Personal information
Sumame l First name
Address
Vittorio de Franciscis
Istituto per l'Endocrinologia e Oncologia Molecolare "G. Salvatore" (leos)
Via Pansini, 5- 80131 Naples ltaly
Telephones
Fax
E-mail
Nationality
Date of birth
Gender
+39 0813722343
+39 0817463308
[email protected]
ltalian
October 3'd 1951
M
Actual Function
Acting Director at the leos
Work experience
Dates
Occupation or position held
Main activities and responsibilities
Dates
2006 al2013
Dr. V. de Franciscis, is Research Director, at the Istituto di Endocrinologia e Oncologia
Sperimentale "G. Salvatore", of the CNR
• By July 2004 to 2009 is Partner of the Network of Excellence "European Mo/ecular lmaging
Laboratories" (No 503569) un der the 6 FP of EC
• By september 2000 to september 2003 is partner of the shared RTD action (QLG1-2000-00562)
"Oiigonucleotide aptamers for in vivo imaging" under the 5 FP of EC ..
1996- 2006:
Occupation or position held
•
•
Research Scientist CNR
Senior grant della EC (cat. 40 BI04-CT97-5078) spent at the il Centre de Génétique
Moléculaire (CNRS), Gif sur Yvette France fora collaborative work with Dr. E.N.
Brody 1997-1998
Education and training
Dates
Principal subjects/Fellowships
Dates
Title of qualification awarded
Name and type of organisation
providing education and training
1976-1979
By 1976 to 1980 he was PhD fellow in Paris at the lnstitut de Biologie Physico-Chemique,
1975
Degree in Physics achieved at the University of Naples, on February, 17, 1975. 110 su 110 e
lode. Thesis work in Naples at the lnternationallnstitute of Genetics and Biophysics C.N.R.
University of Naples ltaly
/
Personal skills and
competences
Organisational skills and
competences
Organisational skills and
Page 1 -Curriculum vitae of
Recent Awarded Research Grants
• 2012 -2015 Dr. V de Franciscis is responsible of a gran t from Associazione Italiana per la Ricerca
sul Cancro (AI.R.C.)"
• 2012 -2015 Dr. V de Franciscis is responsible of a grant from Fondazione San Paolo
• 2011 - Dr. V de Franciscis is responsible of a grant from JDRF
• 2011-2014 Dr. V de Franciscis is responsible of the MIUR grant, MERIT RBNE08YFN3
• 2"0o6 - 2009 Dr. V 'de Franciscis is responsible partner of the MIUR- FIRB lnternational ltaly
USA, (RBIN04J4J7)
• 2004- 2009 Dr V de Franciscis is responsible partner of the Network of Excellence of the SIXTH
FRAMEWORK PROGRAMME of EC "European Molecular l_maging Laboratories
• 2000 2003 Dr. V. de Franciscis is responsible partner of FIFTH FRAMEWORK PROGRAMME of
EC (QLG1-2000-00562) "Oiigonucleotide aptamers for in vivo imaging"
'
1.
Evaluation Experts per i Programmi EU RTD del5 FP e del6 FP; Evaluation
Dr Vittorio de Franciscis, IEOS Naples, ltaly
Teaching Experience
2.
3.
4.
•
•
Commettee Member of the Agence Nationale de la Recherche, France
Expert evaluator of MIUR, ltaly
Expert evaluator of lnstitut National du Cancer france
Expert evaluator of CIVR, ltaly
Teaching staff of the Ph.D Programme in Palhology and Molecular Physiopalhology at
the University of Naples "Federico //" since 2001 to present
Teaching staff at the Scuole di Specializzazione at lhe University of Naples "Federico
//" since 1984 lo presenl
Patents and List of Pubblications
Patents
1.
"A neulralizing RNA aptamer against PDGFR beta an d lhe use thereof in the lherapy an d diagnosis of hyperproliferative diseases" # EP
12187483.8 (lnventors: V de Franciscis, Laura Cerchia, G. Condorelli) (lnventors: V de Franciscis, Laura Cerchia, G. Condorelli)
2.
"A neutralizing aptamer from Celi SELEX lnhibits the AXL Receptor Tyrosine Kinase" # PCT/EP2011/067624 (lnventors: V de Franciscis,
Laura Cerchia)
3.
"A neulralizing RNA aptamer from ceii-SELEX specifically binds lo the extracellular domai n of the EGFR causing selective celi dealh in
vitro and in vivo"# PCT/EP2011/067629 (lnventors: V de Franciscis, Laura Cerchia)
4.
"Melhod for obtaining oligonucleotide aptamers an d uses thereof' # EP 08 105 194.8 Se pt 1sl 2008 (lnvenlors: V de Franciscis, Laura
Cerchia, G. Condorelli), concesso in US (2013).
5.
