SPINTRONIC NANOSENSORS for MEDICINE
Prof. Riccardo Bertacco
Centro LNESS Politecnico di Milano
Via Anzani 42, 22100 Como
[email protected]
Spintronic biosensors for molecular
recognition
streptavidin
2
probe
biotin
R
target
R’
Advantages
 No background
 No bleaching
 High stability
 Molecule handling
Disadvantages
 High biological sensitivity
 Not label free
 Impact of beads on the chemical affinity ?
 Tayloring the dinamic range
 Lab on chip
Riccardo Bertacco
SpinNanoMed FP7: NMP-2008-1.1-1
3
Converging sciences and technologies (nano, bio, info and/or cognitive)
SPINTRONIC NANOSORS for MEDICINE
Preventive medicine and diagnosis (in vitro diagnostic tests)
Specific application:
Early detection of breast cancer via proteome profiling on the serum of patients
Lab on chip approach for point of care applications.
Antibody Microarrays
End users
User Interface, Data correlation Database and Web Group –
and knowledge discovery
Bioinformatics Lab
Signal de-noising and data
Digital Signal Processing Groupanalysis
ISP Lab
Signal read-out and LabOnChip
electronics
Institut fur Mikrotechnok Mainz
Microfluidic transport
GmbH
Surface functionalization
ICRM
Spintronic group at LNESS
Microfabrication of lab on chip
micro arrays of spintronic
biosensors
nanoGune
MIC - Copenhagen
Riccardo Bertacco
C. Borrabaeck, Create
(Sweden)
P. Fraternali, S. Ceri, M.
Masseroli
Politecnico di Milano (Italy)
M. Tagliasacchi
Politecnico di Milano (Italy)
K. S. Drese (Germany)
M. Chiari
CNR (Italy)
R. Bertacco Politecnico di
Milano (Italy)
A. Berger, P. Vavassori
(Spain)
M. F. Hansen (Denmark)
System layout
DSP
Data mining
End user interface
AD conversion
Microfluidics
SiO2 + polymer
Insulating layer
substrate
Read out electronics (ASIC)
Riccardo Bertacco
Biomedical
validation
Electronics
An ASIC, to be placed around the sensor chip, must be
designed and realized with these functionalities:
• front end electronics for the signal read out
• analogical signal processing (filtering, amplification, ...)
A second external circuit will make the analog to digital
conversion and provide suitable signal to an external PC
for data acquisition and analysis.
Riccardo Bertacco