Department of Public Health and Cell Biology
Prof. Claudio Sette
CURRICULUM VITAE
Name: Claudio Sette
Date and Place of Birth: November 24th, 1966, Rome, Italy
Education:
1985: High School Degree, Instituto Liceo G. Piazzi Morlupo (Rome, Italy)
1992: Doctor cum Laude in Biological Sciences, University of Rome La Sapienza
(Rome, Italy)
1998: PhD in Medical Embryology, University of Rome Tor Vergata, (Rome, Italy)
Current Position:
Associate Professor of Anatomy
Department of Public Health and Cell Biology,
School of Medicine
University of Rome Tor Vergata
Via Montpellier 1, 00133, Rome
Telefono 39672596260 FAX 39672596268
Email: [email protected]
Professional Experience:
2010-to date Associate Member of the European Alternative Splicing Network
(EURASNET)
2006-to date Joint appointment as Laboratory Director at the Institute for Experimental
Neurosciences, Fondazione Santa Lucia, Rome (Italy)
2002-to date Associate Professor at the Department of Public Health and Cell biology,
University of Rome Tor Vergata, (Italy)
2001-2002
Researcher at the Department of Public Health and Cell biology,
University of Rome Tor Vergata, (Italy)
1998-2000
Postdoctoral Fellow at the Department of Molecular and Cell Biology,
University of California at Berkeley (California, USA)
1995-1998
PhD student in Medical Embryology at the Department of Public Health
and Cell biology, University of Rome Tor Vergata (Italy)
1995-1996
1993-1995
1990-1992
Invited Scientist at the INSA, School of Engeneering, Department of
Biological Chemistry, INSERM Unit 352 , Lyon, (France). (December
1995- February 1996)
Research Fellow at the Department of Obstetrics and Gynecology,
Stanford University, California U.S.A.
Undergraduate Internship at the Department of Biological Chemistry,
University of Rome La Sapienza (Italy).
Awards:
1992
1993-1995
1998-2000
Research Fellowship by the Fondazione Cenci-Bolognetti, University of
Rome La Sapienza.
Dean’s Fellowship by Stanford University (California, USA).
Postdoctoral Fellowship by the American-Italian Cancer Foundation.
Scientific Experience and Interests
The laboratory of Prof. Sette is involved in several aspects of the biology of germ cells,
neurons and cancer cells.
The major interests are centered around the regulation of the post-transcriptional control
of gene expression. Our laboratory aims at studying the regulation of mRNA processing
and gene expression by RNA-binding proteins whose activity is modulated by signal
transduction pathways, cell differentiation programs or oncogenic transformation. As
prototypic RNA binding protein, we have focused the attention on Sam68, which is
required for male fertility and brain functions and is up-regulated in several cancers,
including prostate, renal and testicular carcinomas. The laboratory is also focused in
developing biological drugs to interfere with the function of proteins in pathological
situations.
Grants obtained in the last 5 years:
2002-2008: “Identification and characterization of small molecole inhibitors of the
MyD88inflammatory pathway”; EURO 60000/year, funded by SIGMA-TAU s.p.a
Pharmaceutical Industry and TECNOGEN Biotechnology.
2004-2006: “Role of the interaction between Src kinase and the RNA-binding protein
Sam68 in human prostate carcinoma” ; EURO 120000, funded by AIRC (Italian
Association for Cancer Research).
2004-2005: “Modulation of gene expression at the translational level by androgens in
prostate cancer cells”. EURO 53000; funded by the Italian Ministry of Education (PRIN
2004).
2004-2006: “Translational control of the molecular mechanisms of the onset of
embryogenesis”. EURO 131500, funded by Telethon
2005-2008: “Centrosome overduplication in human testicular seminomas”. $223000,
funded by the Lance Armstrong Foundation (U.S.A.).
2006-2007: “Post-transcriptional regulation by steroids and growth factors in prostate
cancer cells”. EURO 40000; funded by the Italian Ministry of Education (PRIN 2006).
2007: “Role of Toll-like receptors and MyD88 in multiple sclerosis”. EURO 25000,
funded by Italian Foundation for Multiple Sclerosis (FISM).
