1 DOPAMINE RECEPTORS IN WORKING MEMORY CAPACITY De Risi M., Olivito L., De Leonibus E. Scuola di Dottorato in Neuroscienze, Università degli Studi di Roma „„La Sapienza‟‟, Rome, Italy P25. FEAR MEMORY RE-EVALUATION REQUIRES LATERAL ORBITOFRONTAL CORTEX INTEGRITY D’Alessandro F., Costanzi M., Saraulli D., Cannas S., Rossi-Arnaud C., Cestari V. LUMSA-Libera Università Maria SS Assunta, Rome Italy. P26. MICROGLIA DRIVES COGNITIVE AND EXPERIMENTAL MULTIPLE SCLEROSIS SYNAPTIC DYSFUNCTION IN de Iure A., Di Filippo M., Giampà C., Durante V., Tozzi A., Tantucci M., Mancini A., Mazzocchetti P., Ghiglieri V., Spaccatini C., Costa C., Calabresi P. Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, 06156 Perugia, Italy P27. CEREBRO-CEREBELLAR LOOP: IN VIVO INVESTIGATION OF CONNECTIONS AND NETWORK PLASTICITY Moscato L., De Propris L., Mapelli L., D’Angelo E. Department of Brain and Behavioral Sciences, University of Pavia, Italy P28. CSPGS DEGRADATION PROMOTES FEAR MEMORY ERASURE BY INHIBITING MEMORY-DRIVEN SPINES ENLARGEMENT IN BASOLATERAL AMYGDALA Pignataro A., Middei S., Pagano R., Borreca A., Ammassari-Teule M. Department of Experimental Neurology, Laboratory of Psicobiology, Santa Lucia Foundation, Rome, Italy P29. ROLE OF THE HIPPOCAMPUS AND VENTRAL STRIATUM IN RETRIEVAL OF RECENT AND REMOTE MEMORIES Finocchiaro A., Camon J., D’Uva S., Oliverio A., Mele A. Center for Research in Neurobiology Daniel Bovet, Rome, Italy Neurodegeneration and Neuroprotection P30. ANALYSIS OF THE BEHAVIOURAL SEQUENCES CHARACTERIZING WISTAR RAT INTERACTIVE BEHAVIOUR Casarrubea M., Faulisi F., Cudia A., Cancemi D., Sorbera F., Cardaci M., Magnusson M.S., Crescimanno G. Dept. of Experimental Biomedicine and Clinical Neurosciences (Bio.Ne.C.), Human Physiology Section “Giuseppe Pagano”,Laboratory of Behavioral Physiology,University of Palermo - Palermo, Italy P31. ROLE OF THE VENTRAL SUBICULUM AND THE VENTRAL STRIATUM IN THE PROCESSING OF SPATIAL INFORMATION: INSIGHTS FOR A FUNCTIONAL CROSS-STRUCTURAL INTERACTION. Torromino G., Biasini G.M., Oliverio A., Mele A. Dept. of Biology and Biotechnology "Charles Darwin", and Centre for Research in Neurobiology Daniel Bovet, Sapienza University of Rome, Rome, Italy P32. CEREBELLAR PLASTICITY IN IB2 KO MICE Soda T., Mapelli L., Locatelli F., Prestori F., Botta L., Goldfarb M., D’Angelo E. Brain and Behavioral Sciences, University of Pavia, Pavia, Italy P33. PHARMACOLOGICAL EVALUATION BEHAVIORAL EFFECTS IN RATS OF METHOXETAMINE-INDUCED Zanda M.T., Antinori S., Chiamulera C., Fratta W., Fadda P., Fattore L. Department of Biomedical Sciences,Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Italy P34. EFFECT OF 5-HT1A/1B RECEPTOR AGONIST ON BIDIRECTIONAL STRIATAL SYNAPTIC PLASTICITY IN A RAT MODEL OF L-DOPA-INDUCED DYSKINESIA Vannelli A., Ghiglieri V., Mineo D., Mancini M., Cacace F., Calabresi P., Picconi B. Fondazione Santa Lucia, IRCCS, Rome, Italy P35. PUTATIVE ROLE OF CT FIBERS IN THE MODULATION OF THE HEART RATE VARIABILITY DURING THE SWEEPING MOVEMENT OF GROOMING: A PILOT STUDY IN RHESUS MACAQUE MONKEY Grandi L.C. University of Parma, dipartimento di Neuroscienze, sezione di fisiologia. Via Volturno 39, 43125,Parma,Italia. P36. ROLE OF DORSAL AND VENTRALHIPPOCAMPUS IN SPATIAL WORKING