- AIRC Associazione Italiana per la Ricerca sul Cancro CALL FOR PROPOSALS 2013 Fellowships for Italy Current address: Via San Vito 7, 20123 Milano tel. 02/7797222-374 fax 02/7797259 email: [email protected] Technical support: tel. 02/7797224 Legal address: Via Corridoni 7, 20122 Milano [AIRC – fellowships Italy call 2013] In this Call: 5 triennial fellowships 9 biennial fellowships 5 annual fellowships Fellowships Donors’ requirements 2 triennial fellowships “Borromeo” 2 triennial fellowships “Clienti Carrefour” 1 triennial fellowship “Antonietta Latronico” 1 biennial fellowship “Ferdinando Burigana e Renata Coi” 1 biennial fellowship “Gemma Del Cornò” top priority will be given to applicants intending to move to a different city or region to carry out their research top priority will be given to applicants intending to move to a different city or region to carry out their research top priority will be given to applicants intending to move to a different city or region to carry out their research top priority will be given to applications with a research plan focused on bone cancer top priority will be given to applications with a research plan focused on breast or lung cancer and to be carried out in Lazio top priority will be given to applications with a research plan focused on pancreas or biliary duct cancer top priority will be given to applications with a research plan to be carried out in Veneto top priority will be given to applicants intending to move to a different city or region to carry out their research top priority will be given to applicants intending to move to Veneto or from Veneto to carry out their research top priority will be given to applications with a research plan to be carried out in Veneto top priority will be given to applicants intending to move to a different city or region to carry out their research top priority will be given to applications with a research plan focused on colon or liver cancer and to applicants intending to move to Puglia or from Puglia to carry out their research top priority will be given to applications with a research plan to be carried out in Veneto top priority will be given to applications with a research plan to be carried out in Veneto top priority will be given to applications with a research plan focused on female cancers and to be carried out in Veneto top priority will be given to applications with a research plan to be carried out in Veneto top priority will be given to applications with a research plan focused on colon cancer and to applicants intending to carry out their research in Puglia 1 biennial fellowship “Antonino Ippolito e Luigi Nappa” 1 biennial fellowship “Ermanno Pasquetto e Francesco Scanferla” 1 biennial fellowship “Giovanna Ciani” 1 biennial fellowship “Starwood Hotel Europa & Regina Venezia” 1 biennal fellowship “Volontari del Comitato veneto e Trentino Alto Adige” 1 biennial fellowship “Starwood Hotels and Resorts” 1 biennial fellowship “Salvatore Maisto e Franco Marzano” 1 annual fellowship “Albergatori e Volontari, Città di Jesolo” 1 annual fellowship “Volontari gruppo pro Lughetto (VE)” 1 annual fellowship “Hard Rock Cafe Venice” 1 annual fellowship “Centro Studi Ricerche Ligabue” 1 annual fellowship “Enzo Manduzio” 2 [AIRC – fellowships Italy call 2013] TABLE OF CONTENTS Foreword .............................................................................................................................................. 4 Eligibility criteria for applicants .......................................................................................................... 4 The hosting institution ......................................................................................................................... 4 The research plan ................................................................................................................................. 5 The review process............................................................................................................................... 5 Funding ................................................................................................................................................ 5 Duration and Renewals ........................................................................................................................ 6 Bio-Ethical Requirements .................................................................................................................... 6 Guide to proposal preparation .............................................................................................................. 6 Type of fellowship .......................................................................................................................................................... 7 Your personal data .......................................................................................................................................................... 7 Administrative Data ........................................................................................................................................................ 7 Curriculum vitae ............................................................................................................................................................. 7 Certificate of graduation ................................................................................................................................................. 8 Publications .................................................................................................................................................................... 