Elenco dei brevetti e delle pubblicazioni su riviste internazionali di
Maurizio Taddei,
Professore Ordinario di Chimica Organica,
Facoltà di Farmacia
Università degli Studi di Siena.
Brevetti
I- M. Fiorenza, A. Ricci, M. Taddei, G. Seconi
Procedimento per la conversione regiospecifica di ossirani in alcoli primari bifunzionali.
21880 A/82 1982
II- G. Capozzi, S. Menichetti, A. Ricci, M. Taddei
Procedimento per la produzione dell’esametildistannano
48233 A/87 1987
III- A. Ricci, M. Taddei, G. Rapi, G. Seconi, P. Dembech, A. Omodei-Salé
Biosilani ad attività antibatterica ed antifungina e procedimenti per la loro preparazione
48262 A/87 1987.
IV M. Ruat, H. Faure, E. Traiffort, A. Shoenfelder, A. Mann, M. Taddei, A. Solinas, F.
Manetti
N-Acythiourees at N-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog
PCT Int. Appl. (2009), WO 2009130422 A2 20091029..
V M. Taddei, D. Naldini, P. Allegrini, G. Razzetti, S. Mantegazza
Process for the preparation of bosentan via reaction of (protected) 2-[5-(2-methoxyphenoxy)6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy]ethanol with 4-tert-butylbenzenesulfonamide.
From U.S. Pat. Appl. Publ. (2009), US 2009156811 A1 20090618.
VI Allegrini, P.; Naldini D.; Razzetti G.; Taddei, M.
Procedimento per la produzione di Ezetimibe
ITMI20072013 (A1)
VII M: Ruat, H. Faure, E. Traiffort, H. Roudaut, A. Mann, A. Schoenfelder, M. Taddei, F.
Manetti, A. Solinas
Preparation of acyl guanidine derivatives as inhibitors of the Hedgehog protein signalling
pathway for the treatment of cancer, neurodegenerative diseases and diabetes
PCT Int. Appl. (2011), WO 2011010013 A1 20110127.
VIII M. Taddei, E: Balducci, E. Attolino, S. Mantegazza, G. Dell’Anna
Process for the preparation of statins
Eur. Pat. Appl. (2011), EP 2383260 A2 20111102
IX M. Taddei, A. Russo, E. Cini, R. Riva, M. Rasparini, L.Carcone, L.Banfi, R. Vitale,
S.Roseblade, A.C. Zanotti-Gerosa.
Process for the production of aliskiren
Int Pat. Appl. WO 2011151442 A2 20111208
Monografie e capitoli su volume colettaneo.
1) C. Nativi, A. Ricci, M. Taddei
Stereocontrol by means of organosilanes. Some observations on the chemoselectivity,
stereoselectivity and enantioselectivity in allylsilane chemistry.
Frontiers of Organosilicon Chemistry, E. Bassindale Ed. Royal Soc Chem. Cambridge UK
1991, 332-343.
2) N. Gelsomini, L. Capella, E. Azzari, M. Taddei
Volatile phenol in wine: separation and determination by solid phase extraction and capillary
gas chromatography.
Inter. Symp. CGC XIII P. Sandra ed. Huetig, Brussel, 1991, 753.
3) M. Rodriquez, M. Taddei
Synthesis of Heterocycles via Microwave-Assisted Cycloadditions and Cyclocondensation
Topics in Heterocyclic Chem 2006, 1, 213-266, Springer Verlag Berlin Heidelberg 2006.
4) M. Taddei
Comparison amongs assisted synthetic methodologies for the preparation of antitumor
compounds
in “Seminars in Organic Synthesis” XXXI “A. Corbella Summer School” SCI Editor, ISBN
978-88-86208-50-5, 2007, pag 183.
5) M. Taddei
Bicyclic 5-6 Systems with One Bridgehead (Ring Junction) Nitrogen Atom: One Extra
Heteroatom 0:1.
In Comprehensive Heterocyclic Chemistry III, AR Katritzky, CA Ramsden, EFV Scriven and
RJK Taylor, Eds.; Elsevier: Oxford, 2008; Vol. 11, pp 501 - 550
6) A. Solinas, M. Taddei
Developments of new supported reagents for the synthesis of biologically active molecules.
in “New Methodologies and Techniques for a Suistainable Organic Chemistry”, A. Mordini
and F. Faigl Ed., Springer Science, 2008, pag 253-277 ISBN 978-1-4020-6791-4.
Articoli su riviste ISI con Impact Factor.
1) D. Pietropaolo, M. Fiorenza, A. Ricci, M. Taddei:
Base-catalyzed solvolysis of acylsuilanes.
J. Organomet. Chem. 1980, 197, 7-11.
2) R. Nesi, A. Ricci, M. Taddei, P. Tedeschi, G. Seconi :
Group IV B organometallic derivatives: synthesis and 13C NMR spectra of new silyl and
stannyl isoxazoles
J. Organomet. Chem. 1980, 195, 275-283.
3) A. Ricci, A. Degl’Innocenti, M. Fiorenza, M. Taddei, M.A. Spartera
Fluoride ion induced reactions of organosilanes with electrophiles
Tetrahedron Lett. 1982, 23, 577-578.
4) G. Seconi, M. Taddei, C. Eaborn, J. Stamper
The effectys of ortho substituents on the stability of the phenyl anion. The base cleavage of
aryltrimethylsilane
J. Chem. Soc. Perkin Trans. II 1982, 643-646.
5) R. Pepino, A. Ricci, M. Taddei, P. Tedeschi
Side-chain of heterocyclic derivatives: The synthesis of 3-methyl-5-trimethylsylil 1,2,4oxadiazole and the attempted synthesis of 3-methyl4-nitro-5-trimethylsilyl-isoxazole via
organolithium reagents.
