University of Padua
PhD Programmes
Medical and Biomedical Sciences
PhD STUDENT RESEARCH PROGRAM DAY
MEDICAL AND BIOMEDICAL SCIENCES
(XXIX Cycle)
Tuesday, November 24, 2015
Old University
Archivio Antico-Aula Magna
Palazzo del Bo
Via 8 Febbraio, 2 - 35122 Padova
Organized by
Prof.ssa Annalisa Angelini
Prof. Gaetano Thiene
Department of Cardiac, Thoracic and Vascular Science
In collaboration with:
Alessandra Cervellin
Department of Cardiac, Thoracic and Vascular Science
Tel 049/8272288 – Fax 049/8272294
e-mail: [email protected]
A.R.C.A.
Associazione Ricerche Cardiopatie Aritmiche
Via A. Gabelli, 86
35121 Padova
sito web: http://anpat.unipd.it/ARCA/
OLD UNIVERSITY “GALILEO GALILEI” AULA MAGNA
9.00
OPENING CEREMONY
9.30
AULA MAGNA
Chairperson: Prof. Paola Zanovello
ONCOLOGY AND SURGICAL ONCOLOGY
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 Engin BOJNIK – Tutors: Prof.ssa Anita De Rossi, Prof. Paolo Ghia
“COMBINED ERK AND BTK INHIBITION AS A NOVEL THERAPEUTIC
APROACH IN CHRONIC LYMPHOCYTIC LEUKEMIA”
 Antonella BRUNELLO – Tutors: Dr.ssa Vittorina Zagonel, Dr.ssa
Maria Luisa Calabrò
“EVALUATION OF BIOMARKERS IN HIGH GRADE SOFT TISSUE
SARCOMAS: PRELIMINARY RESULTS RELATED TO A COHORT OF
PATIENTS AFFECTED BY LEIOMYOSARCOMA”
 Sara Josè CANOVAS NUNES – Tutor: Dr. Francesco Piazza
“RHOU EXPRESSION CHANGES IN MULTIPLE MYELOMA REVEAL A
POSSIBLE CORRELATION WITH BONE MARROW DEPENDENCE”
 Maria Vittoria DIECI – Tutor: Prof. Valentina Guarneri
“INTEGRATED TRANSLATIONAL EVALUATION OF MOLECULAR
INTRINSIC SUBTYPES AND IMMUNE MODULATION OF PCR IN HER2POSITIVE BREAST CANCER PATIENTS TREATED WITH
CHEMOTHERAPY HER2-TARGETED AGENTS IN THE PROSPECTIVE
RANDOMIZED CHERLOB TRIAL”
 Alvise FRASSON – Tutor: Prof. Donato Nitti
“ANALISYS OF THE EXPRESSION OF PRO-INFLAMMATORY
CYTOKINES AND VASCULAR ADHESION MOLECULES IN CIRROTHIC
PATIENTS WITH OR WITHOUT HEPATOCARCINOMA”
 Kevin LEONE – Tutor: Dr.ssa Ilaria Marigo
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“DAB2 CONTROLS THE MACROPHAGE-ASSISTED METASTATIC
PROCESS”
 Paolo MACACCARO – Tutor: Dr. Francesco Piazza
“IMMUNOPHENOTYPIC CHARACTERIZATION OF B-LYMPHOPOIESIS
IN KO MICE FOR ONCOGENIC SER/THR KINASES BY
MULTIPARAMETER FLOW CYTOMETRY”
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9.30
 Lisa PERILLI – Tutor: Prof.ssa Paola Zanovello
“ROLE OF MIR-182 IN NEOPLASTIC PROGRESSION OF COLORECTAL
CANCER”
ARCHIVIO ANTICO
Chairpersons: Prof. Gaetano Thiene, Prof.ssa Annalisa Angelini
CARDIOVASCULAR SCIENCES
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 Ahmed Hussien Hussien AL MAMARY – Tutor: Prof. Sabino
Iliceto
“SPONTANEOUS CORONARY ARTERY DISSECTION IN SUDDEN
DEATH VICTIMS AND SURVIVING PATIENTS: WHICH ARE THE
DIFFERENCES?”
