CURRICULUM VITAE
Name
Antonio Uccelli
Coniugal state
Married with Messmer Michele (USA); One child (Cesar)
Home address
Via Albaro 9/10 D
16145 – Genova
Phone: 010/312049
E-mail: [email protected]
Work address
Università degli Studi di Genova
Dipartimento di Neuroscienze, Oftalmologia e Genetica
Via De Toni 5, 16132
Genova, Italia
Phone: (39) 10/3537040/28/48
Fax: (39) 10/3538631
E-mail: [email protected]
Date of Birth
November 18,1964
Genova, Italia
Education
1983
1989
1989
1993
Maturita’: Liceo Classico “A.Doria” Genova
M.D. Degree Magna Cum Laude, Universita’ degli Studi di Genova
Italian Board of Medicine: completed with honors
Italian Board of Neurology: completed with honors
Postdoctoral training
Internships and Residency
1984-1986
1986-1987
1987-1989
1989-1993
Intern in Anatomy with Prof. D. Zaccheo, Istituto di Anatomia,
Universita’ degli Studi di Genova
Intern in Virology with Dr. O. Varnier, Istituto di Microbiologia,
Universita’ degli Studi di Genova
Intern in Neurology with Prof. E. Favale, Clinica Neurologica, Universita’
degli Studi di Genova
Resident in Neurology, Clinica Neurologica, Universita’ degli Studi di
Genova
Research Fellowship
1991-1992
1992
1992-1994
Research fellow with Dr. F. Manca, Istituto di Immunologia, University of
Genoa, Italy
Visiting Scientist at the Department of Neurological and Psychiatric,
University of Florence, Italy
Visiting Scientist with Prof. S.L. Hauser, Department of Neurology,
University of California, San Francisco
Employment
1993-2011
19951998-
Dirigente Medico di I livello (Assistant Professor Level), Department of
Neurosciences, Ophthalmology and Genetics-University of Genoa.
Head of the Neuroimmunology Lab of Department of Neurosciences,
Ophthalmology and Genetics-University of Genoa.
Assistant Professor of “Elements of Neuropatology” in the Residency
Program of Physical Rehabilitation at the University of Genoa
1999-
Assistant Professor of “Elements of Neuroimmunology ” in the Residency
Program of Neurology at the University of Genoa
Member of the “Center of Excellence for Biomedical Research” University of Genoa
Head of the Neuroimmunology Section of the “Center of Excellence for
Biomedical Research” - University of Genoa
Director of the Neuroimmunobiology Laboratory of the Advanced
Biotechnology Center of Genoa
Head Multiple Sclerosis Clinic Department-University of Genoa
Assistant Professor of “Neuropatology” in the Residency Program of
Biotecnology at the University of Genoa
Associate Professor of Neurology, University of Genoa
Coordinator of the Residency School of Neurosurgery, University of
Genoa
Co-founder togheter with Prfessor MS Freedman of the International
Mesenchymal Stem Cells Transplantation Study Group (IMSCTSG). With
this study they estabilited the guidelines for the use of mesenchymal
stem cells for the treatment of multiple sclerosis. This consensus is
based on the results of preclinical research of Prof. Uccelli. It was
published in the Multiple Sclerosis Journal and it is the basis on which it
was designed a phase II international trial for the use of MSC in multiple
sclerosis. Professor Uccelli is the principal investigator for this study.
20002003200720092010201120122012 -
Professional Awards
2001
Rita Levi Montalcini Award. Italian Multiple Sclerosis Researcher of the
Year
2009
Melvin Jones Fellow Award (for dedicated humanitarian services LIONS
CLUBS INTERNATIONAL FOUNDATION)
Scientific collaborations:
-
Vito Pistoia (Pediatric Institute Giannina Gaslini - Genoa).
