Giorgio Ricci took his degree in Chemistry at the University of Rome "La
Sapienza" in1974. He became full professor of Biological Chemistry in 1986 at the
University of Chieti, Faculty of Medicine. In 1991 he moved to the University of
Rome "Tor Vergata" where he had a chair of Biological Chemistry in the Faculty of
Sciences.
His scientific career is documented by about hundred and twenty publications
on relevant international journals. In the last years his research is fully devoted to the
study of cell detoxification and of structure/function of the glutathione transferase
isoenzymes by means of a number of techniques such as dynamic fluorescence,
stopped flow, molecular dynamics simulations.
PUBLICATIONS
1)
The specificity of cysteamine oxygenase.
D. Cavallini, G. Federici, G. Ricci, S. Duprè, A. Antonucci and C.
De Marco.
FEBS Lett. 56, 348-351 (1975);
2)
Alternative pathway of taurine biosyntesis.
D. Cavallini, R. Scandurra, S. Duprè, G. Federici, L. Santoro, G.
Ricci and D. Barra.
in: "Taurine" pp 59-66 (1976) (Huxtable and Barbeau, eds.) Raven
Press, New York;
3)
The metabolism of mercaptoethanol by the living rat.
G. Federici, G. Ricci, S. Duprè, A. Antonucci and D. Cavallini.
Biochem. and Exptl. Biol. 12, 341-345 (1976);
4)
Interazione della fenazina-5-metilsolfato con il solfuro.
G. Ricci, S. Duprè, G. Spoto and G. Federici.
Boll. Soc. Ital. Biol. Sper. 52, 929-932 (1976);
5)
A new spot test for sulphydryl-containing compounds.
G. Ricci, S. Duprè, G. Federici, G. Spoto.
Anal Biochem. 79, 610-611 (1977);
6)
Isethionic acid as a taurine co-metabolite.
D. Cavallini, S. Duprè, G. Federici, G. Spoto, R.M. Matarese, S.P.
Solinas, G. Ricci, A. Antonucci.
in: "Taurine in neurological disorders" pp. 29-34 (1978) (Huxtable
Barbeau, eds.) Raven Press, New York;
and
7)
Oxidation of hypotaurine to taurine by ultraviolet
irradiation
G. Ricci, S. Duprè, G. Federici, G. Spoto, R.M. Matarese and D.
Cavallini.
Physiol. Chem. & Phys. 10, 435-441 (1978);
8)
The enzymatic oxidation of mercaptoethanol to isethinic and
isethionic acid.
S. Duprè, G. Federici, G. Ricci, G. Spoto, R.M. Matarese and D.
Cavallini.
Enzyme 23, 307-313 (1978);
9)
Interaction between γ-carboxyglutamic acid and glutamate
dehydrogenase.
G. Federici, G. Ricci, R.M. Matarese, G. Spoto, S. Duprè and D.
Cavallini.
Arch. Biochem. Biophys. 196, 304-306 (1979);
10)
Cysteamine pathway of taurine biosynthesis.
G. Federici, G. Ricci, L. Santoro, A. Antonucci and D. Cavallini.
in: "Natural Sulfur Compounds" pp. 187-194 (1980) (D.
Cavallini, G.E. Gauli and V. Zappia, eds.) Plenum Publish.
Corp;
11)
Hypotaurine uptake in synaptosomal fraction of rat cerebral
cortex.
R. Federico, G. Ricci, A. Bertollini and G. Federici.
Ital. J. Biochem. 29, 46-49 (1980);
12)
Cystine-ketimine produced by the oxydation of L-cystine by Lamino acid oxidase.
G. Ricci, G. Federici, M. Achilli, R.M. Matarese and D. Cavallini.
Physiol. Chem. & Phys. 13, 341-346 (1981);
13)
Multiple forms of bovine liver rhodanese.
C. Cannella, M. Costa, B. Pensa, G. Ricci, L. Pecci and D.
Cavallini.
Eur. J. Biochem. 119, 491-495 (1981);
14)
The oxidation of sulfur-containing amino acids by L-amino
acid oxidase
D. Cavallini, G. Ricci, G. Federici, M. Costa, B. Pensa, R.M.
Matarese, M. Achilli. in: "Structure and Function in Biochemical
Systems" pp. 359-374
(1982) (F. Bossa, E. Chiancone, A.
Finazzi-Agrò and R. Strom, eds.)
Plenum Publish. Corp.;
15)
L-lanthionine oxidation by snake venom L-amino acid oxidase.
G. Ricci, G. Federici, G. Lucente, M. Achilli and D. Cavallini.
Physiol. Chem. & Phys. 14, 193-199 (1982);
16)
A spectrophotometric method for the determination of
aspartate
amino
transferase
with
5,5'-dithiobis-(2nitrobenzoic acid).