8 Project keywords ............................................................................................................................................................ 9 Research project ............................................................................................................................................................. 9 Head of the hosting lab ................................................................................................................................................... 9 Letter of acceptance by the head of the hosting lab ...................................................................................................... 10 Research and professional experience of the head of the hosting lab ........................................................................... 10 Publications of the head of the hosting lab ................................................................................................................... 10 Head of the laboratory of origin.................................................................................................................................... 10 Letter of presentation by the head of the laboratory of origin (only in case of mobility) .............................................. 10 Bio-Ethical Requirements ............................................................................................................................................. 10 Submission .................................................................................................................................................................... 11 Deadlines ............................................................................................................................................ 12 Keywords………………………..………………………………………………………after page 13 3 [AIRC – fellowships Italy call 2013] Foreword The Associazione Italiana per la Ricerca sul Cancro (AIRC) will award a total of 19 Fellowships in cancer research to highly qualified young graduates and/or post-doctoral fellows or equivalent who wish to broaden or acquire new experience in oncological research in a cancer-focused laboratory. Eligibility criteria for applicants At the deadline for application submission, for any type of fellowship the following eligibility criteria must be met: • applicants must have a degree in Medicine, Biological Sciences, Pharmacy, Chemistry and Pharmaceutical Technology, Medical Statistics, Medical Biotechnologies or other scientific disciplines, provided that the focus of the proposed research plan in the application is cancer; • the degree should be an Italian laurea magistralis, i.e. 5-6 years of undergraduate degree, or an equivalent non Italian degree (candidates who only have a “laurea breve” are not eligible), and it should have been attained after December 31, 2006. Exceptions are allowed only in case of research interruptions due to parental leave, children care, illness. Applications from researchers who do not meet these requirements will be rejected. Furthermore: • the choice to carry out the research activity in an Institute located in a different place from the one of origin will be a determining factor when awarding mobility fellowships (for example, fellowships “Borromeo”), and in general it will be considered a preferential title for all fellowships; • fellowships are not compatible with any other continuous employment income; • several fellowships have specific requirements, asked by the donors and listed on page 2 of this Call. Unless stated otherwise (i.e. “applicants must …”), please note that several of these requirements are not mandatory but only represent a priority criterion. Through the online application form candidates automatically apply to all AIRC fellowships available in this Call. We urge all applicants to apply both to AIRC and FIRC Fellowships for Italy. Applicants can indicate the duration of the fellowship they prefer (1-2-3 years) through the application form. At the end of the review process the staff of the AIRC Peer Review Office will determine which applicants in the fundability range of the final ranking have the characteristics required for each fellowship (see “The review process”, below); • applicants who have already been awarded one triennial AIRC or FIRC fellowship for Italy cannot apply to this Call. Researchers cannot be supported by AIRC/FIRC fellowships for more than three years total (e.g. recipients of a two-year AIRC or FIRC fellowship would be eligible ONLY for an annual fellowship); • a maximum of two candidates per research group (i.e. having the same head of the lab of origin) may apply. The hosting institution The hosting institution must be a non-profit research institution (possible revenues must be reinvested in research activities) in Italy, with the mission to develop biomedical research and to disseminate its results. Successful candidates must operate in the Italian hosting institution for the entire duration of the fellowship. Any change occurring in the relationship between the fellow and the hosting institution (e.g. termination, leave of absence) or in the hosting institution legal entity or organization (e.g. changes in Institution name, merging, Legal representative turn-over, changes in addresses) must be promptly notified to AIRC. 4 [AIRC – fellowships Italy call 2013] Hosting institutions must assure optimal working conditions to the fellows: in addition to providing facilities, equipment, and infrastructure, the hosting institution, and especially the head of the hosting lab, are expected to offer adequate training resources