Denominazione
insegnamento in italiano
Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Biochimica Cellulare II
Cellular Biochemistry II
orale
oral
AIMS
COMPREHENSION OF MECHANISMS REGULATING CELL CYCLE AND CELL PROLIFERATION IN EUKARYOTES. EVOLUTION OF
MOLECULAR CIRCUITS THAT REGULATE GROWTH AND CELL DIVISION.
PROGRAM DETAILS
CONTROL OF G1/S TRANSITION. BUDDING YEAST AS A MODEL. CELL SIZE REGULATION. CYCLINS AND CONTROL OF DNA
SYNTHESIS. CONTROL OF MITOSIS. FISSION YEAST AS A MODEL ORGANISM. EXIT FROM MITOSIS AND CELL DIVISION.
COMPARATIVE ANALYSIS WITH OTHER SYSTEMS. MAMMALIAN CELLS.
LOGIC OF MOLECULAR MECHANISMS THAT REGULATE GROWTH AND CELL DIVISION.
ALTERATION OF CELL CYCLE REGULATION AND NEOPLASTIC GROWTH. ONCOGENES AND ANTI-ONCOGENES. SIGNAL
TRANSDUCTION AND CANCER. IDENTIFICATION OF MOLECULAR TARGETS FOR LEAD COMPOUND WITH ANTINEOPLASTIC AND
ANTIPROLIFERATIVE ACTIVITIES.
Denominazione
insegnamento in italiano
Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Biologia Molecolare
Apllicata
Applied Molecular Biology
orale
oral
AIMS
TO ELUCIDATE AND GET A DEEPER KNOWLEDGE OF THE MOLECULAR BIOLOGY TECHNIQUES AND APPLICATIONS
PROGRAM DETAILS
EXPRESSION SYSTEMS FOR PROKARYOTIC AND EUKARYOTIC MICROORGANISMS: GENOMIC AND CDNA LIBRARIES. PHAGE
VECTORS . PROTEIN EXPRESSION IN ESCHERICHIA COLI . EXPRESSION, PRODUCTION AND SECRETION OF HETEROLOGOUS
PROTEINS IN SACCHAROMYCES CEREVISIAE AND IN NON CONVENTIONAL YEASTS.
EUKARYOTIC EXPRESSION SYSTEMS: THE BACULOVIRUS SYSTEM. TRANSIENT AND STABLE EXPRESSIONS. VIRAL AND
RETROVIRAL VECTORS. TRANSGENIC ANIMALS AND GENE-TARGETING IN MAMMALIAN CELLS. GENE KNOCK -OUT IN MICE .
PROTEIN-PROTEIN INTERACTION: THE TWO-HYBRID SYSTEM AND ITS MODIFICATIONS (REVERSE TWO-HYBRID, THREE HYBRID).
PHAGE-DISPLAY.
FUNCTIONAL GENOMICS AND BIOINFORMATICS: COMPLETE GENOME SEQUENCING . DNA ARRAYS. EXPLORING DNA AND
PROTEIN DATABASES.
Denominazione
insegnamento in italiano
Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Chimica Combinatoria
Combinatorial Chemistry
orale
oral
AIMS
PROVIDE INFORMATION ON THE RECENT TECHNIQUES USED IN DRUG DISCOVERY FOR THE PRODUCTION OF LIBRARIES OF
POTENTIALLY BIOACTIVE COMPOUNDS
PROGRAM DETAILS
INTRODUCTION: COMBINATORIAL CHEMISTRY AS A MODERN TOOL IN DRUG DISCOVERY. MOLECULAR DIVERSITY. D EFINITION
AND TYPES OF COMBINATORIAL LIBRARIES AND BUILDING BLOCKS . EXAMPLES OF THE FIRST PEPTIDE AND OLIGONUCLEOTIDE
LIBRARIES. THE CONCEPT OF “DECONVOLUTION” AND OF “ENCODING”. TECHNIQUES EMPLOYED IN COMBINATORIAL CHEMISTRY:
SOLID PHASE SYNTHESIS, RESINS, LINKERS, SOLVENTS, AND SOLID-SUPPORTED REAGENTS. COMBINATORIAL SYNTHESIS
APPROACHES: PARALLEL SYNTHESIS; “SPLIT AND MIX” AND “SORT AND COMBINE”. COMBINATORIAL SYNTHESIS OF “SMALL
MOLECULES”. PLANNING OF LIBRARIES. DESCRIPTION OF THE INSTRUMENTATION EMPLOYED IN COMBINATORIAL CHEMISTRY:
AUTOMATED SYNTHESIS, HIGH-THROUGHPUT PURIFICATION METHODS AND ANALYTICS.