G. Ricci, S. Duprè, M. Lo Bello, M. Achilli and G. Federici
IRCS Med. Sci. 10, 672-673 (1982);
17)
Separation of octanoic acid and thiaoctanoic acid analogues by
gas-liquid and high-performance liquid chromatography.
G. Federici, A.M. Caccuri, R.M. Matarese, G. Del Boccio and G.
Ricci.
J. Chrom. 249, 405-407 (1982);
18)
Interaction between 1,4 thiazine derivatives and D-amino
acid oxidase.
G. Ricci, M. Nardini, A.M. Caccuri and G. Federici
Biochim. Biophys. Acta 748, 40-47 (1983);
19)
The ketimine derivatives of thialysine, lanthionine,
cystathionine and cystine: preparation and properties.
D. Cavallini, G. Ricci and G. Federici
in: "Sulfur Amino Acids: Biochemical and Clinical Aspects" pp.
355- 363 (1983) (K.
Kuriyama, R.J. Huxtable, H. Iwata, eds.) A.R.
Liss Inc. New York;
20)
Similarity of the oxidation products of L-cystathionine by Lamino acid oxidase to those excreted by cystathioninuric
patients.
G. Ricci, L. Santoro, M. Achilli, R.M. Matarese M. Nardini and D.
Cavallini.
J. Biol. Chem. 258, 10511-10517 (1983);
21)
Enzymatic production of aminoethylcysteine ketimine
R. Chiaraluce, M. Nardini, S. Duprè, G. Ricci and D. Cavallini.
IRCS Med. Sci. 11, 1119-1120 (1983);
22)
Detection and determination od cysteamine at the nanomole
level.
G. Ricci, M. Nardini, R. Chiaraluce, S. Duprè and D. Cavallini.
J. Appl. Biochem. 5, 320-329 (1983);
23)
Gas-chromatographic determination of thiazine
thiazepine derivatives of biological interest.
R.M. Matarese, L. Pecci, G. Ricci and D. Cavallini.
J. Chrom. 294, 413-418 (1984);
24)
Continuous spectrophotometric assay for pantetheinase
activity.
S. Duprè, R. Chiaraluce, M. Nardini, C. Cannella, G. Ricci and D.
Cavallini.
Anal. Biochem. 142, 175-181 (1984);
25)
Determination of rhodanese activity
reduction.
C. Cannella, R. Berni and G. Ricci.
Anal. Biochem. 142, 159-162 (1984);
26)
Detection
of
glutatione
transferase
activity
on
polyacrylamide gels.
G. Ricci, M. Lo Bello, A.M. Caccuri, F. Galiazzo and G. Federici.
Anal. Biochem. 143, 226-230 (1984);
27)
Quantitative analysis of cystathionine and perhydro-1,4thiazepine-3,5- dicarboxylic acid in the urine of a patient
with cystathioninuria using isotachophoresis.
H. Kodama, K. Sasaki, H. Mikasa, D. Cavallini and G. Ricci.
J. Chromat. 311, 183-188 (1984);
by
and
tetrazolium
28)
1,4-Thiomorpholine-3,5-dicarboxylic acid, a novel
imino acid detected in bovine brain.
D. Cavallini, R.M. Matarese, L. Pecci and G. Ricci.
FEBS Lett. 192, 247-250 (1985);
29)
Gas-chromatographic Mass-spectrometric detection of 1,4hexahydrothiazepine-3,5-dicarboxylic acid (cyclothionine) in
bovine brain.
D. Cavallini, L. Pecci, R.M. Matarese, G. Ricci and M. Achilli.
J. Biol. Chem. 260, 15577-15579 (1985);
30)
Enzymatic production of S-(2-hydroxy-2-carboxyethyl)
homocysteine.
M. Nardini, H. Kodama, G. Ricci, G. Federici and D. Cavallini.
Biochem. Int. 11, 789-794 (1985);
31)
Interaction of pantetheinase with sulfhydryl reagents and
disulfides.
G. Ricci, M. Nardini, R. Chiaraluce, S. Duprè and D. Cavallini;
Biochim. Biophys. Acta 870, 82-91 (1986);
32)
The transamination of L-cystathionine, L-cystine and related
compounds by a bovine kidney transaminase.
G. Ricci, M; Nardini, G. Federici and D. Cavallini.
Eur. J. Biochem. 157, 57-63 (1986);
33)
Ketimine rings: useful detectors of enzymatic activities in
solution and on polyacrylamide gel.
G. Ricci, A.M. Caccuri, M. Lo Bello, S.P. Solinas and M. Nardini;
Anal Biochem. 165, 356-361 (1987);
34)
Hexahydro-1,4-thiazepine-3,5-dicarboxylic
acid
and
thiomorpholine-3,5-dicarboxylic acid are present in normal
human urine.