 Maria Stella BACCILLIERI– Tutor: Prof.ssa Cristina Basso
“THE ANATOMICAL CHARACTERISTICS OF RIGHT ATRIAL
CAVOTRICUSPID ISTHMUS CAN AFFECT RADIOFREQUENCY
CATHETER ABLATION IN TERM OF SUCCESSFUL AND
COMPLICATIONS”
 Manuel DE LAZZARI – Tutor: Dr.ssa Martina Perazzolo Marra
“MITRAL VALVE PROLAPSE: ARRHYTHMOGENIC SUBSTRATES BY
CARDIAC MAGNETIC RESONANCE IMAGING”
 Michela FACCHIN – Tutor: Prof. Giuseppe Tarantini
“PREVALENCE AND IMPACT OF ATRIAL FIBRILLATION IN
PATIENTS WITH SEVERE AORTIC STENOSIS UNDERGOING
TRANSCATHETER AORTIC VALVE IMPLANTATION. AN ANALYSIS
FROM THE SOURCE XT PROSPECTIVE MULTICENTRE REGISTRY”
 Cátia Marisa LOURENÇO FIDALGO – Tutor: Prof. Gino Gerosa
“ASSESSMENT OF STERILISATION AND PRESERVATION METHODS
FOR DECELLULARISED SCAFFOLDS”
 Massimo NAPODANO – Tutor: Prof. Sabino Iliceto
“DEVELOPMENT AND VALIDATION OF A DISTAL EMBOLIZATION
RISK SCORE DURING PRIMARY ANGIOPLASTY IN ST-SEGMENT
ELEVATION MYOCARDIAL INFARCTION”
 Vera RENIER – Tutor: Prof. Gaetano Thiene
“CARDIAC TUMORS: SURGICAL SERIES AND FOLLOW-UP”
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 Maria SILVANO – Tutor: Prof. Domenico Corrado
“BENEFIT
AND
COMPLICATIONS
OF
IMPLANTABLE
CARDIOVERTER DEFIBRILLATOR THERAPY IN YOUNG PATIENTS
WITH CARDIOMYOPATHIES: A LONG-TERM SINGLE CENTER
FOLLOW-UP STUDY”
11.00 COFFEE BREAK
11.30 AULA MAGNA
Chairpersons: Prof. Paola Zanovello, Prof. Gian Paolo Rossi
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ONCOLOGY AND SURGICAL ONCOLOGY
 Giorgia PILOTTO – Tutor: Prof. Alberto Amadori
“METABOLIC AND MOLECULAR PROFILING OF OVARIAN CANCER
STEM CELLS AND CANCER NON-STEM COUNTERPART”
 Anna TOSI – Tutor: Prof. Antonio Rosato
“IDENTIFICATION OF A HLA-A*0201-RESTRICTED IMMUNOGENIC
EPITOPE FROM THE UNIVERSAL TUMOR ANTIGEN DEPDC1”
 Carolina VENTUROLI – Tutor: Dr. Stefano Indraccolo
“ANTI-ANGIOGENIC THERAPY AND METABOLIC HETEROGENEITY
IN OVARIAN CANCER”
 Gianpietro ZANCHETTIN – Tutor: Prof. Stefano Merigliano
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“BMP AXIS IN CANCER CACHEXIA”
ARTERIAL HYPERTENSION AND VASCULAR BIOLOGY
 Marilisa CITTON – Tutor: Prof. Maurizio Iacobone
“UNILATERAL ADRENALECTOMY FOR LATERALIZED PRIMARY
ALDOSTERONISM IMPROVES THE MENTAL HEALTH AND
DEPRESSION SCORE AT ONE MONTH”
 Paul-Emmanuel VANDERRIELE – Tutor: Prof. Gian Paolo
Rossi
“ANGIOTENSIN-(1-7) PEPTIDE IS INVOLVED IN ALDOSTERONE
AND CORTISOL PRODUCTION IN HUMAN ADRENOCORTICAL CELL
LINE (NCI-H295)”
 Giovanni VIEL – Tutor: Prof. Maurizio Iacobobe
“CUSHING AND PREGNANCY”
11.30 ARCHIVIO ANTICO
Chairpersons: Prof. Gaetano Thiene, Prof. Roberto Vettor
CARDIOVASCULAR SCIENCES
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 Sugat Ratna TULADHAR – Tutor: Prof. Gino Gerosa
“DEVELOPMENT
OF
A
DECELLULARIZED
PERCUTANEOUS HEART VALVE”
PERICARDIUM
 Alessandro ZORZI – Tutor: Prof. Domenico Corrado
“CLINICAL CHARACTERISTICS AND STRATEGIES FOR EARLY
DIAGNOSIS OF NON-ISCHEMIC LEFT VENTRICULAR SCAR IN
COMPETITIVE ATHLETES”
CLINICAL METHODOLOGY, ENDOCRINOLOGICAL DIABETOLOGICAL
AND NEPHROLOGICAL SCIENCES
 Elisabetta BENETTI – Tutor: Prof. Roberto Vettor
“INTERACTION OF CIRCUMFERENCE , LENGTH AND SHAPE OF
THE ARM IN BLOOD PRESSURE MEASUREMENT IN THE OBESE”
 Lisa GIANESELLO – Tutor: Dr.ssa Dorella Del Prete
“PROTEIN UPTAKE AT GLOMERULAR LEVEL: POSSIBLE
INVOLVEMENT OF AN ENDOCYTIC MACHINARY IN CELL CULTURE
AND IN PATIENTS WITH PROTEINURIC NEPHROPATHY”
 Andrea REBELLATO – Tutor: Prof. Francesco Fallo
“METHYLATION STATUS OF VITAMIN D RECEPTOR GENE
PROMOTER IN BENIGN AND MALIGNANT ADRENOCORTICAL
TUMORS”
 Valentina SCATTOLINI – Tutors: Prof. Angelo Avogaro, Dr.
