“From Molecular Structure to Systems Biology”
Convegno Nazionale della Divisione di Chimica dei Sistemi Biologici
della Società Chimica Italiana
San Vito di Cadore – 9-11 September 2010
PRELIMINARY TIME TABLE
Thursday, 9th September 2010 – Morning Session
Chairmen: G. Colombo, Milano (Italy) and M. Coletta, Roma (Italy)
Computational Biology
8:30-9:30
Registration
9:30-9:40
Opening. Greetings from authorities
9:40-10:20
M. Olivucci, Siena (Italy): Towards a Computational Photobiology
10:20-10:40
D. Piovesan, Bologna (Italy): Protein structure prediction in the genomic era:
annotation-facilitated remote homology detection
Coffee break
10:40-11:10
11:10-11:50
11:50-12:10
12:10-12:30
12:30-14:30
R. Casadio, Bologna (Italy): Trans-linking the protein-protein interactome at the
cell level
G. Morra, Milano (Italy): Structural dynamics and allosteric inhibition of the
chaperone protein Hsp90
A. Genoni, Milano (Italy): Unraveling the resistance shown by the Subtype B /
HIV-1 Protease to currently known inhibitors by means of computational
studies
Lunch
Thursday, 9th September 2010 – Afternoon Session
Chairmen: M. Fasano, Varese (Italy) and C. Isernia, Caserta (Italy)
14:30-15:10
15:10-15:50
15:50-16:10
16:10-16:40
16:40-17:20
17:20-18:00
18:00-19:30
Molecular basis of diseases
G. Superti-Furga, Vienna (Austria): Molecular Networks and the Mechanism of
Action of Drugs
G. Legname, Trieste (Italy): Prion Biology and Disease
G. R. Tundo, Roma (Italy): Somatostatin Modulates Insulin-Degrading-Enzyme
Metabolism: Implication For Alzheimer’s Disease Pathogenesis
Coffee Break
F. Chiti, Firenze (Italy): Identification of the molecular determinants of amyloid
fibril formation in vivo
F. Cantini, Firenze (Italy): Molecular basis of Human diseases: an NMR view
Premio De Santis
Poster Session
Friday, 10th September 2010 – Morning Session
Chairmen: E. Peggion, Padova (Italy) and R. Fattorusso, Napoli (Italy)
Structure and Function of biomolecules I
9:00-9:40
H. Monaco, Verona (Italy): The intriguing role of SOUL protein
9:40-10:00
10:00-10:40
10:40-11:10
11:10-12:00
12:00-12:40
12:40-14:50
D. Montesarchio, Napoli (Italy): CyPLOS, a new family of synthetic ion
transporters
F. Formaggio, Padova (Italy): 2D IR spectroscopy of oligopeptides
conformationally restrained by Cα,α-dialkylated α-amino acid residues
Coffee break
A. Yonath, Rehovot (Israel): The amazing ribosome, its tiny enemies and hints
about its origin
L. Stella, Roma (Italy): Different mechanisms of action of antimicrobial peptides:
insights from fluorescence spectroscopy experiments and molecular dynamics
simulations
Lunch
Friday, 10th September 2010 – Afternoon Session
Chairmen: H. Molinari, Verona (Italy) and R. Purrello, Catania (Italy)
Structure and Function of biomolecules II
14:50-15:10 M. D'Onofrio, Verona (Italy): An NMR study on human Liver FABP as carrier
for MRI contrast agents
15:10-15:30 G. Ponterini, Modena (Italy): Physico-chemical tools in anticancer drug research:
targeting human Thymidylate synthase with synthetic octapeptides
15:30-15:50 M. De Zotti, Padova (Italy): Synthesis, Conformation, and Bioactivity of
Integramide A, a Peptide Inhibitor of HIV-1 Integrase, and Selected Analogs
15:50-16:10 F. Bellia, Catania (Italy): New carnosine derivatives and analogs: synthesis,
carnosinase resistance and characterization of their copper(II) complexes
16:10-16:40 Coffee Break
16:40-17:20
Systems Biology and Chemistry
G. Von Kiedrowski: Systems Chemistry: Replicators and Assemblers
17:20-17:40
R. Di Stasi, Napoli (Italy): Helical peptide as VEGF antagonist
17:40-18:00
18:00-19:00
A. D'Urso, Catania (Italy): Z-DNA recognition in B-Z-B sequences by a cationic
zinc porphyrin
Division Meeting
19:00-19:30
Concert by "San Vito" Choir
20:00
Social Dinner (Borca di Cadore, 4Km from San Vito)
Saturday, 11th September 2010
Chairmen: G. Fossati, Milano (Italy) and A. Rosato, Firenze (Italy)
9:00-9:40
9:40-10:00
10:00-10:20
10:20-10:40
10:40-11:10
11:10-11:50
Macromolecular interactions
M. Bolognesi, Milano (Italy): NF-Y, a sequence-specific histone-like trimer in
complex with the CCAAT box
B. Pagano, Salerno (Italy): Calorimetric approach to the study of quadruplexbinding agents
M. Leone, Napoli (Italy): NMR studies of heterotypic Sam-Sam domain
interactions
A. Bordogna, Milano (Italy): ZADDOCK: incorporating ab initio search into
HADDOCK
Coffee break
12:10-12:20
M. Assfalg, Verona (Italy): Structural plasticity and binding cooperativity make
liver fatty acid binding proteins ideal chaperones of lipids and lipidfunctionalized drugs
B. Mannini, Firenze (Italy): Suppression of protein oligomer toxicity by molecular
chaperones and insight into the molecular mechanism of such suppression
Final Remarks
12:20
Meeting closure
12:25
Bus transfer departure for Venice Airport – "Ve-Mestre" Train station.
11:50-12:10