CURRICULUM VITAE
Cecilia Marino, M.D., Ph. D.
email: [email protected]
Nationality: Italian
Language spoken:
1. Italian, mother language
2. English, optimal level
3. French, intermediate
Licenses:
1990 State Board of the Healing Arts of Milan, Physicians and Surgeons
1993 Ph. D. in Biological Psychiatry, University of Milan
1997 Board Diploma in Psychiatry, University of Milan, School of Medicine
Qualifications
1983 Scientific high school, 'Paolo Giovio', Como, Italy
1990 M.D., University of Milan School of Medicine, 'Magna cum laude'
1993 Ph. D. in Biological Psychiatry, University of Milan
1997 Psychiatrist, University of Milan, 'Magna cum laude'
Further training
1992 Training in molecular genetics (DNA extraction, RFLP/PCR, agarose/polyacrylamide gel runs) and
genetic epidemiology – linkage analyses as applied to schizophrenia, the Clarke Institute of
Psychiatry, Neurogenetics Section, University of Toronto, Canada, prof James L. Kennedy, MD
2001 Training in "Statistical Analyses for Genetic Epidemiology", Bonn, Germany; director Professor Robert
Elston, Case Western Reserve University, Cleveland Ohio, USA
2005 Training in statistical analyses for family-based association studies, FBAT and PBAT software
packages at the Institute of Biology, Lille, France; mentors: Professor Steve Horvath and Professor
Christoph Lange, Departments of Biostatistics and Environmental Health Sciences, Harvard School of
Public Health
Student scholarships
1986-1990 Scholarships for meritorious university student, from O.N.A.O.S.I., a private Italian foundation
that supports orphans of medical parents
1986-1990 Scholarships for meritorious university student from E.N.P.A.M., the social aid Italian foundation
for the medical category, which supports orphans of medical parents
Current positions:
1. Senior Scientist, at the “Eugenio Medea” Scientific Institute, founded and hosted by the "La Nostra
Famiglia" Association in Bosisio Parini (Lecco), a private, non-profit organization.
2. Adjunct Lecturer, “Vita-Salute San Raffaele” University, Faculty of Psychology, Milan, Italy. I teach
‘child neuropsychiatry’ at the undergraduate and graduate level.
3. Member of the scientific board of the “Vita-Salute San Raffaele” University International Ph. D.
Programme in Developmental Psychopathology
Clinical appointments
1993-1997 Resident in Psychiatry at “San Raffaele” Scientific Institute, Department of Psychiatry, Milan,
Italy
1997-2004 Consultant in Child Neuropsychiatry, “Eugenio Medea” Scientific Institute, Department of Child
Neuropsychiatry, Bosisio Parini, Lecco, Italy
Research appointments
1990-1993 Ph. D. student at “San Raffaele” Scientific Institute, Department of Psychiatry
2004-today Scientist, “Eugenio Medea” Scientific Institute, Department of Child Neuropsychiatry.
2005-2010 Visiting Professor of Psychiatric Genetics at the Centre de Récherche Université Laval Robert
Giffard (CRULRG), Québec, Canada.
Professional consultations
Ad-hoc Referee for professional journals, including: Archives of General Psychiatry, Molecular Psychiatry,
Biological Psychiatry, Brain Behavioral Functions, Neurogenetics, Pediatric Research, Genes Brain and
Behaviour.
Ad-hoc Referee for research grants submitted to the Medical Research Council, United Kingdom, 2007
Grants ongoing/recently completed
I obtained annual financial support from the Italian Ministry of Health Research Grant in years 2005, 2006,
2009 and 2010 as a P.I. (average amount 25000 euros per year). The grants are awarded by the Board
Review of Italian Scientific Institutes that meets annually to review submissions nationwide.
2005 (P.Is. C Marino) Italian Ministry of Health Research Grant "Genetics of developmental dyslexia", 12
months
2006 (P.I. C Marino) Italian Ministry of Health Research Grant "Structural imaging and genetics of
developmental dyslexia", 12 months
2009 (P.I. C Marino) Italian Ministry of Health Research Grant "Pleiotropic effects of neurodevelopmental
genes", 12 months
2010 (P.I. C Marino) Italian Ministry of Health Research Grant " Pleiotropic effects of neurodevelopmental
genes ", 12 months
2010 (P.I. C Marino) Grant 2010/1° Fondazione Della Provincia Di Lecco Onlus/Rotary Club Lecco. Project
title: “investigating predictors of developmental dyslexia”. Total sum awarded 20.000,00 euros, 12
months.
