CLINICAL
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clinical-scientific departments
SURGERY
DEPARTMENT
DIRECTOR OF DEPARTMENT: Ugo Pastorino
+39 02 23902906
[email protected]
The Department of Surgery treats oncological diseases that affect all areas of the body except
for the brain, providing elective and emergency surgical activity, in ordinary inpatient and
day hospital regimens, as well as specialist outpatient activity for diagnosis and follow-up.
Routine clinical activity ensures a high standard of care for all surgically-treated patients,
providing conservative surgery (organ/function preserving or minimally invasive) for early
stage disease and combined treatment modalities for advanced disease.
The Department is organized in the following Units:
Gastrointestinal, HepatoPancreatobiliary Surgery, and Liver Transplantation. Has the
goal to improve the standard of care for primary and secondary tumors affecting the liver,
biliary system, pancreas, and gastrointestinal tract. In the field of hepato-oncology, it offers
the complete range of the most up-to-date therapeutic options for liver cancer, including
liver transplantation, minimally-invasive and computer assisted surgery, transarterial
chemo-/radio-embolization, percutaneous and laparoscopic tumor ablation, and targeted
molecular therapies. The Unit is a pioneer in computed-assisted liver surgery performed
using an ultrasound navigation system that allows localization of tumors deep in the liver
that are not visible with conventional ultrasound.
Colorectal Surgery. Devotes special attention to tumors of the distal rectum and has
established high standards of care for the management of this subset of patients.
Conservative, function-preserving surgical techniques to avoid extensive resection
an definitive colostomy have been perfected. The Peritoneal Surface Malignancies
(PSM) program is responsible for the treatment of pseudomyxoma peritonei, peritoneal
mesothelioma, and peritoneal carcinomatosis from colorectal cancers. In 2013, an
important study was published on the role of perioperative systemic chemotherapy in
diffuse malignant peritoneal mesothelioma patients treated with cytoreductive surgery and
hyperthermic intraperitoneal chemotherapy.
Breast Surgery. Clinical activity includes all aspects of breast cancer treatment, i.e.
diagnosis, primary and adjuvant therapy, and follow-up. Enhanced understanding of the
pathogenesis of breast cancer coupled with a growing interest in improved esthetic results
led to the investigation of skin- and nipple-sparing mastectomy as a potential improvement
over conventional mastectomy. In 2013, the longstanding experience on breast conserving
surgical treatment was further strengthened by the publication of the final results of a
randomized controlled clinical trial on breast cancer treatment without axillary surgery.
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SCIENTIFIC REPORT 2013
Melanoma and Sarcoma. Comprises all aspects of melanoma and sarcoma treatment, i.e.
diagnosis, primary and adjuvant therapy, and follow-up. The Unit conducts clinical trials in
the field of adjuvant therapy for melanoma and pre-operative therapy for sarcoma. The Unit
is the referring center for melanoma and sarcoma guidelines.
Diagnostic Endoscopy and Endoscopic Surgery. Includes activities of the multidisciplinary
endoscopy, i.e., diagnostic and therapeutic procedures of the gastrointestinal,
biliopancreatic, respiratory, and urinary tracts. The Unit is particularly committed to cancer
prevention and diagnosis and treatment of early cancers.
Otolaryngology Surgery and Maxillo-Facial Surgery. Specialized in the treatment of
benign and malignant tumors of the head and neck area. State-of-the-art surgical treatment
for patients with head and neck tumors is guaranteed by experts from across disciplines:
otolaryngologists and maxillofacial surgeons.
Gynecologic Oncology. Deals mainly with primary and secondary tumors of the female
genital tract. Surgical research was conducted on the following techniques: nerve
sparing radical surgery, debulking surgery, mini-invasive surgery, laparoscopic surgery in
diagnosis, staging and treatment of early gynecological tumors; sentinel node detection in
endometrial cancer.
