Curriculum Vitae
Nome: CARLO
Cognome: POLIDORI
Affiliazione: Università di Camerino, Italy
Posta Elettronica : [email protected]
Data di Nascita: 8 Febbraio, 1962 Cittadinanza: Italiana
Titoli Accademici:
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1986 Laurea in Chimica e Tecnologia Farmaceutiche
1990 PhD in Modellistica biomedical e Farmacocinetica
1990 Ricercatore universitario presso l’ Università di Camerino
2002 Professore Associato di Farmacologia presso l’
Università di Camerino
- 2008 fino al presente Direttore della scuola di specializzazione
in farmacia ospedaliera dell’ Università di Camerino
Attivita’ didattica
- Farmacologia e farmacoterapia II per la Scuola del Farmaco e
dei prodotti della salute (Facoltà di Farmacia), UNICAM
- Farmacocinetica per la Scuola di specializzazione in Farmacia
Ospedaliera, UNICAM
Attività scientifica e di ricerca
- Dal Novembre 1986 al 1990 dottorato di ricerca. In questi anni
abbiamo studiato il ruolo del sistema tachichininergico
centrale sul controllo dell’assunzione di acqua e soluzioni
saline in ratti.
- 1990-92 PhD Fellowships c/o l’Università of Pennsylvania al
dipartimento di Biologia con il prof. Alan Epstein per lo studio
dei meccanismi centrali coinvolti nell’assunzione di acqua e
soluzioni saline in animali da laboratorio
- 1999-2001 PhD Fellowship presso la Weill Medical College of
Cornell University-New York, USA per lo studio dei meccanismi
dell’ipofagia indotta da CRF in ratte femmine con il prof. Nori
Geary
- Dal 2002 al 2012 presso UNICAM per lo studio dei meccanismi
opioidergici e nocicettinergici centrali regolatori l’assunzione
di cibo in modelli di animali con e senza sindrome metabolica
Collaborazioni Scientifiche Internazionali
- Università di Griefswald, Germania, per lo studio dei
meccanismi opiodergici e nocicettinergici nel controllo
dell’assunzione di cibo in animali con e resistenti alla sindrome
metabolica
- Università di Toulouse, Francia, dottorato in cotutela (progetto
Vinci) per gli anni 2009-2012 per lo studio del sistema
apolipoproteinergico nel controllo dell’assunzione di cibo in
ratti.
Contatti Internazionali per progetti Erasmus
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Università di Greifswald, (Prof.ssa Ingrid Klöting)
Università di Toulouse, (Dr. Philippe Rouet)
Università di Groningen ( Prof. Anton Scheurink)
Università di Lipsia ( Prof. Matthias Blüher)
Università di Aarhus ( Prof. Peter Kristensen)
AgroParis Tech (Dr. Nicholas Darcel) “in process”
Università di Monaco ( Prof. Matthia Tschop) “in process”
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PUBBLICAZIONI SCIENTIFICHE
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Samir G. Sukkar, Carlo Polidori (2011) Biological, ethological, genetical, environmental,
clinical and pharmacological alliance towards obesity control: the target of “The obese
species workshop” in Erice, 21-26 October 2011. Mediterr J.Nutr. Metab. 4: 157-158.
Battistoni S, Kloting I, Cifani C, Massi M, Polidori C, (2011) Gender differences in
Nociceptin/Orphanin FQ-induced food intake in strains derived from rats prone (WOKW) and
resistant (Dark Agouti) to metabolic syndrome: a possible involvement of the cocaine- and
amphetamine-regulated transcript system. Genes Nutr 6:197-202.
Cifani C, Durocher Y, Pathak A, Penicaud L, Smih F, Massi M, Rouet P, Polidori C, (2009)
Possible common central pathway for resistin and insulin in regulating food intake. Acta
Physiol (Oxf) 196:395-400.
Cifani C, Polidori C, Melotto S, Ciccocioppo R, Massi M, (2009) A preclinical model of binge
eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine,
fluoxetine, topiramate, and midazolam. Psychopharmacology (Berl) 204:113-125.
Cifani C, Kloting I, Morini G, Grandi D, Massi M, Polidori C, (2009) Nociceptin/orphanin
FQ-induced food intake and cocaine amphetamine regulated transcript gene expression in
strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome.
Peptides 30:727-734.
Rodi D, Zucchini S, Simonato M, Cifani C, Massi M, Polidori C, (2008) Functional antagonism
between nociceptin/orphanin FQ (N/OFQ) and corticotropin-releasing factor (CRF) in the rat
brain: evidence for involvement of the bed nucleus of the stria terminalis.