and cover expenses to travel to conferences and meetings when they are deemed important for the training and education of the fellow. A letter of acceptance of the applicant by the head of the hosting lab must be included in the application, describing all resources and training opportunities available. The head of the hosting lab is expected to supervise the work of the fellow, and provide training and mentoring. The research plan Applications must include a detailed research plan, agreed with the head of the hosting lab, with a clear focus on cancer. The review process Applications from fellows who meet the eligibility requirements undergo a peer review process that ensures a fair, independent and expert evaluation of applications. Applications will be evaluated by three members of AIRC/FIRC Fellowships Scientific Committee (CSB). Reviewer assignments are made in compliance with conflict of interest and appearance of conflict rules to ensure a review free from inappropriate influence (e.g. no application from a given research Institution is assigned to reviewers from the same Institution or the same city). When accepting to evaluate an application, reviewers agree that they will maintain the confidentiality of the application and associated materials they have received. The following review criteria will be used to evaluate applications: • curriculum vitae and track-record of the applicant; • quality of the hosting laboratory and of the hosting institution (also in terms of training potential); • quality of the research project and its relevance to cancer. For each application, the scores received from all reviewers will be averaged to generate the application’s global score, which will be used to rank the applications. The selection will be exclusively based on this ranking and, subsequently, on the eligibility of each applicant to the specific requirements of each fellowship (fellowships may have requirements, generally asked by donors, in terms of duration, topic of research, region of provenance of the applicants, region where the research has to be carried out; when present, such requirements are indicated on page 2 of the Call). At the end of the review process, on the date indicated in the Deadlines table, all proponents will be notified of the final decision on their application with an official communication from AIRC, and the anonymous reviewers’ comments will be available online for each applicant. The decision concerning the approval of an application cannot be appealed. Funding The gross annual amount of each fellowship is € 20.000 per year, or € 25.000 per year in case of mobility fellowships (i.e. the applicant moves to a hosting institution located in a different city or region than the one of origin). AIRC will transfer the fellowship funds to the hosting institution, which will then pay the fellow directly. Please note that it will not be possible to grant a fellowship if an agreement regulating the administrative responsibilities and management of the fellowship award is not signed between the hosting institution and AIRC. Please note that fellowships are not tax-exempt: revenues taxes will be deducted. 5 [AIRC – fellowships Italy call 2013] Duration and Renewals Fellowships have a duration of either one, two or three years (see page 2). In a specific section of the application form it will be possible to indicate the preference. Independently of the duration, all fellowships will start on January 1st 2014. Renewals for biennial and triennial fellowships must be submitted yearly (see Deadlines), through the appropriate online forms. At the end of the funding period, a final scientific report is required for all fellowships (see Deadlines). Bio-Ethical Requirements Ethics Committee approval is mandatory for studies involving human subjects, human biological samples or animal models, according to current international and national rules, and must be submitted with the full application. The fellowship will not be awarded in the absence of an Ethics Committee clearance. If the approval from the Ethics Committee(s) is not available by the submission deadline, the applicant must obtain it by November 15th 2013 and either upload it as PDF file in the “Personal Area” or send it to the AIRC Peer Review Office by e-mail ([email protected]). Guide to proposal preparation To apply, click on the “Area Ricercatori” of the site www.airc.it PLEASE NOTE: AIRC has redesigned its web-based platform for submitting applications. Please make sure to read the instructions carefully, as there are some major differences with the previous system. • For researchers that already have an AIRC account: access the “Personal Area” with the “old” username but use the password: Airc.2013 You will be asked to change this password on your first login. In the “Old password” field, please enter: Airc.2013 • First-time applicants must register in our system: please click on “Register” and provide the requested information, including your tax code (codice fiscale). The registration will be confirmed by e-mail and a username and password will be provided. To launch the application form for the first time, click on “Calls”, select “Fellowships”, then click on “Apply” in the Fellowships for Italy 2013 section. In the next window, click on “Access the application form”. Subsequently, to access the application in progress, click on “Submissions” and then click on “Access the application form”. We urge all applicants to apply to both AIRC and FIRC Fellowships for Italy: in the “Type of fellowships” section of the online application form, please select “Both” and save. Before continuing, please read the