Thoracic Surgery. Covers all aspects of thoracic oncology, focusing on pulmonary,
mediastinal, chest wall, and esophageal tumors. In the management of lung cancer, the
mainstay of surgical treatment is maximal functional sparing. Innovative techniques
for tridimensional chest wall reconstruction have been developed (rib-like technique),
permitting appropriate reconstruction even in case of removal of an entire hemithorax. In
mediastinal surgery, superior vena cava (SVC) replacement is performed by procedures
not requiring SVC cross-clamping, avoiding intraoperative hemodynamic instability.
Pleuro-pneumonectomy is proposed in limited malignant mesothelioma, after induction
chemotherapy.
Plastic and Reconstructive Surgery. Performs reconstructive surgical procedures related
to extensive breast and head and neck surgery, soft-tissue tumors, chest-wall surgery, and
other types of aggressive oncologic surgery, as well as surgical treatment and repair of skin
cancer. Oncoplastic surgery represents a new standard for reconstructive procedures after
tumor excision.
Urologic Surgery. Strengthens multidisciplinary care and clinical trials in difficult to treat
diseases. In particular, a number of phase II clinical trials have been approved in different
clinical settings of urothelial, testicular, and penile cancer and are initiating in 2014.
Most importantly, a primary objective of the Unit is to develop a modern framework for
clinical research, and with this aim the collaboration with EORTC was fulfilled, together
with the establishment of an urothelial cancer patient advocacy group. The multicentric
international cooperation for next generation sequencing analyses was another endpoint,
and collaboration with MSKCC as well as with UAB Comprehensive Cancer Center of
Alabama has been established in urothelial and penile cancers, respectively. The objective
of these collaborations will be to characterize extreme responders to specific targeted
drugs as well as conventional therapy from a molecular standpoint in order to provide
information to design informed clinical trials in multiple urological cancers.
Pediatric Surgery. Collaborates with pediatric oncologists and provides a high standard of
treatment for the most frequent solid – non-CNS – tumors in children and adolescents. The
role of surgery is established according to ongoing European treatment protocols.
Laser Therapy Unit. Uses high-quality instrumentation including four lasers for a total
of 20 wavelengths. It allows conservative and ablative therapies in diseases where laser
therapy is the first or only treatment choice. Selective photothermolysis laser treatment is
performed for keloids as well as pigmented and vascular lesions, and laser ablation is used
for mucosal and skin cancer lesions requiring histological evaluation.
Day Surgery Unit. Devoted to surgical procedures performed in ambulatory and day
hospital settings. The clinical activity covers many aspects of oncologic surgery, and in
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clinical-scientific departments
particular includes the treatment of different lesions involving skin, soft tissues, breast,
as well lesions in gynecologic, urologic, and head and neck areas. This activity involves the
collaboration of physicians from Units within the Surgical Department.
HIGHLIGHTS
The Liver Transplant Program is mainly focused on establishing oncological guidelines and plays a leading role worldwide in defining
consistent indications and prospective lines of research.
INT is a referral center for soft-tissue sarcomas of the limbs and trunk, as well as retroperitoneal sarcomas, GIST, and axial bone
sarcomas.
A special effort is dedicated to the Regional Colorectal Cancer Screening Program as well as to endoscopic surveillance of patients
affected by familial adenomatous polyposis (FAP) or Lynch syndrome.
Lung cancer early detection program: at INT a large prospective study in heavy smokers volunteers is ongoing, based on plasma miRNA profiling to assess its efficacy as a first line screening test for lung cancer detection (www.biomild.org).
INT is certified as a Center of Excellence by the European Society Neuroendocrine Tumors (ENET).