Psychopharmacology (Berl) 196:523-531.
Filippetti R, Kloting I, Massi M, Cifani C, Polidori C, (2007) Involvement of
cocaine-amphetamine regulated transcript in the differential feeding responses to
nociceptin/orphanin FQ in dark agouti and Wistar Ottawa Karlsburg W rats. Peptides
28:1966-1973.
Broccardo M, Guerrini R, Morini G, Polidori C, Agostini S, Petrella C, Improta G, (2007) The
gastric effects of UFP-112, a new nociceptin/orphanin receptor agonist, in physiological and
pathological conditions. Peptides 28:1974-1981.
Grandi D, Solenghi E, Guerrini R, Polidori C, Massi M, Morini G, (2007) Nociceptin/orphanin
FQ prevents gastric damage induced by cold-restraint stress in the rat by acting in the
periphery. Peptides 28:1572-1579.
Gabbianelli R, Cifani C, Massi M, Polidori C, Falcioni G, (2007) Oxidative damage in rat
erythrocyte membranes following ethanol intake: effect of ethyl pyruvate. Chem Biol Interact
169:122-131.
Fedeli D, Falcioni G, Olek RA, Massi M, Cifani C, Polidori C, Gabbianelli R, (2007) Protective
effect of ethyl pyruvate on msP rat leukocytes damaged by alcohol intake. J Appl Toxicol
27:561-570.
Cifani C, Guerrini R, Massi M, Polidori C, (2006) Chronic intracerebroventricular infusion of
nociceptin/orphanin FQ increases food and ethanol intake in alcohol-preferring rats. Peptides
27:2803-2810.
Polidori C, Geary N, Massi M, (2006) Effect of the melanocortin receptor stimulation or
inhibition on ethanol intake in alcohol-preferring rats. Peptides 27:144-149.
Polidori C, Massi M, Guerrini R, Grandi D, Lupo D, Morini G, (2005) Peripheral mechanisms
involved in gastric mucosal protection by intracerebroventricular and intraperitoneal
nociceptin in rats. Endocrinology 146:3861-3867.
Morini G, De CG, Guerrini R, Massi M, Polidori C, (2005) Nociceptin/orphanin FQ prevents
ethanol-induced gastric lesions in the rat. Regul Pept 124:203-207.
Geary N, Wolfe A, Polidori C, Policani F, Massi M, (2004) Exogeneous and endogenous CCK
inhibit ethanol ingestion in Sardinian alcohol-preferring rats. Peptides 25:1185-1194.
Berrettini M, Fedeli D, Falcioni G, Bevilacqua C, Massi M, Polidori C, (2004) Hippocampal
and striated skeletal muscle changes in fatty acid composition induced by ethanol in
alcohol-preferring rats. Toxicology 199:161-168.
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17 Polidori C, Luciani F, Fedeli A, Geary N, Massi M, (2003) Leptin fails to reduce ethanol intake
in Marchigian Sardinian alcohol-preferring rats. Peptides 24:1441-1444.
18 Fedeli D, Fedeli A, Luciani F, Massi M, Falcioni G, Polidori C, (2003) Lymphocyte DNA
alteration by sub-chronic ethanol intake in alcohol-preferring rats. Clin Chim Acta 337:43-48.
19 Rodi D, Polidori C, Bregola G, Zucchini S, Simonato M, Massi M, (2002)
Pro-nociceptin/orphanin FQ and NOP receptor mRNA levels in the forebrain of food deprived
rats. Brain Res 957:354-361.
20 Polidori C and Geary N, (2002) Estradiol treatment fails to affect the feeding responses to
melanocortin-3/4 receptor agonism or antagonism in ovariectomized rats. Peptides
23:1697-1700.
21 Ciccocioppo R, Polidori C, Antonelli L, Salvadori S, Guerrini R, Massi M, (2002)
Pharmacological characterization of the nociceptin receptor which mediates reduction of
alcohol drinking in rats. Peptides 23:117-125.
22 Polidori C, De CG, Massi M, (2000) The hyperphagic effect of nociceptin/orphanin FQ in rats.
Peptides 21:1051-1062.
23 Massi M, Polidori C, Calo' G, Regoli D, (2000) Preface: material from the guest editors.
Peptides 21:89124 Polidori C, Calo G, Ciccocioppo R, Guerrini R, Regoli D, Massi M, (2000) Pharmacological
characterization of the nociceptin receptor mediating hyperphagia: identification of a selective
antagonist. Psychopharmacology (Berl) 148:430-437.
