INSTITUTIONS WHO PARTICIPATED TO THE STUDY 1) Division of Hematology, Department of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy: Chiara Lobetti‐Bodoni, Barbara Mantoan, Elisa Genuardi, Mario Boccadoro, Marco Ladetto 2) Unit of Cancer Epidemiology, Azienda Ospedaliera Città della Salute e della Scienza, Turin, Italy: Giovannino Ciccone, Andrea Evangelista, Manuela Ceccarelli 3) Division of Hematology 2, Azienda Ospedaliera Città della Salute e della Scienza, Turin, Italy: Carola Boccomini, Annalisa Chiappella, Barbara Botto, Lorella Orsucci, Umberto Vitolo 4) Division of Hematology, Fondazione IRCCS Cà Granda OM Policlinico, University of Milan, Milan Italy: Maria Goldaniga, Francesca Gaia Rossi, Luca Baldini 5) Division of Hematology, Spedali Civili Hospital and University, Brescia, Italy: Chiara Bottelli, Alessandra Tucci, Giuseppe Rossi 6) Division of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy: Alessandro Pulsoni, Federico De Angelis, Eleonora Russo, Maurizio Martelli, Robin Foà 7) Division of Hematology, Oncology, and Clinical Pathology; Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy: Francesco Di Raimondo, Annalisa Chiarenza 8) Hematology Functional Unit, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy: Luigi Rigacci, Benedetta Puccini, Alberto Bosi 9) Istituto Nazionale Tumori, Fondazione ‘G. Pascale’, Istituto Di Ricovero e Cura a Carattere Scientifico IRCCS, Naples, Italy. Antonello Pinto 10) Department of Oncology, Transplants and Advanced Technologies, Section of Hematology, Pisa University, Pisa, Italy: Mario Petrini, Sara Galimberti 11) Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy.: Alessia Bari, Stefano Sacchi, Massimo Federico 12) Universitary Division of Medical Oncology, “Fondazione del Piemonte per l’Oncologia‐Istituto per la Ricerca e la Cura del Cancro”, Candiolo, Turin, Italy. Delia Rota‐Scalabrini, Massimo Aglietta 13) Hematology Unit, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy: Angela Ferrari,Isabel Alvarez De Celis, Francesco Merli 14) Division of Hematology and Bone Marrow Transplantation, Azienda Ospedaliero‐Universitaria Udine, Udine, Italy: Francesco Zaja, Renato Fanin 15) Hematology Department and BMT Unit, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy: Claudia Castellino, Andrea Gallamini 16) Internal Medicine – Hematology, S. Luigi Hospital, University of Turin, Orbassano, Italy: Guido Parvis, Giuseppe Saglio 17) Division of Hematology, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy: Tommasina Perrone, Giorgina Specchia 18) Division of Hematology, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy: Pellegrino Musto 19) Roche, S.p.A., Monza, Italy: Enrica Gamba 20) Hematology and BMT Unit, IRCCS National Institut of Tumor, Milano, Italy: Paolo Corradini 21) Division of Hematology, Department of Clinical and Preventive Medicine, University of Milano Bicocca, Monza, Italy: Enrico Maria Pogliani 22) Internal Medicin Department, Policlinico Monteluce and University, Perugia, Italy: Anna Marina Liberati 23) Hematology Unit, Policlinico Agostino Gemelli and Cattolica University, Roma, Italy: Giuseppe Leone 24) Hematology and BMT Unit, Vincenzo Cervello Hospital, Palermo, Italy: Caterina Patti 25) Hematology Unit, Spirito Santo Hospital and University, Pescara, Italy: Giuseppe Fioritoni 26) Hematology Unit, Niguarda Ca' Granda Hospital: Chiara Rusconi, Enrica Morra 27) Internal Medicine, Ospedale degli Infermi Hospital, Biella, Italy: Anna Tonso 28) Division of Hematology, Businco Hospital, Cagliari, Italy: Giuseppina Cabras, Emanuele Angelucci 29) Hematology Unit, Ospedali Riuniti Hospital and University, Bergamo, Italy: Andrea Rossi, Alessandro Rambaldi 30) Hematology and BMT Unit, San Maurizio Hospital, Bolzano, Italy: Sergio Cortelazzo 31) Division of Hematology, Hospital, Cremona, Italy: Sergio Morandi, Francesco Lanza 32) Hematology and BMT Unit, Policlinico G.B. Rossi and University, Verona, Italy: Giovanni Pizzolo 33) Division of Hematology, S. Eugenio Hospital and Tor Vergata University, Roma, Italy: Sergio Amadori 34) Hematology Unit, Policlinico Sant’Orsola e Malpighi and University of Bologna, Bologna,Italy: Pier Luigi Zinzani 35) Hematology Unit, Bianchi‐Melacrino‐Morelli Hospital, Reggio Calabria, Italy: Caterina Stelitano, Francesco Nobile LEGEND TO SUPPLEMENTAL FIGURES (ON LINE ONLY) Figure 1S. PFS by triple negativity at M8‐M12‐M18 by N‐PCR Figure 2S. PFS by PCR negativity by combined use of N‐PCR and RQ‐PCR at M8