Summary
HORIZON 2020 FUNDING OPPORTUNITIES ON
HEALTH
Presentation of project ideas for consortia building
April 10th 2014
H 15:15-16:45
Novarello – Villaggio Azzurro, Novara, Italy
Catalogue of Participants
1.
Presentation........................................................................................................................ 3
2.
Associazione Vivere la Montagna......................................................................................... 4
3.
HPV-UNIT – Regina Elena National Cancer Institute (IRE)...................................................... 6
4.
Infomedica srl – Medical Education & Information ............................................................... 8
5.
Istituto Nazionale per le Malattie Infettive „Lazzaro Spallanzani“ ...................................... 10
6.
German Cancer Research Centre – Div. of Viral Transformation Mechanisms ..................... 12
7.
Università degli studi del Piemonte Orientale – Dip. di Medicina........................................ 14
8.
Università degli studi del Piemonte Orientale – Dip. di Scienze e Innovazione Tecnologica . 16
9.
Università di Torino – Dip. Surgical Sciences....................................................................... 18
10.
1
Università di Torino of Torino – Dep. of Agricultural, Forest and Food Sciences ............... 20
2
1.
Presentation
Objective of the event:
The special event is organized by Finpiemonte and Unioncamere Piemonte, during the 7th International
Conference on “HPV, Polyomavirus and UV in Skin Cancer”.
The event is organized in the framework of the Enterprise Europe Network (EEN), which is the EU’s largest
business support network promoting competitiveness and innovation in Europe and beyond, with 600
partner organizations in more than 50 countries. One of the most important mission of EEN is to help SMEs,
universities and research organization to build international partnerships and take part to international RTD
projects.
2.
Associazione Vivere la Montagna
Country/Region:
Italy – Piedmont - Cumiana (Torino)
Main objective of the workshop is to present FUNDING OPPORTUNITIES in Horizon 2020 for HEALTH and
to give to the participants the opportunity to present and discuss potential project ideas.
Giorgio Chiaretta – President
Massimo Apicella – Vice-President
Chiara Reggiani – Scientific Committee
Donata Vinelli – Scientific Committee
Name of Researcher:
Added value of the event:
•
Get background information about the Health call in Horizon 2020
•
Meet new partners for potential collaboration on specified issues
•
Facilitate the setup of Horizon 2020 project consortia
•
Present, discuss and develop new project ideas at international level
•
Initiate cross-border contacts
•
Promote your organization and expertise in Europe and USA.
Researcher Contact Details
Phone
+39.011.198.36.595 – 349.67.67.113
E-mail
[email protected]
[email protected]
Thematic focus:
For additional information on Horizon 2020:
Main Sectors of application:
•
Programme Framework
•
Health specific Programme and call information
•
Health, demographic change and wellbeing, Work Programme 2014-2015
For further information: Cristiana Tabacco - [email protected] , tel +39 011 5717814.
3
Human Health and Mountain
Psycho-social rehabilitation and environment
developement
International cooperation experience
Not previously experienced
NO
Involved in international and RTD projects
NO
Experience in the following cooperation and RTD
programmes:
NO
4
Project Description
“Alpinhealth® - A mountain of health”
Alpinhealth® is a project that acts on several levels, which looks at the Highlands as a resource
and as a tool for healthy well-being oriented in the psychological, social, occupational areas and for
rehabilitation.
3.
HPV-UNIT – Regina Elena National Cancer Institute (IRE)
Country/Region:
Alpinhealth ® suggests and develops a kind of interactive approach, both for the inner being for
a person as himself, and for his relationship with the outer environment
Italy
Name of Researcher:
Aldo Venuti
Alpinhealth ® provides an innovative approach for the psycho-physical welfare oriented to
the geographical area, the project can also be an exportable model to other highland areas.
Researcher Contact Details
HPV-UNIT IRE via Chianesi 53 00144 Rome Italy
Phone
+39065266250
E-mail
[email protected]; [email protected]
Type of Partner Searched
Universities, local Authorities, Social-Healthcare Consortia, Banking foundations, Other potential
lenders/investors
Thematic focus:
Main Sectors of application:
Viruses and cancer
Biological (immuno)Therapy, biomarkers, diagnosis
Contacts for further information
International cooperation experience
EEN Partners Cristiana Tabacco
Phone: +39 011 5717814
Not previously experienced
E-mail: [email protected]
Involved in international and RTD projects
Yes, but not European RTD projects (Collab.
projects with Scotland, Argentina and
Australia)
Experience in the following cooperation and RTD
programmes:
None in granted European framework
programmes but participating in
(unfortunately) not granted Projects.
