Direzione Generale Ricerca Sanitaria e
Direzione
Biomedica e della Vigilanza
sugli Enti
Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
Gaetano Guglielmi MD, PHD
) Director Office IRCCS-
Helthcare ad Research Excellence Center
Direzione
Ricerca Sanitaria e
Direzione Generale
RicercaGenerale
Sanitaria e
Biomedica e della
Vigilanza esugli
Enti
Biomedica
della
Vigilanza sugli Enti
Health Research Network of the Ministry of Health
Istituto Superiore di Sanità (National Health Institute)
 INAIL (National Institute for Environmental and Work Related Diseases)
 Agenzia per i Servizi Sanitari Regionali (National Healthcare Agency)
 45 IRCCS Institutes for Healthcare and Scientific Research
10 IZS – Veterinary Institutes
 21 Regions (National Health System)

Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
ISS
MIUR
AIFA
NATIONAL
UNIVERSITIES RESEARCH
COUNCIL
• 40 Schools of Medicine
and Biology
IRCCS
43
•30 Schools of Pharmacy
NATIONAL
HEALTH
SERVICE
• No. Depts and PhD
courses on translational
medicine
•23 Centres of Excellence in
the biotechnology and
biomedicine sectors
• 34 technological districts
• 31 S&T parks
HOSPITALS
REGIONS
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
IRCCS’ Network 2014
48 Research Comprensive
Center -Institutes for
Healthcare and Scientific
Research
IRCCS - Researchers
9.575
IRCCS - Scientific
Publications (*)
10.834
IRCCS - Total Normalised
Impact Factor (*)
43.229
IRCCS - Total Hospital
Beds
17.849
(*) Data are referred to 2012 Activities solely to the
expertise areas of recognition of the different Institutes
2013
2 New Institutes
•Pharmacologu Mario Negri
•Oncological Institutes Candiolo
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
Funds for Health Research of the
Ministry of Health
Global trend in the last 11 years
200
180
E
U
R
O
180
175
185
Ordinary Research (Ricerca Corrente) aimed at the 48
IRCCS
Basic scientific research, leaded by the IRCCS in the areas of recognition,
according to a three-years plan agreed with the Ministry of Health.
Aimed Research (Ricerca Finalizzata)
Aimed to all the Participants belonging to the NHS Research Network
To implement the main biomedical and health objectives of the National
Bandi Altri Fondi
Health Plan, through200
grants that reward the best research projects
192
Ricerca Corrente
190
180
163
161
155
160
Ricerca Finalizzata
174
159
151
150
140
120
100
100
86
84
78
70
80
60
47
52
56
52
40
51
50
45
25
20
20
0
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
* Nella RF 20 milioni riservati agli IRCCS
In Addition € 1 Billion for Salary Costs Permanent Staff for up 10.000 Researchers
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
ITALIAN GOVERNMENTAL
FUNDING FOR TRASLATIONAL RESEARCH
MoH funding of Health Research
MIUR funding of Translational Medicine
2007-2009 = 1.014 MEuro
2007-2009 = 585 MEuro
Translational
Medicine
(75%)
Public
Industrial
+ Public-Industry
Research
2013
EVERY 5 EUROS INVESTED IN BIOMEDICAL RESEARCH
CALL
UP TO 3,5 EUROS FROM MOH – 1,5 EUROS FROM MIUR
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
2013 - Quality and Quantity of the Italian Research in Biomedical Sector
Medicine – Rank Research Quality on
H index and Citation Index
Russian
Federation
Medicine – Rank on Research Activities
Number of Publications
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
EU – CONSULTATION PROCESS
Patient
Stakeholders
National Patients Groups
International Patients Groups
Researcher
Research Institutes / Academias
Patients Groups of Interest
Scientific Societies
Industry
Federations of Scientific Societies
Umbrella Organisations
National Federations of Industries
