Oncologia:novità su onco-metabolismi e connesse
terapie integrate fito bio-enzinutri-dinamiche.
PROBIOTICI:usi innovativi multiattivi e connesse
terapie in oncologia,gastroenteroL.,metab.,antietà,ecc.
NATURFIERA-CATANIA-8GIU.2013
PROF. CALOGERO RINZIVILLO
FA R M A C I S TA - M E D I C O S P E C I A L I S TA
3394201756-3293178092-0953782378
0 9 5 4 3 5 5 6 5 - R I N Z I V I L @ U N I C T. I T T
N U C L I @ P O L I C L I N I C O . U N I C T. I T
- V I C E P R E S . A M I F I T- A S S . I T. M E D . I N T E G R . F I T O T .
Az. Osped.Universit.Policlinico Vittorio Emanuele-Edif.4-via S. Sofia- Catania
Presidente Dr.a Patrizia Tosto
14 Apr.2013-Paradiso Etna1°CongressoNaz.
A.M.I.Fit.
Ass.Italiana Medicina
Integrata e Fitoterapia2
Prof. C. Rinzivillo
(Passione,studio NutriFitoInt.e ter.nat.integr.daì76 =oltre 35anni)
(Cent. m.: Erythraea centaurium, fosfat. col.)
Lauree:Farmacia, Medic.e Special.max voti,lode e proposta premi
Premio Fondazione Internazionale “G.GALILEI” (Ginevra) e Premio Lions per ricerca medica e
nutrizione; Relazione premiata Congresso Nazionale ADI-Giardini-Ass.Diet.Nutr.Clin.(uso integratori
alimentari e cofattori e proteine in operati oncologici stomizzati, preventive o per deficit nutrizionali)
Oltre 150 pubblicazioni scientifiche su temi di gastroenterologia, nutrizione clinica, supporto in
chirurgia, gastroent.,oncologia, malattie metaboliche,medicina benessere e antinvecch.,fito-nutri-int.
Finanz.vari progetti Ateneo\Dip.:terapie mediche integrate,in partic.paz.Chir.,Oncol.,App.dig.,Metab
già o attuale Socio varie Soc.Medico-Scientifiche, fra cui:° New York Academy of Sciences, ° ADI-Ass.
Ital.Diet.Nutriz.Clinica, ° SINPE Soc.Ital. Nutrizione Parent. Enterale, ° AIOT- Ass.It.OmeoTossic.Medic.Biologica- MEDIBIO; °MASTER Annuale e socio AMIDEAV Ass.Medica Ital.Elettr.Agopunt.; ecc.
Resp.1°Prog.Ricerca Finaliz.Sanit.Reg.”NUTRI-FITOINTEGRAT. IN PAZ. CHIRURG.,ONCOL.,DISMETAB.”
3
ONCOLOGIA
 principio attivo antiinfiammat.della curcuma,tradizionale per secoli AY,MTCinese.
 capacità curcumina causare apoptosi solo negli ONCOCITI mentre miglioravan funzioni
‘normali’ di cellule normali-ANDERSON CANCER CENTER TEXAS 2011
 Ciò è confermato da Ospedale Zheijian-Cina, in particolare apoptosi in cellule del BC cancro
mammario TNBC=triplo negativo (recettori E,P, EGrF), più difficile da curare dei BC recett.+.
 Tale effetto è potenziato se si usano cibi e integratori ricchi di flavanoli, in particolare
epigallocatechina gallato (EGCG) del tè verde, effetti ottimi antiox e anti-neoangiogenetico
antiflog.se usato con diferuloilmetano da curcumina.