R.M. Matarese, L. Pecci, G. Ricci, M; Nardini, A. Antonucci and
Cavallini.
Proc. Natl. Acad. Sci. USA 84, 5111-5114 (1987);
D.
35)
cyclic
Cysteamine oxygenase: possible involvement of superoxide ion
in the catalytic mechanism.
G. Ricci, S. Duprè, M. Nardini, G. Spoto and D. Cavallini.
Free Rad. Res. Comm. 3, 365-371 (1987);
36)
Purification and characterization of a ketimine reducing
enzyme.
M. Nardini, G. Ricci, A.M. Caccuri, S.P. Solinas, L. Vesci and D.
Cavallini.
Eur. J. Biochem. 173, 689-694 (1988);
37)
Identification of glutathione transferase isoenzymes of tumour
and non tumour human kidney.
A. Aceto, C. Di Ilio, A.M. Caccuri, M. Lo Bello, R. Massoud and
Ricci
Clin. Chem. Enzym. Comms. 1, 135-143 (1988)
G.
38)
Bovine brain ketimine reductase.
M. Nardini, G. Ricci, L. Vesci, L. Pecci and D. Cavallini.
Biochim. Biophys. Acta 957, 286-292 (1989);
39)
Identification of 1,4-thiomorpholine-3-carboxylic acid (TMA)
in normal human urine.
R.M. Matarese, S.P. Solinas, G. Montefoschi, G. Ricci, and D.
Cavallini.
FEBS Lett. 250, 75-77 (1989);
40)
Photooxidation of hypotaurine to taurine in the presence of
flavins.
G. Ricci, R. Chiaraluce, G. Pitari, S. Duprè, O. Fujii, Y. Hosokawa
and K. Yamaguchi.
J. Nutr. Sci. Vitaminol. 35, 143-153 (1989);
41)
Aortic antioxidant defence mechanism in rabbits subjected to
suprarenal aortic coartation hypertension.
F. Cuccurullo, E. Porreca, D. Lapenna, A. Pennelli, G. Ricci and
G.
Del Boccio in: Advances in Vascular Pathology pp. 10171020 (1989) (A. Strano and S. Novo, eds.) Elsevier Publish. B.V.
42)
Detection
of
2H-1,4-thiazine-5,6-dihydro-3,5-dicarboxylic
acid (lanthionine ketimine) in the bovine brain by a
fluorometric assay.
G. Ricci, L. Vesci, M. Nardini, A. Arduini, S. Storto, N. Rosato
and D. Cavallini.
Biochim. Biophys. Acta 990, 211-215 (1989);
43)
Nonequivalence of the two subunits of horse erythrocyte
glutathione transferase in their reaction with sulfhydryl
reagents.
G. Ricci, G. Del Boccio, A. Pennelli, A. Aceto, E.P. Whitehead
and G. Federici.
J. Biol. Chem. 264, 5462-5467 (1989);
44)
Aortic antioxidant defence mechanisms: time-related changes
in cholesterol-fed rabbits.
G. Del Boccio, D. Lapenna, E. Porreca, A. Pennelli, F. Savini, P.
Feliciani, G. Ricci and F. Cuccurullo.
Atherosclerosis 81, 127-135 (1990);
45)
Detection of 2H-1,4-thiazine-5,6-dihydro-3-carboxylic acid
(aminoethylcysteine ketimine) in the bovine brain.
M. Nardini, R.M. Matarese, L. Pecci, A. Antonucci, G. Ricci and
Cavallini.
Biochem. Biophys. Res. Comm. 166, 1251-1256 (1990);
D.
46)
35S-Lanthionine ketimine binding to bovine brain membranes.
M. Fontana, G. Ricci, S.P. Solinas, A. Antonucci, I. Serao, S.
Duprè
and D. Cavallini.
Biochim. Biophys. Res. Comm. 171, 480-486 (1990);
47)
Detection of cystathionine ketimine in bovine cerebellum.
G. Ricci, L. Vesci, R.M. Matarese, A. Antonucci, A. Maggio, L.
Pecci and D. Cavallini.
J. Neurochem. 55, 1599-1602 (1990);
48)
Interaction
of
glutathione
transferase
from
horse
erythrocytes with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole.
G. Del Boccio, A. Pennelli, E.P. Whitehead, M. Lo Bello, R.
Petruzzelli, G. Federici and G. Ricci.
J. Biol. Chem. 266, 13777-13782 (1991)
49)
Sulfur-containing cyclic ketimines and imino acids.
D. Cavallini, G. Ricci, S. Duprè, L. Pecci, M. Costa, R.M.
Matarese, B. Pensa, A. Antonucci, S.P. Solinas and M. Fontana.
