prof. Giuseppe Bruno – CHIM/03 – PO
Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica
Università di Messina
[email protected]
Curriculum scientifico
Il prof. Giuseppe Bruno ha conseguito la laurea in Chimica nel 1976. In atto è Professore
ordinario nel SSD CHIM/03, Chimica generale. Ha prodotto oltre 190 lavori pubblicati su riviste
recensite ISI. Le tematiche scientifiche, affrontate fin dall'inizio della propria attività di ricerca e
tuttora in continuo sviluppo, possono essere suddivise secondo quattro linee generali:
1) Sintesi, caratterizzazione spettroscopica e strutturale di composti organometallici
2) Studi strutturali su composti organici a potenziale attività biologica.
3) sintesi, caratterizzazione e studio delle interazioni di substrati metallici con recettori biologici.
4) Calcoli ab-initio e DFT su aggregati HB supramolecolari
Il Prof. Giuseppe Bruno ha svolto la propria attività di ricerca avvalendosi delle apparecchiature del
"Centro Interdipartimentale per la Diffrattometria a Raggi-X" dell'Università di Messina, al quale
ha dato, fin dalla costituzione, il proprio determinante contributo alla gestione e allo sviluppo; ha
proposto e curato l'acquisizione di nuove apparecchiature; ha promosso e stimolato nuove ricerche
e collaborazioni in ambito regionale nazionale ed internazionale.
Elenco Lavori scientifici 1998-2007
1 G. Bruno, G. Franciò, R. Scopelliti, C.G. Arena, D. Drommi and F. Faraone. “IrPd, IrHg, IrCu,
IrTl Binuclear Complexes Bridged by the Short Bite Ligand 2-(Diphenylphosphino) pyridine.
Catalytic effect in the Hydroformilation of Styrene due to 2-(Diphenyl-phosphino) pyridine
monodentate P-bonded ligands of trans-[Ir(CO) (Ph2PPy)2 Cl]”. Organometallics (1998), 17,
338-347
2 G. Bruno, R. Maccari, F. Nicolò, R. Ottanà, M. Panzalorto, R. Scopelliti and M.G. Vigorita. "2'[1(4-fluorophenyl) ethyl]isonicotinohydrazide-cyanoborane". Acta Cryst. (1998), C54, 10381040.
3 G. Bruno, F. Nicolò, M. Cusumano, M.L. Di Pietro, R. Scopelliti. "(6,7-Dimethyl-2,3-bis(2pyridyl)-quinoxaline)-dichloro-platinum(II) hydrate". Acta Cryst. (1998), C54, 485-487
4 G. Bruno, G. Franciò, C.G. Arena, M Panzalorto and F. Faraone "Palladium(II) and platinum(II)
complexes containing new phosphinoxy chiral P,N-Ligands." Inorganica Chimica Acta. (1998)
277, 119-126
5 G. Bruno, A Chimirri, R Gitto, F Nicolò and R Scopelliti. “Structure and Conformation of a 2,3Benzothiazepine Derivative” Acta Cryst., (1998), C54, 625
6 G. Bruno, R. Scopelliti, G. Guglielmo and G. Tresoldi "The first N,S-coordination of a molecule
of -2-pyridyl Sulfide (dps) in [Ru2(dps)3] [PF6]2". J. Chem. Soc. Dalton Trans (1998)
7 G. Bruno, F Nicolò, M Cusumano, ML Di Pietro and R Scopelliti “Dichloro[6,7-dimethyl-2,3bis(2-pyridyl-N)-quinaxoline] palladium (II) Monohydrate” Acta Cryst., (1998), C54, 485-487