MEMORY LOAD CAPACITY. Alvino F.G., Carboncino A., Olivito L., Crain J., Giordano N.C., Carella D., De Leonibus E. Institute of Genetics and Biophisics , National ResearchCouncil, 111 Pietro Castellino, 80131, Naples, Italy; TelethonInstitute of Genetics and Medicine, 34 Campi Flegrei, 80078, Pozzuoli, Naples P37. DEVELOPMENT OF AN OPEN FIELD MONITORING APPARATUS FOR RODENT BEHAVIOURAL STUDIES Neurodegeneration and Neuroprotection Florio T.M., Ranieri B., Alecci M., Galante A. Dipartimento Medicina Clinica, Sanità Pubblica, Scienze della Vita e dell'Ambiente, Università degli Studi dell'Aquila, Via Vetoio, 67100 L‟Aquila, Italy P38. SYNAPSIN 1 REGULATES THE BALANCE BETWEEN SYNCHRONOUS AND ASYNCHRONOUS GABA RELEASE OF PARVALBUMIN INTERNEURONS Forte N., Contestabile A., Baldelli P., Benfenati F. Department of Neuroscience and Brain Technologies, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy PSYCHIATRIC DISORDERS (Scientific Committee Fabbene-De Bartolomeis) P39. MK886 REVERTS THE ANTIDEPRESSANT-LIKE EFFECT OF THE SINTHETIC PPAR-Α AGONIST CLOFIBRATE Mameli A., Deidda M., Scherma M., Collu R., Fattore L., Fratta W., Fadda P. Dept. Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, Italy P40. PRECLINICAL MODEL OF NEUROPSYCHOPHARMACOLOGICAL OUTCOME: A CHALLENGE FROM ANTIPSYCHOTICS SWITCHING. Marmo F., Buonaguro E., Latte G., Avvisati L., Tomasetti C., Iasevoli F., de Bartolomeis A. Laboratory of Molecular and TranslationalPsychiatry, Department of Neuroscience, Reproductive and OdontostomatologicalSciences, University School of Medicine of Napoli "Federico II" P41. DYSBINDIN-1 ISOFORMS SHOW A DIFFERENT PATTERN OF EXPRESSION THROUGH MOUSE BRAIN DEVELOPMENT Mastrogiacomo R., Papaleo F. Università di Genova - Istituto Italiano di Tecnologia P42. ANIMAL MODEL OF PANIC DISORDER : THE IMPORTANCE OF EARLY ENVIRONMENT Luchetti A., Battaglia M., D’Amato F.R. Cell Biology and Neurobiology Institute, CNR, Rome NEURODEGENERATION AND NEUROPROTECTION (Scientific Committee: Pignataro- Boscia-Pannaccione-Cantarella) P43. TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND REDUCES THE EXPRESSION OF THE NEUROPROTECTIVE NA+/CA2+ EXCHANGER ISOFORM 3 IN HUMAN NEURONAL CELLS IN VITRO. Valerio O., Di Benedetto G., Lariccia V., Bernardini R., Amoroso S., Cantarella G. Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Catania, Italy; Department of Biomedical Neurodegeneration and Neuroprotection Sciences and Public Health, School of Medicine, University Politecnica of Marche, Ancona, Italy P44. UP-REGULATION OF THE KV3.4 POTASSIUM CHANNEL IN EARLY STAGES OF ALZHEIMER’S DISEASE Ciccone R., Pannaccione A., Franco C., Boscia F., Casamassa A., Vinciguerra A., Di Renzo G., Annunziato L. Division of Pharmacology, Dept of Neuroscience, University of Naples “Federico II” P45. REDUCING EXCITOTOXICITY KNOCKING DOWN MGLUR1: PROLONGED SURVIVAL AND IMPROVED SYMPTOMATOLOGY OF SOD1G93A MOUSE MODEL OF ALS. Cattaneo L., Milanese M., Puliti A., Conti F., Bonifacino T., Gallia E., Rossi P., Musante I., Melone M., Bonanno G. Dept. of Pharmacy, Univ. of Genoa, Italy P46. CEREBELLAR CORTEX NEUROARCHITECTURE IS ALTERED IN PROLIDASE DEFICIENT MICE Insolia V., Coppa F., Gasperini C., Maruelli S., Besio R., Forlino A., Bernocchi G., Bottone M.G. Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia. P47. NCX1 EXCHANGER COOPERATES WITH CALRETININ TO CONFER PRECONDITIONING-INDUCED TOLERANCE AGAINST CEREBRAL ISCHEMIA IN THE STRIATUM de Rosa V., Boscia F., Casamassa A., Secondo A., Esposito A., Pannaccione A., Sirabella R., Pignataro G., Cuomo O., Vinciguerra A., Annunziato L. Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples; 2Fondazione IRCSS SDN, Naples, Italy P48. BRAIN 18F-FDG PET HYPO-AND DEMENTIA WITH LEWY-BODIES. HYPERMETABOLIC PATTERNS IN Iaccarino L., Cerami C., Iannaccone S., Magnani G., Cappa S.F., Perani D. Vita-Salute San Raffaele University, Division of Neuroscience San Raffaele Scientific Institute, Milan, Italy P49. EFFECTS OF MANGANESE ON NEURONAL DIFFERENTIATION IN ZEBRAFISH MODEL A Fasano G., Sordino P., Canzoniero L.M.T. Dipartimento di Scienze e Tecnologie DBT, Università del Sannio, Benevento P50. FUNCTIONAL AND BEHAVIOURAL CHARACTERIZATION OF A PERINATAL STROKE MODEL IN RAT: PRELIMINARY DATA Mattiello A., Cioni G., Berardi N. NEUROFARBA, University of Florence, Florence, Italy Neurodegeneration and Neuroprotection P51. OXIDATIVE STRESS AND INFLAMMATION INDUCED BY DIESEL EXHAUSTED PARTICLES: PILOT STUDY IN A MODEL OF NEURONAL CELLS. Milani C., Farina F., Botto L., Lonati E., Bulbarelli A., Palestini P. Department of Surgery and Translational Medicine, University of Milano-Bicocca, Monza, Italy P52. DOPAMINERGIC NEURONS: SYNERGISTIC EFFECTS OF NURR1 AND LMX1A Pulcrano S., Volpicelli F., De Santis C., Perrone-Capano C., di Porzio U., Bellenchi G.C. Institute of Genetics and Biophysics „„Adriano Buzzati-Traverso‟‟ - CNR, Naples, Italy; P53. ENRICHED ENVIRONMENT REDUCES GLIOMA GROWTH THROUGH IMMUNE AND NON IMMUNE MECHANISMS IN MICE Garofalo S. Physiology and Pharmacology Department, Sapienza, Rome. P54. OXIDATIVE STRESS DURING THE PROGRESSION PATHOLOGY IN THE NEOCORTEX OF TG2576 MICE OF ALZHEIMER Fracassi A., Fanelli F., Cerù M.P., Moreno S. Department of Science, University Roma Tre, viale Marconi 446, Rome 00146, Italy P55. HIGHER OXIDIZED LOW DENSITY LIPOPROTEINS IN ALZHEIMER’S DISEASE PATIENTS. WHICH ROLE FOR PLATELET ACTIVATING FACTOR ACETYL HYDROLASE AND PARAOXONASE-1 ? Turco I., Bacchetti T., Vignini A., Giulietti A., Nanetti L., Provinciali L., Luzzi S., Mazzanti L., Ferretti G. Dipartimento di Scienze cliniche Specialistiche ed Odontostomatologiche (DISCO), Università Politecnica delle Marche. P56. NEUROPROTECTANTS IN DEGENERATING RETINAS Zerti D., Di Paolo M. Department of Biotechnology and Applied Clinical Science, University of L‟Aquila, Italy P57. NEUROTOXIC EFFECTS OF DIFFERENT AMYLOIDOGENIC TTR VARIANTS AND THERAPEUTIC STRATEGY TO STABILIZE THEIR NATIVE STRUCTURE Vigna L., Pradotto L.G., Walker G.E., Morbin M., Mauro A. 1 Laboratory of Clinical Neurobiology, IRCCS Istituto Piancavallo, Verbania Auxologico Italiano, P58. MOLECULAR MECHANISMS INVOLVED IN MITOCHONDRIAL DYNAMICS IN IN VITRO MODELS OF BRAIN ISCHEMIA Ianniello G., Sisalli M.J., Annunziato L., Scorziello A. Division of Pharmacology, Department of Neuroscience, Federico II University of Naples, Naples, Italy Neurodegeneration and Neuroprotection P59. EPILEPSY-CAUSING MUTATIONS IN KV7.2 C-TERMINUS AFFECT BINDING AND FUNCTIONAL MODULATION BY CALMODULIN