Eur. J. Biochem. 202, 217-223 (1991);
50)
Redox forms of human placenta glutathione transferase.
G. Ricci, G. Del Boccio, A. Pennelli, M. Lo Bello, R. Petruzzelli,
A.M. Caccuri, D. Barra and G. Federici.
J. Biol. Chem. 266, 21409-21415 (1991);
51)
Chemical modification of human placental glutathione
transferase by pyridoxal-5'-phosphate.
M. Lo Bello, R. Petruzzelli, L. Reale, G. Ricci, D. Barra and G.
Federici.
Biochim. Biophys. Acta 1121, 167-172 (1992)
52)
Peculiar Spectroscopic and Kinetic Properties of Cys-47 in
Human Placental Glutathione Transferase.
M. Lo Bello, M.W. Parker, A. Desideri, F. Polticelli, M. Falconi,
G.
Del Boccio, A. Pennelli, G. Federici and G. Ricci.
J. Biol. Chem. 268, 19033-19038 (1993)
53)
Conformational states of human placental glutathione
transferase as probed by limited proteolysis.
M. Lo Bello, A. Pastore, R. Petruzzelli, M.W. Parker,M.C.J. Wilce,
G. Federici and G. Ricci
Biochem. Biophys. Res. Commun. 194, 804-810 (1993)
54)
Characterization of [35S] Lanthionine ketimine specific
binding to bovine brain membranes
S. Duprè, M. Fontana, M. Costa, L. Pecci, G. Ricci and D.
Cavallini
Biochim. Biophys. Res. Commun. 195, 673-678 (1993)
55)
Inhibition of human placenta glutathione transferase P 1-1 by
calvatic acid
A.M. Caccuri, G. Ricci, A. Desideri, M. Buffa, R. Fruttero, A.
Gasco, P. Ascenzi.
Biochem. and Mol. Biol. Int. 32, 819-829 (1994)
56)
In human placental glutathione transferase Cys 47 is involved
in an unusual ion pair with Lys 54
M. Lo Bello, A. Pastore, G. Mazzarese, F. Piemonte, G. Federici
G. Ricci.
It. J. Biochem. 43, 83-84 (1994)
and
57)
G.
58)
P.
59)
Colorimetric and fluorometric assays of glutathione
transferase based on 7-chloro-4-nitrobenzo-2-oxa-1,3- diazole
G. Ricci, A.M. Caccuri, M. Lo Bello, A. Pastore, F. Piemonte and
Federici
Anal Biochem. 218, 463-465 (1994)
Are the steady state kinetics of glutathione transferase
always dependent on the
deprotonation of the bound
glutathione?
A. M. Caccuri, P. Ascenzi, M. Lo Bello, G. Federici, A. Battistoni,
Mazzetti and G. Ricci
Biochem. Biophys. Res. Commun.
200, 1428-1434 (1994)
A kinetic study on pantetheinase inhibition by disulfides
G. Pitari, G. Maurizi, P. Ascenzi, G. Ricci and S. Duprè
Eur. J. Biochem. 226, 81-86 (1994)
60) Site-directed Mutagenesis of Human Glutathione Transferase
P 1-1
Mutation of Cys-47 induces a positive cooperativity in
glutathione transferase P1-1
G. Ricci, M. Lo Bello, A.M. Caccuri, A. Pastore, M. Nuccetelli,
M. Parker and G. Federici
J.Biol Chem. 270, 1243-1248 (1995)
61) Site-directed Mutagenesis of Human Glutathione Transferase
P 1-1
Spectral, kinetic and structural properties of Cys-47 and Lys54
mutants
M. Lo Bello, A. Battistoni, A.P. Mazzetti, P.G. Board, M.
Muramatsu, G. Federici and G. Ricci.
J. Biol. Chem. 270, 1247-1253 (1995)
62)
Cytoplasmic and periplasmic production of human placental
transferase in Escherichia Coli
A. Battistoni, A.P. Mazzetti, R. Petruzzelli, M. Muramatzu, G.
Federici, G. Ricci and M. Lo Bello
Prot. Expr. and Pur. 6, 347-355 (1995)
63)
Structural Flexibility Modulates the Activity of Human
Glutathione Transferase P-1-1
Role of Helix 2 flexibility in the catalytic mechanism
G. Ricci, A.M. Caccuri, M. Lo Bello, N. Rosato, G. Mei, M.
Nicotra,
E. Chiessi, A.P. Mazzetti, and G. Federici.
J. Biol. Chem. 271, 16187-16192 (1996)
64)
Structural Flexibility Modulates the Activity of Human
Glutathione Transferase P-1-1
Influece of a poor co-substrate on dynamics and kinetics of
human
glutathione transferase.
A.M. Caccuri, P. Ascenzi, G. Antonini, M.W. Parker, A.J. Oakley,
E.