following general features of our online system: - the system automatically launches the “Type of fellowship” form. All forms that must be filled out are listed on the left side of the page. Click on each one of them and fill in all the mandatory fields (in bold). Make sure to click on “SAVE” after completing each form; - the forms can be filled out at different times and the work can be interrupted/resumed at will; - a number of forms must be submitted as PDF files. Each file cannot exceed 2Mb. Any file exceeding such a limit will be automatically rejected by the system. Secure PDF files 6 [AIRC – fellowships Italy call 2013] cannot be uploaded. Documents submitted as PDF files must be written using an A4 format, single spaced, with margins not less than 2 cm and a font not smaller than 12 point (preferably Palatino, Times, Arial). Do not exceed the page limit indicated for each section: the system will not allow the upload of a number of pages beyond the limit; - the “Summary” section (last title in the list of forms on the left) allows applicants to: a. check and see whether each form has been correctly filled out. Forms that are complete are marked with a green “OK” box; forms that are incomplete have a red “KO” box together with a list of the specific fields that have not been filled out; non mandatory forms are “OK” by default even if they have not been completed; b. view and print the application in its incomplete/complete state. By clicking on “Create draft” and then on “Open submission draft” you can download the PDF draft generated by the system; c. submit the application. Once all mandatory forms are complete, please click on “Submit”. Be aware that after clicking on “Submit” it will not be possible to make any further modifications; - the complete proposal is automatically assembled as a whole PDF file at the end of the online procedure; The application must be written entirely in English. Applications that do not conform to all the requirements in these instructions will be rejected. Type of fellowship Please indicate the preferred duration of the fellowship, and the funding body (AIRC, FIRC, both). We urge applicants to select “Both”. Your personal data Please fill in the requested fields, entering: • the title of the proposal. The title must not exceed 120 characters, small cases, spaces included. It should be neither too specific (abbreviations of molecules names such as “Role of PGCI in tumor progression” may not be clear enough), nor too vague (such as “Analysis of tumor metastatization”); • the applicant’s personal data (title, birth date, gender, etc.), unless already provided when registering into the AIRC website; also, please enter the applicant’s home address and contact data. If possible, please provide a mobile phone number. Please note: the PI is the prospective fellow and not the head of the hosting lab; • all information regarding the degree obtained and, if applicable, the PhD. Administrative Data Please provide the requested information about the Legal representative (Legale rappresentante) of the Institution. The Legal representative will be responsible, along with the fellow’s supervisor, of all the legal and administrative duties of the fellowship award. The “Institution” field is automatically filled out when this information is entered in the “Your personal data” section. Curriculum vitae The Curriculum vitae with a description of the scientific activity carried out must be uploaded as PDF file (maximum 2 pages, approx. 1000 words). If applicable, please indicate whether there have been any research interruptions for periods longer than 6 months between 2008 and 2013 due to parental leave, children care, illness. Include appropriate documentation to certify the career break (e.g. birth certificate in case of maternity leave). The CV and, for research interruptions, supporting documents must be uploaded as a single PDF file. Do not include the applicant’s publications in the CV, as there is a specific section of the online form to upload them. 7 [AIRC – fellowships Italy call 2013] Certificate of graduation The Certificate of graduation with the scores obtained in individual examinations must be attached as PDF file of the scanned original. To facilitate the work of reviewers who may not be familiar with the academic transcripts of the applicant’s country, please include a page with a description (or translation) of the certificate provided and of the score range. For example, explain that the scores of individual exams can range from X to Y, Y being the best score obtainable. Do the same in case there is a final score for the degree obtained. Publications The list of publications of the fellow from the past five years (2008-2013) has to be selected through the online procedure. To do so, a number of options is available; click on any that applies. Add from MyPub This interface lists all publications previously entered into the system (e.g. through prior applications, or entered directly into the MyPub section of the Personal Area). By selecting some or all of these publications, they will be uploaded in the current form; please make sure the flags are correct. Add PubMed publications Within this interface the system launches a PubMed search and provides a list of PubMedrecorded publications spanning from 2008 to 2013. Enter the applicant’s first and middle initials, and click on “Find”. If the applicant has published with a different last name than that used to register into the AIRC account (e.g. married vs maiden name), check the “Change surname” box, and then click on “Find”. Alternatively, search for a specific article by entering its PubMed