8 G. Bruno, A Arena, M Panzalorto, S Patanè, G Saitta and R Scopelliti, “Tetracyano-p-xylene”
Acta Cryst.., (1998), C54, 2003-2005
9 G. Bruno, A. Chimirri, S. Grasso, C. Molica, A.M. Monforte, P. Monforte, F. Nicolò, M.
Zappalà, A. Rao, M. Witvrouw, C. Pannecouque and E. De Clercq. "Synthesis, structure and in
vitro anti-human immunodeficiency virus activity of novel 3-methyl 1H,3H-thiazolo[3,4a]benzimidazoles ". Antiviral Chemistry & Chemotherapy. (1998), 9, 431-438
10 G. Bruno, C.G. Arena, D. Drago, M. Panzalorto and F. Faraone “Diphosphinito-Bridged
Ruthenium(II) and Rhodium(III) complexes with Stereogenic Metal Centres’. Inorg. Chim. Acta
(1999) 292, 84-95
11 G. Bruno, A. Chimirri, R. Gitto, F. Nicolò and R. Scopelliti “7,11b-Dihydro-9,10-dimethoxy3,11b-diphenyl[1,2,4]oxadiazolo[5,4-a][2,3]benzodiazepin-6(5H)-one” Acta Cryst.., (1999),
C55, 685-687
2
12 G. Bruno, Nicolò F., Tresoldi G. {Bis(nitrite)} (nitrosyl) (hydroxy){Bis (2-pyridylN)sulfide}ruthenium(II). Acta Cryst C56, (1999) 282-283 ISSN: 0108-2701.
13 G. Bruno, F. Nicolò and G. Tresoldi. "(2,2’-Dipyridyl sulfide-N,N’)hydroxy-bis(nitritoO)(nitrogen monoxide-N)-ruthenium(III)". Acta Cryst. (2000), C56, 282-283
14 G. Bruno, F. Nicolò, M. Panzalorto, M. Gattuso, and G.L. La Torre. “(E)-3-phenyl-5-(2’-pnitrophenylhydrazone-2’-phenylglyxallil)-isoxazole”. Acta Cryst. C56, (2000), 254-255
15 G. Bruno, F. Nicolò, M. Panzalorto, C.G. Arena, and P. Cardiano. ”{RuCl2(p-cymene) [P(C6H5)
2 (n-C4H9) ]}. Acta Cryst. (2000), C56, e429
16 G. Bruno, S. Lanza, F. Nicolò, A. Rotondo, R. Scopelliti, E. Rotondo “Synthesis,
Stereochemistry and Solution Dynamics of Heterobimetallic Complexes with Metals Connected
by Dithiox-amides in k-S,S' k -N,N' Binucleation Mode. The Molecular Structure of [2(Diphenylphosphino)pyridine Pt Cl (µN,N'- Dibenzyldithiox-bis-amidato k -S,S' Pt -N,N'
Pd)( 3-Allyl) Pd]” Organometallics (2000) 19, 2462-2469
17 G. Bruno, F Nicolò, R Scopelliti, S Grasso, A Rao and M Zappalà “7-Chloro-1-(2,6difluorophenyl)-1H,3H-thiazolo[3,4-a] ben-zimidazole and 1-(2,6-difluorophenyl)-6-methyl1H,3H-thiazolo[3,4-a]benzimidazole” Acta Cryst. (2001), C57, 572-574
18 G. Bruno, F. Nicolo, A. Rotondo, R. Gitto & M. Zappalà ”3,5-Dihydro-7,8-dimethoxy-1-phenyl4H-2,3-benzodiazepin-4-one” Acta Cryst. (2001), C57, 1
19 G. Bruno, S.Lanza, F.Nicolò and R. Scopelliti "A new example of stereoisomerism in Inorganic
Chemistry: Pt-Ru Chiral Axis in [( 6-p-cymene)RuCl(µ-N,N'-dialkyldithiox-amidatoN,N'RuS,S'Pt)Pt(2-diphenylphosphinopirydine)Cl]". Tetrahedron Asymmetry (1996), 7, 12, 33473350
20 G. Bruno, M.C.Aversa, A.Barattucci, P.Bonaccorsi, F. Caruso and P.Giannetto. "Enantiopure 2sulfinylbuta-1,3-dienes in Diels-Alder cycloadditions: a stereoselective approach to an