Denominazione
insegnamento in italiano
6Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Chimica Computazionale dei
Processi Biotecnologici
Computational Chemistry of
Biotechnological Processes
orale
oral
AIMS
TO PROVIDE THE STUDENT THE INSTRUMENTS FOR MULTIVARIATE-DATA TREATMENT, WITH PARTICULAR REGARD FOR
EXPERIMENTAL DESIGN.
PROGRAM DETAILS
MULTIVARIATE STRUCTURE OF COMPLEX DATA. TECHNIQUES OF MULTIVARIATE ANALYSIS. MODEL VALIDATION. INTRODUCTION
TO EXPERIMENTAL DESIGN .
Denominazione
insegnamento in italiano
6Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Chimica Computazionale dei
Processi Biotecnologici –
Mod I
Computational Chemistry of
Biotechnological Processes
orale
oral
AIMS
INTRODUCTION TO THE COMPUTATIONAL TECHNIQUES BASED ON NEURAL NETWORKS AND BAYESIAN NETWORKS FOR ANALYSIS
OF DATA RELEVANT IN BIOTECHNOLOGY.
PROGRAM DETAILS
INTRODUZTION TO THE TEORY OF NEURAL NETWORKS AND BAYESIAN NETWORKS. CLASSIFICATION METHODS OF GENE
ESPRESSION DATA BASED ON BAYESIAN NETWORKS . INFERENCEOF GENE NETWORKS. IDENTIFICATION OF STRUCTURAL MOTIFS
IN PROTEINS WITH STATISTICAL AND NON STATISTICAL METHODS: COMPARISON OF EFFICIENCY. CLUSTERING AND
CLASSIFICATION AS TOOLS FOR ANALYSIS OF METHABOLIC PATHWAYS .
Denominazione
insegnamento in italiano
Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Composti organici di
interesse farmaceutico
Organic compounds of
pharmaceutical interest
orale
oral
AIMS
AIM OF THE COURSE IN TO PROVIDE INFORMATION ON THE MAIN CLASSES OF ORGANIC COMPOUNDS OF PHARMACEUTICAL
INTEREST AND ON THE GUIDELINES USED IN ORGANIC CHEMISTRY FOR DRUG DISCOVERY.
PROGRAM DETAILS
GENERAL ASPECTS OF MEDICINAL CHEMISTRY:
DEFINITION, AIMS , CLASSIFICATION OF DRUGS.
STRATEGIES FOR THE
PRIMARY EXPLORATION OF STRUCTURE-ACTIVITY
RELATIONSHIP. S UBSTITUENTS AND FUNCTIONS: QUALITATIVE AND QUANTITATIVE ASPECTS OF STRUCTURE-ACTIVITY
RELATIONSHIP. TRIDIMENTIONAL ORGANISATION AND RECEPTORIAL MAPPING. CHEMICAL MODIFICATIONS INFLUENCING THE
PHARMACOKINETIC PROPERTIES.
DETERMINATION OF DRUG TARGETS AND PROTOTYPE MOLECULES .
Denominazione
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Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
AIMS
Composti organici di
interesse alimentare e
cosmetico
Organic compounds of
cosmetic and nutritional
interest
orale
oral
PROVIDE INFORMATION ON THE RELEVANCE OF A VARIETY OF ORGANIC COMPOUNDS USED IN COSMETIC AND NUTRITION, SUCH
AS FLAVOURS, COLORANTS , VITAMINS. PROVIDE THE INSTRUMENTS TO GET INFORMATION AND MAKE A RESEARCH IN THIS
FIELD.
PROGRAM DETAILS
INTRODUCTION ON THE VISUAL AND OLFACTOMETRIC PROPERTIES ASSOCIATED TO THE STRUCTURE OF ORGANIC COMPOUNDS:
COLOUR AND FLAVOUR. MARKET CONSIDERATIONS. D ESCRIPTION OF THE MORE RELEVANT FLAVOURS AND COLOUR ADDITIVES
DIVIDED PER CLASSES AND SHORT DESCRIPTION OF THEIR BIOSYNTHESIS. CAROTENOIDS, XANTOFILLES . QUINONES AND
VITAMIN K. METABOLITES OF SHIKIMIC ACID, VANILLIN . RIBOFLAVINS, FLAVONOIDS. FLAVOURS DERIVED FRON FATTY ACIDS
METABOLISM. TERPENES . FLAVOURS DERIVED FROM AMINOACIDS METABOLISM. S ULPHUR CONTAINING FLAVOURS . SHORT
ACCOUNT ON THE PROCEDURES FOR EXTRACTION, SYNTHESIS, FERMENTATION. FLAVOUR POTENTIATORS, PRESERVATIVES. GELS.