Project Description
Search for new viruses associated with human malignancy.
Discovery of new virus-related biomarkers (and biosensor device for their detection) for early diagnosis and
population screening
New personalized (immuno and/or small molecules) therapy against virus/host interacting pathways
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Type of Partner Searched
4.
Bioinformatics for in silico research (metagenomics).
Infomedica srl – Medical Education & Information
Company producing/possessing large arrays of small molecules with interacting activity on different
viral/cellular pathways
Company producing/developing new therapeutic vaccines
Country/Region:
Italy
Clinical Dept with large archival samples/patients
Name of Researcher:
Infomedica – Giorgio Mantovani
Biosensor researchers for the development of new diagnostic device for biomarker detections
Researcher Contact Details
Contacts for further information
Phone
+39 011 859990
E-mail
[email protected]
EEN Partners Cristiana Tabacco
Thematic focus:
Phone: +39 011 5717814
E-mail: [email protected]
Main Sectors of application:
Medical Education & Information
Distance learning (Self-Assessment & Self-Education
Programs / CME Journals / Clinical cases & Interactive study
modules / Information – broadcasting & web)
International cooperation experience
Not previously experienced
Previous international experience with
international private entities
Involved in international and RTD projects
In international private projects
Experience in the following cooperation and RTD
programmes:
Distance learning for health care
professionals
Project Description
Project 1: Compliance / Adherence
Background: For millions of patients, medications for chronic diseases are often misunderstood or misused.
Most patients quickly abandon therapy; many times for the wrong reasons—and with serious consequences.
Objectives: Design & create an integrated system to bring together all parties (patient, physician, care
giver) to improve patients’ experiences with medications, for the benefit of patients, their families and the
entire healthcare system.
Project 2: Share your health knowledge
Background: In medical practice professionals guarantee the best care for their patients by committing to
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life-long learning.
Objectives: Design & implement a virtual meeting place for the promotion of medical & scientific learning
for teachers and learners within the healthcare scenario and throughout all EU. The online courses will be
subject to rigorous peer-review and guaranteed by institutional or academic partners taking part in the
project.
5.
Project 3: Mobility for health workforce (HWF)
Background: According to an estimate, Europe expects a shortage of 1 million health workers by 2020.
Demand, need and supply of the HWF are influenced by multiple factors like ageing population, ageing HWF,
rising care use and rising costs in a context of budget constraints.
Objectives: Analyse and project a platform for the HWF for exchange data/information between EU
countries to support mobility of the HWF.
Istituto Nazionale per le Malattie Infettive „Lazzaro Spallanzani“
Country/Region:
Italy
Name of Researcher:
Garbuglia Anna Rosa
Researcher Contact Details
Phone
+390655170692
E-mail
[email protected]
Type of Partner Searched
Thematic focus:
Project 1: Researchers, physicians, and institutions in the most important EU to map the different situations
and define a possible standard procedures for managing the compliance/adherence in the EU countries. / IT
experts.
Main Sectors of application:
Project 2: Institutions (academic or other), teacher/trainers, educationalists, physicians within the EU to
create a network of experts to create, manage and share knowledge disseminated through e-learning for all
health care workers. / IT experts.
International cooperation experience
Project 3: Institutions) in the most important EU to map the different situations to manage and share a
platform for supply/demand of all the potential mobility EU / IT experts.
Not previously experienced
HPV in oral site
Phylogenetic analysys; potential oncogenicity of HPV
Involved in international and RTD projects
Yes
Experience in the following cooperation and RTD
programmes:PREDEMICS
Contacts for further information
Project Description
EEN Partners Cristiana Tabacco
Phone: +39 011 5717814
In view of the increased life-span of HIV patients undergoing long term highly active antiretroviral therapy
(HAART) as well as the possible etiologic role of the oral HPV in carcinogenesis, aging HIV/HPV-coinfected
patients may be at significant risk as regards HPV-associated lesions and malignancies. Preliminary data
showed that β and γ HPV prevalence was higher than those of α HPV in oropharingeal swabs samples.
Several unclassified genotypes were found (HPV FA12.2; HPV ISOL FA97; HPV ISOL. FA68) and some
rare genotypes, i.e. HPV120, were detected in multiple anatomical sites (oral and anal).