Manocchio L., Ambrosino P., Alaimo A., Bartollino S., De Maria M., Gomis-Perez C., Alberdi A., Scambia G., Lesca G., Villarroel A., Taglialatela M., Soldovieri M.V. Dept. of Medicine and Health Science, Univ. of Molise, Campobasso (Italy) P60. NEURODEGENERATIVE DISEASE AND PALLIATIVE CARE NEED: CHARACTERISTICS OF HOSPITAL CARE IN PATIENTS WITH ADVANCED STAGE OF ALZHEIMER’S DISEASE Mannello L., Ferrara L., David S., Sorvillo F., Benedetti A. Biomedical Science, Università Politecnica delle Marche P61. USING ZEBRAFISH TO EXPLORE THE ROLE OF STXBP1 IN AUTISMEPILEPSY PHENOTYPE Marchese M., Sicca F., Grone B., Baraban S., Santorelli F.M. Molecular Medicine Unit, IRCCS Stella Maris Foundation, Viale del Tirreno 331, Pisa, Calambrone 56128, Italy. P62. DIFFERENTIATION AND MIGRATION OF NEURAL STEM CELLS (NSCS) DURING PRECONDITIONING IN A MOUSE MODEL OF NEONATAL HYPOXIA/ISCHEMIA. Brancaccio P., Anzilotti S., Cerullo P., Cuomo O., Di Renzo G., Annunziato L., Pignataro G. Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, "Federico II" University of Naples. P63. NUCLEAR RECEPTORS AND COREGULATORS IN “NEUROSPHERES” DERIVED FROM FETAL BRAIN VS. ADULT SUBVENTRICULAR ZONE Baldassarro V.A., Fernandez M., Giardino L., Calzà L. Health Science and Technologies, Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, Italy P64. NANOVESICLES FROM MESENCHYMAL STEM CELLS: A NEUROPROTECTIVE EFFECT IN CELLS EXPRESSING DIFFERENT SOD1 MUTATIONS THAT CAUSE AMYOTROPHIC LATERAL SCLEROSIS. Bonafede R., Scambi I., Bonetti B., Mariotti R. Department of Neurological and Movement Sciences, University of Verona, Verona P65. MEF2D-MEF2C PATHWAYS ARE ALTERED IN LYMPHOMONOCYTES OF PATIENTS WITH SPORADIC AND FAMILIAL FORM OF AMYOTROPHIC LATERAL SCLEROSIS Arosio A., Sala G., Gerardi F., Rodriguez-Menendez V., Lunetta C., Tremolizzo L., Ferrarese C. Dept. of Surgery and Translational Medicine, Milan Center for Neuroscience, University of Milano-Bicocca P66. MITOCHONDRIAL RESPIRATORY CHAIN DEFECTS IN SKIN FIBROBLASTS FROM PATIENTS WITH DRAVET SYNDROME Neurodegeneration and Neuroprotection Doccini S., Meschini M.C., Mei D., Nesti C., Pezzini I., Guerrini R., Sicca F., Santorelli F.M. IRCCS Fondazione Stella Maris, Division of Molecular Medicine, Neuromuscular and Neurodegenerative Diseases, Calambrone (Pisa), Italy P67. CHOOSING AN ANIMAL MODEL OF HUNTINGTON'S DISEASE AND SENSITIVE BEHAVIORAL METHODS TO EVALUATE THE THERAPEUTIC EFFECTS OF STEM CELL TRANSPLANTATION Tartaglione A.M., Armida M., Potenza R., Pezzola A., Popoli P., Calamandrei G. Dept. Cell Biology and Neurosciences and Dept. Therapeutic Research Med Evaluation, Istituto Superiore di Sanità, Rome, Italy P68. STUDY OF THE MECHANISMS REGULATING THE LOCALIZATION OF Na+/Ca2+ EXCHANGER 3 IN MITOCHONDRIA AND ITS PATHOPHYSIOLOGICAL IMPLICATIONS Fiorillo S., Scorziello A., Molinaro P., Sisalli M.J., Annunziato L. Division of Pharmacology, Department of Neuroscience, Federico II University of Naples, Naples, Italy P69. DYSFUNCTION OF MITOCHONDRIAL MUTATIONS IN REEP1 FISSION ASSOCIATED WITH Meschini M.C., Doccini S., Storti E., Tessa A., Nesti C., Santorelli F.M. IRCCS Fondazione Stella Maris, Division of Molecular Medicine, Neuromuscular and Neurodegenerative Diseases, Calambrone, Pisa - Italy