Chiessi, M. Nuccetelli, A. Battistoni, A. Bellizia and G. Ricci.
J. Biol. Chem. 271, 16193-16198 (1996)
65)
Crystallographic studies of Pi and Theta class glutathione
transferases
M.C.J. Wilce, A.J. Oakley, J. Rossjohn, S.C. Feil, M. Lo Bello, G.
Ricci, P.G. Board and M.W. Parker (1996) in “Glutathione STransferases”, (N.P.E. Vermeulen, ed.) Taylor & Francis, London.
66)
Modulation of glutathione transferase P1-1 activity
G. Federici, M. Lo Bello, A.M. Caccuri, M.W. Parker and G.
Ricci,
(1996) in “Glutathione S-Transferases”, (N.P.E. Vermeulen,
ed.) Taylor & Francis, London.
67)
Multifunctional Role of Tyr 108 in the Catalytic Mechanism of
Human Glutathione Transferase P1-1. Crystallographic and
Kinetic Studies on the Y108F Mutant Enzyme
M. Lo Bello, A. J.Oakley, A. Battistoni, A.P. Mazzetti, M.
Nuccetelli, G. Mazzarese, J. Rossjohn, M. W. Parker and G.
Ricci.
Biochemistry 36, 6207-6217 (1997)
68)
Inhibition of human placenta glutathione transferase P1-1 by
the antibiotic calvatic acid and its diazocyanide analogue
G. Antonini, G. Pitari, A.M. Caccuri, G. Ricci, D. Boschi, R.
Fruttero, A. Gasco and P. Ascenzi.
Eur. J. Biochem. 245, 663-667 (1997)
69)
The Structures of Human Glutathione Transferase P1-1 in
Complex with Glutathione and Various Inhibitors at High
Resolution
A.J. Oakley, M. Lo Bello, A. Battistoni, G. Ricci, J. Rossjohn,
H.O. Villar, and M.W. Parker.
J. Mol. Biol. 274, 84-100 (1997)
70)
Catalytic Mechanism and Role of Hydroxyl Residues in the
Active Site of Theta Class Glutathione S-Transferases
A.M. Caccuri, G. Antonini, M. Nicotra, A. Battistoni, M. Lo Bello,
P.G. Board, M.W. Parker, and G. Ricci.
J. Biol. Chem. 272, 29681-29686 (1997)
71)
Proton Release upon GSH binding to Glutathione
Transferase P1-1
Kinetic analysis of a multistep GSH binding process
A. M. Caccuri, M. Lo Bello, M. Nuccetelli, M. Nicotra,
P. Rossi, G. Antonini, G. Federici and G. Ricci.
Biochemistry 37, 3028-3034 (1998)
72)
Solution Structure of Glutathione Bound to Glutathione
Transferase P1-1: Comparison of NMR Measurements with
the Crystal Structure.
M. Nicotra, M. Paci, M. Sette, A.J. Oakley, M.W. Parker, M. Lo
Bello,
A.M. Caccuri, G. Federici and G. Ricci.
Biochemistry 37, 3020-3027 (1998)
73)
Flexibility of Helix 2 in the Human Glutathione
Transferase P1-1: Time Resolved Fluorescence Spectroscopy.
L. Stella, A.M. Caccuri, N. Rosato, M. Nicotra, M. Lo Bello, F. De
Matteis, A.P. Mazzetti, G. Federici, and G. Ricci.
J. Biol. Chem. 273, 23267-23273 (1998)
74)
Evidence for an Induced-Fit Mechanism Operating in Pi
Class Glutathione Transferases.
A.J. Oakley, M. Lo Bello, G. Ricci, G. Federici, and M.W. Parker
Biochemistry 37, 9912-9917 (1998)
75)
Mutations of Gly to Ala in Human Glutathione Transferase
P1-1 Affect Helix 2 (G-Site) and Induce Positive
Cooperativity in the Binding of Glutathione.
M. Lo Bello, M. Nuccetelli, E. Chiessi, A. Lahm, A.P. Mazzetti, A.
Battistoni, A.M. Caccuri, A.J. Oakley, M.W. Parker, A.
Tramontano,
G. Federici, and G. Ricci
J. Mol. Biol., 284,1717-1725 (1998)
76)
Shifting Substrate Specificity of Human Glutathione
Transferase (from class Pi to class Alpha) by a Single Point
Mutation.
M. Nuccetelli, A.P. Mazzetti, J. Rossjohn, M.W. Parker, P. Board,
A.M. Caccuri, G. Federici, G. Ricci, and Lo Bello, M.
Biochem. Biophys. Res. Comm. 252, 184-189 (1998).