-
Elena Zocchi (Advanced Biotechnology Center of Genoa)
-
Gianni Bonanno and Ernesto Fedele (DIMES-University of Genoa)
-
Laura Vergani (Institute of Physiology-University of Genoa)
-
Roberto Furlan and Gianvito Martino (IRCCS San Raffaele, Milan)
-
Federica Sallusto and Antonio Lanzavecchia (Institute for Research in Biomedicine,
Bellinzona, CH)
-
Jorge
Oksenberg
and
Sergio
Baranzini
(Department
of
Neurology,
University of California at San Francisco, UCSF)
-
Amit Bar-or (Neurological Institute, McGill University, Montreal)
-
Albert Saiz and Pablo Villoslada (Hospital Clinic-Institut d'Investigacions Biomèdiques,
Barcelona, Spain)
-
Mark Freedman (University of Ottawa, Ottawa Hospital Research Institute, Canada)
-
Andrea Urbani Department of Internal Medicine, University of Rome Tor Vergata)
-
Lorenzo Moretta (Pediatric Institute Giannina Gaslini, Genova)
-
Caterina Bendotti (Laboratory of Molecular Neurobiology, Department of Neuroscience,
Mario Negri Institute for Pharmacological Research, Milano)
2
-
Mauro Maccarone (Institute of Nephrology and Dialysis, University of Chieti)
-
Paolo Muraro (Imperial College, London, UK)
-
Daniela Virgintino (Department of Human Anatomy and Histology, University of Bari)
-
Kevin Tracey (The Feinstein Institute for Medical Research, New York, USA)
-
Roland Liblau and Michel Clanet (Toulouse University Medical School, France)
-
Darwin Prockop (Institute for Regenerative Medicine, Texas, USA)
Membership in Professional and Scientific Society
Italian Society of Neuropathology
Italian Society of Neuroimmunology (2003-2009-Secretary of the Executive Board)
Secretary of the Scientific Board of the Residential Course of Neuroimmunology - CRNI
Program
Italian Society for Multiple Sclerosis (Secretary of the Research Committee 2003-2005)
Member of the Research Committee (2005-2008)
Italian Society of Neurology
Italian Society of Immunology
International Society of Neuroimmunology
Stem Cell Research Italy
The Henry Kunkel Society
Board European School of Neuroimmunology (ESNI)
Ad hoc reviewer for
Scientific Association
Australian MS Society, ELA
Association Européenne contre les Leucodystrophies (ELA) (France)
Hasselt University (Belgium)
Weissman Institute (Israel)
ARSEP (Association pour la Recherche sur la Sclerose en Plaque (France)
INSERM (France)
Italian MS Society
Italian National Council of Research (CNR)
Italian Ministry of Health
New Zeeland Neuroscience Foundation
Swiss National Science Foundation
The National Kidney Research Fund (UK)
UK MS Society (UK)
Wellcome Trust (UK)
Science Foundation of Ireland
Swiss MS Society
Scientific Journals
Acta Neuropatologica
Annals of Neurology
Blood
Bone Marrow Transplantation
Brain
Brain Research
Clinical and Developmental Immunology
Cytotherapy
European Journal of Immunology
European Journal of Neurosciences
Experimental Neurology
Glia
3
Hematologica
Immunogenetics
Immunology Letters
International Immunopharmacology
Journal of Alzaimer’s diseases
Journal of Cellular and Molecular Medicine
Journal of Immunology
Journal of Neurochemistry
Journal of Neuroimmunology
Journal of Neuroscience Research
Lancet
Lancet Neurology
Multiple Sclerosis
Nature Communications
Nature Reviews Immunology
Neurobiology of Diseases
Neurology
Neurogical Sciences
Pharmacological Research
Physiological Genomics
Plos One
Proceedings of the National Academy of Sciences USA (PNAS)
Pediatric Research
Regenerative Medicine (Member of the Editorial Board)
Rheumatology
Stem Cells
Stem Cells and Development
Advisory Board Membership (previous and present):
CARIVERONA, Allergan, Androclus Therapeutics, Merck-Serono, BiogenIdec, Biogen-Dompè,
Bayer-Schering Pharma, Novartis, Genentech, Roche, Juvenile Diabetes Research Foundation,
Regione Liguria.
Membership in Editorial Board:
Journal of Neuroimmuno Pharmacology
Research Activities
•
•
•
•
Clinical Neuroimmunology and multiple sclerosis
Immunology of Multiple Sclerosis and experimental autoimmune encephalomyelitis
Adult Stem cells
Autoimmunity in neurology
Teaching and Mentoring
Formal scheduled classes for University of Genoa students
Academic Yr
2010
Course Title
Biotechnology
Teaching Contribution
Lecturer
Class size
10
Invited Presentations-International (last 2 years)
2011:
- “Spring 2011 External Speaker Programme" University College London, London; UK
(speaker)
- “The enigma of inflammation in ALS: What can be learned from other neurological
diseases?” - Weizmann Institute, Rehovot, Israel (speaker)
- Event “Best Practice & Research Clinical Haematology “, London; UK (speaker)
4
-
Symposium of the Bavarian Reseach Network, Munich; Germany (speaker)
“Multiple sclerosis symposium” - Beirut, Lebanon (speaker)
CMSC Annual Meeting, Montreal; Canada (speaker)
11th ESNI Course - European School of Neuroimmunology, Glasgow, UK (speaker)
35° Congresso Nazionale SIF - Bologna, (speaker)
Lecture: Mesenchymal stem cells: a new cell therapy for the treatment of autoimmunity,
Institute for Research in Biomedicine – Bellinzona, Switzerland.
