European Journal of Neurodegenerative Diseases Founded by Rita Levi-Montalcini Past Honorary President Rita Levi-Montalcini, Nobel Laureate, Rome, Italy Editor-in-Chief Lucio Annunziato (Italy) Associate Editors Cataldi Mauro (Italy) Garaci Enrico (Italy) Moroni Flavio (Italy) Secretariat Esposito Elena (Italy) Merolla Paola (Italy) Executive EditorialCommittee Pignataro Giuseppe (Italy) Scorziello Antonella (Italy) EDITORIAL BOARD Androutsellis-Theotokis Andreas Avila Jesús Bazan Nicolas G. Benfenati Fabio Bernardi Giorgio Björklund Anders Bowery Norman G. Calabresi Paolo Calissano Pietro Cattaneo Antonino Centonze Diego Chao Moses V. Cherubini Enrico Clementi Emilio Collingridge Graham L. Cozzolino Federico DanDan Sun De Simoni Maria Grazia Di Chiara Gaetano Duchen Michael Eisch Amelia Finazzi-Agrò Alessandro Garaci Francesco Gaudio Eugenio Gozes Illana Grassi Claudio Head Elizabeth (Germany) (Spain) (USA) (Italy) (Italy) (Sweden) (UK) (Italy) (Italy) (Italy) (Italy) (USA) (Italy) (Italy) (UK) (Italy) (USA) (Italy) (Italy) (UK) (USA) (Italy) (Italy) (Italy) (Israel) (Italy) (USA) Hewett Sandra Maffei Lamberto Matteoli Michela Meldrum Brian Melino Gerry Memo Maurizio Mercuri Nicola Moncada Salvador Morelli Micaela Nicoletti Ferdinando Nisticò Robert Novelli Giuseppe Palamara AnnaTeresa Piacentini Mauro Piomelli Daniele Pizzi Marina Pocchiari Maurizio Preziosi Paolo Rizzolatti Giacomo Rotilio Giuseppe Schneider Christian Snyder Solomon H. St. George-Hyslop Peter Taglialatela Maurizio Tedeschi Gioacchino Verkhratsky Alexej Zukin Suzanne Xiong Zhigang Former Editor-in-chief Giuseppe Nisticò (Italy) (USA) (Italy) (Italy) (UK) (Italy) (Italy) (Italy) (UK) (Italy) (Italy) (Italy) (Italy) (Italy) (Italy) (Italy) (Italy) (Italy) (Italy) (Italy) (Italy) (Germany) (USA) (UK) (Italy) (Italy) (UK) (USA) (USA) Managing Editor Pio Conti (Italy) European Journal of Neurodegenerative Diseases is owned and published every 4 months by BIOLIFE, s.a.s. The annual subscription rate is: Institutional (all countries) Euro 390.00; personal Euro 290.00. Back issues available at Euro 220.00 for Institutional and Euro 190.00 for personal copy. Payment may be in the form of money order or personal cheque made out to “Biolife, s.a.s.” or bank remittance to: Banca Dell’Adriatico, Via Chieti, 65100 Pescara,Italy, account no. c/c 07400101024 (ABI 5748;CAB 15400) BIOLIFE, s.a.s. (IBAN:IT 70 Y 05748 154000 7400101024E) or Visa/Mastercard. Information concerning personal subscription rates, business matters, advertisements and back numbers should be sent to: Biolife, s.a.s. Via S. Stefano, 39 bis, 64029 Silvi Marina (TE), Italy. Website: www.biolifesas.org e-mail: [email protected] Annunziato, Università Federico II of Naples, Via Pansini 5, 80131, Naples, Italy; Tel.:+39-081-7462103; Fax: +39-081-7463013; e-mail: [email protected] Copyright © 2014 by BIOLIFE, s.a.s. This publication and/or article is for individual use only and may not be further reproduced without wtitten permission from SENT FOR CITATION TO: Index Medicus, Current Contents, SCI Journal Citation Report, Excerpta Medical Electronic Publishing Division, BIOSIS, SUBIS, This journal is printed on acid-free paper