ID in the corresponding box. Once the list of all PubMed publications has been generated, please follow these steps: a. Select papers to be included in the application From the list of all PubMed publications, select the papers published by the applicant and that the applicant wants to include in the proposal by clicking on the “Select this publication” button for each article. Pay special attention to potential homonyms. Do not include abstracts, conference papers, letters to the editor, book chapters and papers published in journals without IF, unless they are new journals. It is possible to select all publications that have been retrieved by the system, and then deselect those that the applicant does not want to include in the application, by clicking on the “Cancel” button of each unwanted article. b. Indicate acknowledgement to AIRC and relevance to cancer research For each publication, please indicate whether it has an acknowledgement to AIRC and whether it is relevant for cancer research by checking either “YES” or “NO” (the default is “NO” for both), then click on “OK” to save this information. Please note: for each selected paper, the system automatically recognizes the position of the applicant in the list of authors; it is possible to amend this information, if incorrect, by providing supporting documentation from the main page of the Publications (see below). c. Certify accuracy of flags, and save records Once all selected publications have been flagged, scroll down to the bottom of the page and check the certification box (“I, the undersigned, certify that all publications have been carefully checked and correctly flagged for authorship. I am aware that any mistake or inaccuracy may impact the evaluation of my track record”) and click on “Add this publication”. 8 [AIRC – fellowships Italy call 2013] Add Web of Science® publications From this section it is possible to enter articles that are included in Web of Science® but not in PubMed (most journals are present in both databases, but there are few exceptions). For each record, please provide the title, list of authors, year, volume, pages, publication date. Select the journal from the drop-down menu, which provides all journals listed in Web of Science®. Mark each paper for authorship, acknowledgement to AIRC, and relevance to cancer research. Please upload the page of the article where the role of the author in the published work is certified (not the full article). Finally, check the certification box and click on “Save” to complete the process. Add papers in press Use this section to submit articles already accepted for publication but not yet available online. For each record, please provide the title, list of authors, year. Select the journal from the drop-down menu, which lists all Web of Science® indexed journals. Mark each paper for authorship, acknowledgement to AIRC, and relevance to cancer research. Please upload a PDF file with the letter of acceptance from the journal. Do not attach the entire manuscript. Finally, check the certification box and click on “Save” to complete the process. All publications entered from any of the above sections will be listed in the “Publications” main page. From here, it is possible to edit the information relative to each paper by clicking on the title of the publication. Once in the “Update publication” window, please check the appropriate authorship box and upload the page of the article where the role of the author in the published work is certified (e.g. for a second or third author who is in fact a co-first author, please upload the PDF file of the page where it is stated that the PI “equally contributed to this work”). Check “not assignable” when a publication stems from a consortium in which the relative contribution of each author is the same. Then check the certification box and click on “Save” to complete the process. Project keywords Project keywords will be used by the AIRC Peer Review Office to assign each application to the most appropriate reviewers. Therefore, a good choice of keywords is extremely important to ensure that reviewers with the most adequate expertise will evaluate the application. Avoid keywords that are too generic or too similar with each other; pick a set of keywords that clearly define the key aspects of your research plan. Keywords are listed at the end of this Call both in alphabetical order and by topic. To enter the project keywords (at least one, maximum five) please click on the button “Enter/Edit Keywords”. In the “Manage Project Keywords” pop-up window, keywords are grouped by their first letter: for example, by clicking on the letter “C” in the menu it is possible to visualize all keywords beginning with the letter C, and to select one. To select a keyword, click on it (the keyword box will turn from grey to blue) and then click on “Save”. You will be automatically redirected in the main keywords page: click on “Save” at the bottom of this page to save the record. Repeat this process for each keyword. Research project A research project, agreed with the head of the hosting laboratory, must be divided into the following sections, to be uploaded individually as PDF files: a. Abstract (max 1 page, approx. 500 words) b. Background (max 1 page, approx. 500 words) c. Proposal main body (max 3 pages, approx. 1500 words) d. Feasibility (max 1 page, approx. 500 words) e. References (max 1 page, approx. 15 references). Head of the hosting lab Please fill in the requested fields, with the personal and institutional data of the head of the hosting lab. 9 [AIRC – fellowships Italy call 2013] Letter of acceptance by the head of the hosting lab A letter of acceptance of the applicant by the head of the hosting lab (max 2 pages, approx. 