J. Organomet. Chem. 1982, 231, 91.
6) F. Bernardi, A. Bottoni, M. Taddei
A quantitative analysis of the factors controlling the structure of AH3 and AH2 molecules
J. Mol. Structure THEOCHEM 1982, 90, 183-186.
7) M. Fiorenza, A. Ricci, M.N. Romanelli M. Taddei, P. Dembech, G. Seconi.
Regioselective functionalisation of the butenolide ring via group IV -B organometallics.
Heterocycles 1982, 19, 2327
8) M. Taddei, A. Papini, M. Fiorenza, A. Ricci, G. Seconi
Ring opening reactions of thiiranes with group IV B organometallics. A new regioselctive
route to β-amino and β-cyanide thiols.
Tetrahedron Lett. 1983, 24, 2311-2314.
9) A. Ricci, M. N. Romanelli, M. Taddei, G. Seconi, A.Shanzer
Ring-opening reactions of lactones with alkylaminostannanes. A new regioselective route to
o-stannoxyamides and related compounds.
Synthesis 1983, 319-322.
10) M. Fiorenza, A. Ricci, M. Taddei, D. Tassi, G. Seconi
Regiospecific conversion of oxiranes into primary alcohols via reactions with organotin
derivatives.
Synthesis 1983, 640-642.
11) M. Fiorenza, G. Reginato, A. Ricci, M. Taddei, P. Dembech
Regioselective functionalisazion of heterocyclic rings. Synthesis and reactions of 1-methyl-2(trimethylsiloxy)pyrrole and thiophene.
J. Org. Chem. 1984, 49, 551-553.
12) A. Papini, A. Ricci, M. Taddei, G. Seconi, P. Dembech
Regiospecific conversion of oxiranes, oxetanes and lactones into difunctional nitrogen
compounds via aminosilanes and aminostannanes
J. Chem. Soc. Perkin Trans I 1984, 2261-2264.
13) L. Lozzi, A. Ricci, M. Taddei
New development in heterocyclci silyl enol ether chemistry: synthesis and lewis acid
mediated reactions of carbon electrophiles of 2,2-bis-(trimethylsiloxy)thiophene and 1methyl-2,5-bis(trimethylsilyl)pyrrole
J. Org Chem. 1984, 49, 3408-3410.
14) S. Roelens, M. Taddei
Group 4 organometallic reagents. A 1H, 13C and 119Sn nuclear magnetic resonance study on
2,2-dibutyl-1,2,3-dioxastannolane structure in solution.
J. Chem. Soc. Perkin Trans II 1985, 799-804.
15) I. Fleming, M. Taddei.
A simple synthesis of 3-tributylstannylfuran and 3-lithiofuran.
Synthesis 1985, 898-899.
16) I. Fleming, M. Taddei
Simple syntheses of 2-silyl_&,3-butadienes
Synthesis 1985, 899-900.
17) M. Taddei, F. Tempesti
Aminosilanes in organic synthesis: preparation of N,N’-disubstituted putresceine derivatives.
Synthetic Commun. 1985, 15, 1019-1024.
18) A. Ricci, M. Taddei, G. Seconi
Trimethylstannyllithium mediated synthesis of 2, 3 and 4-trimethylstannylcyclohexanols
J. Organomet. Chem. 1986, 306, 23.
19) M. Taddei, A. Ricci
Electrophilic hydroxylation with bis(trimethylsylil)peroxide. A synthon for the hydroxyl
cation.
Synthesis 1986, 633-635.
20) A. Mordini, M. Taddei, G. Seconi
Preparion of b- and g-trialkylstannyl acohols and thiols by ring opening of oxiranes, oxetanes,
thiiranes and thiethanes with trimethylstannyllithium.
Gazz. Chim. Ital. 1986, 116, 239-242.
21) J. Wolff, M. Taddei
Some observations on the Brunner reaction
Tetrahedron 1986, 42, 4267-4272.
22) M. Taddei, A. Mann
Cycloaddition reactions of 2-tributylstannyl1,3-butadiene
Tetrahedron Lett. 1986, 27, 2913-2916.
23) L. Camici, A. Ricci, M. Taddei
Heterocyclic sylyl enol ethers chemistry: synthesis and reactivity of 3-trimethylsiloxy furan
and 3-trimethylsiloxythiophene.
Tetrahedron Lett. 1986, 27, 5155-5158.
24) C. Nativi, M. Taddei, A. Mann
A regioselective synthesis of 2-tributylstannyl-1,3-dienes.
Tetrahedron Lett. 1987, 28, 347-350.
25) L. Coppi, A. Ricci, M. Taddei
C-centered optically active organosilanes, 1. Synthesis of new silylated chiral auxiliaries.
Tetrahedron Lett. 1987, 28, 965-968.
26) L. Coppi, A. Mordini and M. Taddei
C-centered optically active organosilanes 2. Application to enantioselective allylation of
carbonyl compounds.
Tetrahedron Lett. 1987, 28, 969-972.
27) L. Coppi, A. Ricci, M. Taddei
Synthesis of 4-halopyrans from allylsilanes and carbonyl compounds in the presence of lewis
acids
Tetrahedron Lett. 1987, 28, 973-976.
28) C. Nativi, A. Ricci, M. Taddei
A simple synthesis of 1-trimethylsilyl-2-3-dienes.
Tetrahedron Lett. 1987, 28, 2751-2752.
29) C. Nativi, M. Taddei
Some observations on the stereochemical and regiochemical outcome of hydrostannylation of
substituted propargylic alcohols.
J. Org. Chem. 1988, 53, 820-826.
30) L. Coppi, A. Ricci, M. Taddei
Lewis acid mediated condensation of alkenols and aldehydes. A selctive synthesis of
tetrahydropyrans and oxepans.
J. Org. Chem. 1988, 53, 911-913.
31) G. Capozzi, S. Menichetti, A. Ricci, M. Taddei
A simple synthesis of hexamethyldistannane from bis(trimethylstannyl)sulphide.