"Aplamers selected from live tumor cells and the use thereof'. (#EP1756305) (lnventors: V de Franciscis, Laura Cerchia, Domenico Libri,
Frederic Ducongè, Bertrand Tavitian)
Recent Publications
1.
Boscia F, Esposilo CL, Casamassa A, de Franciscis V, Annunziato L, Cerchia L 2013 The isoleclin 184 binds RET receptor tyrosine kinase
in microglia. J Neurochem . Feb 16. doi: 10.1111/jnc.122091F. 3.99
2.
Bettazzi F, Hamid-Asl E, Esposito CL, Quintavalle C, Formisano N, Laschi S, Catuogno S, laboni M, Marrazza G, Mascini M, Cerchia L,
De Franciscis V, Condorelli G, and Palchetti l. 2013 Electrochemical detection of miRNA-222 by use of a magnetic bead-based bioassay. Anal
Bioanal Chem. 405(2-3):1025-34 IF. 3.78
3.
Catuogno S., Cerchia L. , Romano G. , Pognonec P. , Condorelli G. , and de Franciscis V. 2013 cMiR-34c may protect lung cancer cells from
paclitaxel-induced apoptosis. Oncogene; 32:341-351 IF. 7.135
4.
Caluogno S, Esposito CL, Quinlavalle C, Condorelli G, de Franciscis V, Cerchia L. 2012 Nucleic acids in human glioma treatment:
innovative approaches and recent results. J Signal Transduct. ;2012:735135
5.
Cerchia L, Esposito CL, Camorani S, Rienzo A, Stasio L, lnsabato L, Affuso A, and de Franciscis V. 2012 Targeting Axl With an Highaffinily lnhibitory Aptamer. Mol Ther. 12:2291-2303 IF. 6.87
6.
Sepe M, Festa L, Tolino F, Bellucci L, Sisto L, Alfano D, Ragno P, Calabrò V, de Franciscis V, La Mantia G, Pollice A. 2011 A regulatory
mechanism involving TBP-1/Tat-Binding Pro te in 1 an d Akt/PKB in the conlrol of celi proliferation. PLoS One;6(1 O):e22800 IF. 4.41
7.
Esposito CL, Passare D, Longobardo l, Condorelli G, Affuso A, Marotta P, de Franciscis V. and Cerchia L. 2011 A neutralizing RNA
aptamer against EGFR causes selective apoptotic celi death. PLoS One 6(9):e24071 IF. 4.41
8.
Cerchia L. and de Franciscis V, Nucleic acid aptamers against protein kinases 2011 Cur( Med. Che m. Aug ,15 IF. 4.86
9.
Esposito CL, Caluogno S, de Franciscis V, Cerchia L. 2011 New insight into clinica! developmenl of nucleic acid aptamers. Discov Med.
Jun;11(61):487-496
1O.
Catuogno S, Esposito CL, Quintavalle C, Cerchia L, Condorelli G an d de Franciscis V. 2011. Recent Advance in Biosensors for
microRNAs Delection in Cancer. Cancers, 3: 1877-1898
11 .
Cerchia L, an d de Franciscis V. 201 OTargeting cancer cells wilh nucleic acid aplamers. Trends Biotechnol. 201 OOct;28(1 0):517-525 IF.
9.64
12.
lnsabato L, Amelio l, Quarto M, Zannetti A, Tolino F, de Mauro G, Cerchia L, Riccio P, Baumhoer D, Condorelli G, Terracciano L and de
Franciscis V. 2009. SHP-1 tyrosine phosphalase defines a subset of high grade breast tumors. Oncology-Karger, 77(6):378-384 IF. 2.54
13.
Cerchia L, Esposito CL, Jacobs AH , Tavitian B, de Franciscis V. 2009 Differential SELEX in human glioma celllines. PLoS One.
4(11):e7971 . 1F. 4.35
14.
de Franciscis V, Esposito CL, Catuogno--S, Celiai L, Cerchia' L. 2009 Aplamers as innovative diagnostic and therapeutic agents in the
centrai nervous system. CNS Neurol Disord Drug Targets. 8(5):393-401. IF. 4.18
15.
Boscia, F, Esposito, CL, Di Crisci, A, de Franciscis, V, Annunziato, L and Cerchia, L. 2009 GDNF selectively induces microglial activation
an d neuronal survival in CA 1 an d CA3 hippocampal subregions exposed lo NMDA insult through Ret/ERK signaling. PLos One 3;4(8):e6486. IF.
4.35
16.
Cerchia L, Giangrande PH, McNamara JO, de Franciscis V. 2009 Cell-specific aplamers for targeled therapies. Methods MoJ Biol.;535:5978. IF. 4.41
Page 2 - Curriculum vitae of
Dr Vittorio de Franciscis, IEOS Naples, Jtaly