3 Pancreatic
Cancer Forum
rd
Milano, November 6th -7th, 2015
San Raffaele Congress Centre
Chairmen of
the Congress
Ospedale San Raffaele, Milano, Italy
Prof. Massimo Falconi
Dr. Michele Reni
Università Vita-Salute San Raffaele, Milano, Italy
Ospedale San Raffaele, Milano, Italy
Prof. Stefano Cascinu
Università Politecnica delle Marche, Ancona, Italy
Prof. Giampaolo Tortora
Università degli Studi di Verona, Italy
Organising
Secretariat
Acheloís Professional Congress Organiser
Via Olgettina 58 - 20132 Milano, Italy
Phone +39 02 2643 6227 - Fax +39 02 2643 3754
e-mail [email protected]
3rd Pancreatic Cancer Forum
Milano, November 6th-7th, 2015
SCIENTIFIC PROGRAMME
Friday, November 6th
09.00-09.15
Welcome and introduction
SESSION 1:
BASIC RESEARCH IN PANCREATIC CANCER: SHIFTING EPIDEMIOLOGY AND
BASIC SCIENCE ADVANCES
Chairmen: N. Funel, M. Löhr, P. Maisonneuve
09.15-09.30
Changing epidemiology of pancreatic cancer: Why is it still increasing?
P. Maisonneuve
09.30-09.45
Why is pancreatic cancer so difficult to detect? The challenge of early
detection
M. Löhr
09.45-09.55
PANEL DISCUSSION
Epidemiology and the difficulties with early detection in pancreatic cancer
and the relevance to clinical practice
P.G. Arcidiacono, N. Funel, M. Löhr, P. Maisonneuve
09.55-10.40
Key advances in basic science
 New 3D-pancreatic cell culture system as a tool to evaluate human
PDAC
V. Corbo
10.40-10.55

Carcinoma-associated fibroblast-derived CXCL12 in pancreatic tumour
cell immune evasion (promise of plerixafor)
L. Magiera

Defective extrusion, due to reduced SP12 in pancreatic cancer may be
involved in tumourigenesis, invasion and metastasis; potential role of
FAK inhibitors
J. Rosenblatt
KEYNOTE LECTURE
Why is pancreatic cancer so difficult to treat? The basic research challenges
M. Hidalgo
Organising Secretariat
Achelois Srl
Via Olgettina 58
20132 Milano (Italy)
Phone: + 39 02 2643 6227
Fax: +39 02 2643 3754
e-mail: [email protected]
www.achelois.eu
www.pancreatic-cancer-forum.com
3rd Pancreatic Cancer Forum
Milano, November 6th-7th, 2015
10.55-11.10
PANEL DISCUSSION
V. Corbo, M. Hidalgo, L. Magiera, J. Rosenblatt
(including audience keypad voting on the pancreatic research challenges)
11.10-11.30
Coffee break
SESSION 2:
BASIC RESEARCH IN PANCREATIC CANCER: IMMUNE ESCAPE MECHANISMS
AND THE PROMISE OF IMMUNOTHERAPY
Chairmen: L. Magiera, M.P. Protti, A. Scarpa
11.30-11.45
How does pancreatic cancer avoid the immune system?
M.P. Protti
11.45-12.00
PANEL DISCUSSION
The immunogenic potential of pancreatic cancer and the relevance
to clinical practice
M.P. Protti, A. Scarpa
12.00-13.00
WORKSHOP A
Group 1: Strategic immunotherapy/vaccine/checkpoint inhibitor workshop
Coordinators: S. Cascinu, M.P. Protti
Group 2: Early detection of pancreatic cancer
Coordinators: P.G. Arcidiacono, M. Löhr
13.00-14.15
Lunch
SESSION 3:
TRANSLATIONAL RESEARCH: GENOMICS AND THE STROMA
Chairmen: A. Biankin, F. De Vita, R. Ramanathan
14.15-14.30
Genomics update: can we translate the promise into clinical trials or daily
practice soon?
A. Biankin
14.30-15.00
CUTTING THE HEDGE - Stroma: Friend or foe?