azasteroidal skeleton". Tetrahedron Asymmetry. (2001) 12, 2901-2908
21 G. Bruno, M.C. Aversa, A. Barattucci, P. Bonaccorsi, P. Giannetto and M. Policicchio.
“Unexpected conversion of vinyl sulfoxides into carbonyl compounds by means of
iodotrimethylsilane” Tetrahedron Letters . (2000) 41, 4441-4445
22 G. Bruno, Ambra De Gregorio, Roberto Battistutta, Nicoletta Arena , Manuela Panzalorto,
Pietro Francescato, Giovanna Valentini and Giuseppe Zanotti. “Functional and structural
characterization of ovine ornithine transcarbamoylase” Org. Biomol. Chem., 2003, 1 (18), 31783185 First published as an Advance Article on the web 20th August 2003
23 G. Bruno, F. Nicolò, A. Rotondo, G. Grassi, F. Foti, F. Risitano and C. Bilardo. “3-Phenylfuro[3,2-c]chromen-4-one”. Acta Cryst. (2001), C57, 493-494
24 G. Bruno, R. Scopelliti, C. Donato and G. Tresoldi. “Incorporation of non-planar chelating
ligands in the coordination sphere of ruthenium(II) complexes. Unusual S-thioether N-pyridyl
chelation mode of di-2-pyridylsulfide (dps) to Ru(N,N-dps)2 core: NMR studies of sterically
induced internal dynamics”. Inorg. Chim. Acta (2001) 313, 43-55
25 G. Bruno, F. Nicolò, A. Rotondo, G. Grassi, F. Foti, F. Risitano and C. Bilardo. “9-(4Methylbenzylidene)-4-8-diphenyl-6-p-tolyl-2-oxa-3,7-diazaspiro [4.4]noa-3,7-dien-1-one”. Acta
Cryst. (2001), E57, o399-o401
26 G. Bruno, F. Nicolò, A. Rotondo, G. Grassi, F. Foti, F. Risitano and C. Bilardo. “9-(2Methoxylbenzylidene)-6-(2-methoxyphenyl)-4,8-diphenyl-2-oxa-3,7-diazaspiro
[4.4]noa-3,7dien-1-one”. Acta Cryst. (2001), E57, o396-o398
27 G. Bruno, F. Nicolò, A. Rotondo, G. Grassi, F. Foti, F. Risitano and C. Bilardo. “9-(2Methoxylbenzylidene)-6-(2-methoxyphenyl)-4,8-diphenyl-2-oxa-3,7-diazaspiro
[4.4]noa-3,7dien-1-one”. Acta Cryst. (2001), E57, o396-o398
28 G. Bruno, F. Nicolò, G. Grassi, F. Foti and F. Risitano “Unprecedented rearrangement reaction
of nitrile oxides and a sterically congested 4-ylidene-5-isoxazolone”. Heterocycles. (2001), 55,
763-768
29 G. Bruno, B.Bottari, R.Maccari, F.Monforte, R.Ottanà, M.G.Vigorita, F.Nicolò, A.Rotondo and
E. Rotondo “Nickel(II)2,6-Diacetylpyridine Bis (isonicotinoyl hydrazonate) and Bis (benzoyl
3
hydrazonate) Complexes:Structure and Anti-mycobacterial Evaluation.Part XI. Bioorganic &
Medicinal Chemistry 9 (2001), 2203-2211
30 G. Bruno, M. Panzalorto, F. Nicolò and M. Giannetto “r-1,c-2,c-3,t-4,5-Pentachloro-6phenyltetralin” Acta Cryst. (2001), E57, o1045-o1046
31 G. Bruno, Francesco Nicolò, Archimede Rotondo, Rosaria Gitto, and Maria Zappalà “4,5Dihydro-7,8-dimethoxy-1-phenyl-3H-2,3 ben-zodiazepin-4-one” Acta Cryst., (2001), C57,
1225-1227
32 G. Bruno, Giovanni Grassi, Francesco Nicolò, Massimiliano Cordaro "Structural Studies of a N[(N-Unsubstituted Pyrrole-3-carbonyl)oxy]benzamide and its Precursor Spiro [isoxazole-4,3’pyrrole]" Hel. Chim. Acta (2002) 85, 196-205
33 G. Bruno, Giovanni Grassi, Francesco Risitano, Francesco Foti, Francesco Caruso, Francesco
Nicolò “4-Arylmethylisoxazol-5-one Derivatives - Novel Synthesis, Structural Studies, and
Supramolecular Self-Assembly through Resonance-Assisted Hydrogen Bonding” European
Journal of Organic Chemistry 2001, 24, 4671-4678
34 G. Bruno, Santo Lanza, Francesco Nicolò, Archimede Rotondo, Giuseppe Tresoldi “Reactions
of Secondary Dithioxamides with [(6-p-cymene)RuCl(-Cl)]2: The Role of Steric Hindrance on
Amidic Nitrogen in Determining the Reaction Products. European Journal of Inorganic
Chemistry, 2002, 1, 65-72
35 G. Bruno, L. Costantino C. Curinga, R.Maccari, F.Monforte, F.Nicolò, R.Ottanà, M.G.Vigorita,
“Synthesis and Aldose Reductase Inhibitory Activity of 5-Arylidene-2,4-thiazolidinediones".