2007-2009: “Role of the RNA-binding protein Sam68 in human prostate carcinoma”.
EURO 140000; funded by funded by AIRC (Italian Association for Cancer Research).
2008-2010: “Role of the RNA-binding protein Sam68 in human prostate carcinoma”.
UK £ 97000; funded by AICR (Association for International Cancer Research).
2009-2012: “Regulation of the alternative splicing of SMN2 by Sam68 and its implication
in Spinal Muscular Atrophy”. EURO 198000; funded by Telethon.
2010-2013: “Role of the multifunctional RNA binding protein Sam68 in human prostate
cancer”. EURO 225000; funded by AIRC (Italian Association for Cancer Research).
2010-2013: “Role of Sam68 in the regulation of SMN2 alternative splicing in SMA cells”.
U.S $ 219000; funded by the Muscular Dystrophy Association (U.S.A.)
2011-2014: “Role of the RNA-binding protein Sam68 in human prostate carcinoma”.
UK £ 135000; funded by AICR (Association for International Cancer Research).
IMPEGNO DIDATTICO-FORMATIVO NELL’AMBITO DEL DOTTORATO
A) Tutor durante l’attività sperimentale, nell’ultimo anno accademico e/o
precedenti, dei seguenti dottorandi:
Manuela Cappellari (2010-2012)
Sara Calabretta (2010-2012)
Chiara Naro (2011-2012)
Maria Blaire Bustamante (2011-2012)
Ilaria Passacantilli (2012)
B) Tutor durante la preparazione della tesi di dottorato, nell’ultimo anno
accademico e/o precedenti, dei seguenti dottorandi:
Valeria Messina (2011)
Simona Pedrotti (2011)
Federica Barbagallo (2010)
Laura Adesso (2010)
C) Attività seminariale, nell’ultimo anno accademico e/o precedenti:
Titolo seminario:
1) Regolazione del differenziamento delle cellule embrionali staminali mediante lo
splicing alternativo di un fattore di trascrizione (2012)
2) Ruolo dello splicing alternative nelle patologie umane e nuovi strumenti per la
sua modulazione in vivo (2011)
List of peer-reviewed articles
1. Capurso G, Sette C, Delle Fave G. (2012) The role of SRC family kinases in
neuroendocrine tumors. Gastroenterology. 142(4):e19.
2. Pedrotti S, Busà R, Compagnucci C, Sette C. (2012) The RNA recognition motif
protein RBM11 is a novel tissue-specific splicing regulator. Nucleic Acids Res.
40:1021-32.
3. Capurso G, Di Florio A, Sette C, Delle Fave G. (2012) Signalling Pathways
Passing Src in Pancreatic Endocrine Tumours: Relevance for Possible Combined
Targeted Therapies. Neuroendocrinology. Mar 21. [Epub ahead of print]
4. De Cola A, Bongiorno-Borbone L, Bianchi E, Barcaroli D, Carletti E, Knight RA,
Di Ilio C, Melino G, Sette C, De Laurenzi V. (2012) FLASH is essential during
early embryogenesis and cooperates with p73 to regulate histone gene
transcription. Oncogene. 31:573-82.
5. Di Florio A, Adesso L, Pedrotti S, Capurso G, Pilozzi E, Corbo V, Scarpa A,
Geremia R, Delle Fave G, Sette C. (2011) Src kinase activity coordinates cell
adhesion and spreading with activation of mammalian target of rapamycin in
pancreatic endocrine tumour cells. Endocr Relat Cancer. 18:541-54.
6. Bielli P, Busà R, Paronetto MP, Sette C. (2011) The RNA binding protein Sam68
is a multifunctional player in human cancer. Endocr Relat Cancer. 18(4):R91R102.
7. Chen J, Melton C, Suh N, Oh JS, Horner K, Xie F, Sette C, Blelloch R, Conti M.
(2011) Genome-wide analysis of translation reveals a critical role for deleted in
azoospermia-like (Dazl) at the oocyte-to-zygote transition. Genes Dev. 2011
25:755-66.
8. Paronetto MP, Messina V, Barchi M, Geremia R, Richard S, Sette C. (2011)
Sam68 marks the transcriptionally active stages of spermatogenesis and
modulates alternative splicing in male germ cells. Nucleic Acids Res.