ACCESS TO INFORMATION AND DATABASES ON THE TOPIC AND PERSONAL RESEARCH OF THE STUDENT ON ONE OR MORE
PRODUCTS.
Denominazione
insegnamento in italiano
Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Economia ed organizzazione
aziendale 2
Business Economics and
Organisation 2
Scritto/orale
written/oral
AIMS
THE COURSE PROVIDES BASIC ELEMENTS OF BUSINESS STRATEGY AND ORGANISATION. IT ALSO SHOWS HOW TO BUILD A
BUSINESS PLAN . THE COURSE IN DEPTH ANALYSES THE CASE OF THE BIOTECH INDUSTRY.
PROGRAM DETAILS
FIRM’S STRATEGY: THE EXTERNAL CONFIGURATION OF THE COMPANY: INDUSTRY ANALYSIS, STRATEGIC POSITION. BUSINESS
UNIT COMPETITIVE ADVANTAGE: COST AND DIFFERENTIATION. BUSINESS PORTFOLIO COMPETITIVE ADVANTAGE:
DIVERSIFICATION . THE INTERNAL CONFIGURATION OF THE COMPANY: THE FIRM’S VALUE CHAIN .
THE COMPANY ORGANISATION: DESIGNING THE FIRM’S ORGANISATION: DIVISION OF LABOUR, COORDINATION MECHANISMS,
JOB POSITIONS, ORGANISATIONAL STRUCTURES.
THE BUSINESS PLAN: STRUCTURE AND BASIC PRINCIPLES OF BUSINESS PLAN.
THE CASE OF BIOTECH INDUSTRY: COMPETITIVE STRATEGIES AND INDUSTRIAL ORGANIZATION.
Denominazione
insegnamento in italiano
Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Enzimologia e Biochimica
Industriale
Industrial Enzymology and
Biochemistry
orale
oral
AIMS
MECHANISMS REGULATING PROTEIN FOLDING AND STABILITY. ENZYMATIC BIOCENVERSIONS. PROTEOME,
PROTEIN/PROTEIN
INTERACTIONS AND SYSTEMS BIOLOGY STUDIES AND THEIR USE IN PROJECTS OF POSSIBLE INDUSTRIAL APPLICATION .
PROGRAM DETAILS
THERMODINAMIC AND KINETIC ASPECTS OF PROTEIN FOLDING. SEARCH FOR NOVEL ENZYME ACTIVITY
AND IMPROVEMENT OF ENZYMES PERFORMANCES BY PROTEIN ENGINEERING (NOTABLY BY “DIRECTED
EVOLUTION” METHODS). INDUSTRIAL USE OF SOLUBLE AND IMMOBILIZED ENZYMES. APPLICATION OF
SEVERAL ENZYME FAMILIES IN CHEMICAL, PHARMACEUTICAL AND FOOD INDUSTRY. ELEMENTS OF
SCALING-UP. METHODOLOGIES TO IDENTIFY PHARMACEUTICAL TARGETS BY INNOVATIVE
APPROACHES, INCLUDING FUNCTIONAL GENOMICS, PROTEOMICS AND SYSTEMS BIOLOGY. REVIEWS,
ORIGINAL PAPERS AND PATENTS WILL USED THROUGHOUT THE COURSE.
Denominazione
insegnamento in italiano
Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Farmacologia Generale
General Principles of
Pharmacology
orale
oral
AIMS
THE PURPOSE IS PROVIDING BASIC KNOWLEDGE ON THE PRINCIPLES OF PHARMACOKINETIC AND TOXICOLOGY OF DRUGS AND
BIOPHAMACEUTIC PRODUCTS.
PROGRAM DETAILS
PHARMACOKINETIC: D RUG FORMULATION INFLUENCE ON PHARMACOKINETIC PROCESS. DRUG METABOLISING ENZYMES
PHARMACOLOGICAL AND TOXICOLOGICAL CONSEQUENCES OF THE METABOLIC ENZYME INDUCTION. FACTORS AFFECTING THE
PHARMACOKINETIC PROCESS . BIOTECHNOLOGY PRODUCT FORMULATIONS AND BIOPHARMACEUTIC CONSIDERATIONS.
DRUG TOXICOLOGY: PRINCIPLES OF TOXICOLOGY. MECHANISMS OF TOXICITY. D RUG ADVERSE AND ALLERGIC REACTIONS. THE
DRUG ABUSE. RISK ASSESSMENT FOR THE DRUGS AND CONCEPT OF THERAPEUTIC INDEX. EVALUATION OF DRUG INTERACTIONS.