KEYWORDS
liver transplantation, peritoneal carcinomatosis, locoregional therapy, immunotherapy, cancer prevention, laser therapy, skin cancer,
lung cancer, screening
GASTROINTESTINAL,
HEPATOPANCREATOBILIARY SURGERY,
AND LIVER TRANSPLANTATION
Head
Vincenzo Mazzaferro, MD
Clinical Research Staff
Carlo Battiston, MD; Sherrie Bhoori, MD (hepatogastroenterologist); Jorgelina C. Coppa, MD; Christian Cotsoglou, MD;
Alessandro Germini, MD; Andrea Pulvirenti, MD;
Enrico Regalia, MD; Raffaele Romito, MD; Carlo F. Sposito MD
COLORECTAL SURGERY
Head
Ermanno Leo, MD
Clinical Research Staff
Dario Baratti, MD; Luigi Battaglia, MD; Filiberto Belli, MD;
Giuliano Bonfanti, MD; Alessandro Cesa Bianchi, MD; Marcello
Deraco, MD; Shigeki Kusamura, MD, PhD; Marco Vitellaro, MD
Residents
Marcello Guaglio, MD; Mario Moschita, MD;
Giovanni Piscitelli, MD; Vincenzo Pruiti, MD; Monica Zisa, MD
Research Staff
Marco A. Bongini, MD; Maria F. Reyes, MD; Daniela Sia, MD;
Elisa Sottotetti, MD
Administrative Personnel
Roberta Aceto
Residents
Davide Citterio, MD; Glenda Grossi, MD; Cecilia Muscarà, MD;
Marco Nencioni, MD; Matteo Origi, MD
Nurses
Fabiana Bettoni, Lucia Caracciolo, Rut Cittadin, Angela Colamonaco,
Stefania Labori, Magdalena-Alonso Manuel, Marica Melis,
Vanessa Neri, Palma, Mirtha Ybazeta Ramos, Riccardo Vacca
Administrative Personnel
Elisa Giavari and Francesco Roncacci (Unit secretaries);
Daniela Guarneri and Nela Zito (scientific secretaries);
Simona G. Marchesi (data manager)
Healthcare Assistants
Monica Anzaghi, Isabella Damasi, Nunzia Di Perna, Fabio Lizzano,
Maria Petrosina
Nurses
Paola Serafin (coordinator), Adriana Blanco, Salvatore Bonafede,
Annateresa Bugada, Morena De Santis, Milda Di Giacomo,
Angela Mihaela Farcas, Stefania Fici, Francesca Maiorano,
Antonella Masiello, Monica Mitarotonda, Nadia Nicoletti,
Patrizia Perotto Ghi, Patrizia Rota, Rossina Sitta, Stefania
Sperandio, Cristina Stracquadaini, Patrizia Valentini
BREAST SURGERY
Head
Roberto Agresti, MD (until 30 November)
Marco Greco, MD (since 1 December)
Healthcare Assistants
Nicoletta Damiani, Rosa De Felice, Mariangela Lopriore,
Annamaria Pancari, Angela Restaini, Enza Spina, Anna Vecchio
Clinical Research Staff
Silvia Bohm, MD; Alberto Rudy Conti, MD; Cristina Ferraris, MD;
Massimiliano Gennaro, MD; Maria Ilaria Grosso, MD;
Gabriele Martelli, MD; Cristina Pellitteri MD (until 30 November);
Domenico Piromalli, MD, Gianbattista Spatti MD
Research Fellows
Mario Rampa, MD; Alessandra Moscaroli, MD (until August 30th),
Ilaria Maugeri, MD
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SCIENTIFIC REPORT 2013
Administrative Personnel
Angela Allegri
Nurses
Irene Alessandrini, Giovanni Cavaliere, Miriam P. Conti, Stefano
Licata, Bruna Nuscis, Maria C. Puddu, Michele Rossello, Gelsomina
Sasso, Francesco A. Spagnolo, Liliane Venafra
Healthcare Assistants
Maria C. Fadda, Luigi Magnifico, Caterina Pianu
MELANOMA AND SARCOMA
Head
Mario Santinami, MD
Clinical Research Staff
Melanoma
Francesco Gallino, MD; Andrea Maurichi, MD; Daniele Moglia, MD;
Roberto Patuzzo, MD; Roberta Ruggeri, MD
Surgery of Sarcoma
Alessandro Gronchi, MD (Head); Marco Fiore, MD; Chiara
Colombo, MD, Stefano Redaelli, MD
