MEETING VENUE
Dear Colleagues,
The pursuit of translational medicine is the conversion of scientific discovery into health improvement, one of
the priority of biomedical science in 21st century. The main goal of this meeting is to bring together clinicians,
research scientists and industry partners for discussing the medical advances from the laboratory to the clinic.
For this reasons, The Italian Society of Immunology, Clinical Immunology and Allergology (SIICA) is pleased to
invite you to attend the “3rd Conference on translational medicine on pathogenesis and therapy of immune-mediated
diseases” to be held at Humanitas Congress Center in Milan (Italy) from September 29th until October 1st, 2014.
This third edition of the workshop has a particular focus on inflammation and innate immunity responses that,
as first lines of defense in several models of human diseases, play a key roles in the pathogenesis of cancer,
autoimmune diseases, inflammatory bowel disorders and viral infections. Indeed, the elucidation of host’s
inflammatory responses within the innate immune compartment is a required experimental step for the
development of novel and alternative therapeutic strategies to cure these diseases.
As occurred in the two past editions of this workshop, you will experience a high quality scientific program with
the presence of word renowned national and international speakers that will discuss the latest advances in their
fields. The meeting will be opened by a lecture given by Jules Hoffmann (awarded with the Nobel Prize for
Medicine in 2011) and will be closed by another lecture delivered by Robert Gallo. We have also scheduled a
satellite symposium on Next Generation Sequencing and Transcriptome, a current hot topic in the field of
molecular immunology. Moreover, there will be two lunchonseminars dedicated to the role of the pathologist
in translational immunology and to the novel therapeutic approaches with cancer stem cells.
Intensive social and interactive programs (happy hours, coffee breaks, poster sections with open bar, scientific
exchanges with pioneers in the fields of translational immunology, etc) are thought to enforce scientific networks
for young scientists.
The detailed program is available on our web site. The meeting is supported by University of Milan, the European
Federation of Immunological Societis (EFIS), Society for Leukocyte Biology (SLB), Associazione Italiana per la
Ricerca Sul Cancro (AIRC) and Humanitas Research Hospital. Several travel awards from SIICA, SLB, AIRC and
EFIS are available for young scientists below 40 years old.
We invite you to actively participate to our meeting by submitting abstracts that will contribute to improve the
level of our scientific program and advance our knowledge in the field.
Hoping to see you in Milan
HUMANITAS CONGRESS CENTRE
Via Manzoni, 113 - Rozzano - Milan
SCIENTIFIC SECRETARIAT
Marco Cassatella | University of Verona, Italy
Carmelo Carlo Stella | University of Milan, Humanitas Research Hospital, Milan, Italy
Silvio Danese | Humanitas Research Hospital, Milan, Italy
Marco Gattorno | Institute Giannina Gaslini, Genova, Italy
Pietro Invernizzi | Humanitas Research Hospital, Milan, Italy
Massimo Locati | University of Milan, Humanitas Research Hospital, Milan, Italy
Enrico Lugli | Humanitas Research Hospital, Milan, Italy
Luis Montaner | Wistar Institute, Philadelphia, PA, USA
Antonino Spinelli | Humanitas Research Hospital, Milan, Italy
Anna Villa | National Research Council, Humanitas Research Hospital, Milan, Italy
ORGANIZING SECRETARIAT
MATERIA PRIMA
T. 03631848776 - F. 03631920301
www.materia1a.it - [email protected]
www.translationalimmunology.it
Workshop SIICA
Italian Society of Immunology
Clinical Immunology and Allergology
Milan | SEPTEMBER 29th - 30th, OCTOBER 1st - 2014
www.translationalimmunology.it
3RD CONFERENCE
of translational medicine on
pathogenesis and therapy of
immune-mediated diseases
4 SIICA travel awards of € 500 for young SIICA members - under 40 years old
A meeting aimed to enhance synergic
interactions between scientists
and physicians working in the field of
clinical and experimental immunology
4 AIRC travel awards of € 500 for young scientist - under 40 years old
Focus on inflammation
TRAVEL AWARDS
1 JLB travel award of $ 1.000 for the best presentation
that will be invited to be published on the journal following a peer-review
PRELIMINARY PROGRAM
10 EFIS travel awards for young scientist - under 40 years old
CHAIRMAN OF THE MEETING
Chairman of the meeting
DEADLINES
Domenico Mavilio
University of Milan
Humanitas Research Hospital, Milan, Italy
JUNE 15th, 2014
Deadline for abstract submission and registration with discounted rate
JULY 15th, 2014
Confirmation of abstract acceptance for both poster and oral presentation
In collaboration with
MONDAY, SEPTEMBER 29th 2014
Early Afternoon SATELLITE SYMPOSIA ON NEXT GENERATION SEQUENCING AND TRANSCRIPTOME
Supported by Illumina and Charles River
Speakers: - Dave Delano, Senior Product Manager Illumina, San Diego, CA, USA
Illumina solutions for trascriptomics
- Yann Herault, IGBMC, Inserm, Strasbourg, France
Mouse phenogenomics to evaluate transcriptome-driven hypothesis
- Enzo Medico, Candiolo Cancer Institute and University of Torino, Italy
Analysis of tumor-stroma interactions by species-specific transcriptional profiling
of patient-derived xenografts
- Raffaele Calogero, University of Torino, Italy
Circulating non-coding RNA as Biomarker in Human Diseases
Open and Welcome Ceremony Domenico Mavilio, Humanitas Research Hospital and University of Milan, Milan Italy
OPENING LECTURE
Chairman: Alberto Mantovani, Humanitas Research Hospital and University of Milan, Milan Italy
Speaker: Jules Hoffmann, University of Strasbourg, France, Nobel Prize for Medicine in 2011
Toll Like Receptors and Innate Immune responses
TUESDAY, SEPTEMBER 30th 2014
Morning Session IMMUNITY, AUTOIMMUNE AND AUTOINFLAMMATORY DISEASES
Chairmen: Marco Gattorno, Istituto Giannina Gaslini, Genova, Italy
Pietro Invernizzi, Humanitas Research Hospital, Milan Italy
Speakers: - David Adams, University of Birmingham, UK
Primary Sclerosing Cholangitis: an autoimmune disease driven by the gut
- Ansgar W. Lohse, University Medical Center, Hamburg, Germany
Pathogenesis of autoimmune hepatitis: too little or too much T reg activity?