77)
Temperature Adaptation of GlutathioneS-Transferase P1-1
A.M. Caccuri, G. Antonini, P. Ascenzi, M. Nicotra, M. Nuccetelli,
A.P. Mazzetti, G. Federici, M. Lo Bello, and G. Ricci.
J. Biol. Chem. 274, 19276-19280 (1999).
78)
Proton Release on Binding of Glutathione to Alpha, Mu and
Delta class glutathione transferase
A.M. Caccuri, G. Antonini, P.G. Board, M.W. Parker, M. Nicotra,
M. Lo Bello, G. Federici, and G. Ricci.
Biochem. J. 344, 419-425 (1999)
79)
Molecular Dynamics Simulations of Human Glutathione
Transferase P1-1: Analysis of the Induced Fit Mechanism
GSH Binding.
L. Stella, M. Nicotra, G. Ricci, N. Rosato, and E. Di Iorio.
Proteins 37, 1-9 (1999)
by
80)
Molecular Dynamics Simulations of Human Glutathione
Transferase P1-1: Conformational Fluctuations of the ApoStructure
L. Stella, E. Di Iorio, M. Nicotra, and G. Ricci.
Proteins 37, 10-19 (1999)
81)
Enzymatic mechanism and molecular dynamics of glutathione
transferase P1-1
G. Ricci, A.M. Caccuri, M. Lo Bello, E. Di Iorio, M. Nicotra, M.
Nuccetelli, L. Stella, G. Antonini, N. Rosato, and G. Federici.
Clin. Chem. Enzym. Commun. 8, 213-221 (2000)
82)
Structure/function Studies on Pi and Theta class Glutathione
transferases
A.J. Oakley, J. Rossjohon, W.J. McKintry, J. Flanagan, P.C.
Board, M. Lo Bello, G. Ricci, and M.W. Board.
Clin. Chem. Enzym. Commun. 8, 231-238 (2000)
83)
Conformational Fluctuations in Human P1-1 Glutathione
Transferase: A molecular Dynamics Simulation
L. Stella, M. Nicotra, G. Ricci, E. Di Iorio
Clin. Chem. Enzym. Commun. 8, 285-288 (2000)
84)
Valine 10 may act as a driver for product release from the
active site of human glutathione transferase P1-1
C. Micaloni, A.P. Mazzetti, M. Nuccetelli, J. Rossjohn, W.J.
McKinstry, G. Antonini, A.M. Caccuri, A.J. Oakley, G. Federici, G.
Ricci, M.W.
Parker, and M. Lo Bello
Biochemistry 39, 15961-15970 (2000)
85)
R.
86)
R.
Human Glutathione Transferase T2-2 Discloses Some
Evolutionary Strategies for Optimization of Substrate Binding
to the Active Site of Glutathione Transferases
A.M. Caccuri, G. Antonini, P.G. Board, J. Flanagan, M.W. Parker,
Paolesse, P. Turella, G. Federici, M. Lo Bello, and G. Ricci.
J. Biol. Chem. 276, 5427-5431 (2001)
Human Glutathione Transferase T2-2 Discloses Some
Evolutionary Strategies for Optimization of the Catalytic
Activity of Glutathione Transferases
A.M. Caccuri, G. Antonini, P.G. Board, J. Flanagan, M.W. Parker,
Paolesse, P. Turella, G. Chelvanayagam, and G. Ricci
J. Biol. Chem. 276, 5432-5437 (2001)
87)
Human glutathione transferase P1-1 and nitric oxide carriers;
a new role for an old enzyme.
Lo Bello M, Nuccetelli M, Caccuri AM, Stella L, Parker MW,
Rossjohn J, McKinstry WJ, Mozzi AF, Federici G, Polizio F, Pedersen
JZ, Ricci G.
J Biol Chem. 276, 42138-45 (2001)
88)
Evolution of functional diversity as observed through
structural studies of glutathione transferases
Parker, M.W., McKinstry, WJ, Oakley, A.J., Polekhina, G.
Rossjohn, J.,
Chelvanayagam, G., Board, P.G., Di Ilio, C., Caccuri,
A.M., Ricci, G., Lo Bello, M.
Chem. Biol. Interact. 133, 8-12 (2001)
89)
Limited proteolysis as a powerful tool for probing flexible
oligopeptide portions among different classes of glutathione
transferases.
Nuccetelli, M., Evangelisti, C., Capo, C., Petruzzelli, R., Parker,
M.W.,
Board, P., Caccuri, A.M., Federici, G., Ricci, G., Lo Bello,
M.
Chem. Biol. Interact. 133, 43-48 (2001)
90)
Evolutionary strategy for optimization of GSH binding and
catalysis in Alpha, Pi, Mu and Theta glutathione transferases
Caccuri, A.M., Antonini, G., Board, P.G., Flanagan, J., Parker,
M.W.,
Paolesse, R., Turella, P., Federici, G., Lo Bello, M., Ricci,
G.