E-mail: [email protected]
Objectives: 1) Charaterization of new HPV types, 2) tropism analysis of rare β and γ HPVs 3) potential
oncogenicity of β and γ HPV in oral site in HIV subjects.
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Type of Partner Searched
6.
•
Bioinformatic expertise in the analysis of new HPV genotypes and in performance of a
metagenomic approach for detecting multiple HPV infections.
•
Know-how in molecular field to analyze transcriptional regulation of viral gene expression in
nonmalignant and malignant cells.
German Cancer Research Centre – Div. of Viral Transformation
Mechanisms
Country/Region:
Germany
Name of Researcher:
Prof. Dr. Frank Rösl / Dr. Sabrina Vinzón
Researcher Contact Details
Phone
+49 6221 42-4922
E-mail
[email protected]; [email protected]
Contacts for further information
EEN Partners Cristiana Tabacco
Thematic focus:
Phone: +39 011 5717814
Development of second generation vaccines against
papillomavirus
E-mail: [email protected]
Main Sectors of application:
Pharmaceutical industry; Human medicine.
International cooperation experience
x
Not previously experienced
Involved in international and RTD projects
Experience in the following cooperation and RTD
programmes:
Project Description
Papillomaviruses are small, non-enveloped viruses which infect the stratified squamous epithelia of skin and
mucosal membranes. Different types of papillomaviruses are involved in the development of a variety of
human cancers. Among them, there are approximately 15 types named high-risk types because they are
considered the etiological agents of most cervical cancers, and are also associated with many penile, vulvar
and anal carcinomas and more than 40% of head and neck cancers. The remaining mucosal types are rarely
found in malignancies and therefore called low-risk. On the other hand, the cutaneous HPV types are
associated with the development of skin warts and also with the development of non-melanoma skin cancer,
especially in organ transplant patients.
The rodent Mastomys coucha is naturally and persistently infected with Mastomys natalensis papilloma virus
(MnPV). The animals are unique in spontaneously developing not only benign skin tumours, such as
papillomas and keratoacanthomas, but also squamous cell carcinomas, for which MnPV is the etiological
agent. Infection occurs early in lifetime, similarly to cutaneous HPVs, and high viral loads can be detected in
the skin of older animals, which trigger the onset of papilloma development. Therefore, M. coucha
represents an excellent read-out model to investigate prophylactic approaches against PV-induced skin
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tumors under natural conditions.
In a recent study, we evaluated the efficacy of a virus-like particle (VLP)-based vaccine on either previously
or newly established infections. VLPs raise a strong and long-lasting neutralizing antibody response that
confers protection even under systemic long-term cyclosporine A treatment. Remarkably, the vaccine
completely prevents the appearance of benign as well as malignant skin tumors. Protection involves the
maintenance of a low viral load in the skin by an antibody-dependent prevention of virus spread. Our results
provide first evidence that VLPs elicit an effective immune response in the skin under immunocompetent and
immunosuppressed conditions in an outbred animal model, irrespective of the infection status at the time of
vaccination. These findings provide the basis for the clinical development of potent vaccination strategies
against cutaneous HPV infections and HPV-induced tumors, especially in patients awaiting organ
transplantation.
7.
Università degli studi del Piemonte Orientale – Dip. di Medicina
Vaccination against genital HPV types is currently being used worldwide to prevent infection and, in turn, the
development of HPV-induced lesions in the mucosa, including cervical carcinoma. The two licensed vaccines
are composed of HPV VLPs, which elicit high titers of neutralizing antibodies that protect from a subsequent
infection by the targeted HPV types. However, these vaccines have several limitations: (i) they target only
two mucosal high-risk types, therefore potentially preventing approximately 70% of the cervical cancer
cases, which leaves 30% of the cases unattended; (ii) they don´t target any cutaneous type; (iii) they are
very costly, making implementation of wide-covering vaccination schedules difficult in underdeveloped
countries.
Country/Region:
Italy
Name of Researcher:
Filippo Renò
Phone
+39-0321-660634
Given the variety of HPV types that could be involved in the development of non-melanoma skin cancer in
humans, as well as the many types causing mucosal tumors, a broadly protective HPV vaccine would be
ideal. The papillomavirus minor capsid protein L2, contains a major cross-neutralizing epitope that could be
used to develop a second generation vaccine.
E-mail
[email protected]
Thematic focus:
Skin disease
The aim of our project is to investigate whether administration of such a broadly protective vaccine (i.e., an
L2-vaccine) is as effective in preventing skin tumors in Mastomys coucha as its L1 counterpart.