International Federations of Industries
Member /Associated States
Government
Min. of Research
Min. of Health
Permanent Representatives
Min. of Industry
Regions
European Institutions
European Council
European Parliament
POLICY and STRATEGIC AGENDA
Min. of Foreign Affairs
European Commission
National Contact Points - NCP
Specific DGs
Exec Agencies
Programme Committee
Advisory Board
POLICY IMPLEMENTATION
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
EU CONSULTATION PROCESS
Inputs
from
Conferences
Workshops
scientific
societies,
etc…
Consultation with Commission (non compulsory)
Workprogramme proposal
Consultation with Commission (compulsory)
Advisory
Workprogramme
Programme
Group
Definitive text
Committee
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
JTIs, JPIs, JPs, Agenzie
DG Salute e Consumatori
(SANCO)
DG Ricerca e Innovazione
(RTD)
Agenzia
Legislation /
regulation
education
access to
cure and
continuity
policy
Public Health
cancer
Ricerca Biomedica
psychology
Society &
Culture
JTIs, JPIs, JPs, Agenzie
DG Informazione e Società
(INFSO)
neurosciences
biotech
cardiovascular
public
health
Systems
medicine
Bioengineering / e-health
ICT
19/34
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
The Last Strategies in Research
Biomedical Sector
THE NATIONAL PILLARS
Direzione
Generale
Ricerca
Sanitaria e
Direzione Generale
Ricerca
Sanitaria
e
Biomedica e della
Vigilanzae sugli
Biomedica
della Enti
Vigilanza sugli Enti
IT MOH Biomedical Research Strategies :
Principal Milestones
• Setup and Support Network for Biomedical
Research
• Support the Italian Researchers involved in
Projects at EU or International Level
• Grant Call: Award the Best Projects
• REMOVE All Programme for Specific Areas
• Support Network between Italian Institutions
and Italian Researchers Abroad
STRESS Quality and Competitiveness’ Italian
Research in Biomedical Sector
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
The Framework for a EU Research
The It-MOH Point of View
NATIONAL
CALL
National
Rules and
Strategies
JOINT
INITIATIVE
Eranet and JPI
Common Tools to
Harmonized the
Different National
Startegies in a EU
Level
EU H2020
Common
Rules and
Strategies at
European
Level
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
EFFECT OF ERANET STRATEGY
Success Rate National Calls
NEUROLOGY VS ONCOLOGY
80,00%
2009
NEURON
70,00%
60,00%
2008
Oncology Programme
2012
TRANSCAN+NEURON
50,00%
40,00%
Neurology
Oncology
30,00%
20,00%
10,00%
0,00%
1
2
3
4
Direzione
Generale
Ricerca
Sanitaria e
Direzione Generale
Ricerca
Sanitaria
e
Biomedica e della
Vigilanzae sugli
Biomedica
della Enti
Vigilanza sugli Enti
Joint EU Projects Supported Directly by
the Italian MOH in the Last Three Years
EUROPEAN PROJECTS:
Support in Joint Call (JTC) with other European Countries
• JTC ERANET TRANSCAN (Oncology) Coordinator IT-MOH
• JTC ERANET NEURON (Neurology)
• JTC ERANET E-RARE (Rare Diseases)
• JTC ERANET EURONANOMED (Nano Medicine)
• JTC ERANET SYSTEM MEDICINE (starting on 2014)
• JTC ERANET CARDIOVASCULAR (starting on 2015)
• Joint Programming Initiative Neurodegenerative Diseases (JPND)
• Joint Programming Initiative More Year Better Life (Ageing and
Demography Change)
• Coordination and Support Action Personalized Medicine (future JTC)
Direzione
Generale
Ricerca
Sanitaria e
Direzione Generale
Ricerca
Sanitaria
e
Biomedica e della
Vigilanzae sugli
Biomedica
della Enti
Vigilanza sugli Enti
NATIONAL CALL – Principal Pillar
LAST
FUNDED
CALL
Introduction
Dec-March 2013
OPEN TO ALL BIOMEDICAL EXPERT AREAS
Free participation to all NHS Researchers
140 million Funding Grant