39(12):4961-74.
9. Loiarro M, Campo S, Arseni B, Rossi S, D'Alessio V, De Santis R, Sette C,
Ruggiero V. (2011) Anti-proliferative effect of a triazole derivative (ST1959) on
LNCaP human prostate cancer cells through down-regulation of cyclin and
androgen receptor expression. Prostate. 71:32-41.
10. Sette C. (2010) Post-translational regulation of star proteins and effects on their
biological functions. Adv Exp Med Biol. 693:54-66.
11. Bianchi E, Barbagallo F, Valeri C, Geremia R, Palustri A, De Felici M, Sette C.
(2010) Ablation of the Sam68 gene impairs fertilità and gonadotropin-dependent
follicle development. Hum. Mol. Genet. 19:4886-94.
12. Valacca C, Bonomi S, Buratti E, Pedrotti S, Baralle FE, Sette C, Ghigna C,
Biamonti G. (2010) Sam68 regulates EMT through alternative splicing-activated
nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene. J Cell Biol.
191:87-99.
13. Pedrotti S, Sette C. (2010) Spinal Muscular Atrophy: a novel player joins the
battle for SMN2 exon 7 splicing. Cell Cycle. (19):3874-9.
14. Capolunghi F, Rosado MM, Cascioli S, Girolami E, Bordasco S, Vivarelli M,
Ruggiero B, Cortis E, Insalaco A, Fantò N, Gallo G, Nucera E, Loiarro M, Sette
C, De Santis R, Carsetti R, Ruggiero V. (2010) Pharmacological inhibition of
TLR9 activation blocks autoantibody production in human B cells from SLE
patients. Rheumatology. 49:2281-9.
15. Busà R, Sette C. (2010) An emerging role for nuclear RNA-mediated responses to
genotoxic stress. RNA Biology. 17; 7(4).
16. Muciaccia B, Sette C, Paronetto MP, Barchi M, Pensini S, D'Agostino A, Gandini
L, Geremia R, Stefanini M, Rossi P. (2010) Expression of a truncated form of
KIT tyrosine kinase in human spermatozoa correlates with sperm DNA integrity.
Hum Reprod. 25:2188-202.
17. Messina V, Di Sauro A, Pedrotti S, Adesso L, Latina A, Geremia R, Rossi P,
Sette C. (2010) Different Contribution of the MTOR and MNK Pathways to the
Regulation of mRNA Translation in Meiotic and Post-Meiotic Mouse Male Germ
Cells. Biol Reprod. 83:607-15.
18. Galli R, Starace D, Busà R, Angelini DF, Paone A, De Cesaris P, Filippini A,
Sette C, Battistini L, Ziparo E, Riccioli A. (2010) TLR stimulation of prostate
tumor cells induces chemokine-mediated recruitment of specific immune cell
types. J Immunol. 184:6658-69.
19. Olshavsky NA, Comstock CE, Schiewer MJ, Augello MA, Hyslop T, Sette C,
Zhang J, Parysek LM, Knudsen KE. (2010) Identification of ASF/SF2 as a
critical, allele-specific effector of the cyclin D1b oncogene. Cancer Res. 70:
3975-84.
20. Bianchi E, Geremia R, Sette C. (2010) Expression of stemness markers in mouse
parthenogenetic-diploid blastocysts is influenced by slight variation of activation
protocol adopted. In Vitro Cell Dev Biol Anim. 2010 Apr 8. [Epub ahead of print].
21. Loiarro M, Ruggiero V, Sette C. (2010) Targeting TLR/IL-1R signalling in
human diseases. Mediators Inflamm. 2010:674363.
22. Pedrotti S, Bielli P, Paronetto MP, Ciccosanti F, Fimia GM, Stamm S, Manley JL,
Sette C. (2010) The splicing regulator Sam68 binds to a novel exonic splicing
silencer and functions in SMN2 alternative splicing in spinal muscular atrophy.
EMBO J. 29:1235-47.
23. Busà R, Geremia R, Sette C. (2010) Genotoxic stress causes the accumulation of
the splicing regulator Sam68 in nuclear foci of transcriptionally active chromatin.