1000 words) must be uploaded as PDF file of the signed, scanned original. In this document, the prospective supervisors must indicate what grant/funding will be used to support the research project described in the application; in addition, they should briefly describe their mentoring activities (e.g. frequency of meetings with fellows, number of PhD students or post doc fellows trained, etc). The letter should also state if the hosting institution will offer adequate training resources. Research and professional experience of the head of the hosting lab Click on “Add new record” and list, in reverse chronological order, the most important positions held by the head of the hosting lab. For each entry, please indicate the Institution, City, Country, time frame and the position held. Publications of the head of the hosting lab Please enter all cancer-related publications published by the head of the hosting lab in the past five years (2008-2013). Click on “Add publications” and follow the online procedure described in “Add PubMed publications” of the section “Publications”, above. Head of the laboratory of origin Please fill in the requested fields, with the personal and institutional data of the head of the laboratory of origin. If there is no mobility, please click on “Same as the Head of the hosting lab”. Letter of presentation by the head of the laboratory of origin (only in case of mobility) A letter by the head of the laboratory of origin, presenting the applicant, must be uploaded as PDF file of the signed, scanned original. Bio-Ethical Requirements Check boxes as applicable for human and animal experimentation. Research on humans Please note that human experimentation is not limited to clinical studies with healthy volunteers and/or patients. It includes use of human biological samples (commercially available human cell lines e.g. from ATCC are exempt), human genetic material and human data collection (e.g. genetic information, health, etc.). For clinical trials involving human subjects, and for studies with human biological samples, the approval of the local Ethics Committee/Institutional Review Board (IRB) together with a copy of the informed consent (if requested by the Ethics Committee) is mandatory. If available at the time of submission, the documentation must be included in the application as PDF file by clicking on “Select” under the “Clearance from Ethic Committee” header. The approval document issued by the Ethics Committee MUST indicate: - the date when the IRB meeting was held: approvals obtained more than 3 years ago (i.e. prior to 2010) are NOT acceptable; - the name of the applicant and/or the name of the head of the hosting lab; - a clear reference to the studies described in the proposal (e.g. the title of the application). In case biospecimens have been obtained by external sources/collaborators, the clearance documents must be provided by the collaborator’s research center. In any case, if the research deals with human biological samples, genetic materials or data collection, the research proposal should include information about: 10 [AIRC – fellowships Italy call 2013] - how the samples, materials or data are collected; whether the samples, materials or data are collected specifically for the proposed research project; how the samples, materials or data are dismissed. If the approval from the Ethics Committee is not available by the submission deadline, the PI must obtain it by November 15th 2013 and either upload it as PDF file in the “Personal Area” or send it to the AIRC Peer Review Office by e-mail ([email protected]) and in paper (Via San Vito 7, 20123 Milano). Research on animals Animal experimentation must conform to all regulations protecting animals used for research purposes according to current international and national rules. If the research plan involves animal experimentation, the applicant must select one of the available options in the online form: • I have obtained the clearance from the competent animal research ethics committee to carry out the described animal experimentation, and I am attaching it to the application; • I have not obtained the clearance from the competent animal research ethics committee yet, but I have requested it and will send it to the AIRC Peer Review Office by November 15th 2013; • there is not active Ethical Committee for animal research at my Institute, but the procedures related to animal use have been communicated to the Italian Ministry of Health and a copy of this communication is attached to the current application; • there is not an active animal research ethics committee in my Institute; I have yet to communicate the procedures related to animal use to the Italian Ministry of Health but I will do so and I will send a copy of this communication to the AIRC Peer Review Office by November 15th 2013. In any case, by signing the Bio-Ethical requirements page the applicant declares that the research studies are accurately described in the proposal and conform to all regulations protecting animals used for research purposes, including those of the DL 116/92. The experiments described in the proposal will be performed following the guidelines described in: Workman P. et al.: “Guidelines for the welfare and use of animals in cancer research”. Br. J. Cancer (2010) 102: 1555-1577. The required documentation for animal experimentation, if not available by the submission deadline, must be sent to AIRC by e-mail ([email protected]) or directly uploaded in the PI’s Personal Area by November 15th 2013. No paper copy of this documentation is required. Please note: Ethics Committee(s) approval(s) for human and/or animal research are not necessary for the assessment of the scientific merit of an application, during the review; however, if the application is approved, funds will be granted only if the required Ethical Committee certifications have been sent to AIRC. AIRC is not responsible for any inaccuracy in the ethical documentation provided and does not accept any liability for harm to participants in AIRC funded trials. Submission To submit the application, go to “Summary” (on the lower left of the main page). All sections must be completed and must have the green “OK” label. Please make sure that all data are correctly reported in the PDF Draft prior to submitting the application. Click on “Submit” to finalize the submission. 