Title to be defined
R. Kalluri,
The Multi-compartment effects of Hedgehog signaling in Pancreatic Cancer
Stroma
K.P. Olive
Organising Secretariat
Achelois Srl
Via Olgettina 58
20132 Milano (Italy)
Phone: + 39 02 2643 6227
Fax: +39 02 2643 3754
e-mail: [email protected]
www.achelois.eu
www.pancreatic-cancer-forum.com
3rd Pancreatic Cancer Forum
Milano, November 6th-7th, 2015
15.00-15.15
PANEL DISCUSSION
Genomics and the stroma and the relevance to clinical practice
A. Biankin, F. De Vita, R. Kalluri, K.P. Olive, R. Ramanathan
15.15-15.30
Coffee break
SESSION 4:
TRANSLATIONAL RESEARCH: RESISTANCE AND STEM CELLS
Chairmen: N. Silvestris, C. Swanton, G. Tortora
15.30-15.45
Implications of intratumour heterogeneity for Drug Development
C. Swanton
15.45-16.00
The role of pancreatic stem cells and how to target them effectively
P. Sancho
16.00-16.15
PANEL DISCUSSION
Key on mechanisms of treatment resistance and stem cells in PDAC and the
relevance to clinical practice
P. Sancho, N. Silvestris, C. Swanton, G. Tortora
16.15-17.15
WORKSHOP B
Group 1: utilizing genomics, epigenetic and molecular profiling in
pancreatic cancer
Coordinators: A. Biankin, G. Tortora
Group 2: Biomarkers: issues and controversies
Coordinators F. De Vita , D. Palmer
17.15-18.00
Chairs’ summary and workshop feedback
Organising Secretariat
Achelois Srl
Via Olgettina 58
20132 Milano (Italy)
Phone: + 39 02 2643 6227
Fax: +39 02 2643 3754
e-mail: [email protected]
www.achelois.eu
www.pancreatic-cancer-forum.com
3rd Pancreatic Cancer Forum
Milano, November 6th-7th, 2015
Saturday, November 7th
08.30-08.35
Introduction of 2nd Day Meeting
SESSION 5:
CLINICAL MANAGEMENT OF PANCREATIC CANCER: EARLY-STAGE AND
LOCALLY ADVANCED DISEASE
Chairmen: M.D. Chuong, M. Falconi, R. Ramanathan, G. Zamboni
08.35-08.50
Neoadjuvant therapy update, issues and future direction
M. Reni
08.50-09.30
CASE STUDY DISCUSSION
Optimal therapy in resectable disease
M.D. Chuong, M. Milella, D. Palmer
Introduced by M. Falconi
09.30-10.10
CASE STUDY DISCUSSION
Downsizing in borderline resectable disease
G. Balzano, W. Scheithauer, A. Morganti
Introduced by R. Ramanathan
10.10-10.15
Pathological controversies and advances
G. Zamboni
10.15-10.30
Update on pathological controversies and advances after resection
C. Doglioni
10.30-10.45
Coffee break
10.45-11.15
CASE STUDY DISCUSSION
Unresectable disease: what are the options when surgery is no longer an
option?
M.D. Chuong, M. Ducreux
Introduced by A. Morganti
Organising Secretariat
Achelois Srl
Via Olgettina 58
20132 Milano (Italy)
Phone: + 39 02 2643 6227
Fax: +39 02 2643 3754
e-mail: [email protected]
www.achelois.eu
www.pancreatic-cancer-forum.com
3rd Pancreatic Cancer Forum
Milano, November 6th-7th, 2015
SESSION 6:
CLINICAL MANAGEMENT OF PANCREATIC CANCER: METASTATIC DISEASE
Chairmen: G. Aprile, C. Bassi, S. Cascinu, A. Zerbi
11.15-11.35
Optimal management of minimal metastatic disease: Role of local treatment
M. Büchler
11.35-11.50
Metastatic pancreatic cancer update
P. Philip
11.50-12.00
PANCREOS Registry
A. Carrato
12.00-12.15
PANEL DISCUSSION
Metastatic disease
G. Aprile, M. Büchler, S. Cascinu, P. Philip, A. Zerbi
12.15-12.35
CASE STUDY DISCUSSION
Optimal treatment in metastatic setting with keypad voting
E. van Cutsem
12.35-12.45
The European Cancer Patient Coalition initiatives
A. Stunt
12.45-13.45
Lunch
13.45-14.00
CASE STUDY DISCUSSION
Optimal treatment in metastatic setting with keypad voting
T. Seufferlein
14.00-14.15
Advancing the management of cancer cachexia: how do we improve patient
outcomes?
J. Arends
14.15-14.25
PANEL DISCUSSION
Advancing the management of cancer cachexia
G. Aprile, S. Cascinu, A. Zerbi
14.25-15.25
WORKSHOP C
Group 1: Optimisation of supportive care
Coordinators: G. Aprile, J. Arends
Organising Secretariat
Achelois Srl
Via Olgettina 58
20132 Milano (Italy)
Phone: + 39 02 2643 6227
Fax: +39 02 2643 3754
e-mail: [email protected]
www.achelois.eu
www.pancreatic-cancer-forum.com
3rd Pancreatic Cancer Forum
Milano, November 6th-7th, 2015
Group 2: Innovation in therapy and management of patients with PDAC
Coordinators: M. Ducreux, P.Corrie
15.25-15.40
Coffee break
15.40-15.55
KEYNOTE LECTURE
Precision, personalisation and the future of pancreatic cancer:
where do we go from here?
Development of a comprehensive clinical and research program in PC
M. Moore
15.55-16.25
Chairs’ summary and workshop feedback
16.30
Departures
Organising Secretariat
Achelois Srl
Via Olgettina 58
20132 Milano (Italy)
Phone: + 39 02 2643 6227
Fax: +39 02 2643 3754
e-mail: [email protected]
www.achelois.eu
www.pancreatic-cancer-forum.com