25 Polidori C, Gentili F, Pigini M, Quaglia W, Panocka I, Massi M, (2000) Hyperphagic effect of
novel compounds with high affinity for imidazoline I(2) binding sites. Eur J Pharmacol
392:41-49.
26 Polidori C, Ciccocioppo R, Regoli D, Massi M, (2000) Neuropeptide Y receptor(s) mediating
feeding in the rat: characterization with antagonists. Peptides 21:29-35.
27 Ciccocioppo R, Panocka I, Polidori C, Regoli D, Massi M, (1999) Effect of nociceptin on
alcohol intake in alcohol-preferring rats. Psychopharmacology (Berl) 141:220-224.
28 Polidori C, Recchi S, Venturi F, Ciccocioppo R, Massi M, (1998) Application of taste reactivity
to study the mechanism of alcohol intake inhibition by the tachykinin aminosenktide. Peptides
19:1557-1564.
29 De CG, Polidori C, Beltz TG, Johnson AK, (1998) Area postrema, lateral parabrachial
nucleus, and the antinatriorexic effect of bombesin. Peptides 19:1399-1406.
30 Ciccocioppo R, Panocka I, Polidori C, Froldi R, Angeletti S, Massi M, (1998) Mechanism of
action for reduction of ethanol intake in rats by the tachykinin NK-3 receptor agonist
aminosenktide. Pharmacol Biochem Behav 61:459-464.
31 Polidori C, Ciccocioppo R, Nisato D, Cazaubon C, Massi M, (1998) Evaluation of the ability of
irbesartan to cross the blood-brain barrier following acute intragastric treatment. Eur J
Pharmacol 352:15-21.
32 Panocka I, Ciccocioppo R, Polidori C, Angeletti S, De CG, Massi M, (1998) Sensitivity of
brain sites to the inhibitory effect on alcohol intake of the tachykinin aminosenktide. Peptides
19:897-905.
33 Polidori C, Ciccocioppo R, De CG, Massi M, (1998) Further evidence that central tachykinin
NK-1 receptors mediate the inhibitory effect of tachykinins on angiotensin-induced drinking in
rats. Peptides 19:149-155.
34 De CG, Polidori C, Menani JV, Johnson AK, (1997) Bombesin affects the central nervous
system to produce sodium intake inhibition in rats. Physiol Behav 63:15-23.
35 Ciccocioppo R, Panocka I, Polidori C, Dourish CT, Massi M, (1997) Blockade of pre- and
post-synaptic 5-HT1A receptors does not modify the effect of fluoxetine or
5-hydroxytryptophan on ethanol and food intake in rats. Psychopharmacology (Berl)
134:55-63.
36 Pompei P, Angeletti S, Polidori C, Ciccocioppo R, De CG, Massi M, (1997) Regulation of
preprotachykinin-A mRNA in genetic hypertensive and normotensive rats. Brain Res Mol
Brain Res 47:78-86.
37 Ciccocioppo R, Panocka I, Polidori C, De CG, Regoli D, Massi M, (1997) Stimulation of
tachykinin NK-3 receptors in the nucleus basalis magnocellularis reduces alcohol intake in
rats. Peptides 18:1349-1355.
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38 Polidori C, Panocka I, Ciccocioppo R, Broccardo M, Improta G, Regoli D, Massi M, (1997)
Further evidence that the tachykinin PG-KII is a potent agonist at central NK-3, but not NK-1,
receptors. Peptides 18:825-833.
39 Panocka I, Ciccocioppo R, Polidori C, Romagnoli S, Froldi R, Massi M, (1996) Possible
mechanism of action for the attenuation of ethanol intake induced by ritanserin in rats.
Psychopharmacology (Berl) 128:181-190.
40 Giardina D, Crucianelli M, Marucci G, Melchiorre C, Polidori C, Pompei P, Massi M, (1996)
Pharmacological evaluation of prazosin- and doxazosin-related compounds with modified
piperazine ring. Arzneimittelforschung 46:1054-1059.
41 Polidori C, Pompei P, Ciccocioppo R, De CG, Massi M, (1996) Effects of the selective
tachykinin NK3 receptor agonist NH2-senktide on intraoral intake and taste reactivity
responses elicited by NaCl in sodium-replete rats. Regul Pept 66:101-104.
42 Galaverna O, Polidori C, Sakai RR, Lienard F, Chow SY, Fluharty SJ, (1996) Blockade of
central angiotensin II type 1 and type 2 receptors suppresses adrenalectomy-induced NaCl
intake in rats. Regul Pept 66:47-50.
43 Polidori C, Ciccocioppo R, Pompei P, Cirillo R, Massi M, (1996) Functional evidence for the
ability of angiotensin AT1 receptor antagonists to cross the blood-brain barrier in rats. Eur J
Pharmacol 307:259-267.