11 [AIRC – fellowships Italy call 2013] Deadlines DEADLINES ARE STRICTLY ENFORCED: applications submitted after the deadline will not be accepted. Deadlines for applications (by 23:59, Central European Time, of the indicated dates): New applications online form release date April 29, 2013 electronic submission deadline June 24, 2013 paper submission (postmark) deadline (*) June 26, 2013 notification of results November 30, 2013 start of fellowship January 1, 2014 (*) Only the following pages are required in paper format and must be mailed by the indicated deadline: • • • • Title Page, signed by the applicant and Legal representative of the hosting institution Abstract Bioethical requirements page, signed by the PI Only if research in humans is planned: Clearance from the Ethics Committee. Send all paper documentation to the following address: AIRC Direzione Scientifica via San Vito 7 20123 Milano *** Paper documentation marked with “draft” is not valid. Please print the requested pages only after completion of the online submission *** If these documents are not sent by the indicated deadline, applications will not be sent out for review. Make sure to keep a receipt with the mailing date. 12 [AIRC – fellowships Italy call 2013] Deadlines for renewals and final report (by 23:59, Central European Time, of the indicated dates): Annual fellowships Final report online form release date November 10, 2014 electronic submission deadline December 10, 2014 online form release date April 14, 2014 electronic submission deadline June 3, 2014 online form release date November 10, 2015 electronic submission deadline December 14, 2015 online form release date April 14, 2014 electronic submission deadline June 3, 2014 online form release date April 14, 2015 electronic submission deadline June 3, 2015 online form release date November 10, 2016 electronic submission deadline December 14, 2016 Biennial fellowships Renewal for 2nd year of funding Final report Triennial fellowships Renewal for 2nd year of funding Renewal for 3rd year of funding Final report The deadlines for renewal requests and final reports may be subjected to changes. In this case, fellows will be notified of the new deadlines by e-mail. 13 KEYWORDS IN ALPHABETICAL ORDER Adenovirus Caveolin Adhesion dynamics CD133/Stem cell markers Adjuvant therapy Cell adhesion and/or cell adhesion molecules Aging Cell cycle AIDS/HIV/Kaposi Cell cycle checkpoint G1/S ALL Cell cycle checkpoint G2/M AML Cell differentiation and/or differentiation therapy Androgen and/or receptors Cell migration, motility and/or invasion Aneuploidy Cell polarity Angiogenesis and/or vasculogenesis Cell signaling Animal models Centrosome Anti-angiogenic therapy Cervix or endometrial ca. Antibody/mAb therapy Chemistry Apoptosis Chemokines Aromatase and/or inhibitors Chemotherapy and/or chemotherapic drugs ATM pathway Chromatin remodeling ATR pathway Circulating tumor cells Autoimmunity/Autoantibodies Clinical practice guidelines Autophagy Clinical trials B cells CLL bcl2 family CML BCR-Abl/Abl Colorectal and/or Intestinal ca. Beta-catenin/Wnt pathway Combination therapy Biochemistry Comparative genomics hybridization (CGH) Bioinformatics Computational biology Biomarkers Computer Tomography (CT Scan) Biomolecular modelling Costimulatory molecules Biophysics COX2 Bladder tumor Crosstalk Body mass index (BMI) and/or obesity Crystallography Bone disease CTL Bone morphogenetic protein (BMP) Cyclic AMP BRAF/RAF kinases Cyclins and/or inhibitors Brain and/or nervous system tumors Cytogenetics and/or chromosome alterations BRCA Cytokines/Interleukins Breast ca. Cytoskeleton Burkitt lymphoma Dendritic cells C.elegans Diagnosis Cachexia Diet Cadherins DNA damage Cancer stem cells DNA double strand break repair (DSBR) Carcinogenesis DNA methylation Caspases DNA recombination KEYWORDS IN ALPHABETICAL ORDER DNA repair Glioma and/or glioblastoma DNA replication Glucocorticoids and/or receptors DNA single strand break repair (SSBR) Glucose metabolism and/or Warburg effect Docking Glycoproteins and/or glycosylation Drosophila Golgi Drug delivery G-proteins and/or GPCR Drug discovery and/or development Granulocytes Drug response and/or resistance Growth factors and/or receptors Drug screening Growth induction and/or growth arrest Drug toxicity GVDH and/or Graft versus Tumor EGF and/or receptors Gynecological tumors Embryonic development Head and neck ca. Endocrinology Heat shock proteins (HSP) Endocytosis Hedgehog pathway Endoplasmic reticulum (ER) Hematologic malignancies Endothelial cells Hematopoiesis Epidemiology Hematopoietic stem cells Epigenetics Hepatitis B virus (HBV) Epithelial mesenchyme transition (EMT) Hepatitis C virus (HCV) Epstein-Barr Virus (EBV) Hepatocellular carcinoma (HCC) Estrogens and/or receptors HER1-2-3-4 Extracellular Matrix (ECM)/Stroma Hereditary DNA repair