Î.Ï Ð 1st MGMC W orkshop on New Perspectives in Drug Research !#"%$&('*)+-,/.103254(687:9;=<:>!?A@CBEDFGIHKJ/H1LNMPOEQ R S TU V WYXZ%X[5\/]EW_^`-a%bcdfehg5ih\fjkX]lW=X1\/`-Zb^md!X5e8ZnWo`1[5\/]EWoe p3qsrtvu wyxzus{}|!p~-{}u |{u N :z s%Y s% yI v %¢¡¤£ ¥¤§¦ K ¨}%%©:¡¡ s%ª-% £s syn«y s¬ ®¯ °±±²²%³´µ¶·¸º¹¼»y½¾¸¿ À=Á%¶·Â}Ãs¸·ÃÄÅ·ÃsÁ%´ÆÇý ÈÊÉÌ˧Í-ÎÍÏËÊÐsÉ}ÑÓÒ3ÍÔÕ}Ö-ÉÐ ÏËÐ ÔCÐsÉ ×Ø ÙÚÛÜ×ÝØsÞÛvß*ÛàÚ}áãâØsÞ}ä¤ØsÞ}ÙÓå3ßäáPåfæç ÛàØsèç Ø éØ ÛÜêmëÛYÛàÚ}áãì í îï ð ñòóºòôõ§öñ÷ø ù3ú-ù%û}ú-üýþÿ }ú ý ý (þ-ù Pýþ "! #$&%'($$() *,+.-0/2143*6587 9:<;>=;:8? @; =BADC>9 EF(G HI<GEKJ LNMOMPMO QRDJ RSH TUEFI<G GVR0GI8J G(RWH TXI<G LNGYZEH[I\O J ]MP(^R_(M R0G ^`H[PEKFGaMIbQOYJYGI<M cZJPGedgfhJPh(LOJ ^JP(G ij(k lm<no(pq(rstlm8u(vwlum<r s x y<z { |~}(N ( (0 B < wS( ( < w}(b( N<}( V( w}(K} ( ( t( Z [ t8 ¡¢¡£¤<¥S ¦ §¡¤¨K©(£&(£ Z ª£¦ §¬«(©(¤<£ ¥( «Z K©(£§¬«©(N£¬( N®¯°Z±8²³8´ ®°(µ ¶¸·.°¹º t±4» ¼[¯(²V±8®`±½(²V±8®¾(®¿[³<º¾½ZÀ`®¹ ÁÂ(ÃÄÅDÁÃÆbÇÈ É0Ã`ÉÆ<ÃÊÄ ÉNÃË Ì ÍÎ(Ï`ÐNÑÍKÒ ÓÔÒ ÐaÎ(Ï Ñ ÕÓ Ö~ÍKÎÏ ×Ø ÙÚÛ(ÜÝWÞWØ ÙßZàUÙØ á âäãå8Ø ÙØÛ¨àãæÚVå<âÝtãÛ(ÚÛZàUÜ çÛÚÞØ èäØÛZà8âå<Ú èàKØ ã[ÛäéSØ àßSà8éêãÙ[×ëZàÚÞSÚà8âVå<â(ÝØ Üë(â Ý(ì í~î(ïð0ñòóô ïõö ÷¢øùñ ú÷î(ïüûýþ(ÿý þ ÿ[ý ÿý ÿ ý ¬ýþ ýþSý ýþ ý ÿ!þ"# $%$&' $() *,+.-0/213*547698;:=<>?#>@ AB C.D E FGIH JG,KGLF KMGN7MOMGP5QNRSH T=PIU VH WHX!QYHV!Z[NZL \]=K#P^IPQNW _a`!bcedf g bhijkdhdlIjmgS_ndolqplIc#lr7dsg ptf juh__.lIcedlIvOw7xyplzIlpj7f w!i xqw!fbv fb{|i f {!hbvyhbvyv f __.lplbd jkdshdljugS_ }~OI#}s0 y~Ik}s #I .