P r e l i m i n a r y
P r o g r a m
Photo Credit: KHM, Wein
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S u p p o rt e r s :
I n t e r n at i o n a l S o c i e t y f o r S t e m C e l l R e s e a r ch
D i sc o v e r th e l at e st sc i e n c e a n d
p i o n e e r i n g c l i n i c a l r e s e a r ch ,
F o r g e c o l l a b o r at i o n s w i th
p e e r s , & E x ch a n g e i d e a s i n a
c o l l e g i a l s e tt i n g
Dear colleagues,
On behalf of the International Society for Stem Cell Research, we are
delighted to invite you to “Stem Cells in Translation,” our Regional Forum
in Florence, Italy, on September 15-18.
ISSCR Regional Forums complement our highly regarded Annual Meeting
by highlighting key areas of stem cell research rather than providing an
overview of the entire field. “Stem Cells in Translation” will focus on
progress being made at the frontier of discovery as researchers seek to
deliver the incredible promise of stem cell engineering to patients in a
clinical setting.
The heart of ISSCR gatherings is the exchange of information between
leading figures in stem cell research. It’s this unique confluence of passion,
information and knowledge that stimulates thought and propels advances in
our dynamic and challenging field. For this Forum, we’re proud to convene
a compelling group of speakers that includes practicing physicians with clinical
cell and gene therapy experience speaking on an array of exciting topics.
The Forum’s relaxed, collegial setting gives you ample time to ask
questions, exchange information and share ideas with some of your most
prominent and knowledgeable peers, either at poster presentations or
during our receptions.
Experience all this in historic Florence, the birthplace of the Renaissance, a
city whose beauty and culture has inspired artists and scientists for centuries.
We believe you’ll find this Forum stimulating, insightful and thought-provoking.
Please join us, won’t you?
Best Regards,
Cedric Blanpain,
Michele De Luca,
Université Libre de Bruxelles, Belgium
University of Modena and Reggio Emilia, Italy
Ronald McKay,
Richard Young,
Lieber Institute for Brain Development, USA
Whitehead Institute for Biomedical Research, USA
Organizing Committee
ISSCR Regional Forum, Florence 2013
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I n t e r n at i o n a l S o c i e t y f o r S t e m C e l l R e s e a r ch
k e yn ot e S p e ak e r s
Dr. John Dick
Dr. Gordon Keller
Dr. John Dick is a Senior Scientist at the Princess Margaret Cancer
Centre and the McEwen Centre for Regenerative Medicine
of the University Health Network and Professor of Molecular
Genetics at the University of Toronto. Dr. Dick is also Director
of the Program in Cancer Stem Cells at the Ontario Institute
of Cancer Research (OICR). His seminal contributions to the
fields of molecular hematology, stem cell biology and oncology
have been recognized by numerous prestigious awards at the
provincial, national and international levels.
Dr. Dick has achieved groundbreaking findings in the areas
of hematopoiesis and cancer. Through his work, he has
pioneered the field of cancer stem cell biology, transformed
our views of the origin and nature of cancer, and laid the
foundation for new approaches to cancer therapy.Two of the
most important achievements were developing a system for
transplanting normal and malignant human hematopoietic cells
into immune-deficient mice; and using this method to identify
and characterize both normal and leukemic human stem cells.
Dr. Gordon Keller is the Director of the McEwen Centre for
Regenerative Medicine at the University Health Network
in Toronto. Dr. Keller is also a founding member and past
president of the Board of Directors of the International
Society of Stem Cell Research and is a member of the Scientific
Advisory Board for the Burnham Institute for Medical Research.
Throughout his remarkable career, Dr. Keller has received
numerous awards, including the “100 Alumni of Influence”
Alumni award from the University of Saskatchewan and a Tier
I Canada Research Chair in Embryonic Stem Biology.
Dr. Keller is best known for his breakthrough success to
differentiate human embryonic stem (ES) cells into cardiac
lineages. His current research aims to elucidate a better
understanding of the mechanisms that control mesoderm and
endoderm induction and specification in mouse and human
embryonic stem (ES) cell cultures. His studies focus specifically
on the generation of the following derivative lineages:
hematopoietic, vascular, cardiac, hepatic and pancreatic.