Gian Paolo Fadini
“IN VIVO IMAGING OF THE DIABETIC MICROCIRCULATION”
 Giovanna SPIRO – Tutor: Prof. Roberto Vettor
“MUSCLE STEM CELLS AND EXTRACELLULAR MATRIX IN
SARCOPENIC OBESITY”
 Eva ZABEO – Tutor: Prof. Roberto Vettor
“DYNAMICS OF CIRCULATING MICROPARTICLES IN OBESITY
AFTER WEIGHT LOSS”
13.00 LUNCH
14.00 AULA MAGNA
Chairpersons: Prof. Stefano Piccolo, Prof. Carlo Giaquinto
MOLECULAR MEDICINE
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 Giusy BATTILANA – Tutor: Prof. Stefano Piccolo
“YAP/TAZ/TEAD COOPERATE WITH AP-1”
 Veronica DI ANTONIO – Tutor: Prof. Ignazio Castagliuolo
“IDENTIFICATION OF SMALL MOLECULES INHIBITING THE
DIMERIZATION OF HCMV DNA POLYMERASE PROCESSIVITY
FACTOR UL44”
 Vittoria RAIMONDI – Tutors: Prof. Stefano Piccolo, Prof.
Vincenzo Ciminale
“ROLE AND REGULATION OF MIR-34A IN HTLV-1 INFECTED
CELLS”
REGENERATIVE MEDICINE
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 Francesco PETRELLA – Tutor: Prof. Maria Teresa Conconi
“EXPERIMENTAL AND CLINICAL AIRWAY RESTORATION BY
MESENCHYMAL STROMAL CELL AUTOLOGUS TRANSPLANTATION”
PEDIATRIC ONCOHEMATOLOGY, MEDICAL GENETICS, RARE
DISEASES, EPIDEMIOLOGY AND COMMUNITY MEDICINE
 Stefania BELLESSO – Tutors: Dr.ssa Rosella Tomanin, Prof.
Maurizio Scarpa
“DEREGULATED FGF SIGNALING SUBSTANTIALLY CONTRIBUTES
TO EARLY OSTEOGENIC DEFECTS IN MUCOPOLYSACCHARIDOSIS
TYPE II”
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 Annagiulia BONIZZATO – Tutor: Dr.ssa Geertruy Te Kronnie
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“INTEGRATED IMAGING TO EVALUATE CARDIAC PERFORMANCE
IN FONTAN PATIENTS”
“PORTRAYING THE TRANSCRIPTIONAL LANDSCAPE OF NORMAL
HEMATOPOIESIS”
 Biagio CASTALDI – Tutor: Prof. Ornella Milanesi
 Ilaria DE BARBIERI – Tutor: Prof. Giorgio Perilongo
“RELATIONSHIP-BASED-CARE MODEL IN PEDIATRIA: STUDIO
RANDOMIZZATO CONTROLLATO PER IMPLEMENTARE LA QUALITÀ
DELLE CURE”
 Francesca GRANDI – Tutor: Prof. Piergiorgio Gamba
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“SHORT BOWEL SYNDROME IN PEDIATRIC AGE: A NEW
REGENERATIVE APPROACH”
 Elena MARIOTTO – Tutors: Prof. Giuseppe Basso, Prof.