44 Panocka I, Ciccocioppo R, Polidori C, Pompei P, Massi M, (1995) The 5-HT4 receptor
antagonist, GR113808, reduces ethanol intake in alcohol-preferring rats. Pharmacol Biochem
Behav 52:255-259.
45 Polidori C, Staffinati G, Perfumi MC, De CG, Massi M, (1995) Neuropeptide gamma: a
mammalian tachykinin endowed with potent antidipsogenic action in rats. Physiol Behav
58:595-602.
46 Panocka I, Ciccocioppo R, Mosca M, Polidori C, Massi M, (1995) Effects of the dopamine D1
receptor antagonist SCH 39166 on the ingestive behaviour of alcohol-preferring rats.
Psychopharmacology (Berl) 120:227-235.
47 Polidori C, Ciccocioppo R, Pompei P, Cirillo R, Massi M, (1995) The selective angiotensin
AT1 receptor antagonist LR-B/081 potently inhibits drinking induced by central injection of
angiotensin II in rats. Eur J Pharmacol 277:223-228.
48 Ciccocioppo R, Panocka I, Pompei P, Polidori C, De CG, Massi M, (1995) Subcutaneous
injections of the tachykinin senktide reduce alcohol intake in alcohol-preferring rats. Peptides
16:533-537.
49 Polidori C, Ciccocioppo R, Epstein AN, De CG, Massi M, (1994) Effect of tachykinins on the
need-free sodium intake of female rats: a continuous intracerebroventricular infusion study.
Physiol Behav 56:877-882.
50 Ferrante F, Abbate F, Ciriaco E, Polidori C, Amenta F, (1994) Protective effect of nicardipine
treatment on renal microanatomical changes in spontaneously hypertensive rats. Clin Exp
Hypertens 16:415-429.
51 Bronzetti E, Felici L, Polidori C, Amenta F, (1994) Interactions between calcium channel
blockers and alpha-adrenoceptors in the human coronary and mammary arteries: a
radioligand binding study. J Auton Pharmacol 14:79-85.
52 Ciccocioppo R, Polidori C, Pompei P, De CG, Massi M, (1994) Inhibition of isotonic sodium
chloride intake in the rat by selective tachykinin agonists. Pharmacol Biochem Behav
47:609-615.
53 Polidori C, Venturi F, De CG, (1994) Sex difference in sensitivity to exogenous oxytocin in
different models of sodium appetite in the rat. Acta Biomed Ateneo Parmense 65:261-280.
54 Panocka I, Ciccocioppo R, Polidori C, Massi M, (1993) The nucleus accumbens is a site of
action for the inhibitory effect of ritanserin on ethanol intake in rats. Pharmacol Biochem
Behav 46:857-862.
55 Polidori C, Zeng YC, Zaccheo D, Amenta F, (1993) Age-related changes in the visual cortex:
a review. Arch Gerontol Geriatr 17:145-164.
56 Venturi F, Polidori C, De CG, (1993) [The effect of the angiotensin III (Sar1, Ile7) Ang III, on
water intake of Wistar rats]. Acta Biomed Ateneo Parmense 64:33-38.
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57 Pompei P, Tayebati SJ, Polidori C, Perfumi M, De CG, Massi M, (1993) Hypotensive effect of
intravenous injection of tachykinins in conscious, freely moving spontaneously hypertensive
and Wistar Kyoto rats. Peptides 14:97-102.
58 Polidori C, Panocka I, Perfumi M, Pompei P, De CG, Massi M, (1992) Inhibition of cell
dehydration-induced drinking by tachykinins: evaluation of possible renal effects accounting
for the long-lasting inhibition. Physiol Behav 52:153-158.
59 Massi M, Saija A, Cristalli G, Polidori C, Perfumi M, Costa G, (1992) Release of atrial
natriuretic factor induced by the A1 adenosine receptor agonist
2-chloro-N6-cyclopentyl-adenosine in the rat. Pharmacol Res 25:393-402.
60 Achapu M, Pompei P, Polidori C, De CG, Massi M, (1992) Central effects of neuropeptide K
on water and food intake in the rat. Brain Res Bull 28:299-303.
61 Massi M, Polidori C, Perfumi M, Ciccocioppo R, De CG, Bacciarelli C, Manzini S, (1991)
Effect of capsaicin neonatal treatment on the salt intake of the adult rat. Pharmacol Biochem
Behav 40:163-168.
