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CONTROL ID: 883275
TITLE: TOPEM: a PET TOF probe, compatible with MRI and MRS for diagnosis and follow up of prostate
cancer
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AUTHORS (FIRST NAME, LAST NAME): Franco Garibaldi , Raffaele De Leo , Paolo Musico , Roberto
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Perrino , Antonio Ranieri , Maurizio Foresta , Francesco Loddo , Camillo Tamma , Alessandro Gabrielli ,
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Franco Meddi
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Maraviglia
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, Francesco Giorgi , Roberto Fonte , Francesco Librizzi , Paolo Finocchiaro , Bruno
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, Luigi Cosentino , Federico Giove , Tommaso Gili , Francesco Cusanno , Angelo Rivetti , Neal
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Clinthorne , Stan Majewski , Sam Huhss
INSTITUTIONS (ALL): 1. INFN Roma1, Rome, Italy.
2. INFN Bari, Bari, Italy.
3. INFN Bologna, Bologna, Italy.
4. INFN Catania, Catania, Catania, Italy.
5. INFN Genova, Genova, Italy.
6. INFN LNS, Catania, Catania, Italy.
7. INFN Lecce, Lecce, Lecce, Italy.
8. Physics, University of Rome, Rome, Rome, Italy.
9. Radiology, University of Michigan, Ann Arbor, MI, United States.
10. Radiology, University of West Virginia, Morgantown, WV, United States.
11. INFN Torino, Torino, Torino, Italy.
PRESENTATION TYPE: Oral Preferred
EMPHASIS: Development/Novel Use of Imaging Probes
CATEGORY: Multi-modality Probes
AWARDS:
Close to Clinical: Yes, this abstract describes research that is expected to be applied to human studies in
clinical settings within the next 5 years.
ABSTRACT BODY:
Abstract Body:
Prostate cancer (PC) is the most common disease and a leading cause of cancer death. The current standard
for diagnosing PC is transrectal biopsy; however, it is far from perfect. Multimodality imaging can play a
significant role by merging anatomical and functional details from simultaneous PET and MRI (and MRS)
scans for guiding biopsy, diagnosis and follow up . Due to sub-optimal prostate imaging geometries, generic
scanners prevent separation of the signal from surrounding organs with sensitivity, spatial resolution and
contrast inferior to what is achievable with dedicated prostate imagers. Our project (TOPEM) is developing an
endorectal PET-TOF MRI probe. Exploiting the TOF capability allows an increase in the SNR/NECR and also
permits elimination of bladder background. The internal probe is used in coincidence with an external
dedicated detector and/or a standard PET ring. Performance is dominated by the endorectal detector with
improvements in both spatial resolution and efficiency. The electronics must measure coincidences with a
precision of 300 ps or less, and be small enough to be connected to the internal detector. For compactness
and MRI compatibility, Silicon Photomultipliers (SiPM) are used. Their time jitter is negligible so the expected
time resolution is a direct function of the sqrt of photoelectron number related to the PDE. Extensive ongoing
simulation by Geant4 allows study of the scintillator geometry, coupling to the SiPMs and their pixel
dimensions. Measurements for characterization of the performance of different SiPMs (temperature behavior,
PDE etc) are ongoing. A discrete electronics system has been built to perform measurements until the
dedicated electronics system, namely the challenging ASIC (the design of it is ongoing), is available.
Simulation results show spatial resolution of 1.5 mm - 2 mm for source distances of 10–20 mm, with improved
efficiency over external PET. Depending on the reconstructed resolution desired, noise can be reduced by up
to ~7x over external ring PET alone giving improvements of effective NEC of ~50x. Timing resolution (only the
electronics) of 100 ps has been obtained with the discrete electronic system. A minidetector prototype (LYSO
coupled to a SiPM array) has been built and will be tested in a 3 T MRI soon. We have preliminary results of
measurements and simulations; results from a more advanced stage of the project will be presented at the
conference.
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COI:
Franco Garibaldi: No COI to disclose.
Raffaele De Leo: No Answer.
Paolo Musico: No Answer.
Roberto Perrino: No Answer.
Antonio Ranieri: No Answer.
Maurizio Foresta: No Answer.
Francesco Loddo: No Answer.
Camillo Tamma: No Answer.
Alessandro Gabrielli: No Answer.
Franco Meddi: No Answer.
Francesco Giorgi: No Answer.
Roberto Fonte: No Answer.
Francesco Librizzi: No Answer.
Paolo Finocchiaro: No Answer.
Bruno Maraviglia: No Answer.
Luigi Cosentino: No Answer.
Federico Giove: No Answer.
Tommaso Gili: No Answer.
Francesco Cusanno: No Answer.
Angelo Rivetti: No Answer.
Neal Clinthorne: No Answer.
Stan Majewski: No Answer.
Sam Huhss: No Answer.
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