C o nfi r m e d S PE A K ER S
Salvador Aznar-Benitah
Robin Franklin
Graziella Pellegrini
Chris Baum
Elaine Fuchs
Shahin Rafii
Paolo Bianco
Bobby Gaspar
Yoshiki Sasai
Luca Biasco
Holger Gerhardt
David Sassoon
Hans Clevers
Mauro Giacca
Ben Simons
Giulio Cossu
Margaret Goodell
Deepak Srivastava
George Q. Daley
Markus Grompe
John Stingl
Fred de Sauvage
Frank Luyten
Lorenz Studer
Dieter Egli
Paolo Macchiarini
Shahragim Tajbakhsh
Tariq Enver
Frank McKeon
Didier Trono
Alain Fischer
Sean Morrison
Sally Temple
Stuart Forbes
Luigi Naldini
Institute for Biomedical Research (IRB), Spain
Hannover Medical School, Germany
Sapienza University of Rome, Italy
San Raffaele Telethon Institute for Gene Therapy, Italy
Hubrecht Institute, Netherlands
University College London, UK
Boston Children’s Hospital, USA
Genentech Inc., USA
New York Stem Cell Foundation, USA
UCL Cancer Institute, University College London, UK
CHU Necker INSERM U768, France
University of Edinburgh, UK
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Wellcome Trust and MRC Cambridge Stem Cell Institute, UK
The Rockefeller University, USA
UCL Institute of Child Health, UK
London Research Institute-Cancer Research UK, UK
International Centre for Genetic Engineering and Biotechnology, Italy
Baylor College of Medicine, USA
Oregon Health and Science University, USA
University Hospitals KU Leuven, Belgium
ACTREM, Karolinska Institute, Sweden
Jackson Laboratory for Genomic Medicine, USA
Children’s Medical Research Institute at UT Southwestern, USA
University of Modena and Reggio Emilia, Italy
Cornell Medical College & Angiocrine Bioscience, USA
Center for Developmental Biology RIKEN, Japan
INSERM, University of Pierre and Marie Curie-Sorbonne University, France
University of Cambridge, UK
The Gladstone Institutes, USA
Cancer Research UK Cambridge Research Institute, UK
Sloan-Kettering Institute for Cancer Research, USA
Pasteur Institute, Stem Cells & Development, France
Federal Polytechnic School of Lausanne EPFL, Switzerland
Neural Stem Cell Institute, USA
San Raffaele Scientific Institute, Italy
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I n t e r n at i o n a l S o c i e t y f o r S t e m C e l l R e s e a r ch
P ro g r am S ch e d u l e
Sunday, September 15
2:00-2:05 Chair overview
9:55-10:20Paolo Macchiarini, ACTREM, Karolinska Institute, Sweden
Interaction Between Mesenchymal Stromal
Cells, Bioengineered Tissues and Organs,
and Human Body
2:00-9:00 PM Registr ation Open
2:05-2:30 Shahin Rafii, Cornell Medical College & Angiocrine Bioscience, USA
7:00-9:00 PM Opening Session
Vascular Niche to Stem Cell Self-Renewal and Organ Regeneration
10:20-10:45Refreshment Break
7:00-7:15 Opening Remarks: Michele De Luca, University of
Modena and Reggio Emilia, Italy
2:30-2:55 Markus Grompe, Oregon Health and Science University, USA
10:45-11:10 Giulio Cossu, University College London, UK
7:15-8:30 Keynote: John Dick, Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Canada
The Role of Epithelial Progenitors in
Liver Injury
A Phase I/II Cell Therapy Trial for Duchenne Muscular Dystrophy
2:55-3:20 Deepak Srivastava, The Gladstone Institutes, USA
11:10-11:35 Frank Luyten, University Hospitals KU Leuven, Belgium
Stem Cells in Cancer: Do They Matter?
