Piruvato deidrogenasi
e
ciclo di Krebs
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Piruvato deidrogenasi
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Intermedi di reazione
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
1
Tiammina pirofosfato (TPP)
Tiammina (vitamina B1)
Anello
tiazolico
Anello pirimidinico
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Acetaldeide
attiva
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Meccanismo di
decarbossilazione
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
2
Intermedi di reazione
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Acido lipoico
Forma
ossidata
Forma
ridotta
Forma
acetilata
Acido
lipoico
Residuo
di lisina
dell’E2
Catena polipeptidica
dell’E2 (di idrolipoiltransacetilasi)
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Ossidata
Ridotta
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
3
Ridotta
Acetilata
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Intermedi di reazione
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Coenzima A (CoA)
Gruppo tiolico
reattivo
Adenina
β-mercaptoetanolammina
Acido pantotenico
Ribosio 3’-fosfato
3’-fosfoadenosina difosfato
Acetil-CoA
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
4
Intermedi di reazione
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Siti reattivi
FAD
Riduzione del FAD
Forma ossidata
(FAD)
Forma ridotta
(FADH2)
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
5
Intermedi di reazione
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Ciclo di Krebs
Vuota
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Citrato sintasi
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
6
Aconitasi
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Isocitrato deidrogenasi
Isoenzima NAD+ mitocondriale
NADP+ mitocondiale e citosolico
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
α-chetoglutarato deidrogenasi
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
7
Succinil CoA sintetasi
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Succinato deidrogenasi
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Fumarasi
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
8
Malato deidrogenasi
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Reazioni anaplerotiche 1
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
Reazioni anaplerotiche 2
Nelson and Cox: Lehninger Principles of Biochemistry.
Third Edition © 2000 Worth Publishers, Inc.
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