J. Organomet. Chem. 1988, 344, 285-287.
32) A. Mann, C. Nativi, M. Taddei
Acetal-initiated cyclisation of allylsilanes to highly functionalised piperidine derivatives
Tetrahedron Lett. 1988, 29, 3247-3250.
33) L. Camici, P. Dembech, A. Ricci, G. Seconi, M. Taddei
Synthesis of trimethylsilyloxy and hydroxy compounds from carbanions and
bis(trimethylsilyl)peroxide.
Tetrahedron 1988, 44, 4197-4206.
34) A. Mordini, G. Palio, A. Ricci, M. Taddei
A simple regio-and stereocontrolled synthesis of a-branched allylsilanes
Tetrahedron Lett. 1988, 29, 4991-4994.
35) A. Mann, A. Ricci, M. Taddei
The reaction of allylsilanes with phenylthioacetals in the presence of aluminium trichloride
Tetrahedron Lett. 1988, 29, 6175-6176.
36) L. Capella, A. Degl’Innocenti, G. Reginato, A. Ricci, M. Taddei
Silylcupration mediated synthesis of 2-substituted allylamines.
J. Org. Chem. 1989, 54, 1473.
37) C. Nativi, M. Taddei, A. Mann
Stannyldiens, new tools for organic synthesis. Preparation and reactivity.
Tetrahedron 1989, 45, 1131-1144.
38) A. Ricci, M. Taddei, P. Dembech, A. Guerrini, G. Seconi
reactions of terminal alkynes with bis(trimethylsilyl)peroxide and zinc iodide: a convenient
method for the preparation of 1-iodo-alkynes.
Synthesis 1989, 461-463.
39) S. T. Nigam, A. Mann, M. Taddei, C-G. Wermuth
Selective removal of tert-butoxycarbonyl group from secondary amines: ZnBr2 as the
deprotecting reagent.
Synthetic Communic. 1989, 19, 3139-3142.
40) G. Capozzi, S. Menichetti, M. Nicastro, M. Taddei
Cyclisation using methyl(bismethylthio)sulphonium salts. Part 6. Synthesis of 2methylthiomethylated tetrahydropyrans.
Heterocycles 1989, 29, 1703-1708.
41) A. Ricci, G. Seconi, M. Taddei
Bioorganosilicon chemistry: trends and perspectivies.
Chimica Oggi, 1989, Sept, 15-28.
42) E. Azzari, C. Faggi, N. Gelsomini, M. Taddei
Allylsilanes derived from α- and β-ionone. Synthesis and unusual reactivity with
electrophiles.
Tetrahdron Lett. 1989, 30, 6067.
43) I. Jako, P. Uiber, A. Mann, M. Taddei, C-G Wermuth
Diastereoselectivity in conjugate addition of alkylcuprates to vinilogous ester of N-Odiprotected serinal.
Tetrahedron Lett. 1990, 31, 1011-1014.
44) E. Azzari, C. Faggi, N. Gelsomini, M. Taddei
Trasformation of α and β-ionones into α and β-damascone and β-damascenone using
allylsilanes chemistry
J. Org. Chem. 1990, 55, 1106-1108.
45) P. Dembech, A. Guerrini, A. Ricci, G. Seconi, M. Taddei
Trasformation of α-assisted carbanions into the corresponding trimethylsiloxy derivatives
using bis(trimethylsilyl) peroxide
Tetrahedron 1990, 46, 2999-3006.
46) C. Nativi, A. Ricci, M. Taddei
Synthesis of 4-(trimethylsilyl)- and 4-(tributylstannyl-2-azetdinones and some of their
applications to β-lactam chemistry.
Tetrahedron Lett. 1990, 31, 2637-2640.
47) C. Nativi, N. Ravidà, A. Ricci, G. Seconi, M. Taddei
C-centered optically active organosilanes. A rational approach to an efficient silylated chiral
auxyiiary
J. Org. Chem. 1991, 56, 1951-1956.
48) G. Capozzi, S. Menichetti, A. Ricci, M. Taddei
Direct stannylation of aromatic derivatives using bis(trimethylstannyl)sulphide and sodium.
Gazz. Chim. Ital. 1990, 120, 721-722.
49) C. Nativi, G. Palio, M. Taddei
Acyclic stereoselection in the reaction of chiral allylslanes with electrophiles.
Tetrahedron Lett. 1991, 32, 1583-1586.
50) C. Nativi, E. Perrotta, A. Ricci, M. Taddei
Synthetic approaches towards 4-(silylmethyl)2-azetidinones.
Tetrahedron Lett. 1991, 32, 2265-2268.
51) M. Franciotti, A. Mann, M. Taddei
Stereoselective vinylation of amino aldehydes using 2trimethylsilylidentriphenylphosphorane.
Tetrahedron Lett. 1991, 32, 6783-6786
52) M. Franciotti, A. Mordini, M. Taddei
Chiral allylsilanes derived from naturally occurring a-amino acids.
Synlett, 1992, 137-138
53) F. D’Aniello, M. Taddei
A stereoselective method for the rpeparation of HIV-1 protease inhibitors based on the lewis
acid mediated reaction of allylsilanes and N-boc-amino aldehydes.
J. Org. Chem. 1992, 57, 5247-5250.
54) F. D’Aniello, S. Gehanne, M. Taddei
A convenient approach to hydroxyethylene dipeptide isosteres using allylsilane chemistry.
Tetrahedron Lett. 1992, 33, 5621-5624.
55) M.Franciotti, A.Mann, A.Mordini, M.Taddei:
Allylsilanes derived from aminoacids in the synthesis of piperidine and pyrrolidine
derivatives
Tetrahedron Lett. 1993, 34, 1355
56) F.D'Aniello, D.Mattii, M.Taddei:
2(-Chloromethyl)-2-(trimethylsilyl)-1-propene: a convenient reagent for the synthesis of
methylentetrahydrofurans and methylenbutyrrolactones
Synlett 1993, 119.
