Isolation, structure elucidation and total synthesis of a cytotoxic dienone from Echinacea pallida Stefania Morandia,b, Federica Pellati*a, Claudia Orib, Barbara Adinolfic, Paola Nieric, Stefania Benvenutia, Fabio Prati*b Supplementary Information Page 1 Page 2 Page 3 Page 4 Page 5 Page 6 1 H NMR of the natural compound 10 C NMR of the natural compound 10 1 H NMR of the synthetic compound 10a 13 C NMR of the synthetic compound 10a 1 H NMR of the synthetic compound 10b 13 C NMR of the synthetic compound 10b 13 Supplementary Material (ESI) for Organic & Biomolecular Chemistry This journal is (c) The Royal Society of Chemistry 2008 Natural Compound 10 O 1 Natural Compound 10 O 2 Synthetic Compound 10a O 3 Synthetic Compound 10a O 4 Synthetic Compound 10b O 5 Synthetic Compound 10b O 6