Denominazione
insegnamento in italiano
Denominazione
insegnamento in inglese
Tipologia dell’esame
Genetica Molecolare
Molecular Genetics
orale
(scritto- scritto/orale –
orale)
oral
AIMS
THE COURSE IS AIMED TO PROVIDE THE STUDENTS WITH THE INSTRUMENTS FOR THE CRITICAL READING OF ORIGINAL PAPERS
DEALING WITH THE MOLECULAR GENETICS OF DIFFERENT ESSENTIAL PROCESSES IN EUKARYOTIC CELLS .
PROGRAM DETAILS
ORIGINAL SELECTED PAPERS WILL BE READ AND DISCUSSED IN DETAILS TO ANALYZE THE DIFFERENT APPROACHES USED TO STUDY
THE MOLECULAR GENETIC BASIS OF SOME FUNDAMENTAL PROCESSES IN EUKARYOTIC CELLS , AMONG WHICH: CONTROL OF
CELLULAR RESPONSE TO DNA DAMAGE AND TO ALTERATIONS IN THE MITOTIC APPARATUS ; CONTROL OF GENE EXPRESSION
THROUGH ALTERNATIVE RNA SPLICING; CONTROL OF MRNA STABILITY AND TRANSLATION ; POST-TRANSALATIONAL CONTROLS
OF GENE EXPRESSION.
Denominazione
insegnamento in italiano
Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Immuno-genomica
Immuno-genomics
orale
oral
AIMS
THE COURSE GIVES A CRITICAL OVERVIEW OF THE NEW EXPERIMENTAL APPROACHES IN THE FUNCTIONAL GENOMICS FIELD WITH
PARTICULAR EMPHASIS TO THE STUDY OF THE COMPLEX FUNCTIONS OF THE IMMUNE SYSTEM.
PROGRAM DETAILS
THE COURSE WILL COVER THE FOLLOWING TOPICS. INTRODUCTION TO THE FUNCTIONAL GENOMICS AND THE TECHNOLOGY OF
MICROARRAYS FOR GENE EXPRESSION ANALYSIS WITH PARTICULAR EMPHASIS TO THE EXPERIMENTAL DESIGN. DATA MINING:
DATA GENERATION, DATA PROCESSING, IDENTIFICATION OF DIFFERENTIALLY EXPRESSED GENES. S UPERVISED AND
UNSUPERVISED CLUSTERING, FUNCTIONAL CLUSTERING. REDUCTIONISM AND COMPLEXITY IN BIOLOGICAL SYSTEMS AND IN THE
DEFINITION OF THE IMMUNE SYSTEM FUNCTIONS. FUNCTIONAL GENOMICS APPLIED AT THE STUDY OF INNATE AND ADAPTIVE
IMMUNITY. FUNCTIONAL GENOMICS FOR THE RECONSTRUCTION OF THE COMPLEXITY OF BIOLOGICAL PHENOMENA.
Denominazione
insegnamento in italiano
Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Ingegneria Metabolica
Metabolic Engineering
orale
oral
AIMS
THE COURSE AIMS TO THE INTRODUCTION AND ANALYSES OF THE METABOLIC ENGINEERING APPLICATIONS.
PROGRAM DETAILS
METABOLIC ENGINEERING AND MODELING. ANALYSES AND DEVELOPMENTS OF METABOLIC ENGINEERING APPLICATIONS.
PRODUCTION OF HETEROLOGOUS METABOLITES AND IMPROVED HETEROLOGOUS PROTEIN PRODUCTIONS BY MEANS OF METABOLIC
ENGINEERING APPLICATIONS. QA (QUALITY ASSURANCE), GLP (GOOD LABORATORY PRACTICE), GMP (GOOD MANUFACTURING
PRACTICE). COSTS ANALYSES.
Denominazione
insegnamento in italiano
Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Laboratorio di
Purificazione, Analisi e
Controllo del Prodotto
Laboratory of purification
and analysis of bioactive
molecules
Scritto/orale
written/oral
AIMS
THE AIM OF THIS COURSE IS TO PROVIDE THE BASICS OF NMR, IR AND MASS SPECTROSCOPY FOR THE IDENTIFICATION OF
ORGANIC COMPOUNDS .
PROGRAM DETAILS
NMR THEORY: 1D AND 2D PROTON SPECTRA AND CARBON SPECTRA. BASIC PRINCIPLES OF IR AND MASS SPECTROSCOPY.
