& (19) (11) EP 1 939 217 A3 EUROPEAN PATENT APPLICATION (12) (88) Date of publication A3: (51) Int Cl.: C07K 14/71 (2006.01) 03.09.2008 Bulletin 2008/36 (43) Date of publication A2: 02.07.2008 Bulletin 2008/27 (21) Application number: 08004513.1 (22) Date of filing: 13.10.2005 (84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: HR (30) Priority: 15.10.2004 IT MI20041965 (62) Document number(s) of the earlier application(s) in accordance with Art. 76 EPC: 05795953.8 / 1 809 668 (71) Applicants: • Amici, Augusto 62032 Camerino (MC) (IT) • Marchini, Cristina 62012 Civitanova Marche (IT) • Quaglino, Elena 10127 Torino (IT) (54) • Cavallo, Federica 10073 Cirie’ (IT) • Forni, Guido 10123 Torino (IT) (72) Inventors: • Amici, Augusto 62032 Camerino (MC) (IT) • Marchini, Cristina 62012 Civitanova Marche (IT) • Quaglino, Elena 10127 Torino (IT) • Cavallo, Federica 10073 Cirie’ (IT) • Forni, Guido 10123 Torino (IT) (74) Representative: Banfi, Paolo Bianchetti Bracco Minoja S.r.l. Via Plinio, 63 20129 Milano (IT) Plasmids coding for p185neu protein sequence variants and therapeutic uses thereof pressing tumors, and pharmaceutical compositions thereof are described. EP 1 939 217 A3 (57) DNA plasmids containing sequences coding for different fragments of 185neu oncoprotein which are able to induce an immune response against p185neu-overex- Printed by Jouve, 75001 PARIS (FR) EP 1 939 217 A3 2 EP 1 939 217 A3 3 EP 1 939 217 A3 4 EP 1 939 217 A3 5 EP 1 939 217 A3 6 EP 1 939 217 A3 7 EP 1 939 217 A3 8 EP 1 939 217 A3 9