62 Perfumi M, Polidori C, Pompei PL, De CG, Massi M, (1991) The tachykinin NH2-senktide
inhibits alcohol intake in alcohol-preferring rats. Pharmacol Biochem Behav 38:881-887.
63 Massi M, Sajia A, Polidori C, Perfumi M, Costa G, Melchiorre C, (1991) The release of atrial
natriuretic factor induced by central carbachol injection may be mediated by muscarinic M1
receptors. Eur J Pharmacol 195:245-250.
64 Polidori C, Pompei PL, Perfumi M, Melchiorre C, Massi M, (1991) Natriuresis, kaliuresis and
antidiuresis induced by central carbachol injection are mediated by muscarinic M1 receptors.
Eur J Pharmacol 195:139-143.
65 Massi M, Saija A, Polidori C, Perfumi M, Gentili L, Costa G, De CG, (1991) The hypothalamic
paraventricular nucleus is a site of action for the central effect of tachykinins on plasma
vasopressin. Brain Res Bull 26:149-154.
66 Massi M, Polidori C, Perfumi M, Gentili L, De CG, (1991) Tachykinin receptor subtypes
involved in the central effects of tachykinins on water and salt intake. Brain Res Bull
26:155-160.
67 Polidori C, Saija A, Perfumi M, Costa G, Cristalli G, Massi M, (1990) The A1 adenosine
receptor agonist 2-chloro-N6-cyclopentyl adenosine (CCPA) potently stimulates the release
of atrial natriuretic factor in the rat. Pharmacol Res 22 Suppl 3:109-110.
68 Polidori C, Massi M, Lambrecht G, Mutschler E, Tacke R, Melchiorre C, (1990) Selective
antagonists provide evidence that M1 muscarinic receptors may mediate carbachol-induced
drinking in the rat. Eur J Pharmacol 179:159-165.
69 Pompei P, Polidori C, Perfumi M, Massi M, (1990) Sensitivity of spontaneously hypertensive
and of Wistar Kyoto rats to the antidipsogenic action of eledoisin. Regul Pept 28:119-129.
70 Polidori C, Saija A, Perfumi M, Gentili L, De CG, Costa G, Massi M, (1989) The
paraventricular nucleus as a site of action for the vasopressin releasing effect of tachykinins.
Pharmacol Res 21 Suppl 1:141-142.
71 Polidori C, Saija A, Perfumi M, Costa G, De CG, Massi M, (1989) Vasopressin release
induced by intracranial injection of tachykinins is due to activation of central neurokinin-3
receptors. Neurosci Lett 103:320-325.
72 Massi M, Polidori C, Melchiorre C, (1989) Methoctramine, a selective M2 alpha muscarinic
receptor antagonist, does not inhibit carbachol-induced drinking in the rat. Eur J Pharmacol
163:387-391.
73 Saija A, Polidori C, Massi M, Perfumi M, De CG, Costa G, (1989) Label distribution after
injection of labelled tachykinins into the rat lateral cerebroventricle. Res Commun Chem
Pathol Pharmacol 64:99-110.
74 Perfumi MC, Polidori C, Caraffa E, Cucculelli M, Fede M, Fiorelli A, (1989) [Effects of
eledoisin on water intake induced by subcutaneous injection of hypertonic NaCl in the rat].
Acta Biomed Ateneo Parmense 60:103-111.
75 Perfumi M, De CG, Panocka I, Polidori C, Massi M, (1988) Effects of kassinin, a tachykinin of
the skin of the African frog Kassina senegalensis, on body fluid homeostasis in rats.
Pharmacol Res Commun 20 Suppl 5:67-70.
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76 Massi M, Polidori C, Gentili L, Perfumi M, De CG, Maggi CA, (1988) The tachykinin
NH2-senktide, a selective neurokinin B receptor agonist, is a very potent inhibitor of salt
appetite in the rat. Neurosci Lett 92:341-346.
77 Perfumi M, Sajia A, Costa G, Massi M, Polidori C, (1988) Vasopressin release induced by
intracranial injection of eledoisin is mediated by central angiotensin II. Pharmacol Res
Commun 20:811-826.
78 Perfumi M, Polidori C, Massi M, De CG, (1988) Neurokinin A selectively inhibits water intake
in the rat. Neuropharmacology 27:909-914.
79 Polidori C, Perfumi M, Massi M, De CG, (1988) Neurokinin A and osmotic thirst: a
behavioural and renal study. Pharmacol Res Commun 20:605-606.
80 Massi M, Perfumi M, Polidori C, De CG, (1987) Effect of kassinin, neurokinin A and
neurokinin B on drinking behaviour in the pigeon. Regul Pept 17:85-97.
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