57) M.Giammaruco, M.Taddei, P.Ulivi
A modification of the Hiyama reaction. Synthesis of homo allylic amines from imines and
allylic bromiders in presence of CrCl2
Tetrahedron Lett. 1993 34, 3653
58) S.leCoz, A.Mann, F.Thureau, M.Taddei
Synthesis of heliotridane and isoretronecanol via conjugate addition of organocuprates to an
enone derived from proline
Heterocycles, 1993, 2073.
59) M.Muller, A.Mann, M.Taddei.
A new method for the preparation of 2-amino-5-phosphonopentanoic acid.
Tetrahedron Lett.1993, 34, 3289.
60) S.Gehanne, M.Giammaruco, M.Taddei, P.Ulivi
Approaches to the synthesis of 2-sila-1-carba-cephalosporins
Tetrahedron Lett. 1994, 35, 2047.
61) P.Ciapetti, M.Taddei, P.Ulivi
Mediated allylation of N-protected amino aldehydes. A versatile synthesis of polypeptide
containing an hydroxyethylene isoster
Tetrahedron Lett. 1994, 35, 3183.
62) F.Corelli, A.Crescenza, D.Dei, M.Taddei, M.Botta
Cyclic dipeptides. A stereocontrolled synthesis of butoxycarbonylamino-3-methoxycarbonyl2-methyl-5-oxoperhydro-1,4-thiazepine
Tetrahedron Asymmetry 1994, 5, 1569.
63) F.D'Aniello, A.Mann, M.Taddei, C-G.Wermuth
1,3-Diastereocontrol with bromoallenes. Synthesis of enentiomerically pure β-branched αamino acids
Tetrahedron Lett. 1994, 35, 7775.
64) F. D'Aniello, A.Mann, D.Mattii, M.Taddei.
Stereoselective ene reaction of allylsilanes with amino aldehydes. An application to the
synthesis of potential HIV-1 protease inhybitors.
J.Org.Chem. 1994, 59, 3762
65) A.Lenzi, G.Reginato, M.Taddei :
Synthesis of N-Boc amino acids with nucleobase residue as building blocks for the
preparation of chiral PNA
Tetrahedron Lett. 1995, 36, 1713.
66) A.Lenzi, G.Reginato, M.Taddei, E.Trifilieff.
Solid phase synthesis of a self complementary (antiparallel) chiral peptidic nucleic acid strand
Tetrahedron Lett. 1995, 36, 1717.
67) M.Altamura, M.Giammaruco, M.Taddei, P.Ulivi
Free-radical cyclisation in the synthesis of 1-aza-5-silabicyclo[5.2.0]nonan-9-one a silicon
containing β-lactam
J. Org. Chem. 1995, 60, 8403.
68) A. Mann, L.Quaranta, G. Reginato, M.Taddei
A General synthesis of oligopeptides containing an oxirane ring in the place of a peptidic
bond
Tetrahedron Lett. 1996, 37, 2651
69) F.D'Aniello, M. Falorni, A. Mann, M. Taddei
Stereocontrolled synthesis of γ-branched amino acids. TiCl4 mediated addition of (E)crotylsilane to N O-protected serine aldehyde
Tetrahedron Asymmetry 1996, 4, 1217.
70) P. Ciapetti, M. Falorni and M. Taddei
CrCl2 Mediated Addition of Allylic Halides or Phosphates to N-Protected -Amino
Aldehydes. Stereocontrolled Synthesis of a New Core for C2 Symmetric HIV-Protease
Inhibitors
Tetrahedron (Symposia in Print: New Methodology in Organic Chemistry) 1996, 52, 7379.
71) F. D'Aniello, A. Mann and M. Taddei
1,3-Stereocontrol with bromoallenes. Synthesis of N-Boc-ADDA, the unique amino acid
present in several inhibitors of serine/threonine phosphatases.
J. Org. Chem. 1996, 61, 4870.
72) M.-R. Schneider, A. Mann, M. Taddei
Ring opening of phenylaziridines with allylsilanes
Tetrahedron Lett. 1996, 37, 8493.
73) M.Rohr, S.Chayer, F. Garrido, A. Mann, M.Taddei, C-G. Wermuth
Synthesis of 2-or/and 6-methylated analogues of isoguvacine, a GABAA angonist
Heterocycles, 1996, 43, 2131.
74) F.D'Aniello, A. Schoenfelder, A. Mann, M.Taddei
Stereospecific substitution of silylated bromoallenes with organocopper reagents
J. Org. Chem. 1996, 61, 9631.
75) P. Denbech, A. Ricci, G. Seconi, M. Taddei
Preparation of Bis-(trimethylsilyl) peroxide
Org. Syn. 1996, 74, 84.
76) P.Ciapetti, F.Soccolini, M.Taddei
Synthesis of N-Fmoc-α-amino acids carrying the four DNA nucleobases in the side chain
Tetrahedron, 1997, 53, 1167
77) F. D'Aniello, A. Mann, A. Shoenfelder, M. Taddei
Stereoconvergent synthesis of (2S,3S,8S,9S,4E,6E)N-Boc-ADDA starting from (S)-Serine
and (S)-Phenyllactic acid
Tetrahedron 1997, 53, 1447.
78) M. Falorni, G. Giacomelli, F. Nieddu, M. Taddei
A New Diketopiperazine tetra-Carboxylic Acid as Template for the Homogeneous Phase
Synthesis of Chemical Libraries
Tetrahedron Lett. 1997, 38, 4663.
79) P. Ciapetti, A. Mann, A. Shoenfelder, I. Canet, M. Taddei, E. Trifilieff,
Design and Synthesis of Chiral Peptidic Nucleic Acids (C-PNA)
Letters in Peptide Science (LIPS), 1997, 4, 1.
80) P. Ciapetti, A. Mann, M. Falorni, M. Taddei:
2-Amino-4-bromobutanoic acid. A versatile reagent for the synthesis of nonnatural amino
acids.