- David Jones, Newcastle University, U.K.
Autoimmune liver diseases - Primary Biliary Cirrhosis
- Dan Kastner, NHGRI, NIH, Bethesda, MD, USA
Autoinflammatory diseases
- Anna Rubartelli, IRCCS, San Martino Hospital, Genova, Italy
The critical role of stress in IL-1β and regulatory cytokine production
by healthy and NLRP3-mutated monocytes
- Richard Siegel, NIAIMS, NIH, Bethesda, MD, USA
Autoinflammatory diseases
- Dirk Foell, University Hospital Muenster. Germany
Autoinflammatory diseases and Rheumatoid Arthritis
Four short talks (10 minutes) selected from submitted abstracts
LUNCHONSEMINAR: ROLE OF THE PATHOLOGIST IN PROJECTS OF TRANSLATIONAL IMMUNOLOGY
Suported by Space
Speaker: Claudio Doglioni, Istituto San Raffaele, Milan, Italy
Afternoon Session INNATE IMMUNITY AND VIRUSES
Chairmen: Luis Montaner, Wistar Institute, Philadelphia, PA, USA
Enrico Lugli, Humanitas Research Hospital, Milan, Italy
Speakers: - Marco Colonna, Washington University, St. Louis, MO, USA
ΝΚ cells/Dendritic Cells and viruses
- Michael Malim, Kings College, London, U.K
HIV-1 Infection, Type-1 Interferon and Viral Restriction
- Daniel Douek, VRC, NIAID/NIH, Bethesda, MD, USA
Perturbing Type I Interferon Signaling in Acute SIV Infection
- Julie Dechanet-Merville, CNRS, Bordeaux, France
Cell stress recognition by CMV-induced gamma-delta T cells Cell stress recognition
by CMV-induced gamma-delta T cells
- Christian Munz, University of Zurich, Switzerland
NK cells and viruses
- Luigi Naldini, Istituto San Raffaele and Telethon Insitute, Milan, Italy
Lentiviruses and gene therapy
- Matteo Iannacone, Istituto San Raffaele, Milan, Italy
In vivo imaging of antiviral immune responses in the liver
Four short talks (10 minutes) selected from submitted abstracts
WEDNESDAY, OCTOBER 1st 2014
Morning Session INNATE IMMUNITY AND TUMOR IMMUNOLOGY
Chairmen: Massimo Locati, Humanitas Research Hospital and University of Milan, Milan Italy
Carmelo Carlo Stella, Humanitas Research Hospital and University of Milan, Milan Italy
Speakers: - Adrian Hayday, King’s College, London, UK
A new (and optimistic) perspective on the suppression of Tumour-Infiltrating Lymphocytes
- Jo Van Ginderachter, VIB, Gent, Belgium
Macrophage and dendritic cell heterogeneity in the tumor microenvironment
- Vincenzo Bronte, University of Verona, Italy
Myeloid suppressor cells and inflammation-driven tumors
- Haribabu Bodduluri, University of Lousville, KY, USA
Leukocyte networks in tumors
- Ralf Küppers, University of Duisburg-Essen, Germany
The role of the microenvironment in lymphoma pathogenesis
- Constantine Mitsiades, Dana-Farber Cancer Institute, Boston, USA
Host immune response in multiple myeloma
Four short talks (10 minutes) selected from submitted abstracts
LUNCHONSEMINAR: CANCER STEM CELLS: MOLECULAR IDENTITY AND CLINICAL SIGNIFICANCE
Suported by Dompè
Speaker: Piero Dalerba, Stanford School of Medicine, Standford, CA, USA
Afternoon Session INNATE IMMUNITY AND INFLAMMATORY BOWEL DISEASES
Chairmen: Silvio Danese, Humanitas Research Hospital, Milan Italy
Antonino Spinelli, Humanitas Research Hospital and University of Milan, Milan Italy
Speakers: - Stefania Vetrano, Humanitas Research Hospital, Milan, Italy
The epithelium in IBD: a break in the wall?
- Christoph Becker, Friedrich-Alexander-University, University Medical Center, Erlangen, Germany
Is Crohn’s disease an immune defect or an immune excess?
- Britta Siegmund, Charité – Universitätsmedizin Berlin
Cross-Talk of non-immune cells and immune cells in the regulation of IBD
- Nicola Gagliani, Yale University, New Haven, CT, USA
The complex role of Th17 and Tr1 cells in the regulation of intestinal homeostasis
- Matthieu Allez, University of Paris, France
Manipulation of the innate or the adaptive immune system as a novel approach for IBD?
Four short talks (10 minutes) selected from submitted abstracts
CLOSING LECTURE
Chairman: Domenico Mavilio, Guido Poli
Speaker: Robert Gallo, Institute of Human Virology, University of Maryland, Baltimore, MD USA
Pathogenesis of HIV-1 Infection