Bioorganic & Medicinal Chemistry 10 (2002), 1077-1084
36 G. Bruno, F. Nicolo', G. Tresoldi and S. Lanza "Trans-bis(acetonitrile)-bis(di-2-pyridylsulfideN,N') ruthenium(II) bis(tetrafluoroborate) monohydrate" Acta Cryst. (2002), C58, m56-m58
37 G. Bruno, Giovanni Grassi, Francesco Nicolò and Roberto Romeo "Ab initio and DFT study on
isoxazol-5-one: consequences of strong intermolecular hydrogen bond formation in
supramolecular structures" Hel. Chim. Acta (2002) 85, 2364-2376
38 G. Bruno, Santo Lanza, Francesco Nicolò, Giuseppe Tresoldi and Giuseppe Rosace ( 3-Allyl2k3C)(chloro-1kCl)(µ-N,N’-diethyldithioxa-midato-1:2k4S,S’:N,N’)-[diphenyl
(2-pyridyl)
phosphine-1kP]- palladium(II) platinum(II) chloroform solvate. Acta Cryst. (2002), C58, m316m318
39 G. Bruno, Santo Lanza, Francesco Nicolò, Giuseppe Tresoldi and Giuseppe Rosace “N,N’dibenzyldithiooxamide” Acta Cryst. (2002), C58, o608-o609
40 G. Bruno, Paola Conti, Marco De Amici, Samuele Joppolo di Ventimiglia, Tine B. Stensbøl, Ulf
Madsen, Hans Bräuner-Osborne, Emilio Russo, G. De Sarro and Carlo De Micheli “Synthesis
and Anticonvulsant Activity of Novel Bicyclic Amino Acids”. Jour. & Med. Chem. 46 (2003),
3102-3108
41 G. Bruno, Francesco Nicolò, Rosaria Gitto, Nicola Micale and Giuseppe Rosace “5-Phenyl-9H1,3-dioxolo[4,5-h][2,3]-benzodiazepin-8(7H)-one” Acta Cryst. C59, (2003), o117-o119
42 G. Bruno, Stocco G, Petruso S, Pierattelli R, Giuliani AM, Guli G. “Bis[2-benzoylpyrrolato(N,O)]copper(II): X-Ray structure, solution properties and intercalating ability towards DNA”.