Giampietro Viola
“IN VITRO AND IN VIVO PHARMACOLOGICAL STUDY OF EB-3D, A
NOVEL CHOLINE KINASE INHIBITOR FOR BREAST CANCER
TREATMENT”
14.00 ARCHIVIO ANTICO
Chairpersons: Prof. Elena Pegoraro
NEUROSCIENCE
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 Luca BELLO – Tutor: Prof. Elena Pegoraro, Dr. Eric P. Hoffman
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“PROFILES OF VERBAL MEMORY IMPAIRMENT IN DEMENTIA
WITH LEWY BODIES VERSUS ALZHEIMER DISEASE”
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“VALIDATION, FUNCTIONAL STUDIES, AND DISCOVERY OF
GENETIC MODIFIERS OF DUCHENNE MUSCULAR DYSTROPHY”
 Francesca BURGIO – Tutor: Prof. Carlo Semenza
“NADL-FINANCIAL: A NEW TOOL FOR THE ASSESSMENT OF
FINANCIAL ABILITIES. A STUDY ON MILD COGNITIVE
IMPAIRMENT”
 Cinzia BUSSE’ – Tutor: Prof. Carlo Semenza
 Valeria GIANNUNZIO – Tutor: Prof. Angela Favaro
“DECISION MAKING IN ANOREXIA NERVOSA”
 Sonia MARCATO – Tutor: Prof. Elena Pegoraro
“EMPATHY AND EXECUTIVE FUNCTIONS IN NEUROMUSCULAR
DISEASES”
 Lucia NARDETTO – Tutor: Prof. Elena Pegoraro
“HEMATOMA EXPANSION IN ACUTE PRIMARY INTRACEREBRAL
HEMORRHAGE”
 Davide POGGIALI – Tutor: Prof. Elena Pegoraro
“RELIABLE
METHODS
FOR
FUNCTIONAL VS. ANATOMICAL”
MULTIMODALITY
IMAGING:
 Claudio SEMPLICINI – Tutor: Prof. Elena Pegoraro
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“WIDENING THE CLINICAL AND MUTATIONAL SPECTRUM OF
CASQ1-RELATED MYOPATHY”
 Marco SOLMI – Tutor: Prof. Angela Favaro
“5-HTTLPR POLYMORPHISM IN EATING DISORDERS”
 Filippo VALENTE – Tutor: Prof. Alessandro Martini
“NANOPARTICLES AND STEM CELLS PROTOCOLS AGAINST DRUG
OTOTOXICITY”
 Marco ZOCCARATO – Tutor: Prof. Elena Pegoraro
“GLUTAMIC
ACID
DECARBOXYLASE
ANTIBODIES
IN
NEUROLOGICAL
DISEASES:
CLINICAL
RETROSPECTIVE
EVALUATION OF DIAGNOSIS PERFORMED BY ENZYME-LINKED
IMMUNOSORBENT ASSAY”
16.00 COFFEE BREAK
16.30 AULA MAGNA
Chairperson: Prof. Carlo Giaquinto
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PEDIATRIC ONCOHEMATOLOGY, MEDICAL GENETICS, RARE
DISEASES, EPIDEMIOLOGY AND COMMUNITY MEDICINE
 Francesca MAULE – Tutors: Prof. Giuseppe Basso, Dr. Luca
Persano
“ANNEXIN A2 IS A KEY DETERMINANT OF GLIOBLASTOMA
AGGRESSIVENESS
BY
CONTROLLING
CANCER
CELL
DISSEMINATION AND PROLIFERATION”
 Silvia ROSSI – Tutor: Prof. Maurizio Clementi
“APPLICATION OF METHODS OF MASSIVE PARALLEL SEQUENCING
IN THE DIAGNOSIS OF CERTAIN GENETIC AUTOSOMAL
DOMINANT DISEASES”
PROGRAMMING SCIENCE
 Francesca MENEGAZZO – Tutor: Prof. Paola Facchin
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“CODING RARE DISEASES IN HEALTH INFORMATION SYSTEMS:
DESIGN, IMPLEMENTATION AND TESTING OF THE PILOT STUDY
FOR THE EUROPEAN JOINT ACTION ON RARE DISEASES”