2010 (P.I. C Marino) Grant “Cooperazione Scientifica e tecnologica”, by Lombardy region. Project title: ‘The
role of genes, environment and cognitive functions in understanding developmental disorders’. Total
sum awarded: 152.780,00 euro, 18 months
2010 (P.I. C Marino) Grant from the provincial government of the Veneto Region, ULSS 20 Veneto –
Verona. Project title: ‘Genetic and environmental substrates of developmental dyslexia as a form of
prevention strategy in the population’. Total sum awarded: 100.000,00 euros, 3 years.
Teaching appointments
2004-2005 Adjunct Lecturer, Undergraduate in Occupational Therapy, University of Insubria, School of
Medicine, Varese; course title: 'Psychiatric Rehabilitation’; 30 hours/year; 50 students.
2009-today Member of the scientific board of the “Vita-Salute San Raffaele” University International Ph. D.
Programme in Developmental Psychopathology, 3 year course, directed by Prof Marco
Battaglia in partnership with Laval University, Québec, Canada. I am involved in curricula
planning and students’ selection procedures.
2010-today Adjunct Lecturer, San Raffaele University, Faculty of Psychology, Milan: course title ‘Child
Neuropsychiatry’; 20 hours/year; 20 students. This course has been rated between very good
and excellent by students’ anonymous rating.
Publications in International peer-reviewed journals
1) Macciardi F, Lucca A, Catalano M, Marino C, Zanardi R, Smeraldi E. Amino acid patterns in schizophrenia: some
new findings. Psychiatry Research 32:63-70, 1990
2) Macciardi F, Kennedy JL, Ruocco L, Giuffra L, Carrera P, Marino C, Rinaldi V, Smeraldi E, Ferrari M. A genetic
linkage study of schizophrenia to chromosome 5 markers in a northern Italian population. Biological Psychiatry 31:720728, 1992
3) Marino C, Nobile M, Bellodi L, Smeraldi E. Delusional disorder and mood disorder: can they coexist?
Psychopathology 26:53-61, 1993
4) Macciardi F, Petronis A, Van Tol HH, Marino C, Cavallini MC, Smeraldi E, Kennedy JL. Analysis of the D4 dopamine
receptor gene variant in an Italian schizophrenia kindred. Archives of General Psychiatry 51:288-293, 1994
5) Nobile M, Begni B, Giorda R, Frigerio A, Marino C, Molteni M, Ferrarese C, Battaglia M. Effects of serotonin
transporter promoter genotype on platelet serotonin transporter functionality in depressed children and adolescents.
Journal of the American Academy of Child and Adolescent Psychiatry 38:1396-1402, 1999
6) Nobile M, Marino C, Molteni M, Battaglia M. Some ado about a polymorphism. American Journal of Psychiatry
157:1886-1888, 2000
7) Battaglia M, Ogliari A, Maffei C, Marino C, Molteni M, Nobile M.: Cautionary note: complex (dys)function of the
serotonin transporter. Biological Psychiatry 48: 334-335, 2000
8) Nobile M, Bellotti B, Marino C, Molteni M, Battaglia M. An open trial of paroxetine in the treatment of children and
adolescents diagnosed with dysthymia. Journal of Child & Adolescent Psychopharmacology 10:103-109, 2000
9) Nobile M, Cataldo MG, Marino C, Molteni M. Diagnosis and treatment of dysthymia in children and adolescents. CNS
Drugs 17: 927-946, 2003
10) Marino C, Giorda R, Vanzin L, Molteni M, Lorusso ML, Nobile M, Baschirotto C, Alda M, Battaglia M. No evidence
for association and linkage disequilibrium between dyslexia and markers of four dopamine-related genes. European
Child and Adolescent Psychiatry 12: 198-202, 2003
11) Marino C, Giorda R, Vanzin L, Nobile M, Lorusso ML, Baschirotto C, Riva L, Molteni M, and Battaglia M. A locus on
15q15-15qter influences dyslexia: further support from a transmission/disequilibrium study in an Italian speaking
population. Journal of Medical Genetics 41: 42-46, 2004
12) Nobile M, Cataldo MG, Giorda R, Battaglia M, Baschirotto C, Bellina M, Marino C, Molteni M. A case-control and
family-based association study of the 5-HTTLPR in pediatric-onset depressive disorders. Biological Psychiatry 56:
292-5, 2004
13) Marino C, Vanzin L, Giorda R, Frigerio A, Lorusso ML, Nobile M, Molteni M, Battaglia M. An assessment of
transmission disequilibrium between quantitative measures of childhood problem behaviors and DRD2/TaqI and
DRD4/48bp-repeat polymorphisms Behavior Genetics 34(5): 495-502, 2004
14) Battaglia M, Ogliari A, Zanoni A., Citterio A, Pozzoli U., Maffei C., Giorda R., Marino C.: Influence of the Serotonin