Molecules Online 1998, 2, 86-93
81) M. Taddei:
Synthesis of oligopeptides containing an oxirane ring in the place of a peptidic bond.
Methods in Molecular Biology, vol XX Peptidomimetics Protocol, W.M. Kazmiersky Ed.,
Humana Press, Totowa (USA), 1999, 189-207.
82) J. Szyrwiel, P.Mlynarz, H, Kozlowsi, M. Taddei:
Chiral peptidic nucleic acids. A new family of ligands for metal ions.
J. Chem. Soc. Dalton Comm. 1998 1263-1264.
83) P.Ciapetti, A.Mann, A. Shoenfelder, M.Taddei:
Nucleophilic substitution of protected 2-amino-4-bromobutanoic acid. An easy route to
exotic amino acids and conformationally contrained peptides.
Tetrahedron Lett. 1998,39, 3843-3846.
84) S.N Filigheddu, M.Taddei:
Small ring constrained peptidomimetics. Synthesis of parallel β-sheet mimetics
Tetrahedron Lett. 1998, 39, 3857-3860.
85) P. Ciapetti, M. Taddei:
A simple preparation of N-Vinyl derivatives of DNA nucleobases.
Tetrahedron 1998, 54, 11305-11310.
86) A.Esposito, M. Falorni, M. Taddei:
Synthesis of amphiphilic polyhydroxylated pyrrolidines as potential glycosidase inhibitors.
Tetrahedron Lett 1998 39, 6543-6546.
87) A. Esposito, M.G. Perino, M.Taddei:
Synthesis of Acyclic Carba-nucleoside Phosphonates, Structural Analogues to Natural
Deoxyribonucleotides
Eur. J. Org. Chem. 1999, 931-936.
88) M. Falorni, A. Porcheddu, M. Taddei
Mild reduction of carboxylic acids to alcohols using cyanuric chloride and sodium
borohydride
Tetrahedron Lett. 1999, 40, 4395-4396.
89) M. Demarcus, S. N. Filigheddu, A. Mann, M. Taddei:
Stereoselective addition of phenyl selenyl chloride to methoxy alkenes derived from Nprotected chiral α-amino acids
Tetrahedron Lett. 1999, 40, 4417-4420
90) A. Esposito, M. Taddei
Synthesis of new Acyclic Nucleoside Vinyl Phosphonates
Nucleos. Nucleot. 1999, 18, 985-986.
91) S.N. Filigheddu, S. Masala, M. Taddei
Solid phase synthesis of aziridine 2-carboxylates.
Tetrahedron Lett. 1999, 40, 6503-6506.
92) S. Masala, M. Taddei
Solid-supported chloro-(1,3,5)-triazine. A versatile new synthetic auxiliary for the synthesis
of amide libraries.
Org Lett. 1999, 1, 1355-1357.
93) M. Falorni, G. Giacomelli, A. Porcheddu, M. Taddei
A simple method for the reduction of carboxylic acids to aldehydes or alcohols using H2 and
Pd/C.
J. Org. Chem. 1999, 64, 8962-8964
94) M. Falorni, G. Giacomelli, A. Porcheddu, M. Taddei:
Solution phase synthesis of mixed amide libraries "via" simultaneous addition of
functionalities (SPSAF) to a diketopiperazine tetra-carboxylic acid scaffold monitored by GC
analysis of isobutanol.
Eur. J. Org. Chem, 2000, 1669-1675
95) A. Falchi, G. Giacomelli, A. Porcheddu, M. Taddei.
“4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl-morpholinium
chloride.
A
Valuable
Alternative to PyBOP for Solid Phase Peptide Synthesis”
Synlett 2000, 275-277.
96) J. Brasun, P. Ciapetti, H. Kozlowski, S. Oldziej, M. Taddei, D. Valensin, G. Valensin, N.
Gaggelli.
“Chiral Peptide nucleic acids having thymine and adenine in their side chain are specific
ligands for Ni(II) and Cu(II) ions"
J. Chem. Soc. Dalton Trans. 2000, 2639-2644.
97) M. E Attardi, G. Porcu, M. Taddei
“Malachite green; a valuable reagent to monitor the presence of free –COOH on solid phase”
Tetrahedron Lett, 2000, 41, 7391-7394.
98) M. E. Attardi, A. Falchi, M. Taddei
“A sensitive visual test for detection of –OH groups on resin.”
Tetrahedron Lett., 2000, 41, 7395-7399
99) A.Falchi, M. Taddei.
"PEG-dichlorotriazine (PEG-DCT): A New Soluble Polymer-Supported Scavenger for
Alcohols, Thiols, Phosphines, and Phosphine Oxides,"
Org. Lett. 2000, 2, 3429-3431.
100) A. Esposito, M. Taddei.
"The Kulinkovich reaction of Lactones. A convenient approach to functionalized
cyclopropanols"
J. Org. Chem. 2000, 65, 9245-9248.
101) M.M. Meloni, M. Taddei
"Solid-phase synthesis of β-lactams via the Miller hydroxamate approach"
Org. Lett. 2001, 3, 337-340.
102) M. Demarcus, M.L Ganadu, G.M. Mura, A. Porcheddu, L. Quaranta, G. Reginato, M.
Taddei
"Small ring constrained peptidomimetics. Synthesis of epoxy peptidomimetics inhybitors of
cysteine proteases"
J. Org. Chem. 2001, 66, 697-706.
103) L. De Luca, G. Giacomelli, G. Porcu, M. Taddei
"A new supported reagent for the photochemical generation of radicals in solution"
Org. Lett. 2001, 3, 855-857.
104) M.E. Attardi, M. Taddei
"Addendum to: A sensitive visual test for detection of –OH groups on resin."
Tetrahedron Lett, 2001, 42, 2927.
105) L. De Luca, G. Giacomelli, M. Taddei
"An easy and conveninet synthesis of Weinreb amides and hydroxamates."