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“POISONING IN PATIENTS EVALUATED FOR ALLEGED CHILD
ABUSE AND NEGLECT”
 Giulia MENEGHEL – Tutors: Prof. Paola Facchin, Dr. Melissa
Rosa Rizzotto
 Elena RIZZARDI – Tutor: Prof. Paola Facchin, Dr. Monica
Mazzucato
“FROM A GENERALIZED CLINICAL DATABASE TO THE CREATION
OF REGISTERS OF RARE DISEASES”
16.30 ARCHIVIO ANTICO
Chairpersons: Prof. Paolo Angeli, Prof. Andrea Doria
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HEPATOLOGY AND HEPATOBILIARY SURGERY AND
TRANSPLANTATION
 Irene BERTOZZI – Tutor: Prof. Maria Luigia Randi
“VALIDATION OF WHO-2008 CRITERIA IN PEDIATRIC ESSENTIAL
THROMBOCYTHEMIA: RELEVANCE OF BIOMOLECULAR AND
HISTOLOGICAL CRITERIA”
 Riccardo BOETTO – Tutor: Prof. Umberto Cillo
“EXTREME
HEPATECTOMIES
AND
NON-RESECTABILITY
TECHNICAL BREAKTHROUGH FOR LIVER NEOPLASIA, FOCUSING
ON COLORECTAL METASTASES: EXPERIMENTAL PILOT STUDY ON
SAFETY, EFFICACY, AND REGENERATION PATTERNS WITH NEW
INSIGHT ON ALLPS-LT HYBRID TECHNIQUES”
 Alessandra BROCCA – Tutor: Prof. Paolo Angeli
“CHARACTERIZATION OF MOLECULAR PATHWAYS INVOLVED IN
ACUTE AND ACUTE-ON-CHRONIC LIVER DISEASE”
 Paola PESCE – Tutor: Prof. David Sacerdoti
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“IDENTIFICATION OF EARLY MARKERS OF EVOLUTIVE NON
ALCOHOLIC FATTY LIVER DISEASE”
 Marina POLACCO – Tutor: Prof. Umberto Cillo
“RESECTION-BENEFIT IN R1 LIVER RESECTION IN COLO-RECTAL
LIVER METASTASES AND IN CHOLANGIOCARCINOMA”
RHEUMATOLOGICAL SCIENCES
 Ada AITA – Tutor: Prof. Leonardo Punzi
“THE MEFV R202Q VARIANT: A GENETIC RISK FACTOR FOR
SERONEGATIVE SPONDYLOARTHRITIS”
 Marianna BEGGIO – Tutor: Prof. Andrea Doria
“IN VITRO EFFECTS OF ESTROGENS ON BLyS mRNA EXPRESSION
IN A HUMAN MYELOID CELL LINE”
 Rossella TALOTTA – Tutor: Prof. Andrea Doria
“IMMUNOGENICITY
DURING
TREATMENT
OF
CHRONIC
RHEUMATIC DISEASES: FOCUS ON TH9 LYMPHOCYTES”
18.00 CLOSING REMARKS
PHD PROGRAMMES (XXIX CYCLE)
1. BIOMEDICINE
Coordinator: Prof. Stefano Piccolo
Curricula:
- MOLECULAR MEDICINE
- REGENERATIVE MEDICINE
2. INTERNATIONAL DOCTORATE PROGRAM ARTERIAL
HYPERTENSION AND VASCULAR BIOLOGY
Coordinator: Prof. Gian Paolo Rossi
3. DEVELOPMENTAL MEDICINE AND HEALTH PLANNING
SCIENCES
Coordinator: Prof. Carlo Giaquinto
Curricula:
- PEDIATRIC ONCOHEMATOLOGY, MEDICAL GENETICS, RARE
DISEASES, EPIDEMIOLOGY AND COMMUNITY MEDICINE
- PROGRAMMING SCIENCE
4. ONCOLOGY AND SURGICAL ONCOLOGY
Coordinator: Prof.ssa Paola Zanovello
5. MEDICAL CLINICAL AND EXPERIMENTAL SCIENCES
Coordinator: Prof. Gaetano Thiene
Curricula:
- CARDIOVASCULAR SCIENCES
- CLINICAL METHODOLOGY, ENDOCRINOLOGICAL
DIABETOLOGICAL AND NEPHROLOGICAL SCIENCES
- HEPATOLOGY AND HEPATOBILIARY SURGERY AND
TRANSPLANTATION
- NEUROSCIENCES
- RHEUMATOLOGICAL SCIENCES