Curriculum Vitae
Dr. Fulvio Baggi
Born: Bergamo, July 29th, 1959
Position Title: Senior Scientist, Head of Preclinical Neuroimmunology Laboratory, Neurology IV
Unit, Fondazione Istituto Neurologico "Carlo Besta", Milan, Italy
Contact details:
Fondazione Istituto Neurologico "Carlo Besta"
Via Celoria 11, 20133 Milan, Italy
e-mail: [email protected]
Tel: +39-0223942369
FAX: +39-0270633874
Education/Training
Month/Year
Institution
Degree
Field of study
Dec 1986
University of Milan,
Milan, Italy
Biological Sciences
(cum laude)
Biochemistry of muscle contractile
proteins
Positions held
Dec 2009now
Head of the Preclinical Neuroimmunology Laboratory, Neurology IV, Fondazione
Istituto Neurologico "Carlo Besta", Milan, Italy. The research team is involved on
translational and preclinical research on: a) role of dendritic cells and regulatory T
cells in the induction and in disease progression in the Experimental Myasthenia
Gravis, b) identification of demyelination and remyelination processes in the
Theiler's virus-induced and in the cuprizone-induced oligodendrogliopathy
experimental models, c) cellular interactions between neural stem cells and
autologous/heterologous immune competent cells.
Responsible for the development, maintenance, and update of clinical-scientific
databases; data mining and demographic/epidemiological analyses.
Dec 20072010
Responsible for the Quality Controls at the Cell Factory – UPTC, Fondazione
Istituto Neurologico "Carlo Besta".
2005-2009
Responsible for research activities in "Experimental models for specific
immunotherapy".
Oct 19932004
Senior Scientist in staff, Neurology IV – Neuromuscular Diseases and
Neuroimmunology Unit, Fondazione Istituto Neurologico "Carlo Besta", Milan,
Italy. Research activities: induction of AChR tolerance in the experimental model of
MG; studies on T and B cell reactivity in MG patients; immunological aspects of
muscle inflammation.
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Dec 19901992
Visiting Scientist at the Neurosciences Group, Institute of Molecular Medicine, John
Radcliffe Hospital, Oxford (UK), with the supervision of Prof. Angela Vincent.
Research activities were focused on: identification of AChR-derived MHC-Class I
epitopes, functional characterization of AChR-specific T-cell lines/clones from MG
patients, antigen-specific activation of AChR-specific T-cells by HLA-DR2
transfected TE671 rabdomyosarcoma cell line presenting endogenous AChR.
Nov-Dec
1989
Professional training on cloning of AChR-specific T cells from MG and healthy
subjects, at the Neurosciences Group, IMM, John Radcliffe Hospital, Oxford, UK.
1986-1989
Research Scientist at the Department of Neuromuscular Diseases, National
Neurological Institute “Carlo Besta”, Milan, Italy. Research activities:
determination of anti-AChR antibodies in MG; studies of AChR-specific
proliferative responses of T lymphocytes in MG and healthy subjects.
July-1986
Visiting scientist at the Service de Neurologie, CHUV Lausanne (CH) under the
supervision of Dr. T. Barkas on neurotoxins purification (alpha cobra-toxin and
alpha bungaro-toxin) from snake crude venoms by ion exchange chromatography.
National and International activities:
Feb-Aug
2012
Member of the Working Group for the development of Common Data Elements
for Myasthenia Gravis, coordinated by the National Institute of Neurological
Disorders and Stroke (NINDS), National Institutes of Health (NIH).
May 2011now
Chairperson of the Board of Directors of the European Myasthenia Gravis
Association (EuMGA).
May 2009
Member of the Scientific Committee of the Associazione Italiana Miastenia e
Malattie Immunodegenerative (AIM)
Mar 2009now
Member and co-founder of the European Myasthenia Gravis Association (EuMGA),
on behalf of the Associazione Italiana Miastenia e Malattie Immunodegenerative
(AIM).