J. Org. Chem. 2001, 66, 2534-2537.
107) M.E. Attardi, M. Taddei
"The Barton radical decarboxylation on solid phase. A versatile synthesis of peptides
containing modified amino acids.
Tetrahedron Lett, 2001, 42, 3519-3522.
108) J. Brasun, S. Oldziej, M. Taddei, H. Kozlowski: "Impact of Cu(II) and Ni(II) on the
structure of chiral peptide nucleic acids having four, six and eight thymines in a peptide side
chain.
Journal of Inorg. Biochem. 2001, 85, 79-87.
109) M.C. Daga, M. Taddei, G. Varchi: " Rapid microwave-assisted deprotection of N-Cbz
and N-Bn derivatives"
Tetrahedron Lett. 2001, 42, 5191.
110) A. Esposito, P. P. Piras, D. Ramazzotti, M. Taddei
First Stereocontrolled Synthesis of (S)-Cleonin and Related Cyclopropyl-Substituted Amino
Acids
Org. Lett. 2001, 3, 3273-3275.
111) G. Reginato, M. Taddei
Organometallic Chemistry on Solid-phase. An overview
Il Farmaco, 2002, 57, 373-384.
112) G. Giacomelli, A. Porcheddu, M. Salaris, M. Taddei
Microwaves-Assisted solution synthesis of 1,4,5-trisubstituted pyrazoles
Eur. J. Org. Chem. 2003, 537-541.
113) A. Porcheddu, G.F.Ruda, A. Sega, M. Taddei
A new rapid general protocol for the synthesis of organic molecules supported on
methoxypolyethylen glycol (MeOPEG) under microwaves.
Eur. J. Org. Chem. 2003, 907-912.
114) G. Dessole, M. Marchetti, M. Taddei
Hydroformylation of terminal alkenes supported on Solid Phase. Synthetic tools for
combinatorial chemistry.
J. Comb. Chem. 2003, 5, 198-200
115) D. Conti, M. Rodriquez, A. Sega, M: Taddei
1,3-Cycloaddition of nitrile oxides in ionic liquids. An easier route to 3-carboxy isoxazolines,
potential constrained glutamic acid analogues
Tetrahedron Lett. 2003, 44, 5327-5330.
116) L. De Luca, G: Giacomelli, A. Porcheddu, M. Salaris, M. Taddei
Cellulose beads: a new versatile solid support for microwave-assisted synthesis. Preparation
of pyrazole and isoxazole libraries.
J. Comb. Chem. 2003, 5, 465-468.
117) L.R.Lampariello, D. Piras, M. Rodriquez, M. Taddei
Solid-phase synthesis of conformationally constrained peptidomimetics based on a 3,6disubstituted 1,4-diazepan-2,5-dione core.
J. Org. Chem. 2003, 68, 7893-7895.
118) L. De Luca, G. Giacomelli, A. Porcheddu, M. Salaris M. Taddei
Preparation of pyrazole and isoxazole libraries on cellulose beads: a new cheap and versatile
biopolymer.
Comptes Rendus Chimie, 2003, 6, 607-611
119) M. Rodriquez, A. Sega and M. Taddei
Ionic liquid as suitable phase for multistep parallel synthesis of an array of isoxazolines
Org. Lett. 2003, 5, 4029-4031.
120) M. Marchetti, C. Botteghi, S. Paganelli, M. Taddei
Solid-Liquid Biphasic Hydroformylation of Olefins Catalyzed by Rhodium Carbonyl
Complexes.
Adv. Synthesis & Catalysis 2003, 345, 1229-1236.
121) G. Minetto, L. F. Raveglia, M. Taddei
Microwave assisted Paal-Knorr reaction. A rapid approach to polysusbstituted furans and
pyrroles.
Org. Lett. 2004, 6, 389-392.
122) F. Gaggini, A. Porcheddu, G. Reginato, M. Rodriquez, M. Taddei
Colorimetric tools for solid–phase organic synthesis
J. Comb. Chem. 2004, 6, 805.
123) D. Donati, C. Morelli, A. Porcheddu, M. Taddei
A new polymer supported reagent for the synthesis of beta-lactams in solution
J. Org. Chem. 2004, 69, 9316-9318
124) M. Rodriquez, M. Taddei
A simple procedure for the transformation of L- Glutamic acid into the corresponding galdehyde
Synthesis (PSP), 2005, 493-496.
125) C. Ghiron, L. Nannetti and M. Taddei
Alkene epoxidation with urea-hydrogen peroxide complex and PS-DVB supported phthalic
anhydride
Tetrahedron Lett, 2005, 46, 1643-1645
126) D. Donati, C. Morelli, M. Taddei
Rapid microwave-assisted esterification utilizing the Mukaiyama supported reagent
Tetrahedron Lett., 2005, 46, 2817-2819.
127) L.R. Lampariello, D. Peruzzi, A. Sega, M. Taddei
Some observations on the preparation of amides and their reduction to amines in Ionic
Liquids
Lett. Org. Chem. 2005, 2, 136-138.
128) M. Rodriquez, C. Bassarello, G. Bifulco, L. Gomez-Paloma, A. Mann, M. Marchetti, M.
Taddei
Synthesis of Kainoids via a highly stereoselective hydroformylation of kainik acid.
Synlett, 2005, 1581-1585.
129) M. Alongi, G. Minetto, M. Taddei
New Pyrrole-based amino acids for the synthesis of peptidomimetic constrained scaffolds
Tetrahedron Lett, 2005, 46, 7069-7072.
130) G. Minetto, L. R. Lampariello, M. Taddei
Microwave-assisted synthesis of polysubstituted pyridazines
Synlett 2005, 2743-2746.
131) F. Cardullo, D. Donati, G. Merlo, A. Paio, M. Salaris, M. Taddei.
Deprotection of o-Nitrobenzensulfonyl (Nosyl) Derivatives of Amines Mediated by a Solid
Supported Thiol.