Nucleic Acids Res. 38: 3005-18.
24. Paronetto MP, Cappellari M, Busà R, Pedrotti S, Vitali R, Comstock C, Hyslop T,
Knudsen KE, Sette C. (2010) Alternative splicing of the cyclin D1 protooncogene is regulated by the RNA-binding protein Sam68. Cancer Res. 70:22939.
25. Sette C, Messina V, Paronetto MP. (2010) Sam68: A New STAR in the Male
Fertility Firmament. J Androl. 31:66-74.
26. Paronetto MP, Sette C. (2010) Role of RNA-binding proteins in mammalian
spermatogenesis. Int J Androl. 33: 2-12.
27. Brignatz C, Paronetto MP, Opi S, Cappellari M, Audebert S, Feuillet V, Bismuth
G, Roche S, Arold ST, Sette C, Collette Y. (2009) Alternative splicing modulates
auto-inhibition and SH3 accessibility in the Src kinase Fyn. Mol Cell Biol.
29(24):6438-48.
28. Loiarro M, Gallo G, Fantò N, De Santis R, Carminati P, Ruggiero V, Sette C.
(2009) Identification of critical residues of the MyD88 death domain involved in
the recruitment of downstream kinases. J Biol Chem. 284:28093-103.
29. Paronetto MP, Messina V, Bianchi E, Barchi M, Vogel G, Moretti C, Palombi F,
Stefanini M, Geremia R, Richard S, Sette C. (2009) Sam68 regulates translation
of target mRNAs in male germ cells, necessary for mouse spermatogenesis. J Cell
Biol. 185:235-49.
30. Barbagallo F, Paronetto MP, Franco R, Chieffi P, Dolci S, Fry AM, Geremia R,
Sette C. (2009) Increased expression and nuclear localization of the centrosomal
kinase Nek2 in human testicular seminomas. J Pathol. 217:431-41.
31. Bianchini A, Loiarro M, Bielli P, Busà R, Paronetto MP, Loreni F, Geremia R,
Sette C. (2008) Phosphorylation of eIF4E by MNKs supports protein synthesis,
cell cycle progression and proliferation in prostate cancer cells. Carcinogenesis.
29:2279-88.
32. Ehrmann I, Dalgliesh C, Tsaousi A, Paronetto MP, Heinrich B, Kist R, Cairns P,
Li W, Mueller C, Jackson M, Peters H, Nayernia K, Saunders P, Mitchell M,
Stamm S, Sette C, Elliott DJ. (2008) Haploinsufficiency of the germ cell-specific
nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in
the mouse. Hum Mol Genet. 17:2803-18.
33. Paronetto MP, Bianchi E, Geremia R, Sette C. (2008) Dynamic expression of the
RNA-binding protein Sam68 during mouse pre-implantation development. Gene
Expr. Patterns, 8:311-22 .
34. Fedele M, Franco R, Salvatore G, Paronetto MP, Barbagallo F, Pero R, Chiaritoti
L, Sette C, Tramontano D, Chieffi G, Fusco A, Chieffi P. (2008) PATZ1 gene has
a critical role in the spermatogenesis and testicular tumours. J. of Pathology,
215:39-47.
35. Iwasaki T, Koretomo Y, Fukuda T, Paronetto MP, Sette C, Fukami Y, Sato K.
(2008) Expression, phosphorylation, and mRNA-binding of heterogeneous
nuclear ribonucleoprotein K in Xenopus oocytes, eggs, and early embryos. Dev
Growth Differ. 50:23-40.
36. Paronetto MP, Achsel T, Massiello A, Chalfant CE, and Sette C. (2007) The
RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x. J Cell
Biol. 176:929-39.
37. Godmann M, Auger V, Ferraroni-Aguiar V, Di Sauro A, Sette C, Behr R,
Kimmins S. (2007) Dynamic regulation of histone H3 methylation at lysine 4 in
mammalian spermatogenesis. Biol Reprod. 77:754-764.
38. Busà R, Paronetto MP, Farini D, Pierantozzi E, Botti F, Angelini DF, Attisani F,
Vespasiani G, and Sette C. (2007) The RNA-binding protein Sam68 contributes
to proliferation and survival of human prostate cancer cells. Oncogene, 26:437282.