Transporter Promoter Gene and Shyness on Children’s Cerebral Responses to Facial Expressions. Archives of
General Psychiatry 62(1): 85-94, 2005
15) Marino C, Giorda R, Lorusso ML, Vanzin L, Salandi N, Nobile M, Battaglia M, Molteni M. A family-based association
study of the DYX1C1 gene on 15q21.1 in Developmental Dyslexia. European Journal of Human Genetics 13(4): 4919, 2005
16) Frigerio A, Vanzin L, Pastore V, Nobile M, Giorda R, Marino C, Molteni M, Rucci P, Ammaniti M, Lucarelli L, Lenti C,
Walder M, Martinuzzi A, Carlet O, Muratori F, Milone A, Zuddas A, Cavolina P, Nardocci F, Tullini A, Morosini P, Polidori
G, De Girolamo G. The Italian preadolescent mental health project (PrISMA): rationale and methods. International
Journal of Methods in Psychiatric Research 15(1): 22-35, 2006
17) Battaglia M, Zanoni A, Giorda R, Pozzoli U, Citterio A, Beri S, Ogliari A, Nobile M, Marino C, Molteni M. Effect of the
catechol-O-methyltransferase val(158)met genotype on children’s early phases of facial stimuli processing. Genes Brain
& Behavior 6 (4): 364-374, 2007
18) Marino C, Citterio A, Giorda R, Facoetti A, Menozzi G, Vanzin L, Lorusso ML, Nobile M, Molteni M. Association of
short-term memory with a variant within DYX1C1 in developmental dyslexia. Genes Brain & Behavior 6(7): 640-6, 2007
19) Nobile M, Giorda R, Marino C, Carlet O, Pastore V, Vanzin L, Bellina M, Molteni M, Battaglia M. Socioeconomic
status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region
repeat polymorphisms to externalization in preadolescence. Development and Psychopathology 19(4):1147-60, 2007
20) Battaglia M, Marino C, Maziade M, Molteni M, D'Amato F. Gene-environment interaction and behavioral disorders: a
developmental perspective based on endophenotypes. Novartis Foundation Symposium 293:31-41; discussion 41-7,
68-70, 2008
21) Maziade M, Rouleau N, Gingras N, Boutin P, Paradis ME, Jomphe V, Boutin J, Létourneau K, Gilbert E, Lefebvre
AA, Doré MC, Marino C, Battaglia M, Mérette C, Roy MA. Shared Neurocognitive Dysfunctions in Young Offspring at
Extreme Risk for Schizophrenia or Bipolar Disorder in Eastern Quebec Multigenerational Families. Schizophrenia
Bullettin 35(5): 919-30, 2009
22) Nobile M, Rusconi M, Bellina M, Marino C, Giorda R, Carlet O, Vanzin L, Molteni M and Battaglia M. The influence
of family structure, the TPH2 G-703T and the 5-HTT serotonergic genes upon affective problems in children aged 10-14
years. Journal of Child Psychology and Psychiatry 50(3): 317-25, 2009
23) Nobile M, Rusconi M, Bellina M, Marino C, Giorda R, Carlet O, Vanzin L, Molteni M, and Battaglia M. COMT
Val158Met polymorphism and socioeconomic status interact to predict Attention Deficit/Hyperactivity Problems in
children aged 10-14. European Child and Adolescent Psychiatry 19 (7): 549-557, 2010
24) Maziade M, Rouleau N, Merette C, Cellard C, Battaglia M, Marino C, Jomphe V, Gilbert E, Achim A, Bouchard R,
Paccalet T, Paradis ME, and Roy MA. Verbal and Visual Memory Impairments Among Young Offspring and Healthy
Adult Relatives of Patients With Schizophrenia and Bipolar Disorder: Selective Generational Patterns Indicate Different
Developmental Trajectories. Schizophrenia Bullettin 2010, Apr 21 (epub ahead of print)
25) Marino C, Mascheretti S, Riva V, Cattaneo F, Rigoletto C, Rusconi M, Gruen JR, Giorda R, Lazazzera C and
Molteni M. Pleiotropic effects of DCDC2 and DYX1C1 genes on mathematical and language quantitative phenotypes in
nuclear families of developmental dyslexia. Behavior Genetics 41 (1) 67-75, 2011
26) Marino C, Meng H, Mascheretti S, Rusconi M, Cope, Giorda R, Molteni M, and Gruen JR. DCDC2 genetic variants
and susceptibility to Developmental Dyslexia. Psychiatric Genetics Aug 30, 2011
Books Chapters (Italian and English language)
Smeraldi E, Marino C, Macciardi F: Some new hypothesis on the genetic of schizophrenia. In: Functional psychoses
today, 109-112. John Libbey CIC, Aguglia and Ban eds, 1989
Macciardi F, Kennedy JL, Cavallini MC, Marino C, et al.: a linkage study in italian schizophrenic families: testing the
chromosome 5 hypothesis. In: Psychiatry and advanced technologies. Raven Press, Ltd, New York, ed by Ravizza,
Bogetto and Zanalda, pp 269-277, 1993.