XXIX Conferenza Nazionale Di Citometria, Salerno, (speaker)
5th Joint Triennial Congress of the European and Americas Committees for Treatment and
Research in Multiple Sclerosis (ECTRIMS and ACTRIMS) – Amsterdam; Holland (Speaker)
Convegno uniStem 11ªGiornata di Studio sulle Cellule Staminali - Unistem, Milano (speaker)
Insubria Autumn School Of Neuroimmunopharmacology, University of Insubria, Varese –
Italy (speaker)
2011 Henry Kunkel Society meeting, Washington, DC (speaker)
-
2012
- Congress “Cellule staminali realtà e speranze” – Genova – Italia (speaker)
- Course “Translational & clinical issues in paedriatic rheumatology” – Genova –Italia
(speaker)
- Event scienza/spettacolo per le scuole medie superiori – “20 regioni unite per la scienza” “Il
lungo e affascinante viaggio della ricerca sulle cellule staminali” – Genova – Italia (speaker)
- Open day 2012 CEBR Centre of Excellence for Biomedical Research “ Circuiti
Immunoregolatori: dall’immunologia di base alla clinica” – Genova – Italia (speaker)
- Seminary presso l'istituto Mario Negri “Mesenchymal stem cells: a new treatment for
autoimmune disease” – Milano – Italia (speaker).
- Seminary "Mesenchymal stem cells for the treatment of multiple sclerosis and other
neurological diseases” Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano
(Torino), Italy (Speaker)
- Lecture Cellule Staminali Mesenchimali: Nuova Terapia Cellulare per la Sclerosi Multipla ed
altre Malattie Neurodegenerative, Palermo Italia
- INTERNATIONAL SUMMER COURSE. MURCIA UNIVERSITY 2012, Aguilas. Murcia. Spain
(Speaker)
- Seminary “Mesenchymal stem cells exert a remarkable neuroprotective effect requiring
minimal CNS integration”, Genova IIT (Speaker)
- European Congress of Immunology, Glasgow, UK (Speaker)
GRANTS (last 4 years)
2012
ƒ
Fondazione ARSEP: “A French-Italian collaboration for the MESEMS (MEsenchymal StEm
cells for the therapy of Multiple Sclerosis) trial” (totale support for project 175.000,00
euro)
2011
ƒ ITALIAN MINISTRY OF HEALTH “Preclinical evaluation of the NAMPT inhibitor FK866 for
the treatment of autoimmunity and lymphoblastic leukemia”(631.111 euro)
ƒ Biogen Idec “Sponsored Research Agreement (SRA) – Characterization of effect of BG12
on activated microglia: implication for the treatment of Multiple Sclerosis” (73.500 euro)
ƒ Merck Serono “Charaterization of the effects of cladibrine on adaptive immune responses
in mice and humans” (240.000 euro)
ƒ ITALIAN FOUNDATION FOR MULTIPLE SCLEROSIS 2011-2013: “Progetto Speciale Cellule
Staminali”. PI: Antonio Uccelli (901.000 euro)
5
ƒ
ITALIAN MINISTRY OF UNIVERSITY AND RESEARCH – PRIN 2009 “Identification of new
sources of stem cells for the treatment of multiple sclerosis” (278.454 euro)
2010
ƒ REGIONE LIGURIA 2010: “The trafficking of hematopoietic stem cells and their bone
marrow homing as the prerequisites to improve the outcome of transplant"P.I. Francesco
Frassoni (281.600,00).
ƒ RICERCA SANITARIA REGIONE LIGURIA 2009: ”Studio del traffico e della distribuzione di
cellule staminali mesenchimali ematopoietiche, mesenchimali ed endoteliali per disegnare
appropriatamente le terapie cellulari; P.I. F.Frassoni (216.400 euro)
2009
ƒ PROGETTO DI COLLABORAZIONE SCIENTIFICA REGIONE LIGURIA (CBA Genova) –
REGIONE PIEMONTE (CBM Torino) 2009: “Caratterizzazione delle proprietà terapeutiche
delle cellule staminali mesenchimali umane e della loro interazione con i tessuti”. (P.I. A.