8:30-10:00 PmOpening Reception
Monday, September 16
9:00 AM-12:00 PM Session II: Tissue Homeostasis
Chair: Sally Temple, Neural Stem Cell Institute, USA
9:00-9:10 Nancy Witty, ISSCR
Contribution of the Reprogrammed Reprogramming Approaches to
Cardiovascular Disease
Cell Based Therapeutics for
Skeletal Applications
3:20-3:45Refreshment Break
11:35-12:00 Mauro Giacca, International Centre for Genetic Engineering
and Biotechnology, Italy
3:45-4:10 Lorenz Studer, Sloan-Kettering Institute for Cancer Research, USA
Human ES Cell Derived Midbrain
Dopamine Neurons for Cell Therapy in
Parkinson’s Disease
4:10-4:35Robin Franklin, Wellcome Trust and MRC Cambridge Stem
Cell Institute, UK
9:10-9:15 Chair overview
Towards Regenerative Medicine for
Multiple Sclerosis
9:15-9:40 Hans Clevers, Hubrecht Institute, Netherlands
4:35-5:00 Dieter Egli, New York Stem Cell Foundation, US
Wnt Signaling, Lgr5 Stem Cells and Cancer
9:40-10:05 Frank McKeon, Jackson Laboratory for Genomic Medicine, USA
Dissecting the Stem Cell Component of
Precancerous Lesions
10:05-10:30Elaine Fuchs, The Rockefeller University, USA
Skin Stem Cells in Silence, Action and Cancer
10:30-10:55Refreshment Break
10:55-11:20 Ben Simons, University of Cambridge, UK
Mouse Spermatogenic Stem Cell Self-Renewal
11:20-11:45 Sean Morrison, Children’s Medical Research Institute at UT
Southwestern, USA
Stem Cells: Lost in Translation
11:45-12:10 Holger Gerhardt, London Research Institute-Cancer Research UK, UK
From Cells to Networks-Principles of Vascular Pattern Formation
12:10 -2:00PM Lunch Break, Exhibits and Poster viewing
2:00-5:00 PM Session III: Cell Fate Control
Chair: Richard Young, Whitehead Institute for Biomedical
Research, USA
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Secreted Factors and MicroRNAs Inducing Cardiac Regeneration
12:00 -2:00 PM Lunch Break, Exhibits and Poster viewing
2:00 -5:00 PM Session V: Gene Ther apy
Chair: Henrik Semb, Lund University, Sweden
2:00-2:05 Chair overview
Genome Exchange in Human Oocytes
2:05-2:30 Bobby Gaspar, UCL Institute of Child Health, UK
Gene Therapy for Severe Immunodeficiencies
5:00-5:30 Sponsored by BD Biosciences:
Mirko Corselli, Research and Development, BD Biosciences 2:30-2:55 Luca Biasco, San Raffaele Telethon Institute for Gene Therapy, Italy
Flow Cytometry Applications for Isolating
and Analyzing Complex Heterogeneous Stem Cell Cultures
5:30 -7:00Poster Presentation and Reception
Tuesday, September 17
9:00 AM-12:00 PM Session IV: Cell Ther apy
Chair: Michele De Luca, University of Modena and Reggio Emilia, Italy
9:00-9:05 Chair overview
9:05-9:30 Yoshiki Sasai, Center for Developmental Biology RIKEN, Japan
Self-organization of Neural Structures in 3D Stem Cell Culture
9:30-9:55 Graziella Pellegrini, University of Modena and Reggio Emilia, Italy
Biological Parameters Determining the Clinical Outcome of Autologous Cultures of Limbal Stem Cells
Uncovering Hematopoietic Stem Cells Dynamics and Activity in vivo Through Vector Insertion Site Barcoding in Humans
2:55-3:20 Alain Fischer, CHU Necker INSERM U768, France
Adaptive Immunodeficiency and Gene Therapy
3:20-3:45Refreshment Break
3:45-4:10 Chris Baum, Hannover Medical School, Germany
Preclinical Genotoxicity Testing of Stem
Cell Products
4:10-4:35 Didier Trono, Federal Polytechnic School of Lausanne
EPFL, Switzerland
Endogenous Retroelements, KRAB’n’KAP,
and the Preservation of Stem Cell
Transcriptional Dynamics
4:35-5:00 Luigi Naldini, San Raffaele Scientific Institute, Italy
Genetic Engineering of Hematopietic
Stem Cells
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I n t e r n at i o n a l S o c i e t y f o r S t e m C e l l R e s e a r ch
PRO G R A M S ch e d u l e
(continued)
Wednesday, September 18
9 :00 AM-12:00 PM Session VI: Defining Regenerative Mechanism
Chair: Ronald McKay, Lieber Institute for Brain Development, USA
9:00-9:05 Chair overview
9:05-9:30Paolo Bianco, Sapienza University of Rome, Italy
Commercial Stem Cells - the Lesson from
the MSC Case
9:30- 9:55 Shahragim Tajbakhsh, Pasteur Institute, Stem Cells &
Development, France
Molecular Regulation of Skeletal Muscle Stem Cells
9:55-10:20 David Sassoon, INSERM, University of Pierre and Marie
Curie-Sorbonne University, France
Dissecting the Stem Cell Niche for
Therapeutic Targeting
11:35- 12:00 Stuart Forbes, University of Edinburgh, UK
The Control of Hepatic Progenitor Cells for Liver Regeneration