• Up to 60 million for young researchers
• Feasibility of co-financing with participation of Regions, Private
Company and Stakeholders
Final Rank
31 Jan 2014
Projects Submitted 4.158
Projects Evaluated
3.158
•
50% Funding to biomedical research (Early Translational) and
•
50 % to clinical-healthcare research (Later Translational)
• classification of projects according to rankings derived from NIHCSR in order to facilitate the Automatic and Blind Link Referee – Project
Funded Projects 294 •
Ratings by Referee reported by the NIH-CSR and living outside Italy
The list of projects for funding is pursuant only to the scientific
quality independently from the Expertise Area
This is the call of the Italian National Health System
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
LAST FUNDED CALL RF2011-2012
3.158 PROPOSED APPLICATION EXPERTISE AREAS DISTRIBUTION
1,8%
2,5% 2,2%
1,0% 1,0%
1,7% 1,3% 1,0%
0,6%
1,5%
1,7%
0,1%
391 Projects Funded
0,1%
21,3%
2,5%
2,7%
3,0%
12,6%
3,0%
3,1%
3,4%
3,9%
11,3%
5,1%
5,4%
Brain Disorders and Clinical Neuroscience
Oncology 1 - Basic Translational
Cardiovascular and Respiratory Sciences
Musculoskeletal, Oral and Skin Sciences
Biobehavioral and Behavioral Processes
Molecular, Cellular, and Developmental Neuroscience
Healthcare Delivery and Methodologies
Vascular and Hematology
Cell Biology
AIDS and Related Research
Emerging Technologies and Training in Neurosciences
Biology of Development and Aging
Veterinary
6,2%
REAL NHS
CONTRIBUTION – DIRECT
AND INDIRECT COSTSTOTAL VALUE FUNDED
PROJECTS
800 Million euros
Oncology 2 - Translational Clinical
Genes, Genomes and Genetics
Immunology
Infectious Diseases and Microbiology
Endocrinology, Metabolism, Nutrition and Reproductive Sciences
Bioengineering Sciences and Technologies
Surgical Sciences, Biomedical Imaging, and Bioengineering
Integrative, Functional, and Cognitive Neuroscience
Digestive, Kidney and Urological Systems
Risk, Prevention and Health Behavior
Population Sciences and Epidemiology
Biological Chemistry and Macromolecular Biophysics
Interdisciplinary Molecular Sciences and Training
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
New CALL: start 18 June 2014
Budget 74 Milion
New Diagnostic, Therapeutic and Healthcare Strategies in :
1‐ Dis-metabolism and Cardiovascular Dieseases
2‐ Neurology Diseases
3‐ Oncology
4‐ Immunologic and Infectious Diseases
5‐ New Biotechnology
6‐ Food Safety and Veterinary Health
7‐ Environmental and Work Related Diseases
8 – Public Health Organisation
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
New CALL: June 2014
74 Million Euros
• 10 Million for Great Network Projects
• 10 Million for Collaboration Projects with Italian
Researchers Abroad
• 5 Million for Industry Collaboration Projects
• 27,5 Million in for Italian Young Researchers
• Other Fund is allocate to the Best Projects
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
Unità di Coordinamento misto MdS-IRCCS / CNRS
Network degli IRCCS
Coordinamento scientifico
Researchers
Relationship
Management
Networking
Integrazione con le Regioni
Contributo
coordinato
Policy
Support
REGIONI / Conferenza S-R
Territorio
(Servizi,
Produttive)
Attività
Consultazione non-obbligatoria (lobby)
Administrative &
Management
Support
National Contact Point (APRE)
MIUR - ISS
Comitati di Programma /
Advisory Boards
Consultazione
obbligatoria
ISTITUZIONI EUROPEE
17/34
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
Struttura DTS
IRCCS INTERNATIONAL ACTIVITIES NETWORK
GENETICS-BIOTECHNOLOGIES-RARE DISEASE
ONCOLOGY
NEUROLOGY – HEATHY AGEING
HEALTH-DEMOGRAPHICCHANGE-WELLBEING
21
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
