Resorption
Haptenation
Results interpretation
2
Factor A
Resorption
1.5
Factor B
Haptenatio
n
Factor C
↑IL18
1
0.5
Factor D
Acute
Cytotoxicity
0
Irritation
index
Non
Sensitizer
(No Effect)
Non
Sensitizer
(Irritant)
Sensitizer
Sensitization
index
Keratinocytes
NCTC2544
Xenobiotic
Endogenous protein
Keratinocyte
Dendritic cell
(Langerhans cell)
T Lymphocyte
Interleukin 18
Resorption
Haptenation
Sensitization index
Irritation index
Xenobiotic
Endogenous protein
Keratinocyte
Dendritic cell
(Langerhans cell)
T Lymphocyte
Interleukin 18
Resorption
Haptenation
Sensitization index
Irritation index
Xenobiotic
Endogenous protein
Keratinocyte
Dendritic cell
(Langerhans cell)
T Lymphocyte
Interleukin 18
Resorption
Haptenation
Sensitization index
Irritation index
Resorption
Haptenation
Results interpretation
2
Factor A
Resorption
1.5
Factor B
Haptenatio
n
Factor C
↑IL18
1
0.5
Factor D
Acute
Cytotoxicity
0
Irritation
index
Non
Sensitizer
(No Effect)
Non
Sensitizer
(Irritant)
Sensitizer
Sensitization
index
Keratinocytes
NCTC2544
Test molecule
Resorption
Haptenation
Results interpretation
2
Factor A
Resorption
1.5
Factor B
Haptenatio
n
Factor C
↑IL18
1
0.5
Factor D
Acute
Cytotoxicity
0
Irritation
index
Non
Sensitizer
(No Effect)
Non
Sensitizer
(Irritant)
Sensitizer
Sensitization
index
Keratinocytes
NCTC2544
Test molecule
Endogenous protein
Resorption
Haptenation
Results interpretation
2
Factor A
Resorption
1.5
Factor B
Haptenatio
n
Factor C
↑IL18
1
0.5
Factor D
Acute
Cytotoxicity
0
Irritation
index
Non
Sensitizer
(No Effect)
Non
Sensitizer
(Irritant)
Sensitizer
Resorption
Haptenation
Results interpretation
2
Factor A
Resorption
1.5
Factor B
Haptenatio
n
Factor C
↑IL18
1
0.5
Factor D
Acute
Cytotoxicity
0
Irritation
index
Non
Sensitizer
(No Effect)
Non
Sensitizer
(Irritant)
Sensitizer
Sensitization
index
Keratinocytes
NCTC2544
Resorption
Results interpretation
Haptenation
2
Factor A
Resorption
1.5
Factor B
Haptenation
1
Factor C
↑IL18
0.5
0
Irritation
index
Non
Sensitizer
(No Effect)
Non
Sensitizer
(Irritant)
Sensitizer
Factor D
Acute
Cytotoxicity
Sensitization
index
Keratinocytes
NCTC2544