Main Sectors of application:
Dermatology, inflammation, pharmacology
Researcher Contact Details
International cooperation experience
Type of Partner Searched
Academic.
Not previously experienced
Industrial.
Involved in international and RTD projects
x
Experience in the following cooperation and RTD
programmes:
Contacts for further information
EEN Partners Cristiana Tabacco
Phone: +39 011 5717814
Project Description
E-mail: [email protected]
Autonomic dysfunction has been associated with human inflammatory diseases including rheumatoid
arthritis, diabetes and sepsis; whether this dysfunction results from the inflammatory component of these
diseases, or is actually an underlying cause, is not clear. Recently, a neural circuit has been identified that
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controls the inflammatory response in a reflex- involving the vagus nerve which is able to sense
inflammation and to respond to it by releasing acetylcholine (Ach) which inhibits macrophage cytokine
production interacting specifically with macrophage alpha7 subunits of nicotinic ACh receptors. Others
Immune cells, including lymphocytes, express muscarinic and nicotinic acetylcholine, and agonist
stimulation of these AChRs causes functional and biochemical changes in the cells. In addition, a recently
discovered endogenous allosteric α7 nAChR ligand, SLURP-1, also appears to be involved in modulating
both normal T cell function and keratinocyte behaviour. Since nicotinic AChRs have been shown to regulate
SLURPs production, these peptides have been suggested as prototype drugs for the treatment of wounds
that fail to heal.
8.
Università degli studi del Piemonte Orientale – Dip. di Scienze e
Innovazione Tecnologica
The aims of the project are:
Country/Region:
Itay/Piemonte
1) to investigate the role of the “vagal tone” in the onset of inflammatory and autoimmune disease
cutaneous effects;
Name of Researcher:
M. Botta, L. Tei, F. Carniato
Researcher Contact Details
Dr. Lorenzo Tei
2) to test the ability of physical exercise, colinomimetic drugs and acetylcholine synthesis and degradation
modulators to mitigate cutaneous effects
3) to design new therapeutic and pharmacological approaches to inflammatory and autoimmune disease
cutaneous effects;
Phone
0131 360208
E-mail
[email protected]
Thematic focus:
Type of Partner Searched
Theranostic nanoparticles
Main Sectors of application:
Personalise nanomedicine
Type of Partner Searched
International cooperation experience
Clinical centres, university research groups, biotech and pharmaceutical companies
Not previously experienced
Involved in international and RTD projects
Participation in EU Projects (coordinator Prof. S. Aime,
University of Torino, Italy):
Contacts for further information
European Networks of Excellence (6th EU Framework
Programme): “European Molecular Imaging Laboratories
- EMIL” (2004-2009).
EEN Partners Cristiana Tabacco
“Diagnostic Molecular Imaging DiMI” (2005-2010).
Phone: +39 011 5717814
Experience in the following
cooperation and RTD programmes:
E-mail: [email protected]
MEDITRANS (NMP4-CT-2006-026668), Targeted Delivery
of Nanomedicine (2006-2011).
Members of EU COST Action TD 1004: “Theranostics imaging
and therapy: an action to develop novel nanosized systems
for imaging-guided drug delivery” (2012 – 2016).
EU COST Actions D38 and D18: "Metal-Based Systems for
Molecular Imaging Applications" (2006-2011) and “Lanthanide
Chemistry for Diagnosis and Therapy” (2001-2006).
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Project Description
Use of functionalised Gd-loaded mesoporous silica nanoparticles or efficient Gd-based liposomes for imaging
guided drug delivery and for theranostic applications
Optimization of: i) the contrast efficiency; ii) the modulation of drug loading and release; iii) the selectivity
of the nanoparticle targeting to malignant tissues
9.
Type of Partner Searched
Università di Torino – Dip. Surgical Sciences
Country/Region:
ITALY/ PIEMONTE
1) Academic groups specialized in “in vitro” and “in vivo” application of theranostic agents or high field MRI
contrast agents.
Name of Researcher:
ELISABETTA RADICE
2) Pharmaceutical companies for development of novel drug delivery systems.
