Grazie per aver scelto di utilizzare
a scopo didattico questo materiale
delle Guidelines 2011 libra.
Le ricordiamo che questo
materiale è di proprietà
dell’autore e fornito come
supporto didattico per uso
personale.
Systems medicine & COPD
Alvar Agustí
Data-free lecture
(almost)
Systems medicine: basic hypothesis
• Diseases arises as a consequence of one or
more biological networks in the relevant
organ that have become disease-perturbed
through genetic and/or environmental
pathogenic changes.
Galas DJ, Hood L. IBC 1 (6):1-4, 2009
Barabasi AL. N Engl J Med 357 (4):404-407, 2007
The human disease network
Goh et al. PNAS104 (21):8685-8690, 2007
The disease gene network
Goh et al. PNAS104 (21):8685-8690, 2007
Goh et al. PNAS104 (21):8685-8690, 2007
Goh et al. PNAS104 (21):8685-8690, 2007
Vestbo et al. ERJ 31 (4):869-873, 2008
Regan EA et al. COPD 7 (1):32-43, 2010
http://www.cancold.ca
http://www.cscc.unc.edu/spir/
Synergy
Unbiased Biomarkers
for the Prediction
of Respiratory Disease
Outcomes
Airway Disease PRedicting
Outcomes through Patient
Specific Computational
Modelling
High throughput technology
Bioinformatics
Systems medicine & COPD
Environmental
network
Pollution
Diet
Temperature
Smoking
COPD
Clinical network
Infections
Allergens
Metab Syn.
Cancer
Osteoporosis
Myopathty
Innate
inmunity
CVD
Acquired
immunity
Biological network
Life-style
 Modifiable factors
Repair
Clinical phenotypes
 Integrated care
 Personalized medicine
 Guidelines network
Oxidative stress
Ageing
Intermediate pathophenotypes
 Diagnostic biomarkers
 Therapeutic targets
Bioenergetics
Genetic network
GWAS
Genetic markers
 Risk assessment
Epigenetics
miRNA
miDNA
ncRNA
Agusti A , Vestbo J AJRCCM 2011
N=30.000.000 individuos
(Medicare)
Traditional medicine
Reactive = centered around diseases
P4 Medicine
P4= centered on health
Thanks for your attention
[email protected]
International Centre for
Advanced Respiratory Medicine