Synlett 2005, 2996-2998
132) G, Minetto, L. Raveglia, A. Sega, M. Taddei,
“ Microwave Assisted Paal-Knorr Reaction. Three step Regiocontrolled Synthesis of
Polysubstituted Furans, Pyrroles and Thiophenes”
Eur. J. Org. Chem., 2005, 5277-5288
133) M. Rodriquez, I.Bruno, E. Cini, M. Marchetti, M. Taddei, L. Gomez-Paloma
“Synthesis of 2-amino-8-oxadecanoic acids (Aodas) present in natural hystone deacetylase
inhybitors”
J. Org. Chem. 2006, 71, 103-107
134) M. Rodriquez, S. Terracciano, E. Cini, G: Settembrini, I. Bruno, G. Bifulco, M. Taddei,
L. Gomez-Paloma
Total Synthesis, NMR Solution Structure, and Binding Model of the Potent Histone
Deacetylase Inhibitor FR235222
Angew. Chem. Int. Ed. Engl. 2006, 45, 423-427
135) M. Rodriquez, M. Aquino, I. Bruno, G. De Martino, M. Taddei, L. Gomez-Paloma
Chemistry and Biology of Chromatin Remodeling Agents: State of Art and Future
Perspectives of HDAC Inhibitors.
Curr. Med. Chem. 2006, 13, 1119-1139
136) I. Bianchi, R. Forlani, G Minetto, I. Peretto, N. Regalia, M. Taddei, L. Raveglia
Solution Phase Synthesis of a Library of Tetrasubstituted Pyrrole Amides
J. Comb. Chem. 2006, 8, 491-499
137) E. Petricci, A. Mann, A. Rota, A. Schoenfelder, M. Taddei
Microwaves make hydroformilation a rapid and easy process
Org. Lett. 2006, 8, 3725-3727
138) F. Cardullo, D. Donati, V. Fusillo, G. Merlo, A. Paio, M. Salarisi, A. Solinas, M. Taddei,
Parallel protocol for the selective alkylation of primary amines.
J. Comb. Chem. 2006, 8, 834.
139) S. Ferrini, F. Ponticelli, M. Taddei
Rapid approach to 3,5-disubstituted 1,4-benzodiazepine via the photo-Fries rearrangment of
anilides
J. Org. Chem. 2006, 71, 9217.
140) S. Ferrini, F. Ponticelli, M. Taddei
Convenient synthetic approach to 2,4-disubstituted quinazolines
Org. Lett. 2007, 9, 69-72.
141) E. Petricci, M. Taddei
Microwave assisted reaction with gas reagents
Chimica Oggi 2007, 25 (3) 45-49.
142) A. Solinas, M. Taddei
Solid-supported reagents and catch-and-release techniques in organic synthesis
Synthesis (Review) 2007, 2409-2453.
143) L. Gomez-Paloma, I. Bruno, E. Cini, S. Khochbin, M. Rodriquez, M. Taddei, S.
Terracciano, K. Sadoul
Design and Synthesis of Cyclopeptide Analogues of the Potent Histone Deacetylase Inhibitor
FR235222
ChemMedChem 2007, 2, 1511-1519.
144) E. Petricci. A. Mann, J. Salvadori, M. Taddei
Microwave assisted hydroaminomethyaltion of alkenes.
Tetrahedron Lett. 2007, 48, 8501-8504.
145) A. Massaro, A. Mordini, G. Reginato, F. Russo, M. Taddei
Microwave-assisted transformation of esters into hydroxamic acids.
Synthesis 2007, 3201-3204.
146) L. Piras, C. Ghiron, G. Minetto, M. Taddei
Microwave-assisted synthesis of tetrahydroindoles
Tetrahedron Lett. 2008, 49, 459-462.
147) A. Petrella, C.W. D’Acunto, M. Rodriquez, M. Festa, A. Tosco, I. Bruno, S.
Terracciano, M. Taddei, L. Gomez-Paloma
Effects of FR235222, a novel HDAC inhibirtor, in proliferation and apotosis of human
leukemia cell lines: Role od annexin A1
Eur. J. Cancer, 2008, 44, 740-749.
148) L. Piras, E. Genesio, C. Ghiron, M. Taddei
Microwave-assisted hydrogenation of pyridines
Synlett 2008, 1125-1128.
149) L. Piras, E. Genesio, C. Ghiron, M. Taddei
Scaffold preparation and parallel synthesis of arrays of 5,6,7,8-tetrahydropyrrolo-azepinones
in the solution phase
Eur. J. Org. Chem. 2008, 2789-2797
150) S. Di Micco, S. Terracciano, I. Bruno, M. Rodriquez, R. Riccio, M. Taddei, G. Bifulco
Molecular modeling studies toward the structural optimization of new cyclopeptide-based
HDAC inhibitors modeled on the natural product FR235222
Bioorg & Med. Chem. 2008, 16, 8635-8642
151) E. Airiau, T. Spangenberger, N. Girard, A. Schoenfelder, J. Salvadori, M. Taddei, A.
Mann
A General approach to aza-heterocycles by means of domino sequences driven by
hydroformylation
Chemistry Eur. J. 2008, 14, 10938-10948.
152) F. Cardullo, D. Donati, G. Merlo, A. Paio, E. Petricci, M. Taddei
Microwave-assisted aminocabonylation of aryl bromides at low carbon monoxide pressure.
Synlett 2009, 47-50.
153) E. Cini, L.R. Lampariello, M. Rodriquez, M. Taddei
Synthesis and application in SPPS of a stable amino acid isostere of palmitoyl cysteine.
Tetrahedron 2009, 65, 844-848.