Publications (2007-2012)
Complete stable remission and autoantibody specificity in myasthenia gravis. Baggi F, Andreetta F,
Maggi L, Confalonieri P, Morandi L, Salerno F, Bernasconi P, Montomoli C, Barberis M, Mantegazza
R, Antozzi C. Neurology 2012 in press.
Patient Registries: useful tools for clinical research in Myasthenia Gravis. Baggi F, Mantegazza R,
Antozzi C, Sanders D. Annals NY Acad Sci 2012 in press.
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Acetylcholine receptor-induced experimental myasthenia gravis: what have we learned from
animal models after three decades? Baggi F, Antozzi C, Toscani C, Cordiglieri, C. 2012. Arch
Immunol Ther Exp. 60: 19-30.
The thymus in myasthenia gravis: Site of "innate autoimmunity"? Cavalcante P, Le Panse R,
Berrih-Aknin S, Maggi L, Antozzi C, Baggi F, Bernasconi P, Mantegazza R. Muscle Nerve. 2011.
44(4):467-84.
Type I interferon and Toll-like receptor expression characterizes inflammatory myopathies.
Cappelletti C, Baggi F, Zolezzi F, Biancolini D, Beretta O, Severa M, Coccia EM, Confalonieri P,
Morandi L, Mora M, Mantegazza R, Bernasconi P. Neurology. 2011. 76(24):2079-88.
Naturally occurring CD4+CD25+ regulatory T cells prevent but do not improve experimental
myasthenia gravis. Nessi V, Nava S, Ruocco C, Toscani C, Mantegazza R, Antozzi C, Baggi F. J
Immunol. 2010. 185(9):5656-67.
Detection of poliovirus-infected macrophages in thymus of patients with myasthenia gravis.
Cavalcante P, Barberis M, Cannone M, Baggi F, Antozzi C, Maggi L, Cornelio F, Barbi M, Didò P,
Berrih-Aknin S, Mantegazza R, Bernasconi P. Neurology. 2010. 74(14):1118-26.
Risk factors for tumor occurrence in patients with myasthenia gravis. Citterio A, Beghi E, Millul
A, Evoli A, Mantegazza R, Antozzi C, Baggi F, Cornelio F, Durelli L, Clerico M, Piccolo G, Cosi V.
J Neurol. 2009. 256(8):1221-7.
Thymoma-associated myasthenia gravis: outcome, clinical and pathological correlations in 197
patients on a 20-year experience. Maggi L, Andreetta F, Antozzi C, Baggi F, Bernasconi P,
Cavalcante P, Cornelio F, Muscolino G, Novellino L, Mantegazza R. J Neuroimmunol. 2008. 201202:237-44.
Effect of IgG immunoadsorption on serum cytokines in MG and LEMS patients. Baggi F, Ubiali F,
Nava S, Nessi V, Andreetta F, Rigamonti A, Maggi L, Mantegazza R, Antozzi C. J Neuroimmunol.
2008. 201-202:104-10.
Pixantrone (BBR2778) reduces the severity of experimental autoimmune myasthenia gravis in
Lewis rats. Ubiali F, Nava S, Nessi V, Longhi R, Pezzoni G, Capobianco R, Mantegazza R, Antozzi
C, Baggi F. J Immunol. 2008. 180(4):2696-703.
The kinesin superfamily motor protein KIF4 is associated with immune cell activation in
idiopathic inflammatory myopathies. Bernasconi P, Cappelletti C, Navone F, Nessi V, Baggi F,
Vernos I, Romaggi S, Confalonieri P, Mora M, Morandi L, Mantegazza R. J Neuropathol Exp
Neurol. 2008. 67(6):624-32.
Allorecognition of human neural stem cells by peripheral blood lymphocytes despite low
expression of MHC molecules: role of TGF-beta in modulating proliferation. Ubiali F, Nava S,
Nessi V, Frigerio S, Parati E, Bernasconi P, Mantegazza R, Baggi F. Int Immunol. 2007. 19(9):106374.
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