Smeraldi E, Nobile M, Marino C: situazioni cliniche complesse: disturbi dell'umore e psicosi. In: I disturbi dell'umore:
clinica e terapia. A cura di Smeraldi E, Edi Ermes, Milano, pp 112-119,1993
Marino C, Nobile M: Terapia dei disturbi deliranti. In: I disturbi dell'umore: clinica e terapia. A cura di Smeraldi E, Edi
Ermes, Milano, pp 292, 1993
Marino C, Battaglia M: Disturbi Somatoformi in età evolutiva. In: Trattato Italiano di Psichiatria. Coordinatori Pancheri P
e Cassano GB, Masson, Milano, pp 2979-2983, 1999.
Marino C: Disturbi da uso di alcol: fattori causali e genetici. In: Trattato Italiano di Psichiatria. Coordinatori Pancheri P e
Cassano GB, Masson, Milano, 1445-1448, 1999.
Marino C and Molteni M: Chromosome 15 and Developmental Dyslexia. In: The Dyslexic Brain. New pahtways in
neuroscience discovery. Ed by Glenn D. Rosen. Lawrence Erlbaum Associates, Inc, Publishers, Mahway, New Jersey,
pp 107-119, 2006
Marino C, Mascheretti S, Facoetti A, and Molteni M: Investigation of Candidate Genes in Families with Developmental
Dyslexia. In: Developmental Dyslexia: Cross-Disciplinary Insights on Early Precursors, Expression, and Remediation.
Extraordinary Brain Series, ed by April Benasich and R. Holly Fitch. Brookes Publishing Co., Baltimore, Maryland, in
press.
Invited oral presentations (Italian and English language)
‘Chromosome 15 and Developmental Dyslexia’ at The Dyslexia Foundation Symposium: The development of the
Extraordinary Brain. June, 2004, Como, Italy
‘Pleitropic effects of neurodevelopmental genes upon cognitive dysfunctions: a new hypothesis’ at Canadian
Academy of Child and Adolescent Psychiatry (CACAP) –XXVII Annual Meeting, 11-13 novembre 2007, Montréal
(Québec), Canada
‘Genetic association between candidate genes and reading-related quantitative traits’ at Third International Congress of
MAGI Association: Advances in Diagnosis and Treatment of Multifactor Genetic Diseases. 26th and 27th September
2008, Rovereto, Trento, Italy
‘Associazione genetica tra recettori colinergici nicotinici e dislessia evolutiva: rilevanza del fenotipo attentivo spaziale’ at
Associazione Italiana Psicologia (AIP), Sezione Sperimentale, XIV Congresso Nazionale. 18-20 settembre 2008,
Padova, Italy
‘Associazione genetica tra recettori colinergici nicotinici e dislessia evolutiva: rilevanza del fenotipo attentivo spaziale’ at
‘Dislessia Evolutiva: una prospettiva multifattoriale’, 17 Settembre 2009, Facoltà Di Psicologia, Università Di Bologna,
Aula Magna, Cesena.
‘Genetica dei Disturbi di Apprendimento’ at XVIII Congresso Nazionale AIRIPA, I Disturbi dell’Apprendimento, La
Spezia, 23-24 Ottobre 2009
‘Investigation of Candidate Genes in Families with Developmental Dyslexia’ at The Dyslexia Foundation, 12th
Extraordinary Brain Symposium: Developmental Dyslexia: Early Precursors, Neurobehavioral Markers and Biological
Substrates. June 27th-July 2nd, 2010, Ashford Castle, Cong, County Mayo, Ireland
Moderator at the symposium ‘Neuropsicologia e Psicopatologia dell’Età Evolutiva’ at ‘Giornate Di
Neuropsicologia Dell’eta’ Evolutiva’, VI Edition, January 2011, Bressanone, Italy.
‘Investigation of Candidate Genes in Families with Developmental Dyslexia’ at Società Italiana di
Neuropsichiatria dell’Infanzia e dell’Adolescenza (SINPIA), XXV Congresso Nazionale: la Neuropsichiatria
dell’Infanzia e dell’Adolescenza: dalla Ricerca alla Clinica. 11-14 maggio 2011, Pisa, Italy
th
October 8 , 2011