JOURNAL OF INORGANIC BIOCHEMISTRY 86 (1): 444-444 AUG 2001
43 G. Bruno, G. Grassi, F. Foti, F. Risitano and A. Rotondo “Diastereoselective Synthesis and
Structure of Spirooxindole Derivative” Heterocycles 60, (2003), 857-863
44 G. Bruno, S. Lanza, F. Nicolò, G. Callipari and G. Tresoldi “Trinuclear Heterobimetallic
Complexes with Binucleating Dithioxamides. Stereoselective Synthesis and Solution Behaviour
Involving Pd-N bond ropture”. Inorg. Chem. 42 (2003), 4545-4552
45 G. Bruno, Enrico Rotondo, Giuseppe Bruschetta, Archimede Rotondo, Maria Letizia Di Pietro,
and Matteo Cusumano. “NMR investigation and dynamic behaviour of [2,2’-dipyridyl(bispyridine) platinum(II)]2+ and related cationic complexes. Crystal structure of
[Pt(bipy)(py)2](PF6)2. European Journal of Inorganic Chemistry, 2003, 14, 2612-2618
46 G. Bruno, Francesco Nicolò, Fausto Puntoriero, Gaetano Giuffrida, Vittorio Ricevuto and
Giuseppe Rosace. “(4-Dimethylamino-benzylidene)-(3,5-bis(2-Pyridyl)-1,2,4-triazol-4-yl)amine” Acta Cryst. C59, (2003), o390-o391
4
47 G. Bruno, Giovanni Grassi, Francesco Nicolò, Francesco Risitano, Francesco Foti and
Massimiliano Cordaro. “Regio and Diastereoselective Lactonisation of Enolisable 1,3dicarbonyles by Reaction with Mesoionic 1,3-Oxazolium-5-olates” Chem Comm. (2003), 18681869
48 G. Bruno, M.C. Aversa, A. Barattucci, P. Bonaccorsi and P. Giannetto and P. Rollin. “The role
of the exo-anomeric effect in the stereoselective oxidation of 1-thioglycosides: a contribution in
the a-D-glucopyranoside series using X-ray crystallography ”. Lett. Org. Chem, (2004), 1, 148150.
49 G. Bruno, Grassi, F. Foti, F. Risitano, M. Cordaro and F. Nicolò. “Synthesis, structural and
theoretical studies of new ring-chain adducts of 5(4H)-oxazol-5-ones and aldehyde
methylhydrazones”. Journal of Molecular Structure . (2004), 698, 81-86
50 G. Bruno, GianPiero Calabrò, Dario Drommi and Felice Faraone. “Effect of chelating vs.
bridging coordination of chiral short-bite P–X–P (X = C, N, O) ligands in enantioselective
palladium-catalysed allylic substitution reactions”. Dalton Transactions, (2004), (Advance
Article) 81-89
51 G. Bruno, Simona Rubino, Salvatore Petruso, Roberta Pierattelli, Giancarlo Stocco, Luca
Steardo and the late Giancarlo Gulì. “ Synthesis, characterization, and cytotoxic activity of
copper(II) and platinum(II) complexes of 2-benzoylpyrrole and X-ray structure of bis[2benzoylpyrrolato(N,O)]copper(II)”. Journal of Inorganic Biochemistry 98 (2004) 2071–2079
52 G. Bruno, F. Nicolò, A. Rotondo, M. C. Aversa, A. Barattucci, P. Bonaccorsi, P. Giannetto.
“Structure Reports (8aR,SS)-Dimethyl 3,5,6,7,8,8a-hexahydro-4-{[(1S)-exo-2-hydroxy-7,7dimethylbicyclo-[2.2.1]heptan-1-yl]methylsulfinyl}-1,2-naphthalene dicarboxylate”. Acta Cryst.
(2004), E60, o733-o735
53 G. Bruno, Archimede Rotondo, Lidia De Luca, Silvio Sammartano and Francesco Nicolò.
“N,N,N’,N’-Tetramethylethylenediammonium-succinate-succinic acid (1/1/1)” Acta Cryst.
