Programme March 31st, Monday 08:30 Registration 10:00 Opening session 10:20 – 12:40 Chairpersons: Session I Structural Biology Giuseppe Zanotti (Padova) – Martino Bolognesi (Milano) – Menico Rizzi (Novara) 10:20 Guillermo Montoya (Madrid, Spain) Structural insignts into the TRiC/CTT complex function and mechanism 10:50 Sebastiano Pasqualato (Milano) Structural insight into the mechanism of action of Nedd4 family HECT ubiquitin ligases 11:20 Roberto Battistutta (Padova) Structural basis of protein kinase CK2 regulation by autoinhibitory oligomerization 11:40 Nicola Doniselli (Parma) Synergic and opposite effects of two stringent response modulators on bacterial transcriptional initiation complexes 12:00 Vincenzo De Filippis (Padova) Novel Interactions of Thrombin 12:20 Stefano Stella (Madrid) BuD, a novel DNA-binding domain for genome modification 12:40 Lunch – NH Mantegna Restaurant (12th floor) 14:00 – 16:00 Chairpersons: 14:00 Session II Enzymology Loredano Pollegioni (Varese) – Andrea Mozzarelli (Parma) Nicholas Turner (Manchester, UK) Design and Evolution of New Biocatalysts for Organic Synthesis Programme 14:30 Riccardo Percudani (Parma) Identification and characterization of enzymes for their use in a genetic form of hyperuricemia 15:00 Francesca Valletti (Torino) A novel [FeFe]-hydrogenase from c. perfringens. Characterization and immobilization on TiO2 electrodes as catalyst for hydrogen producing devices 15:20 Deborah Balzano (Madrid) Mechanisms of Phosphorylation of Protein Kinase B 15:40 Stefano Bruno (Parma) Targeting Cystalysin, a virulence factor of treponema denticola-supported peridontitis 16:00 Coffee break (bar, ground floor) and Poster session (1st floor) 17:40 Sponsored Presentation – NanoTemper 18:00 – 19:00 Chairperson: Plenary Lecture Silvia Onesti (Trieste) 18:00 Musa Mhlanga (Pretoria, South Africa) Chromosomal Contact Permits Transcription between Co-regulated Genes 20:00 Social Dinner – NH Mantegna Restaurant (12th floor) April 1st, Tuesday 0900 – 11:30 Chairpersons: Session III Protein Folding and Misfolding Vittorio Bellotti (Pavia) – Stefano Gianni (Roma) 09:00 John Christodoulou (London, UK) Protein folding on the ribosome 09:30 Stefano Piana-Agostinetti (New York, USA) Long-timescale equilibrium simulations of protein folding 10:00 Coffee Break (bar, ground floor) 10:30 Laura Tosatto (Cambridge, UK) Single molecule fluorescence approach to investigate alpha-synuclein oligomer formation Programme 10:50 Stefano Ricagno (Milano) D76N Beta-2 microglobulin an amyloidogenic and pathologic mutant (clues on the native and on the fibrillar states) 11:10 Elisa Bianchini (Padova) Smalls molecules “to cure” -sarcoglycan mutated protein: new perspectives for a neglected muscular dystrophy 11:30 Poster session (1st floor) 12:30 Lunch – NH Mantegna Restaurant (12th floor) 14:00 – 16:00 Session IV Computational Biology Chairpersons: Rita Casadio (Bologna) – Silvio C.E. Tosatto (Padova) 14:00 Alex Bateman (Cambridge, UK) Why biologists should care about Wikipedia 14:30 Gianni Cesareni (Roma) Combining protein interaction and logic networks to understand the anti-tumor activity of the anti-diabetic drug metformin 15:00 Gustavo Parisi (Quilmes, Argentina) Conformational diversity: the missing link in protein structure prediction 15:20 Antonio Trovato (Padova) The BACH scoring function: a common approach to evaluate the quality and predict the affinity of protein complexes 15:40 Massimo Bellanda (Padova) Structural peculiarities of monothiol Grx1 from the parassite Trypanosoma brucei 16:00 Closing Remarks