39. Sette C. (2007) Rational design of MyD88 inhibitors--new pathways to
inflammatory control: an interview with Dr. Claudio Sette by Helene F.
Rosenberg. J Leukoc Biol. 82:811-812.
40. Loiarro M, Capolunghi F, Gallo G, Fantò N, De Santis R, Carminati P, Carsetti R,
Ruggiero V, and Sette C. (2007) Inhibition of MyD88 dimerization and of
recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound. J
Leukoc. Biol. 82:801-10.
41. Di Florio A, Capurso G, Milione M, Panzuto F, Geremia R, delle Fave GF, and
Sette C. (2007) Src-related kinase activity regulates adhesion, spreading and
migration of pancreatic endocrine tumour cells. Endocrine-related Cancer.
14:111-24.
42. Paronetto MP, Zalfa F, Botti F, Geremia R, Bagni C, and Sette C. (2006) The
nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates
with the polysomes in mouse spermatocytes. Mol Biol Cell. 17:14-24.
43. Vicini E, Loiarro M, Di Agostino S, Corallini S, Capolunghi F, Carsetti R, Chieffi
P, Geremia R, Stefanini M, and Sette C. (2006) 17-β-estradiol elicits genomic and
non-genomic responses in mouse male germ cells. J. Cell Physiol. 206(1):238-45.
44. Loiarro M, Sette C, Gallo G, Fantò N, Mastroianni D, Carminati P, and Ruggiero
V. (2005) Peptide-mediated interference of TIR domain dimerization in MyD88
inhibits IL-1-dependent activation of NF-B. J. Biol. Chem. 280: 15809-15814.
45. Capurso G, Crnogorac-Jurcevic T, Milione M, Panzuto F, Campanini N, Dowen
SE, Di Florio A, Sette C, Bordi C, Lemoine NR, Delle Fave G. (2005) Peanutlike 1 (septin 5) gene expression in normal and neoplastic human endocrine
pancreas. Neuroendocrinology. 81:311-21.
46. Paronetto MP, Giorda E, Carsetti R, Rossi P, Geremia R, and Sette C. (2004)
Functional interaction between p90(Rsk2) and Emi1 contributes to the metaphase
arrest of mouse oocytes. EMBO J. 23: 4649-4659.
47. Di Agostino S, Botti F, Di Carlo A, Sette C, and Geremia R. (2004) Meiotic
progression of isolated mouse spermatocytes under simulated microgravity.
Reproduction. 128:25-32.
48. Venables JP, Dalgliesh G, Paronetto MP, Skitt L, Thornton JK, Saunders PT,
Sette C, Jones KT, and Elliott DJ. (2004) SIAH1 targets the alternative splicing
factor T-STAR for degradation by the proteasome. Hum. Mol. Genet. 13:15251532.
49. Sammarco I, Capurso G, Coppola L, Bonifazi AP, Cassetta S, Delle Fave G,
Carrara A, Grassi GB, Rossi P, Sette C, and Geremia R. (2004) Expression of the
proto-oncogene c-KIT in normal and tumor tissues from colorectal carcinoma
patients. Int J Colorectal Dis. 19 :545-553.
50. Rossi P, Dolci S, Sette C, Capolunghi F, Pellegrini M, Loiarro M, Di Agostino S,
Paronetto MP, Grimaldi P, Merico D, Martegani E, and Geremia R. (2004)
Analysis of the gene expression profile of male meiotic germ cells. Gene Expr.
Patterns 4:267-281.
51. Paronetto MP, Farini D, Sammarco I, Maturo G, Vespasiani G, Geremia R, Rossi
P, and Sette C. (2004) Expression of a truncated form of the c-Kit tyrosine kinase
receptor and activation of Src kinase in human prostatic cancer. Am. J. of
Pathology. 164: 1243-1251.
52. Di Agostino S., Fedele M., Chieffi P., Fusco A., Rossi P., Geremia R., and Sette
C. (2004) Phosphorylation of High Mobility Group Protein A2 by Nek2 Kinase
During the First Meiotic Division in mouse spermatocytes. Mol Biol Cell. 15:
1224-1232.