154) E. Balducci, L: Bellucci, E. Petricci, M. Taddei, A. Tafi
Microwave-Assisted Intramolecular Huisgen Cycloaddition of Azido Alkynes Derived from
α-Amino Acids
J. Org. Chem. 2009, 74, 1314-1321.
155) M. Irfan, E. Petricci, T. N. Glasnov, M. Taddei, C. O. Kappe
Continuous Flow Hydrogenation of Functionalized Pyridines
Eur. J. Org. Chem. 2009, 1327-1334.
156) E. Cini, G. Giorgi, M. Rodriquez, M. Taddei
Transformation
of
Glutamic
Acid
into
(S)-Benzyl
2-(dibenzylamino)-
(dimethoxyphosphoryl)-5-oxohexanoate for a Convenient Access to 5-Substituted Prolines.
Synlett, 2009, 1562-1566
157) E. Cini, C. B. Botta, M. Rodriquez, M. Taddei
Microwaves enhance cyclisation of tetrapeptides
Tetrahedron Lett, 2009, 50, 7159-7161.
158) E. Airiau, N. Girard, A. Mann, J. Salvadori, M. Taddei
Four-Component Reactions toward Fused Heterocyclic Rings
6-
Org. Lett. 2009, 11, 5314-5317.
159) S. Forte, J. Polak, D.Valensin, M.Taddei, R. Basosi, S. Vanhulle, A. Jarosz-Wilkolazka,
R. Pogni
Synthesis and structural characterization of a novel phenoxazinone dye by use of a fungal
laccase
J. Mol. Catalysis B: Enzymatic, 2010, 63, 116–120
160) J. Salvadori, E. Balducci, S. Zaza, E. Petricci, M. Taddei
Microwave-Assisted Carbonylation and Cyclocarbonylation of Aryl Iodides under Ligand
Free Heterogeneous Catalysis
J. Org. Chem. 2010, 75, 1841-1847.
161) J Salvadori, E. Airiau, N. Girard, A. Mann, M. Taddei
Rhodium-catalyzed multicomponent synthesis of chiral oxazolopiperidines
Tetrahedron, 2010, 66, 3749-3753
162) C.W. D’Acunto, B. Fontanella, M. Rodriquez, M. Taddei, L. Parente, A. Petrella
Histone deacetylase inhibitor FR235222 sensitizes human prostate adenocarcinoma cells to
apoptosis through up-regulation of Annexin A1.
Cancer Lett. 2010, 295, 85-91.
163) C.W. D’Acunto, A. Carratù, M. Rodriquez, M. Taddei, L. Parente, A. Petrella
LGP1, A Histone Deacetylase Inhibitor Analogue of FR235222, Sensitizes Promyelocytic
Leukaemia U937 Cells to TRAIL-mediated Apoptosis
Anticancer Res., 2010, 30, 887-894
164) E. Airiau, C. Chemin, N. Girard, G. Lonzi, A. Mann, E. Petricci, J. Salvadori, M. Taddei
Microwave assisted domino hydroformylation cyclization reactions. Scope and limitations
Synthesis, 2010, 2901-2914.
165) F. Manetti, H. Faure, H. Roudaut, T. Gorojankina, E. Traiffort, A. Schoenfelder, A.
Mann, A. Solinas, M. Taddei, M. Ruat
“Virtual Screening-Based Discovery and Mechanistic Characterization of the Acylthiourea
MRT-10 Family as Smoothened Antagonists”
Mol. Pharmacol., 2010, 78, 658-665.
166) E. Airiau, N. Girard, M. Pizzetti, J. Salvadori, M. Taddei, A. Mann
Hydroformylation
of
Alkenylamines:
Concise
Approaches
toward
Piperidines,
Quinolizidines, and Related Alkaloids.
J. Org. Chem. 2010, 75, 8670-8673.
167) E. Balducci, E. Attolino, M. Taddei
A Stereoselective and Practical Synthesis of (E)-α,β-Unsaturated Ketones from Aldehydes
Eur. J. Org. Chem., 2011, 311-318.
168) E. Cini, E. Airiau, N. Girard, A. Mann, J. Salvadori, M. Taddei
Microwave assisted hydroformylation without syngas
Synlett 2011, 199-204.
169) H. Roudaut, E. Traiffort, T. Gorojankina, L. Vincent, H. Faure, A. Schoenfelder, A.
Mann, F. Manetti, A. Solinas, M. Taddei M. Ruat
Identification and Mechanism of Action of the Acylguanidine MRT-83, a Novel Potent
Smoothened Antagonist
Mol. Pharmacol. 2011, 79, 453-460.
170) C. B. Botta, W. Cabri, E. Cini, L. De Cesare, C. Fattorusso, G. Giannini, M. Persico, A.
Petrella, F. Rondinelli, M. Rodriquez, A. Russo, M. Taddei
Oxime Amides as a Novel Zinc Binding Group in Histone Deacetylase Inhibitors: Synthesis,
Biological Activity, and Computational Evaluation
J. Med. Chem. 2011, 54, 2165-2182.
171) G. Arena, N. Zill, J. Salvadori, N. Girard, A. Mann, M. Taddei
Cyclohydrocarbonylation-based strategy toward poly- susbtituted piperidines
Org. Lett. 2011, 13, 2294-2297.
172) G. Guerrini, M. Taddei, F. Ponticelli
Synthesis of Functionalized Quinolines and Benzo[c][2,7]naphthyridines Based on a PhotoFries Rearrangement
J. Org. Chem. 2011, 76, 7597–7601
173) A. Solinas, H. Faure, H. Roudaut, E. Traiffort, A. Schoenfelder, A. Mann, F. Manetti, M.
Taddei, . M. Ruat
Acylthiourea, Acylurea, and Acylguanidine Derivatives with Potent Hedgehog Inhibiting
Activity
J. Med. Chem. 2012, 55, 1559-1571.
174) N. Zill, A. Schoenfelder, N. Girard, M. Taddei, A. Mann
Stereoselective multicomponent assembly of enantiopure oxazolopiperidines and –azepines
J. Org. Chem. 2012, 77, 2246-2253.