(2004), C60, 0287-0289
54 G. Bruno, A. Rotondo, G. Grassi, F. Foti, F. Risitano and F. Nicolò. “5-Benzoylamino-3-bromo4-(4-methoxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic-acid” Acta Cryst. (2004), C60, 04960497
55 G. Bruno, F. Nicolo, A. Rotondo, F. Foti, F. Risitano and G. Grassi “Four bromo-substituted
pyrazoline and isoxazolinone spiro derivatives” Acta Cryst. (2004), C60, o879-o88356 G. Bruno, A. Rotondo, F. Nicolo, F. Foti, G. Grassi and F. Risitano “10-(4-methoxy-phenyl)-9phenyl-2,4,8,9-tetraaza-spiro[5.4]dec-7-ene-1,3,5-trione” Acta Cryst. (2005). E61, o139-o141
57 G. Bruno, A. Rotondo, F. Nicolo, F. Foti, G. Grassi and F. Risitano “9-Bromo-7,10-diphenyl2,4,7,8-tetraaza-spiro[5.4]dec-8-ene-1,3,5-trione” Acta Cryst. (2005). E61, o142-o144
58 G. Bruno, A. Rotondo, F. Nicolo, G. Tresoldi and S. Lanza. “Bis(di-2-pyridyl sulfide-k2N,N’)(4-methylpyrimidin-2-yl 2-pyridylmethyl sulfide k2N,S)ruthenium(II) bis (hexafluorophosphate)
acetonitrile solvate”. Acta Cryst. (2005). C61 m169-172
59 G. Bruno, R. Ottanà, R. Maccari, M. L. Barreca, A. Rotondo, A. Rossi, G. Chiricosta, R. Di
Paola, L. Sautebin, S. Cuzzocrea and M. G. Vigorita "5-Arylidene-2-imino-4-thiazolidinones:
Design and synthesis of novel anti-inflammatory agents” Bioorganic & Medicinal Chemistry 13
(2005) 4243–4252
60 G. Bruno, Nicolò F, Rotondo A, Cordaro M, Risitano F, Grassi G. “ An unusual acid:(+/-)-3benzoyl-1,2-dimethyl-8a-phenyl-2-benzo-thieno[2,3-b]pyrrole-1,2-dicarboxylic
anhydride”.
Acta Cryst. (2005) C61, pp. 0610-0612 ISI: 000232353900019.
61 G. Bruno, N. Marino, A. Rotondo, G. Brancatelli, F. Nicolò. “2,5-Dicarboxyanilinium chloride
monohydrate”. Acta Cryst. (2006) C62, pp. 587-589 ISSN: 0108-2701
62 G. Bruno, F. Nicolò, A Rotondo, Grassi, F. Foti, F. Risitano “Structural Investigation on
Bridgehead Aziridine. Synthesis, Theoretical and Crystallographic Study of 2,4,6-triphenyl-1,3diaza-bicyclo[3.1.0]hex-3-ene”. Hel. Chim. Acta (2006) 89, 190-200
63 G. Bruno, Dario Drommi, Maria Saporita, Felice Faraone, Patrizia Scafato and Carlo Rosini.
“Origin of enantioselectivity in palladium-catalyzed asymmetric allylic alkylation reactions
5
using chiral N,N-ligands with different rigidity and flexibility “Dalton Trans., (2007), 15091519
64 G. Bruno, F. Nicolò, G. Tresoldi, S. Lanza and A. Rotondo, “Ab initio and DFT calculation of
molecular structure and proton affinity for selected chalcogenobispyridines” Journal of
Molecular Structure Theochem. (2007) 818, 131-139
65 G. Bruno, R. Gitto, R. Ficarra, R. Stancanelli, M. Guardo, L. De Luca, M. L. Barreca, B.
Pagano, A. Rotondo, E. Russo Gi. De Sarro and A. Chimirri “Synthesis, Resolution,
Stereochemistry, and Molecular Modeling of (R)- and (S)-2-acetyl-1-(4′-chlorophenyl)-6,7dimethoxy-1,2,3,4-tetrahydroisoquinolines AMPAR Antagonists” Bioorganic & Medicinal
Chemistry, (2007) 15, 5417-5423
66 G. Bruno, A. Rotondo, F. Nicolo and S. Lanza “N,N –Diisopentyldithiooxamide ” Acta Cryst.
(2007). E63, o3595-o3596
67 G. Bruno, G Cafeo, F H. Kohnke and F Nicolò “Tuning the anion binding properties of
calixpyrroles by means of p-nitrophenyl substituents at their meso-positions” Tetrahedron
(2007) 63, 10003–10010
68 G. Bruno, Calabro M.L., Raneri D., Ficarra P., Ferreri G., De Sarro G., Zappala M., Micale N.,
Grasso S. “Enantioseparation, absolute configuration determination, and anticonvulsant activity
of (+/-)-1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro)-4H-2,3-benzodiazepin-4one.
Chirality. (2007) vol. 19, pp. 16 - 21 ISSN: 0899-0042, ISI:000242838300004