Organizing committee: Scientific committee: Prof. Pietro Matricardi Prof. Ida Genta Dr. Rossella Dorati Dr. Barbara Colzani Dr. Giuseppe Tripodo Prof. Paolo Caliceti Prof. Bice Conti Prof. Elias Fattal Prof. Gennara Cavallaro Dr. Giuseppe De Rosa CRS workshop 21st-23rd November 2013 Design and Industrial Development of Advanced Drug Delivery Systems Invited speakers: Prof. Piero Baglioni, University of Florence, Italy - Invited lecture: Monitoring the Interaction of Nucleolipoplexes with Model Membranes Prof. Kevin Breackmans, University of Ghent, Belgium - Invited lecture: Studying nanomedicine biobarriers by advanced fluorescence microscopy methods Prof. Alberto A. Gabizon, The Hebrew University of Jerusalem, Israel Invited lecture: Liposomes in Cancer Drug Delivery: Improvements and Challenges Prof. Wim Hennink, University of Utrecht, Netherland - Invited lecture: Polymeric Nanoparticles for Targeted Drug Delivery Prof. Felix Kratz, University of Freiburg, Germany - Invited lecture: Albumin-based Drug Delivery Systems in Oncology Prof. Moein Moghimi, University of Copenhagen, Denmark - Invited lecture: Acute infusion-related adverse reactions to particulate and polymer medicines: structural causes and pathophysiological modulators Prof. Helder Santos, University of Helsinki, Finland - Invited lecture: Porous Silicon Nanomaterials to Revolutionize Drug Targeting and Delivery Prof. Paolo Decuzzi, The Methodist Hospital Research Institute, Houston, Texas USA - Invited lecture: Shifting the ‘100 nm paradigm’: an early Saturday morning discussion 2 CRS workshop 21st-23rd November 2013 Design and Industrial Development of Advanced Drug Delivery Systems November 21st, Thursday afternoon 2.00 - 2.30 pm - Symposium opening, Aula Scarpa, University of Pavia Chairmen: Prof. I. Genta, Dr. B. Ruozi 2.30 - 3.20 pm - Felix Kratz, University of Freiburg, Germany - Invited lecture: Albumin-based Drug Delivery Systems in Oncology 3.20 - 4.10 pm - Alberto A. Gabizon, The Hebrew University of Jerusalem, Israel - Invited lecture: Liposomes in Cancer Drug Delivery: Improvements and Challenges 4.10 - 4.40 pm coffee break, University of Pavia Discussant panel: Prof. W. Hennink, Prof. M. Moghimi, Prof. B.Sarmento 4.40 - 5.25 pm - Barbara Stella, University of Turin, Italy: Squalenoyl nanoassemblies: past and future 5.30 - 6.15 pm - Emanuela Fabiola Craparo, University of Palermo, Italy: Polymer-based therapeutics for the treatment of liver diseases 6.20 - 7.30 pm - Poster and Sponsor presentations 8.00 pm - Welcome Cocktail, Il Caffé all’Università, University of Pavia 3 CRS workshop 21st-23rd November 2013 Design and Industrial Development of Advanced Drug Delivery Systems November 22nd, Friday morning Aula Scarpa, University of Pavia Chairmen: Dr. G. De Rosa, Prof. R. Cavalli 9.00 - 9.50 am - Prof. Wim Hennink, University of Utrecht, Netherland Invited lecture: Polymeric Nanoparticles for targeted drug delivery 9.55 - 10.45 am - Prof. Kevin Breackmans, University of Ghent, Belgium Invited lecture: Studying nanomedicine biobarriers by advanced fluorescence microscopy methods 10.45 - 11.10 am Coffee Break, University of Pavia Discussant panel: Prof. A. Gabizon, Prof. P. Decuzzi, Prof. F.Kratz 11.10 - 11.55 am - Pietro Matricardi, University of Rome, Italy: Nanohydrogels based on modified-polysaccharides for drug delivery applications 12.00 am - 12.45 pm - Stefano Salmaso, University of Padua, Italy: Development of pH responsive and multimodal targeted liposomes for drug and protein delivery to cancer tissues 12.50 - 1.30 pm - Sponsor presentation 1.30 - 2.30 pm Poster session 4 CRS workshop 21st-23rd November 2013 Design and Industrial Development of Advanced Drug Delivery Systems November 22nd, Friday afternoon Aula Scarpa, University of Pavia Chairmen: Prof. A. Gazzaniga, Prof. G. Cavallaro 2.30 - 3.20 pm - Prof. Piero Baglioni, University of Florence, Italy – Invited lecture: Monitoring the Interaction of Nucleolipoplexes with Model Membranes 3.20 - 4.10 pm - Prof. Moein Moghimi, University of Copenhagen, Denmark – Invited lecture: Acute infusion-related adverse reactions to particulate and polymer medicines: structural causes and pathophysiological modulators 4.10 - 4.40 pm Coffee Break, University of Pavia Discussant panel: Prof. H.Santos, Prof. P. Baglioni, Dr. P. Bigini 4.40 - 5.25 pm - Giovanni Tosi, University of Modena Reggio Emilia, Italy: Nanomedicine for Central Nervous System: polymeric nanoparticles for therapeutic strategies in neurological disorders 5.25 - 6.15 pm - Gianfranco Pasut, University of Padova, Italy: The use of transglutaminase for enzymatic polymer conjugation 6.20 - 7.30 pm - Poster and Sponsor presentations 5 CRS workshop 21st-23rd November 2013 Design and Industrial Development of Advanced Drug Delivery Systems November 23rd, Saturday morning Aula Scarpa, University of Pavia Chairmen: Dr. P. Blasi, Dr. R. Dorati 9.00 - 9.50 am - Paolo Decuzzi, The Methodist Hospital Research Institute, Houston, Texas USA - Invited lecture: Shifting the ‘100 nm paradigm’: an early Saturday morning discussion 9.55 - 10.45 am - Helder Santos, University of Helsinki, Finland - Invited lecture: Porous Silicon Nanomaterials to Revolutionize Drug Targeting and Delivery 10.45 - 11.00 am Coffee Break, University of Pavia Discussant panel: Prof. K.Breackmans, Prof. B.Sarmento, Dr. A. Maiocchi 11.00 – 11.45 am - Giuseppina Sandri, University of Pavia, Italy: Chitosan/montmorillonite nanocomposites for drug delivery: opportunities and challenges 11.50 am - 12.35 pm - Mario Grassi, University of Trieste, Italy: Product Development: economical and strategical considerations 12.35 – 12:55 pm – Alessandra Rossi, University of Parma, Italy: In vitro and in vivo release of two drug’s combination from multi-kinetics three layer 12.55 - 13.10 pm - Paolo Bigini, Mario Negri Institute Pharmacological Research, Italy: Multimodal imaging nanopharmacology: from sub-cellular organelles to the whole organisms for in Concluding remarks 6