Chem. Biol. Interact. 133, 163-166 (2001)
91)
Exit of products from the active site of human glutathione
transferase P1-1 is promoted by valine 10
Micaloni, C., Mazzetti, A.P., Nuccetelli, M., Rossjohn, J.,
McKinstry, W.J., Antonini, G., Caccuri, A.M., Oakley, A.J., Federici,
G., Ricci, G.,
Parker, M.W., Lo Bello, M.
Chem. Biol. Interact. 133, 192-195 (2001)
92)
GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in
the evolutionary pathway from a redox enzyme to a
conjugating enzyme.
Caccuri A.M., Antonini, G., Allocati, N., Di Ilio, C., De Maria, F.,
Innocenti, F., Parker, M.W., Masulli, M., Lo Bello, M., Turella, P.,
Federici, G. and Ricci, G.
J Biol Chem. 277,18777-18784 (2002)
93)
Properties and utility of the peculiar mixed disulfide in the
bacterial glutathione transferase B1-1.
Caccuri, A.M., Antonini, G., Allocati, N., Di Ilio, C., Innocenti, F.,
De Mari, F., Parker, M.W., Masulli, M., Polizio, F., Federici, G.,
and Ricci, G.
Biochemistry 41, 4686-4693 (2002)
94)
Engineering a new C-terminal tail in the H-site of human
glutathione transferase P1-1: Structural and functional
consequences
Micaloni, C., Kong, G.K.-W., Mazzetti, A.P., Nuccetelli, M.,
Antonini, G., Stella, L., McKinstry, W.J., Polekhina, G., Rossjohn,
J., Federici, G., Ricci, G., Parker, M.W., Lo Bello, M., Huber, R.
J. Mol. Biol. 325, 111-122 (2003)
95)
Proline-glutamate chimeras in isopeptides. Synthesis and
biological evaluation of conformationally restricted glutathione
analogues
Paradisi, M.P., Mollica, A., Cacciatore, I., Di Stefano, A., Pinnen,
F., Caccuri, A.M., Ricci, G., Duprè, S., Spirito, A., Lucente, G.
Bioorg. Med. Chem. 11, 1677-1683 (2003)
96)
Synthesis and activity of novel glutathione analogues
containing an urethane backbone linkage
Cacciatore, I., Caccuri, A.M., Di Stefano, A., Luisi, G., Nalli, M.,
Pinnen, F., Ricci, G., Sozio, P.
Farmaco 58, 787-793 (2003)
97)
The specific interaction of dinitrosyl-diglutathionyl-iron
complex, a natural NO carrier, with the glutathione transferase
superfamily: Suggestion for an evolutionary pressure in the
direction of the storage of nitric oxide
De Maria, F., Pedersen, J.Z., Caccuri, A.M., Antonini, G., Turella,
P., Stella, L., Lo Bello, M., Federici, G., Ricci, G.
J. Biol. Chem. 278, 42283-42293 (2003)
98)
Glutathione Transferase Superfamily Behaves Like Storage
Proteins for Dinitrosyl-Diglutathionyl-Iron Complex in
Heterogeneous Systems
Turella, P., Pedersen, J.Z., Caccuri, A.M., De Maria, F.,
Mastroberardino, P., Lo Bello, M., Federici, G., Ricci, G.
J. Biol. Chem. 278, 42294-42299 (2003)
99)
Glutathione transferase P1-1: Self-preservation of an anticancer enzyme
Ricci, G., Caccuri, A.M., Lo Bello, M., Parker, M.W., Nuccetelli,
M., Turella, P., Stella, L., Di Iorio, E.E., Federici, G.
Biochem. J. 376, 71-76 (2003)
100) Binding and kinetic mechanisms of the Zeta class glutathione
transferase
Ricci, G., Turella, P., De Maria, F., Antonini, G., Nardocci, L.,
Board, P.G., Parker, M.W., Carbonelli, M.G., Federici, G., Caccuri,
A.M.
J. Biol. Chem. 279, 33336-33342 (2004)
101) Cooperativity and pseudo-cooperativity in the glutathione Stransferase from Plasmodium falciparum
Liebau, E., De Maria, F., Burmeister, C., Perbandt, M., Turella, P.,
Antonini, G., Federici, G., Giansanti, F., Stella, L., Lo Bello, M.,
Caccuri, A.M., Ricci, G.