PRACTICAL USE OF NMR SPECTROMETER (VARIAN MERCURY 400 MHZ) AND MASS SPECTROMETER (MALDI-TOF).
INTERPRETATION OF NMR, IR AND MASS SPECTRA FROM WEB DATABASES.
Denominazione
insegnamento in italiano
Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Prodotti e Processi
Biotecnologici
Biotechnological Products
and Processes
orale
oral
AIMS
DESCRIPTIONS OF THE MOST IMPORTANT PRODUCTS, PROCESSES AND EQUIPMENTS USED IN THE INDUSTRIAL BIOTECHNOLOGY.
PROGRAM DETAILS
SOME INDUSTRIAL ENZIMATIC PROCESSES ,
MOST IMPORTANT PHARMACEUTICAL PRODUCTS AND FINE CHEMICALS OBTAINED WITH BIOTECHNOLOGY,
DESCRIPTION OF THE PRODUCTION , RECOVERY, PURIFICATION OF SOME PHARMACEUTICAL PRODUCTS:
INSULINE, HUMAN GROWTH HORMONE , TPA, MONOCLONAL ANTIBODY, INTERFERONS , SOME ANTIBIOTICS ,
SOME ECONOMICAL INFORMATIONS:
THE ECONOMIC TURNOVER IN THE LAST YEAR IN THE WORLD OF THE MOST IMPORTANT BIOTECHNOLOGICAL
PRODUCTS,
MOST IMPORTANT BIOTECHNOLOGICAL INDUSTRIES IN THE WORLD.
Denominazione
insegnamento in italiano
Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Laboratorio di Sviluppo e
Validazione dei Processi
Practical Developing of a
Biotechnological Microbial
Process
orale
oral
AIMS
AIM OF THIS COURSE IS TO ILLUSTRATE THE TOOLS FOR THE BIOTECHNOLOGICAL MANIPULATION AND EXPLOITATION OF
NATURAL AND RECOMBINANT MICRORGANISMS , IN ORDER TO PRODUCE PROTEINS AND METABOLITES .
PROGRAM DETAILS
THE COURSE IS STRUCTURED IN TWO MODULES. M ODULE 1 WILL BE DEVOTED TO THE “CONSTRUCTION” OF RECOMBINANT
ORGANISM. D URING THE HERE PRESENTED M ODULE 2, SAID MICROORGANISM WILL BE GROWN IN BIOREACTOR, TESTING
DIFFERENT FERMENTATIVE STRATEGIES (BATCH, FED-BATCH), AIMED TO PURSUE HIGH LEVELS OF PRODUCTION, PRODUCTIVITY
AND YIELD. THE PRODUCTS OF THE FERMENTATIONS WILL BE PURIFIED AND ASSAYED DURING THE FOLLOWING COURSE
“PURIFICATION AND ANALYSIS OF BIOACTIVE MOLECULES (DOWNSTREAM)”
THESE EXPERIENCES REFER TO ACTUAL BIOTECHNOLOGICAL RESEARCH PROJECT.
Denominazione
insegnamento in italiano
Denominazione
insegnamento in inglese
Tipologia dell’esame
(scritto- scritto/orale –
orale)
Laboratorio di Sviluppo e
Validazione dei Processi
Mod I
Practical Developing of a
Biotechnological Microbial
Process Mod 1
Scritto/orale
written/oral
AIMS
AIM OF THIS COURSE IS TO ILLUSTRATE THE TOOLS FOR THE BIOTECHNOLOGICAL MANIPULATION AND EXPLOITATION OF
NATURAL AND RECOMBINANT MICRORGANISMS , IN ORDER TO PRODUCE PROTEINS AND METABOLITES .
PROGRAM DETAILS
THE COURSE IS STRUCTURED IN TWO MODULES. THE HERE PRESENTED MODULE 1 WILL BE DEVOTED TO THE “CONSTRUCTION” OF
RECOMBINANT ORGANISM. D URING MODULE 2, SAID MICROORGANISM WILL BE GROWN IN BIOREACTOR, TESTING DIFFERENT
FERMENTATIVE STRATEGIES (BATCH, FED-BATCH), AIMED TO PURSUE HIGH LEVELS OF PRODUCTION , PRODUCTIVITY AND YIELD .
THE PRODUCTS OF THE FERMENTATIONS WILL BE PURIFIED AND ASSAYED DURING THE FOLLOWING COURSE “PURIFICATION AND
ANALYSIS OF BIOACTIVE MOLECULES (DOWNSTREAM)”
THESE EXPERIENCES REFER TO ACTUAL BIOTECHNOLOGICAL RESEARCH PROJECT.