Uccelli) (300.000 euro)
ƒ
ƒ
MIUR – PRIN: 2005-2007: “Stem cell therapy in autoimmune demyelinating disorders of
nervous system” Coordinatore nazionale: G. Comi. Co-PI: Mancardi G – Uccelli A.
(117.000 euro)
ITALIAN FOUNDATION FOR MULTIPLE SCLEROSIS 2007-2010: “Progetto Speciale Cellule
Staminali”. PI: Antonio Uccelli (900000.00 euro)
Publications on Journals covered by the Institute for Scientific Information
(last 2 years - total impact factor:683,489 - mean IF/publication: 6,328)
Dr Uccelli’s C.I. (Citation Index) is 6.355 - H Index is 31 – G Index is 72 – E Index 52.
1.
Uccelli A, Laroni A, Freedman MS. Mesenchymal stem cells as treatment for MS – progress
to date". Multiple Sclerosis Journal 2012 accepted for publication IF: 4.255
2.
Errede M, Girolamo F, Ferrara G, Strippoli M, Morando S, Boldrin V, Rizzi M, Uccelli A,
Perris R, Bendotti C, Salmona M, Roncali L, Virgintino D. Blood-Brain Barrier Alterations in
the Cerebral Cortex in Experimental Autoimmune Encephalomyelitis. J Neuropathol Exp
Neurol. 2012 Oct;71(10):840-854. IF: 4.258
3.
Giunti D, Parodi B, Usai C, Vergani L, Casazza S, Bruzzone S, Mancardi G, Uccelli A.
Mesenchymal Stem Cells Shape Microglia Effector Functions Through the Release of
CX3CL1. Stem Cells. 2012 Jul 20. doi: 10.1002/stem.1174. [Epub ahead of print] IF:
7.781 C.I:0
4.
Sallusto F, Impellizzieri D, Basso C, Laroni A, Uccelli A, Lanzavecchia A, Engelhardt B. Tcell trafficking in the central nervous system. Immunol Rev. 2012 Jul;248(1):216-27.
IF:13.462 CI: 0
5.
Pardini M, Capello E, Krueger F, Mancardi G, Uccelli A. Reward responsiveness and fatigue
in multiple sclerosis. Mult Scler. 2012 Jun 21. [Epub ahead of print] IF: 4.230 CI: 0
6.
Laroni A, Giacomazzi CG, Grimaldi L, Gallo P, Sormani MP, Bertolotto A, McDermott JL,
Gandoglia I, Martini I, Vitello G, Rinaldi F, Barzon L, Militello V, Pizzorno M, Bandini F,
Capello E, Palù G, Uccelli A, Mancardi GL, Varnier OE Urinary JCV-DNA Testing during
Natalizumab Treatment May Increase Accuracy of PML Risk Stratification. J Neuroimmune
Pharmacol. 2012 May 16 IF: 4,212 CI:0
6
7.
Mirabelli-Badenier M, Morana G, Pinto F, Uccelli A, Veneselli E, Battaglia FM, Biancheri R,
Baglietto MG, Vincent A, Mancardi MM. Anti-Glutamic Acid Decarboxylase Limbic
Encephalitis Without Epilepsy Evolving Into Dementia With Cerebellar Ataxia. Arch Neurol.
2012 Apr 16. [Epub ahead of print] IF: 7.108 CI:0
8.
Uccelli A, Milanese M, Principato MC, Morando S, Bonifacino T, Vergani L, Giunti D, Voci A,
Carminati E, Giribaldi F, Caponnetto C, Bonanno G. Intravenous Mesenchymal Stem Cells
Improve Survival and Motor Function in Experimental Amyotrophic Lateral Sclerosis. Mol
Med. 2012 Apr 2. doi: 10.2119/molmed.2011.00498. [Epub ahead of print] IF: 5.908 CI: 0
9.