53. Sato K-I, Sette C, Kurokawa M, Paronetto MP, Iwasaki T, Fukami Y, and Fissore
RA. (2004) Fertilizome project: Proteomics of Fertilization signaling, the
biological bridge between gametogenesis and embryogenesis. Current
Proteomics, 1:231-246.
54. Paronetto MP, Venables JP, Elliott DJ, Geremia R, Rossi P, Sette C. (2003) Tr-kit
promotes the formation of a multimolecular complex composed by Fyn,
PLCgamma1 and Sam68. Oncogene. 22:8707-8715.
55. Naro F, De Arcangelis V, Sette C, Ambrosio C, Komati H, Molinaro M, Adamo
S, Nemoz G. (2003) A bimodal modulation of the cAMP pathway is involved in
the control of myogenic differentiation in l6 cells. J Biol Chem. 278:49308-49315.
56. Rossi P, Dolci S, Sette C, Geremia R. (2003) Molecular mechanisms utilized by
alternative c-kit gene products in the control of spermatogonial proliferation and
sperm-mediated egg activation. Andrologia. 35:71-78.
57. Sette, C., Paronetto, M.P., Barchi, M., Bevilacqua, A., Geremia, R., and Rossi, P.
(2002) Tr-kit-induced resumption of the cell cycle in mouse eggs requires
activation of a Src-like kinase. EMBO J. 21:5386-5395.
58. Diaz, O., Berquand, A., Dubois, M., Di Agostino, S., Sette, C., Lagarde, M.,
Nemoz, G., and Prigent, A-F. (2002) The mechanism of docosohexcaenoic acidinduced phospholipase D activation in human lymphocytes involves exclusion of
the enzyme from lipid rafts. J. Biol. Chem., 277:39368-78.
59. Di Agostino S., Rossi P:, Geremia R., and Sette C. (2002) The MAPK pathway
triggers Nek2 activation during chromosome condensation in mouse
spermatocytes. Development, 129, 1715-1727.
60. Kunzler M., Trueheart J., Sette C., Hurt E., and Thorner J. (2001) Mutations in
the yrb1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic
transport and suppress yeast mating defects. Genetics. 157:1089-105.
61. Sette C., Inouye C.J., Stroschein S.L., Iaquinta P.J., and Thorner J. (2000)
Mutational analysis of STE5: evidence that activation occurs by relief of
intramolecular inhibition. Molecular Biology of the Cell. 11:4033-49.
62. Sette C., Dolci S., Geremia R., and Rossi P. (2000) Role of c-kit in the
establishment, maintainance and function of germ cells. Int. J. Dev. Biol. 44:599608.
63. Rossi P., Sette C., Dolci S., Geremia R. (2000) Role of c-kit in mammalian
spermatogenesis. J. Endocrinol. Invest. 23:609-15.
64. Grange, M., Sette, C., Prigent, A.F., & Nemoz, G. (2000) Activation of PDE4D3
by direct binding of phosphatidic acid. J. Biol. Chem., 275:33379-87.
65. Naro F., Sette, C., Vicini, E., Grange, M., Conti, M., Lagarde, M., Molinaro, M.,
Adamo, S., Nemoz, G. (1999) Involvement of type 4 cyclic AMPphosphodiesterase in the myogenic differentiation of L6 cells. Molecular Biology
of the Cell, 10, 4355-4367.
66. Sette, C., Barchi, M., Bianchini, A., Conti, M., Rossi, P., and Geremia, R. (1999)
Activation of the mitogen activated protein kinase ERK1 during the G2/M
progression of mouse pachitene spermatocytes. J. Biol. Chem., 274, 3357133579.
67. Grange M, Sette C, Prigent AF, Lagarde M, Nemoz G. (1999) Regulation of
cAMP-phosphodiesterases by phosphatidic acid binding. Lipids. 34, Suppl:S83.
68. Naro F, Vicini E, Sette C, Grange M, Prigent AF, Curci R, Lagarde M, Nemoz G,
Adamo S. (1999) Phosphatidic acid-dependent activation of adenosine-3',5'cyclic-monophosphate-phosphodiesterase is necessary for Arg-vasopressin
induction of myogenesis. Lipids. 34, Suppl:S81-2.