}k}se}!y}~|!0q };7! ! }} I I¡¢ ¡¤£#¥¦q§ O¨¥I©! ª!«t ¬I .®¯0¦° y¥©© ¢ ¢ ¦¥°;¢ ¦±¨u²¥¢ ¦2©!¥¥«¢°°³§ y¥§° 2.I¬!¢ ©! ´µ¶ ·!´¸¹#´uº ¸¼»½´¿¾´À¶ ÁÂ!¶ À¶ »YÃmºIij»½´u· ¶ ÄÄ.´¾´¸»Â!¶¸· ¶ ¸Å2ÆÁ¾Á·0¶ Å ÇȱÆ!¾º ƺ!È#´·³É ÊIË!ÌÎÍÏÐÌÑÒ ÌÐ!Ó ÍÏÐÕÔÖÒ Ñu×ØÌÙ ÚkÒ ÛuÒIÜ;ÍÏÐÝÌÐIÚË!Þ ÍÚÒ ßÍsØÙÛÐIà¤ÜÌáÒ ÑÙÛà ÙÌÐIÔkÍnØÛà¿à ÙÌÐIÔeͯØ××!ÌÒ!ØIÔÏÐÚ¼Ø!Þ â ãä å æçèéê!ë!ê ì ê!í î ï#ðìnï#ê ñòî ë!çóðèaî ê ñòyè.êôçõë óðIöñê÷ñ|èéçøë!çóî ùðèî ê ñêIú¿û!éðóæðIïÖê ûéê óî ïéüûêIèéçò#çIò ýþÿ¤ ý þ þ ý !"#"$%% & ')(+*-,(/.0&.1& '2*3,5467$896';:*<,/2=$.#.#>.& '?*<, 2@!AB6DCD$DEF'G1*<,/H;6>EI$JK';L*<,/M!7N6.1'2*<,O8>#.& ' PRQ<SNTUVWUX YZ\[Z<]NY=^_`ba c_#a deYZfZ<]Ng^ih#^_^Dj#^klkKa demZnRZ<]NoBc_p^qrd;s t5u1t\vNw1xtRyzwD{|t }~~ 1 ## DD#\# 5+<;/b# <¡<#¢# £D3\=##¢## £D<+=¤¥D¦D1§b ¨1<\©¢§BªK «¬<|®¯°±²D³µ´¬<¶´@·²¸ ¹ ¯²¹ ³µ´¬eº/¬<|»·½¼#·²·1¾·¿r¿À¹ ³ÂÁ¬eÃR¬<|¼ÄŲ#¹ ³Ãe¬<|Ʊ°·D±³Â´¬Æ¬<ÇÃ È ÉÊ9ËÈ ÌÎÍRÏ<Ð ÑÒÓÔÕÀÖ ×¶Ø ÙÎÚ1Ù¶ÛÜDÝÙßÞà#ÜDáâÙ ãäää å æbç èßéDêDê1ë ì íDîïîðâñDòôóõöö÷ø øù úÂû+ð<ü|û/ýþbùý#ù ú ÿð< ü ÷ ú ð<ü !"#$%!'&(*)+,-./01%2' 3$45#67%8'&9&: <;=>1?=< @BA C>DE<CF%GH IJBKLNML O?P?DQE/PRHNH LNM'ISO<TD6U%VXWYZL [9[\GKD6]+^`_G+M%abL I+MXL O<_0DNP?DE>c dfeg dh%ijklmn<opXqXq%dr rNg kts/mQn?s?h%i'gNhg k u0vw>x6yfzy{%y|y'}9}(~ +v>v \X / <NB> B% ¡'¢£! ¤$!¥ ¤¥f(¤ ¦¦.§¦ ¨©ª\« ¬N®¯/°±¯t²!©³%©´!®¶µ0°·/° ¸*¹Xº»9¼½ ¾ ¿ÀtÀtÁ  Ã'Ä Å?Æ%ÇÈÆ É Ê%Ë'ÌÌÍ