Research Staff
Valentina Girgenti, MD; Roberto Grillo, MD; Elena Tolomio, MD
Residents
Consuelo Barbieri, MD; Federica Marazza, MD
OTOLARYNGOLOGY SURGERY
Head
Gabriele Scaramellini, MD
Clinical Research Staff
Roberto Bianchi, MD; Sarah Colombo, MD; Walter Fontanella,
MD; Marco Guzzo, MD; Tullio M. Ibba, MD, PhD; Natalia R. E. Pizzi,
MD; Madia Pompilio, MD; Stefano Riccio, MD
Nurses
Vincenzo Spanò (coordinator), Giovanna V. Bello, Petronilla
D’Agostino, Elena Cotellessa, Angelo Di Caro, Giorgio Fumi,
Giorgio Inverni, Carmen Minio, Rosita A. Nanna, Laura Ongari,
Daniele Pezzera, Francesca Pisano, Federica Prudenzano, Raffaella
Repetto, Maura Rimoldi, Maria S. Selva
Technicians
Pablita Endaya, Vincenzo Marotta, Giuseppe Messana, Laura
Somma
Administrative Personnel
Sabrina Zazzera
GYNECOLOGIC ONCOLOGY
Head
Francesco Raspagliesi, MD
Administrative Personnel
Antonella Vescera
Clinical Research Staff
Antonino Ditto, MD; Rosanna Fontanelli, MD; Barbara Grijuela,
MD; Domenica Lorusso, MD; Marina Merola, MD; Andrea Papadia,
MD; Eugenio Solima, MD; Flavia Zanaboni, MD
Data Managers
Annabella Di Florio, Adele Di Fazio, Giulia Bonarini
Research Fellows
Fabio Martinelli, Stefano Ramondino, Maria Mancini, Italo Sarno
Research Nurse
Gabriella Nicolò
Nurses
Patricia A. Costa, Alice Casali, Francesco Crugliano, Floriana Dimo,
Lorenza Greco, Eva Guitti, Antonio Micello, Marianna Miranda,
Claudio Oppido, Rossana Penasa, Ylenia Ponti, Paolo Re, Patrizia
Valente
Nurses and Healthcare Assistants
Giovanna Lomartire (coordinator), Nicola Abatangelo, Roberta
Allenza, Annamaria Biondo, Sonia Cappellini, Annarita Carluccio,
Alessio Cremonesi, Nello Curatolo, Floarea Dorca, Loridana
Marino, Silvana Mirante, Erica Panigada, Giusy Pede, Lucia
Preto, Esther Reinoso Crespo, Francesca Ruiu, Claudia Sonzogni,
Antonella Tomasicchio, Monica Ullio, Addolorata Volpe
DIAGNOSTIC ENDOSCOPY AND ENDOSCOPIC
SURGERY
Head
Emanuele Meroni, MD
Clinical Research Staff
Giovanni Ballardini, MD; Giuseppe Calarco, MD; Gabriele
Delconte, MD; Gianfranco Di Felice, MD; Massimo Falsitta, MD;
Andrea Mancini, MD
Nurses
Vittorio Mauro (coordinator), Francesco Bottani, Raffaele Calò,
Roberto Fiocco, Daniele Lo Curcio, Francesca Mannai, Giovanni
Sammartino, Raffaele Quagliolo
Technicians
Silvia Cara, Rosanna Loi, Salvatore Morfeo
Administrative Personnel
Concetta Di Quattro, Annamaria Mercuri
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Health Care Assistants
Rosa Farro, Alessia Formicola, Natalia Munante, Cecilia
Muzzupappa
Administrative Personnel
Cinzia Marretta, Rosella Zennoni, Stefano Ramondino, Maria
Mancini, Italo Sarno
THORACIC SURGERY
Head
Ugo Pastorino, MD
Clinical Research Staff
Andrea Billè, MD, PhD student; Leonardo Duranti, MD, PhD student; Riccardo Giovannetti, MD; Francesco Leo, MD, (until March
2013); Paolo Scanagatta, MD; Luca D. Tavecchio, MD
Fellows
Giuseppe Garofalo, MD; Mara Gisabella, MD; Stefano Sestini, MD
Resident
Lara Girelli, MD
Nurses
Federica Pirovano (coordinator), Brice Atiomeguim, Francesco
Auletta, Marcella Bernardo, Claudia Costa, Yesica Del Rio Mendez,
Antonino De Vita, Raffaele Di Nino, Margherita Fersurella, Hilda A.