J. Biol. Chem. 280, 26121-26128 (2005)
102) 7-Nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide
inhibitors for glutathione S-transferases: Mechanism of action
of potential anticancer drugs
Ricci, G., De Maria, F., Antonini, G., Turella, P., Bullo, A., Stella,
L., Filomeni, G., Federici, G., Caccuri, A.M
J. Biol. Chem. 280, 26397-26405 (2005)
103) Nitrosylation of human glutathione transferase P1-1 with
dinitrosyl diglutathionyl iron complex in vitro and in vivo
Cesareo, E., Parker, L.J., Pedersen, J.Z., Nuccetelli, M., Mazzetti,
A.P., Pastore, A., Federici, G., Caccuri, A.M., Ricci, G., Adams,
J.J., Parker, M.W., Lo Bello, M.
J. Biol. Chem. 280, 42172-42180 (2005)
104) Potent isozyme-selective inhibition of human glutathione
S-transferase A1-1 by a novel glutathione S-conjugate
Cacciatore, I., Caccuri, A.M., Cocco, A., De Maria, F., Di Stefano,
A.G. Luisi, G., Pinnen, F., Ricci, G., Sozio, P., , and P. Turella, P.
Amino Acids 29, 255-261 (2005)
105) A strong glutathione S-transferase inhibitor overcomes the Pglycoprotein-mediated resistance in tumor cells: 6-(7-nitro2,1,3- benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a
caspase-dependent apoptosis in MDR1-expressing leukemia
cells
Turella, P., Filomeni, G., Dupuis, M.L., Ciriolo, M.R., Molinari,
A., De Maria, F., Tombesi, M., Cianfriglia, M., Federici, G., Ricci,
G., and Caccuri, A.M.
J. Biol. Chem. 281, 23725-23732 (2006)
106)
Glutathione transferases sequester toxic dinitrosyl-iron
complexes in cells: A protection mechanism against excess
nitric oxide
Pedersen, J.Z., De Maria, F., Turella, P., Federici, G., Mattei, M.,
Fabrini, R., Dawood, K.F., Massimi, M., Caccuri, A.M., and Ricci,
G.
J. Biol. Chem. 282, 6364-6371 (2007)
107) Electrostatic association of glutathione transferase to the
nuclear membrane: Evidence of an enzyme defense barrier at
the nuclear envelope
Stella, L., Pallottini, V., Moreno, S., Leoni, S., De Maria, F.,
Turella, P., Federici, G., Fabrini, R., Dawood, K.F., Lo Bello, M.,
Pedersen, J.Z., and Ricci, G
J. Biol. Chem. 282, 6372-6379 (2007)
108) Tetramerization and cooperativity in Plasmodium falciparum
glutathione S-transferase are mediated by atypic loop 113-119
Liebau, E. , Dawood, K.F. , Fabrini, R. , Fischer-Riepe, L.,
Perbandt, M. , Stella, L. , Pedersen, J.Z., Bocedi, A., Petrarca, P.,
Federici, and G., Ricci, G.
J.Biol. Chem. 284, 22133-22139 (2009
109) Monomer-dimer equilibrium in glutathione transferases: A
critical re-examination
Fabrini, R. , De Luca, A. , Stella, L. , Mei, G. , Orioni, B. ,
Ciccone, S., Federici, G. , Lo Bello, M. , and Ricci, G.
Biochemistry 48, 10473-10482 (2009)
110) Trypanothione efficiently intercepts nitric oxide as a harmless
iron complex in trypanosomatid parasites
Bocedi, A., Dawood, K.F., Fabrini, R., Federici, G., Gradoni, L.,
Pedersen, J.Z., and Ricci, G.
FASEB J. 24, 1035-1042 (2010)
111) Nuclear Shield: A Multi-Enzyme Task-Force for Nucleus
Protection
Fabrini, R., Bocedi, A., Pallottini, V., Canuti, L., De Canio, M.,
Urbani, A., Marzano, V., Cornetta, T., Stano, P., Giovanetti, A.
Stella, L., Canini, A., Federici, G., and Ricci, G.
PLoSONE 10.1371/journal.pone.0014125 (2010)
112) The extended catalysis of Glutathione Transferase
R. Fabrini, A. Bocedi, K. F. Dawood, P. Turella, L.
Stella, M. W. Parker, J. Z. Pedersen, G. Federici, G.
Antonini and G. Ricci
FEBS Lett. 585, 341-345 (2011)
113) Erythrocyte glutathione transferase: a potential new
biomarker in chronic kidney diseases which correlates with
plasma homocysteine
M. Dessì, A. Noce, K. F. Dawood , F. Galli, M. Taccone-Gallucci,
R. Fabrini, A. Bocedi, R. Massoud, G. Fucci, A. Pastore, S. Manca
di Villahermosa, V. Zingaretti, G. Federici, and G. Ricci
Amino Acids (2011) in press
114) Spectrophotometric assay for serum GST: a critical
rexamination
Bocedi, A., Fabrini, R., Massoud, R. and Ricci, G.
Clin. Biochem. 45, 668-671 (2012)