Author's response to reviews
Title: Functional Correlates of Apolipoprotein E Genotype in Frontotemporal Lobar Degeneration
Authors:
Barbara Borroni ([email protected])
Daniela Perani ([email protected])
Silvana Archetti ([email protected])
Chiara Agosti ([email protected])
Barbara Paghera ([email protected])
Giuseppe Bellelli ([email protected])
Monica DiLuca ([email protected])
Alessandro Padovani ([email protected])
Version: 4 Date: 16 August 2006
Author's response to reviews: see over
UNIVERSITA’ DEGLI STUDI DI BRESCIA
Dipartimento Scienze Mediche e Chirurgiche
Centro per lo Studio
dell'Invecchiamento Cerebrale e delle
CLINICA NEUROLOGICA
Malattie Neurodegenerative
Brescia, August 16th, 2006
Dear Editor,
Please find enclosed our re-revised manuscript entitled “Functional Correlates of
Apolipoprotein E Genotype in Frontotemporal Lobar Degeneration” by Barbara Borroni
and colleagues.
We have taken into consideration the points that were raised by the referees, and the manuscript
has been amended accordingly.
We hope that in the present form the manuscript will be finally suitable for publication in BMC
Neurology.
Looking forward to learning your decision
Best regards,
Barbara Borroni, M.D.
Clinica Neurologica, c/o Spedali Civili di Brescia
Università degli Studi di Brescia
Tel. 030/3995631, Fax. 030/3995027
E-mail. [email protected]
Centro per lo Studio dell'Invecchiamento Cerebrale e delle Malattie Neurodegenerative
Clinica Neurologica-Spedali Civili
Telefono: 030-3995632, FAX: 030-3995027
e-mail: [email protected]
Review 1
We fully agree with review’s suggestion.
1. We made clear what criteria were used for SD and PNFA.
2. We showed the details of overall ApoE epsilon4 frequency in whole FTLD patients and in
FTLD subgroups.
3. As suggested, we changed the term Pick’s Complex, adopting again FTLD.
4. In the discussion, we added the comment on ApoE genotype frequency in our sample.
UNIVERSITA’ DEGLI STUDI DI BRESCIA
Dipartimento Scienze Mediche e Chirurgiche
Centro per lo Studio
dell'Invecchiamento Cerebrale e delle
CLINICA NEUROLOGICA
Malattie Neurodegenerative
Review 3
We amended the manuscript according to the issues raised by Prof. Sjogren.
-
We made more clear the results in Table 2, explaining then in the title of the table.
-
We included some text in the Figure to specify ApoE positive/negative.
Centro per lo Studio dell'Invecchiamento Cerebrale e delle Malattie Neurodegenerative
Clinica Neurologica-Spedali Civili
Telefono: 030-3995632, FAX: 030-3995027
e-mail: [email protected]