Direzione Tecnico-Scientifica
componenti del Board
Rappresentanti degli IRCCS:
Claudio Bordignon, Ospedale San Raffaele
Bruno Dellapiccola, Ospedale Pediatrico Bambin Gesù
Giovanni De Girolamo, Centro san Giovanni di Dio Fatebenefratelli
Giuseppe Ippolito, Istituto per le Malattie Infettive Lazzaro Spallanzani
Antonio Moschetta, Istituto Tumori Giovanni Paolo II
Pier Giuseppe Pelicci, Istituto europeo di Oncologia
Angelo Luigi Vescovi, Ospedale Casa Sollievo della Sofferenza
Rappresentanti degli altri Destinatari Istituzionali:
Stefano Cinotti, IZS Lombardia ed ER
Roberto Grilli, Regione Emilia Romagna,
Sergio Iavicoli, INAIL
Giada Li Calzi, Regione Sicilia,
Massimo Mirandola, MATTONE Internazionale,
Fabrizio Oleari, ISS
Gabriella Paoli, Regione Liguria,
Alberto Zanobini, MATTONE Internazionale
22
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
Direzione Tecnico-Scientifica
Esperti d’Area
Genetics, Biotechnologies, Rare Diseases
Del Mistro Annarosa, Istituto Oncologico Veneto
Gasparini Paolo, Ospedale infantile Burlo Garofolo
Martini Alberto, Istituto Giannina Gaslini
Nicoletti Ferdinando, Istituto Neurologico Mediterraneo Neuromed
Peyvandi Flora, Fondazione Ca'Granda – Ospedale Maggiore Policlinico
Picardo Mauro, Istituti fisioterapici ospitalieri - Istituto Dermatologico Santa Maria e San Gallicano
Russo Giandomenico, Istituto Dermopatico dell'Immacolata (IDI)
Sangiorgi Luca, Istituto Ortopedico Rizzoli
Information and Communication Technologies
Andrich Renzo, Fondazione Don Carlo Gnocchi
Annicchiarico Roberta, Fondazione Santa Lucia
Moretti Matteo, Istituto Ortopedico Galeazzi
Benfenati Emilio, Istituto Mario Negri
Epidemiology
Baiardi Paola, Fondazione Salvatore Maugeri
23
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
Direzione Tecnico-Scientifica
Esperti d’Area
Neurology, Healthy Ageing
Antonini Angelo, Ospedale San Camillo
Blandini Fabio, Fondazione Istituto Neurologico Casimiro Mondino
Marino Silvia, Centro Neurolesi Bonino Pulejo
Martinuzzi Andrea, Istituto Eugenio Medea
Tagliavini Fabrizio, Fondazione Istituto Neurologico Carlo Besta
Health, Demographic Change, Wellbeing
Klersy Catherine, Fondazione Policlinico San Matteo
Oncology
Allavena Paola, Istituto Clinico Humanitas
Colombatti Alfonso, Centro di riferimento oncologico di Aviano
Piaggio Giulia, Istituto Nazionale Tumori Regina Elena
Krogh Vittorio, Fondazione Istituto Nazionale per lo studio e la cura dei tumori
Bruzzi Paolo, Azienda ospedaliera universitaria San Martino - IST
Paganelli Giovanni, IRST Meldola
Buonaguro Luigi, Istituto nazionale tumori Fondazione Giovanni Pascale
24
Direzione
Generale
Ricerca
Sanitaria e
Direzione Generale
Ricerca
Sanitaria
e
Biomedica e della
Vigilanzae sugli
Biomedica
della Enti
Vigilanza sugli Enti
“We must assure to the citizens that we can choose the best
projects, which, for their quality, should be the more functional to
the growth of the country; essentially we have to guarantee that
the taxpayers' money is well spent.
Thus the satisfaction of the scientific world is only a consequence of
the serious work done, but primarily we have to respond to the
citizen on the proper use of resources”.
A PHILOSOPHY OF TRANSPARENCY
At the end of the assessment process the Principal Investigator has
access to all the information related to the evaluation of his project
and all the Ranking List and Official Document of the Evaluation
Procedure are published on Ministerial Official Web Site.
Direzione
Generale
Ricerca
Sanitaria e
Direzione Generale
Ricerca
Sanitaria
e
Biomedica e della
Vigilanzae sugli
Biomedica
della Enti
Vigilanza sugli Enti