ACCADEMIA NAZIONALE DEI LINCEI FONDAZIONE «GUIDO DONEGANI» IVANO BERTINI’s MEMORIAL CONFERENCE STRUCTURE AND DYNAMICS OF BIOLOGICAL MACROMOLECULES 8 – 9 Aprile 2014 Comitato ordinatore: R. UGO, A. BALLIO, L. BANCI, M. BOLOGNESI, M. BRUNORI, S. CALIFANO, S. CARRÀ, D. GATTESCHI, G. GIACOMETTI, C. LUCHINAT, G. MARINO, S. PONTREMOLI Comitato organizzatore: L. BANCI, M. BRUNORI (Chair), D. GATTESCHI, C. LUCHINAT, G. MARINO PROGRAMMA - INVITO Tuesday, 8 April 14.00 Welcome addresses: the President of the Accademia dei Lincei and Renato UGO (Linceo, Milano) 14.30 Claudio LUCHINAT (Università di Firenze): Ivano Bertini's human and scientific legacy Session 1 - Chairs: Israel PECHT (Rehovot, IL) - Sergio CARRÀ (Linceo, Milano) 15.00 Israel PECHT (Weizmann Institute of Science, Rehovot, IL): Proteins' three dimensional structures: more avenues to functional insights? 15.10 Kurt WÜTHRICH (Nobel Laureate in Chemistry 2002, Scripps Research Institute, La Jolla, USA, and ETH Zürich, CH): From inorganic chemistry to NMR with proteins 16.10 Henriette MOLINARI (Università di Verona): Intracellular lipid binding proteins as versatile hosts of small hydrophobic ligands 16.55 Coffee break Session 2 - Chairs: Maurizio BRUNORI (Linceo, Roma) - Dante GATTESCHI (Linceo, Firenze) 17.15 Lucia BANCI (Università di Firenze): From single proteins to cellular functions: the unique contribution of NMR 18.00 The EMBO Lecture by Ada E. YONATH (Nobel Laureate in Chemistry 2009, Weizmann Institute of Science, Rehovot, IL): Can Structures lead to better therapeutics? 19.00 Conclusion Wednesday, 9 April Session 3 - Chairs: Harry B. GRAY (Linceo, Pasadena, USA) - Sandro PONTREMOLI (Linceo, Genova) 9.15 David STUART (University of Oxford, UK): Integrated structural biology and viruses 10.00 Martino BOLOGNESI vaccinology 10.45 Coffee break (Linceo, Università di Milano): Chasing melioidosis antigens through structural Session 4 - Chairs: Alessandro BALLIO (Linceo, Roma) - Gennaro MARINO (Linceo, Napoli) 11.15 Silvio AIME (Università di Torino): From relaxation enhancers to frequency-encoding agents: the role of paramagnetic metal complexes in MRI 12.00 Maurizio BRUNORI (Linceo, Sapienza Università di Roma): Protein folding and binding dynamics 12.45 Break Session 5 - Chairs: Vincenzo BARONE (Linceo, Pisa) - Vincenzo SCHETTINO (Linceo, Firenze) 14.00 Michele PARRINELLO (Linceo, ETH Zürich and USI Lugano, CH): Simulating millisecond processes without special-purpose computers 14.45 Paolo CARLONI (German Research School for Simulation Sciences, Jülich, DE): Predicting conformational ensembles of intrinsically disordered proteins using molecular simulation 15.30 Coffee break Session 6 - Chairs: Salvatore CALIFANO (Linceo, Firenze) - Giovanni GIACOMETTI (Linceo, Padova) 16.00 Anna TRAMONTANO (Sapienza Università di Roma): Macromolecular interactions: the computational perspective 16.45 Alex PINES (University of California, Berkeley, USA): Hyperactive NMR 17.30 Harry B. GRAY (Linceo, Caltech, Beckman Institute, Pasadena, USA): Structures and dynamics of metalloproteins: a tribute to Ivano Bertini 18.15 Closing of the conference The Conference is organized with the support of EUROPEAN MOLECULAR BIOLOGY ORGANIZATION BRACCO IMAGING SPA BRUKER BIOSPIN SAPIO PRODUZIONE IDROGENO OSSIGENO SRL ROMA PALAZZO CORSINI - VIA DELLA LUNGARA, 10 Segreteria del convegno: [email protected] www.lincei.it Fino alle ore 10 è possibile l’accesso anche da Lungotevere della Farnesina, 10