69. Giordano D, Giorgi M, Sette C, Biagioni S, Augusti-Tocco G (1999) cAMPdependent induction of PDE5 expression in murine neuroblastoma cell
differentiation. FEBS Lett 446:218-22.
70. Sette, C., Bevilacqua, A., Geremia, R., and Rossi, P. (1998) Involvement of
phospholipase Cg1 in mouse egg activation induced by a truncated form of the ckit tyrosine kinase present in spermatozoa. J. Cell Biol 142, 1063-1074.
71. Iona, S., Cuomo, M., Bushnik, T., Naro, F., Sette, C., Hess, M., Shelton, E.R., and
Conti, M. (1998) Characyerization of the rolipram-sensitive, cAMP-specific
phosphodiesterases: identification and differential expression of immunologically
distincts forms in the rat brain. Molecular Pharmacology 53, 23-32.
72. El Bawab, S., Macovschi, O., Sette, C., Conti, M., Lagarde, M., Nemoz, G., and
Prigent, A-F. (1997) Selective stimulation of cAMP-specific phosphodiesterase
(PDE4A5) isoform by phosphatidic acid molecular species endogenously formed
in rat thymocytes. European Journal of Biochemistry, 247, 1151-1157.
73. Sette, C., Bevilacqua, A., Bianchini, A., Mangia, F., Geremia, R., and Rossi, P.
(1997) Parthenogenetic activation of mouse eggs by microinjection of a truncated
c-kit tyrosine kinase present in spermatozoa. Development, 124, 2267-2272.
74. Nemoz, G., Sette, C., and Conti, M. (1997) Selective activation of rolipramsensitive, cAMP-specific phosphodiesterase isoforms by phosphatidic acid.
Molecular Pharmacology, 51, 242-249.
75. Sette, C., and Conti, M. (1996) Phosphorylation and activation of a cAMPspecific phosphodiesterase by the cAMP-dependent protein kinase: involvement
of serine 54 in the activation. J. Biol. Chem., 271, 16256-16534.
76. Nemoz, G., Zhang, R., Sette, C., and Conti, M. (1996) Identification of cyclic
AMP-phosphodiesterase variants expressed from the PDE4D gene in human
peripheral mononuclear cells. FEBS Letters, 384, 97-102.
77. Albanesi, C., Geremia, R., Giorgio, M., Dolci, S., Sette, C., and Rossi, P. (1996)
A cell- and developmental stage-specific promoter drives the expression of a
truncated c-kit protein during mouse spermatid elongation. Development, 122,
1291-1302.
78. Alvarez R., Sette, C., Yang, D., Eglen, R.M., Wilhelm, R., Shelton, E.R., and
Conti, M. (1995) Activation and selective inhibition of a cyclic AMP-specific
phosphodiesterase (PDE4D3). Molecular Pharmacology, 48,616-622.
79. Nemoz, G. Sette, C., Hess, M., Muca, C., Vallar, L., and Conti, M. (1995)
Activation of cyclic nucleotide phosphodiesterases in FRTL-5 thyroid
cellsexpressing a constitutively active Gs. Molecular Endocrinology, 9,12791287.
80. Conti, M., Nemoz, G., Sette, C., and Vicini, E. (1995) Recent progress
inunderstanding the hormonal regulation of phosphodiesterases. Endocrine
Reviews, 16, 370-389.
81. Sette, C., Vicini, E., and Conti, M. (1994) The ratPDE3/IVd gene codes for
multiple proteins differentially activated by cAMP-dependent protein kinase. J.
Biol. Chem., 269, 18271-18274.
82. Sette, C., Iona, S., and Conti, M. (1994) The short-term activation of arolipramsensitive, cAMP-specific phosphodiesterase by TSH in thyroid FRTL-5 cells is
mediated by a cAMP-dependent phosphorylation. J. Biol. Chem., 269, 9245-9252.
83. Sette, C., Vicini, E., and Conti, M. (1994) Modulation of cellular responses by
hormones: role of cAMP-specific, rolipram-sensitive phosphodiesterase.
Molecular and Cellular Endocrinology, 100, 75-79.