OPEN SOURCE BRAIN
Realistic modeling
the cerebellar cortex
Sergio Solinas, Egidio D’Angelo
University of Pavia
IRCCS C. Mondino
Alghero 13-15 May 2013
1958
“a lattice” 55 years later
OSB website
Parasagittal organization
Golgi cell axon
Barmack & Yakhnitsa J. Neurosci. 2008
Parasagittal organization
Mossy fiber branching
Wu et al. J. Comparative Neurology 1999
Lattice arrangement
Purkinje cell
Stellate cell Golgi cell
dendritic fields axonal field axonal field
Parallel Golgi cell
fibers
dendritic field
Pellionisz & Szentágothai Brain Research 1973
Network picture from otto
Input of the cerebellar cortex
Convey channel:
Cerebral cortex
Sensory nuclei
Center/ surround effect
Spot scale 200 µm
Parallelf fiber scale 2 mm:
Lateral inhibition
Collaborative development
Sheffield: tests and analysis procedures
Amrita: LFP reconstruction &
Multicompartmenteal GRC model
Field Programmable Gate Array (FPGA)
PhD Thesis Alessandra Majani
Hart beat discrimination
F1 engine monitor
NEURON simulator
FPGA simulator
Single compartment model of Cerebellar granule cell
(D’Angelo et al. 2001, Solinas et al .2010)
FPGA simulator
Architecture
N° CELLs
FPGA complexity
Expandable
SOFTWARE
100
LOW
YES
HARDWARE 1
300
LOW
NO
HARDWARE 2
150
HIGH
LIMITS
HARDWARE 3
2500-5000
MEAN
YES
HARDWARE 4
50000-100000
MEAN
LIMITS
Neurophysiology Lab in Pavia
Brain Connectivity Center IRCCS C. Mondino
Egidio D’Angelo
Francesca Prestori
Lisa Mapelli
Daniela Gandolfi (Modena)
Jonathan Mapelli (Modena)
Francesca Locatelli
Luigi Congi
Ramakrishnan K. B.
Licia de Propris
Martina Sgritta
Martina Pagani
Paolo Pozzi
Jesus Garrido
Stefano Masoli
Sathyaa Subramaniyam
Timoteo Colnaghi
Fulvia Palesi
Gloria Castellazzi
Jessica Monaco
Stefano Casali
Alessandra Majani
Irene Solinas
Leda Ruggeri