SITI WWW. : -greenmedinfo.com/substance/curcumin;
naturalnews.com/037879_curcumin_cancer_cells_turmeric.html
 ncbi.nlm.nih.gov/pubmed/23740392 (Singh&Misra.Interdisc.Sc.2013 June)
(diferuloyl methane) and its naturally analogs demethoxy, bisdemethoxy and cyclocurcumin, present in
rhizomes of curcuma species turmeric, inhibit the proliferation of a wide variety of tumor cells. AA.shows
that Curcumin targets (EpiG.n)nuclear protein HPV16E6,major protein actively developing oral&cervical K
 Curr Cancer Drug Targets,2013 Apr 17. [ahead of print], Clinical Oncology, Queen Elizabeth HospitalHONG KONG-By Wang Y e C.: Genetic And Epigenetic Studies For Determining Molecular
Targets Of Natural Product Anticancer Agents->EGCG, curcumin, genistein, sulforaphane
and resveratrol have anticancer properties through the mechanisms of altering
epigenetic processes [including DNA methylation, histone modification, chromatin
remodeling, microRNA (miRNA) regulation] and targeting cancer stem cells (CSCs)
ONCOLOGIA
 Chem.Commun.(Cambridge Press) 2013 Jul-Cl.study c3cc41858h. Ahead of PRINT
Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor.
by Margarucci L. e C.-Dipart.Farmacia Univ. SalernoHsp90 is a key target in cancer therapy. Oleocanthal, olive oil active compound, is its inhibitor.
 Nutr Metab Cardiovasc Dis.2013 Feb 25.(ahead of print]
Mediterranean diet and non enzymatic antioxidant capacity in the PREDIMED study:
Evidence for a mechanism of antioxidant tuning. By Zamora R.e C.
1-year of correct MED diet increases plasma TAC:TOTAL ANTIOXIDANT Capacity level.
 Colloids Surf B Biointerfaces.2013 Jun.Ahead of print.Elsevier Scient.Intern.Publish.
Spontaneous ultra fast synthesis of gold nanoparticles using Punica granatum for cancer
targeted drug delivery.-By Ganeshkumar M.&C.-India-CSIR Counc.Scient.Ind.Res.
Free 5-Fu,vs [email protected] was investigated against MCF-7 cells (breast cancer)and we observed
that amount of 5Fluoruracil(CH)required to achieve 50%of growth-inhibition was much lower VS free 5Fu.
 ->cytochrome P450 enzyme, CYP1B1, is a target in prostate cancer.Compounds inhibiting CYP1B1
activity are contemplated to exert beneficial effects at three stages of prostate cancer development, that
is, initiation, progression, and development of drug resistance.
Pomegr.ellagitannins/intest.microbial metabolites/: Urolithin A was the most potent
uncompetitive inhibitor of CYP1B1,with a dual mode mechanism by decreasing CYP1B1 metabolic
activity and expression (epigenetics). Punicalins and punicalagins exhibited potent CYP1A1
inhibition, also-J Agric Food Chem.2009 Nov<-Missisippi Un.->AND J Agric Food Chem.2010 Feb:
Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins
ONCOLOGIA
 J Mol Endocrinol.2013 May 29. [Ahead of print]
Antioxidant and anti-growth action of peracetylated oleuropein in thyroid
cancer
Bulotta S.e C.
phenolic components oleuropein and its derivatives.OLE inhibited significantly proliferation
This effect was paralleled by a reduction of basal phospho-Akt and phospho-ERK levels and
H2O2induced ROS levels. A stronger effect by Ac-OLE in inhibiting cell growth and as
antioxidant(vitro).
 Cytotechnology.-2009 Jan;59(1) Anti-proliferative and apoptotic effects of
oleuropein and hydroxytyrosol on human breast cancer-University of TsukubaJapan-by Han J. & c. Effects of anthocyanidins (cyanidin, delphinidin, malvidin, peonidin, petunidin,
pelargonidin) on the aryl hydrocarbon receptor (AhR)-CYP1A1 signaling pathway in
human hepatic&intest.K cells.
Pelargonidin can bind to and activate the AhR and AhR-dependent gene expression, and
pelargonidin and delphinidin inhibit the CYP1A1 catalytic activity
-UNIV. BARCELLONA (Zamora R. e C.) sta approfondendo DIETA MED.e effetti
suoi principi attivi già dimostrati in vivo e vitro come antiox e antitum.di
supporto PRINCIPI (MALVIDINA ecc.): vedi Br. J. Nutrition 2012 e altre riviste
s
ONCOLOGIA
 PASTEUR EFFECT
 WARBURG EFFECT
 REVERSE WARBURG EFFECT (LISANTI)
 CRABTREE EFFECT
NUTRIENTI ENZIMATIZZATI
BIODINAMICI OTTIMIZZATI