DNA Methylation in Normal and
Malignant Hematopoiesis
12:00-2:00 PM Lunch Break, Exhibits and Poster viewing
Directed Differentiation of Human
Pluripotent Stem Cells
2:00-2:05 Chair overview
2:05-2:30Tariq Enver, UCL Cancer Institute, University College London, UK
2:00 -5:30 PM Session VII: Lineage Epigenetics
5:20-5:30 Closing Remarks: Michele De Luca and Ronald McKay
Systems Level Analysis of Hematopoiesis
2:30-2:55 Fred de Sauvage, Genentech Inc., USA
Targeting Developmental Pathways in Stem Cells and Cancer Stem Cells
2:55-3:20 Salvador Aznar-Benitah, Institute for Biomedical
Research (IRB), Spain
Characterizing Cell Heterogeneity and
Metastasis Initiating Events in Human SCC
10:45-11:10 Sally Temple, Neural Stem Cell Institute, USA
Retinal Repair
3:45-4:10 John Stingl, Cancer Research UK Cambridge Research Institute, UK
Intratumoural Heterogeneity in Human 11:10-11:35 George Daley, Boston Children’s Hospital, USA
4:35-5:20 Closing Keynote-Gordon Keller, McEwen Center for Regenerative Medicine/University Health Network, Canada
Chair: Cedric Blanpain, Université Libre de Bruxelles, Belgium
10:20-10:45Refreshment Break
Developing Human RPE Stem Cells for
4:10-4:35 Margaret Goodell, Baylor College of Medicine, USA
3:20-3:45Refreshment Break
R e g i st r at i o n h o u r s
Sunday: 2:00 – 9:00PM
Monday: 8:00AM – 7:00PM
Tuesday: 8:30AM – 5:00PM
Wednesday: 8:30AM – 2:30PM
P ost e r & E x h i b i t S e t U p
Sunday 2:00 – 6:00PM
Serous Ovarian Carcinoma
Pluripotent Stem Cells in Disease Modeling
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I n t e r n at i o n a l S o c i e t y f o r S t e m C e l l R e s e a r ch
H ot e l and T r av e l I nf o r mat i o n
Meeting Venue
Firenze Fiera Congress and Exhibition Center
Piazza Adua, 1, 50123
Florence, Italy
(Central train station is situated directly across the street from
the Firenze Fiera Congress and Exhibition Center)
H e a d q ua rt e r s H ot e l
Grand Hotel Baglioni
Piazza Unita Italiana 6, 50123
Florence, Italy
Telephone: +39.041.5310699
Email: [email protected]
Click here to view the list of recommended hotels
IN S T R U C T ION S F OR B OO K ING YO U R H OT EL
Hotel reservations for the Regional Forum are to be made directly
between the attendee and the desired hotel property. Once the hotel
receives your request, the hotel property will contact you to finalize and
confirm your reservation.
Please note that there are a limited amount of rooms available for the
Regional Forum. Rooms and rates will be based upon availability so we
strongly encourage attendees to book their hotel rooms in advance.
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T RAVEL IN F ORMAT ION
R e g i st r at i o n
Florence is well-connected with the rest of Italy and with Europe, and is easy
to get to by air or train.
Registration Rates for 2013 Regional Forum Stem Cells in Translation
A i r p o rt
CategoryRegularRegular FeeOn-siteOn-site Fee
Fee (USD) + VAT (USD)
Fee (USD)
+ VAT (USD)
For most people, flying to Florence actually means flying into Pisa’s Galileo
Galileo airport, which is 80 minutes away by train. Pisa is a central Italian
hub and flights arrive from many European centers. A handful of European
and domestic flights serve Florence’s smaller Amerigo Vespucci airport. You
could also fly into Bologna and then take a train south.
Member$700
Associate$300
Non-Member $950
G ro u n d T r a n sp o rtat i o n
Florence is a key node on the Italian railway network. It has good connections
with the main cities in the north, while to the south Rome is only about an
hour and a half away.
The A1 motorway, the main road artery linking the north and south of the
country, runs past Florence and has four exits.
T RAVEL VI S A S
ISSCR recommends international attendees review Italy’s visa requirements
before traveling. To check whether you will need a visa, please visit www.esteri.it.
June 29 - September 14
$847
$363
$1,149.50
September 15
$850
$400
$1,100
$1,028.50
$484
$1,3331
Note: All prices are in US dollars. Registration prices listed above do not include
21% VAT. Visit www.xe.com to see currency rates in Euros.
C lick h e r e t o r e gis t e r
INQUIRIES
If you have questions regarding registration or membership, please
contact our customer service department at +1-224-592-5700 or via
email at [email protected].
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