Lugaresi A., Florio C., Brescia-Morra V., Cottone S., Bellantonio P., Clerico M., Centonze
D., Uccelli A., Di Ioia M., De Luca G., Marcellusi A., Paolillo A. and the BRIDGE Study
group. Patient adherence to and tolerability of self-administered interferon beta-1a using
an electronic autoinjection device: a multicentre, open-label, phase IV study” BMC
Neurology 2012 March, 12:7. IF CI: 0
10. Freedman MS, Uccelli A. Neurorepair with mesenchymal stem cells: hope or hype? Lancet
Neurol. 2012 Jan 9 IF:21.659 CI:0
11. Morando S, Vigo T, Esposito M, Casazza S, Novi G, Principato MC, Furlan R, Uccelli A. The
therapeutic effect of mesenchymal stem cells transplantation in experimental autoimmune
encephalomyelitis
is
mediated
by
peripheral
and
central
mechanisms.
Stem Cell Res. Ther. 2011 Dec. Tracked for IF CI: 0
12. Mancardi G, Sormani M, Di Gioia M, Vuolo L, Gualandi F, Amato M, Capello E, Currò
D, Uccelli A, Bertolotto A, Gasperini C, Lugaresi A, Merelli E, Meucci G, Motti L, Tola M,
Scarpini E, Repice A, Massacesi L, Saccardi R. Autologous haematopoietic stem cell
transplantation with an intermediate intensity conditioning regimen in multiple sclerosis:
the Italian multi-centre experience. Mult Scler. 2011 Nov 29. [Epub ahead of print] IF:
4.230 C.I:1
13. Conti L., De Palma R., Rolla S., Boselli D., Rodolico G, Kaur S., Silvennoinen O., Niccolai
E., Amedei A., Ivaldi F., Clerico M., Contessa G., Uccelli A., Durelli L., Novelli F. Th17 cells
in multiple sclerosis express higher levels of JAK2, which increases their surface expression
of IFN-γR2. Journal of Immunology.2011 IF: 5.745 C.I:0
14. Chiesa S. Morbelli S., Morando S., Massollo M., Marini C.,Bertoni A, Frassoni F., Tabera
Bartolomé S., Sambuceti G., Traggiai E., Uccelli A. Mesenchymal stem cells impair in vivo
T cell priming by dendritic cells. Proceedings of the National Academy of Sciences USA
(PNAS) 2011 Oct 18;108(42):17384-9. Epub 2011 Sep 29 IF:9.771 C.I:4
15. Ghezzi A, Carone R, Del Popolo G, Amato MP, Bertolotto A, Comola M, Del Carro U, Di
Benedetto P, Giannantoni A, Lopes de Carvalho ML, Montanari E, Patti F, Protti A, Rasia S,
Salonia A, Scandellari C, Sperli F, Spinelli M, Solaro C, Uccelli A, Zaffaroni M, Zipoli V;
The Multiple Sclerosis Study Group, Italian Society of Neurology. Recommendations for the
management of urinary disorders in multiple sclerosis: a consensus of the Italian Multiple
Sclerosis Study Group. Neurol Sci. 2011 Sep 24. [Epub ahead of print] IF:1.220 C.I:0
16. Laroni A, Giacosa A, Uccelli A, Mancardi GL. Can we kill an extra bird with the same
stone? Inflamm Bowel Dis. 2011 Jun; 17(9):124-125. doi: 10.1002/ibd.21802. IF:4.613
C.I:0
17. Uccelli A, Laroni A, Freedman MS Mesenchymal stem cells for the treatment of multiple
sclerosis and other neurological diseases. Lancet Neurol. 2011 Jul;10(7):649-56 IF:
21.659 C.I : 13
18. Oddo S, Laroni A, Uccelli A, Giusti M A case of thyroiditis during natalizumab therapy for
multiple sclerosis. J Endocrinol Invest. 2011 May;34(5):408-9. IF: 1.476 C.I:0
7
19. Uccelli A, Ginocchio F, Mancardi GL, Bassetti M. Primary varicella zoster infection
associated with fingolimod treatment. Neurology. 2011 Mar 15;76(11):1023-4. IF: 8.017
C.I : 4
20. Uccelli A, Benvenuto F, Laroni A, Giunti D. Neuroprotective features of mesenchymal
stem cells. Best Pract Res Cl Ha. 2011 Mar;24(1):59-64. Epub 2011 Feb 25. IF 2.178
C.I.:24
21. Laroni A.; Bedognetti M.; Uccelli A.; et al. Association of melanoma and natalizumab
therapy
in
the
Italian
MS
population:
a
second
case
report
Neurol Sci. 2011 Feb; 32(1):181-182 IF:1.220 CI: 4
8