Martinez, Daniele Marino, Maria L. Quitadamo, Anna M. Panareo,
Antonio Pantano, Antonella Prete, Antonino Proto
clinical-scientific departments
Technicians Oss
Nekpen Eguavoen, Angela Di Luglio, Diego Risuglia, Svitlana
Shulzhenko, Pamela K. Soto Fernandez
Administrative Personnel
Tiziana Negri (Unit secretary)
Research Staff
Elena Bertocchi (Research Coordinator) Anna Maria Calanca,
Carolina Ninni (Scientific secretaries), Claudio Jacomelli
(Informatics); Paola Suatoni (Biol Sci D)
External Collaborator
Nicola Sverzellati (Radiologist)
Testicular Cancer Surgery
Nicola Nicolai, MD (Coordinator)
Pediatric Surgery
Luigi Piva, MD (Coordinator)
Nurses
Graziella Russo (coordinator), Rosanna Candigliota, Maria
L. Cennamo, Anna M. Cercaci, Zino Ferro, Francesca Marelli,
Lucia Mesiano, Arturo Monetta, Valentina Musarò, Giuseppa
Napoli, Veronica P. Rojas, Annalisa Simone, Raffaella Rossi, Rita
Sciancalepore
Administrative Personnel
Maria G. Bodini
PLASTIC AND RECONSTRUCTIVE SURGERY
Head
Maurizio B. Nava, MD
Technicians
Elena Cristiani, De La Cruz, Velesmoro Rocio Del Pilar, Olimpia
Liberatore, Anna Mastroianni, Isabella Vurchio,
Clinical Research Staff
Novella Bruno, MD; Pierfrancesco Cadenelli, MD; Umberto
Cortinovis, MD; Joseph Ottolenghi, MD; Angela E. Pennati, MD;
Egidio Riggio, MD; Andrea Spano, MD
LASER THERAPY
Head
Anna Colombetti, MD
Nurses
Maria Saracino (coordinator), Samantha F. Castelli, Cinzia Gentilini,
Giusppe L’Abbate, Marisa Labò, Giovanna Melia, Caterina Pireddu,
Irene Rossi, Raffaella Tupputi
Technicians
Nadia Casati, Provvidenza Peci, Nomi Ibazeta Ramos, Iolanda
Panipucci, Annunziata Rugolo
Administrative Personnel
Luisa Morandi
UROLOGIC SURGERY
Head
Roberto Salvioni, MD
Clinical Research Staff
Davide Biasoni, MD; Mario A. Catanzaro, MD; Alessandro Crestani,
MD (Fellow, University of Padua School of Urology); MD; Elena
Farè, MD (Fellow, University of Milan School of Medicine); Patrizia
Giannatempo, MD (Resident, Department of Medical Oncology,
Medical Oncology Unit 2); Andrea Guttilla, MD (Fellow, University
of Padua School of Urology); Massimo Maffezzini, MD; Andrea
Necchi, MD (Faculty, Department of Medical Oncology, Medical
Oncology Unit 2); Daniele Raggi, MD (Fellow, University of Milan
School of Medicine); Silvia Stagni, MD; Tullio Torelli, MD
Clinical Research Staff
Silvia Aiello, MD; Mario Z. Raso, MD
Nurses
Maria Saracino (coordinator), Emilia D’Arrigo
Healthcare Assistant
Domenica Lo Prete
Administrative Personnel
M. Rosaria Aceto
DAY SURGERY
Head
Aldo E. Bono, MD
Nurses
Giovanna R. Colaci, Mariangela Lena, Mara D. Luisoni, Pina P. Mele,
Anna Picciallo, Domenica Violi, Marina Zocchi
Healthcare Assistants
Antonella Bordoni, Silvia Cara, Rosa Selvati
Administrative Personnel
Maria R. Bignamini, Anna Corella, Loredana Orezzi
FOR MORE INFORMATION ABOUT THE UNITS, VISIT US ONLINE AT WWW.ISTITUTOTUMORI.MI.IT
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