Researcher Contact Details
Contacts for further information
Phone
+39 011/0915385
E-mail
[email protected]
EEN Partners Cristiana Tabacco
Thematic focus:
Phone: +39 011 5717814
E-mail: [email protected]
Main Sectors of application:
Cancer research,pre-clinical/clinical application
Colorectal cancer (CRC), pelvic floor pathologies
International cooperation experience
Not previously experienced
x
Involved in international and RTD projects
Experience in the following cooperation and RTD
programmes:
H2020 - PHC13 – innovative therapy against
CRC
Project Description
Each project involving: Clinical and pre-clinical research (basic/traslational research, TRL 1-4)
Pelvic floor pathology, cancer research (i.e. CRC, etc.)
Mini-invasive sirurgy
Robotic sirurgy
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Nanomedicines pre-clinical/clinical application
Type of Partner Searched
Universities (medicine and surgery department)
Researchers (clinical pre-clinical studies)
Hospitals and research center/labs (public/private)
Pharmaceutical/Nutreceutical manufacturer
10. Università di Torino of Torino – Dep. of Agricultural, Forest and
Food Sciences
Country/Region:
Italy/Piedmont
Name of Researcher:
Valentina Scariot
Researcher Contact Details
Via Leonardo da Vinci 44, 10095, Grugliasco, Torino
healthcare SME
Contacts for further information
Phone
+390116708935
E-mail
[email protected]
EEN Partners Cristiana Tabacco
Phone: +39 011 5717814
E-mail: [email protected]
Thematic focus:
Main Sectors of application:
Ornamental and medicinal plants
Biology, biotechnology, sustainable practices
International cooperation experience
X
Not previously experienced
Involved in international and RTD projects
Experience in the following cooperation and RTD
programmes:
Project Description
Plant secondary metabolites do not play a major role in growth and development. Conversely, their
production and accumulation are fundamental for plant survival under extreme environmental conditions
(abiotic stresses). Many of these are important bioactive compounds potentially beneficial for human health.
The pharmacological involvement of so-called “medicinal plants”, which include the Lamiaceae, Labiatae,
Asteraceae, Cistaceae, Punicaceae, and Oleaceae families, has long time been known. Concerning
pharmacologal aspects, the metabolic syndrome incidence (dyslipidemia, insulin resistance and hypertension)
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is increasing in Western countries and represents a risk factor for many cardiovascular diseases. Nowadays,
the identification of dietary supplements that can reduce these possible cardiovascular complications is
therefore of considerable pharmacological interest. Thus, the main purpose of this project will be to evaluate
the dietary pharmacological properties of essential oils extracted from Melissa officinalis L., Salvia fruticosa
L., Helichrysum italicum (Roth) Don, Artemisia princeps Pamp, Cistus populifolius Mill., Punica granatum L.,
and Olea europea L., in conditions of abiotic stress, with a view to health promotion and disease prevention
(Horizon 2020).
The study of the biosynthesis of plant compounds will be conducted through in vivo and in vitro approaches.
In both cases, plants will be cultivated under drought, cold, and ozone stress. In particular, for all trials a
multidisciplinary approach will be undertaken, ranging from ecophysiological characterization (for example
osmotic potential, turgor loss, cell walls elasticity, leaf conductance, gas exchange, xanthophylls cycle),
through the analysis of primary metabolism, the characterization of secondary metabolite classes, the
quantification of phytohormones (HPLC), and the characterization of volatile compounds (GC and SPME), to
proteomics studies (LC and Q-trap MS-MS). In order to better understand the molecular basis of stress
response, the total transcriptome of stressed plants will be sequenced by means of Next Generation
Sequencing (NGS) using the RNA-Seq technique. Plants subjected to different theses will be submitted to the
extraction of essential oils through two techniques, i.e. the ultrasound-assisted and the microwave-assisted
extraction. These methodologies are known to be high throughput and to yield high-quality oils through a
rapid protocol, reducing solvent consumption as well (green extraction). Finally, the extracted plant
compounds will be tested in vivo in animal models with fat dietary, miming a condition of human metabolic
syndrome. In parallel, in vitro studies will be aimed to the analysis of potential antiflammatory effects of
essential oils by usingvascular endothelial cells (Human Umbilical Vein Endothelial Cells, HUVEC), the main
target tissue of the metabolic syndrome, and polymorphonuclear cell, as reference target. As a final aim, it
will be of high scientific interest to integrate physiology, morphology, metabolomics and transcriptomics, in
order to identify molecules that can potentially have a positive activity on human health.
Type of Partner Searched
We are searching for partner mainly involved in the medicinal and pharmacological aspects related to the
activity of natural compounds.
Contacts for further information
EEN Partners Cristiana Tabacco
Phone: +39 011 5717814
E-mail: [email protected]
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