disorders Fas and/or FasL Hereditary tumors FGF and/or receptor Herpes virus Flow cytometry High Mobility Group Proteins (HMG) Fluorescence in situ hybridization (FISH) Hippo pathway Fluorescence resonance energy transfer (FRET) Histone modifications Focal Adhesion/FAK HLA/Major Histocompatibility Complex (MHC) Folate and/or receptor Hodgkin's lymphoma Functional genomics Homologous recombination Functional validation of target genes Hormones Fusion genes Human Papilloma Virus (HPV) Gastric ca. Hypoxia/Hypoxia-inducibile Factors (HIF-1) Gene alteration/gain or loss Immune escape Gene expression and/or profile Immunization Gene regulation Immuno-editing Gene therapy Immunohistochemistry Genetics Immunosuppression and/or suppressor cells Genome wide screening/GWAS Immunotherapy Genomic imprinting In vitro imaging and/or live cell imaging Genomic/Genetic instability In vivo imaging Genomics Infection Genotoxicity Inflammation and/or inflammatory cytokines KEYWORDS IN ALPHABETICAL ORDER Inhibitor of apoptosis proteins (IAPs) mRNA translation Innate immunity Multidrug resistance (MDR) Insulin Mutation (somatic and/or germline) Insulin-like growth factor (IGF) and/or receptors Myc Integrins and/or Integrin-linked kinase (ILK) Myeloma Interferons Nanotechnology/Nanoparticles Ion channels Netrin receptors Jak/Stat pathway Neuroblastoma Kidney ca. Next generation sequencing Kinase/Kinome NF-kB family Lentivirus Nitric oxide Leukaemia NK and/or NKT cells Lipid metabolism NMR spectroscopy Liver development and/or regeneration Non apoptotic cell death Loss of heterozygosity (LOH) Non melanoma skin tumors Lung ca. Normal stem cells Lymphatics and/or lymphangiogenesis Notch pathway Lymphocyte differentation Nuclear medicine Lymphomas Nuclear receptor Macrophages and/or monocytes Nuclear structures Magnetic resonance imaging (MRI) Oncogenes MAP Kinases Oncogenic virus/Viral oncology Mass spectrometry Organic compounds Mathematical modeling Osteopontin Matrix metalloproteases (MMP) and/or inhibitors Osteosarcoma MDM2 Ovarian ca. Medulloblastoma Oxidative stress and/or Reactive Oxygen Species (ROS) Melanoma p21 - activated kinases (PAK) Membrane biology p53, p63, p73 Mesothelioma Palliative care MET/HGF Pancreas ca. Metabolism/Metabolomics PDGF and/or receptors Metastasis Pediatric tumors Microarrays Peptides as drugs Microenvironment PET and/or PET-CT microRNA Phage display Microscopy Phagocytes and/or phagocytosis Minimal Residual Disease (MRD) Pharmacogenetics/Pharmacogenomics Mitochondria Pharmacokinetics Mitosis Pharmacology Monoclonal antibodies (mAbs) and/or immunoconjugates Phosphatases Mouse models Phospholipids mRNA processing Phosphorylation KEYWORDS IN ALPHABETICAL ORDER PI3K/Akt/PTEN/mTOR pathway Surgery Poly-ADP-ribose polymerase (PARP) Survival analysis Polymorphisms/SNPs Synthetic lethality Post-translational modification Systems biology Precancerous lesions T cells/TCR Preclinical studies T helpers Prevention and/or chemoprevention Target therapy Prognosis Telomere and/or telomerase Prostaglandins Testis ca. Prostate ca. TGF and/or receptors Proteasome Thymoma Protein microarrays Thyroid ca. Proteomics Thyroid hormone Radionuclide therapy Tissue microarrays (TMA) Radiosensitivity and/or resistance TNF and/or receptors Radiotherapy Tolerance Radiotoxicity Toll-like receptors (TLR) RAS/RAS inhibitors Topoisomerase Rb/Rb family TRAIL Response and/or resistance to therapy Transcription RET Transcription factors Retinoic acid and/or receptors Transformation assays Retrospective studies Transgenic mice Rho GTPases family Translesion synthesis Risk factors Translocation RNA binding proteins Transplantation RNA splicing Treg cells Sarcoma Triple negative breast ca. Screening Tumor antigen Senescence Tumor dormancy Signal transduction inhibitors Tumor suppressor genes siRNA and/or non coding RNA Tumor-stroma interaction Small molecule inhibitors Tyrosine kinase receptors (TKR) and/or inhibitors Smoking Ubiquitin and/or ubiquitination Soft tissue tumors Urokinase-Plasminogen System (uPA, uPAR, PAI) Solid tumors Vaccine SPECT VEGF and/or receptor Spheroids/3D cultures Virology Src family Von Hippel-Lindau (VHL) Staging Wilms' Tumor Gene (WT1) Statistics Xenopus Stress response Yeast SUMO and/or sumoylation Zebrafish KEYWORDS BY TOPIC Adhesion and stroma Angiogenesis Adhesion dynamics Angiogenesis and/or vasculogenesis Cadherins Endothelial cells Caveolin Hypoxia/Hypoxia-inducibile Factors (HIF-1) Cell adhesion and/or cell adhesion molecules Lymphatics and/or lymphangiogenesis Cell migration, motility and/or invasion VEGF and/or receptor Cell polarity Von Hippel-Lindau (VHL) Cytoskeleton Extracellular Matrix (ECM)/Stroma Focal Adhesion/FAK Integrins and/or Integrin-linked kinase (ILK) Matrix metalloproteases (MMP) and/or inhibitors Microenvironment Osteopontin Tumor-stroma interaction Urokinase-Plasminogen System (uPA, uPAR, PAI) KEYWORDS BY TOPIC Cell death and apoptosis Clinical topics Apoptosis Cachexia Autophagy Computer Tomography (CT Scan) bcl2 family Diagnosis Caspases Drug toxicity Fas and/or FasL Endocrinology Inhibitor of apoptosis proteins (IAPs) GVHD and/or Graft versus Tumor Mitochondria Magnetic resonance imaging (MRI) Non apoptotic cell death Metastasis p53, p63, p73 Minimal Residual Disease (MRD) Senescence Nuclear medicine TRAIL Palliative care PET and/or PET-CT Prognosis Retrospective studies SPECT Staging Survival analysis Transplantation KEYWORDS BY TOPIC Genes, proteins and miscellanea ATM pathway Poly-ADP-ribose polymerase (PARP) ATR pathway Proteasome BCR-Abl/Abl RNA binding proteins Bone morphogenetic protein (BMP) Stress response BRAF/RAF kinases SUMO and/or sumoylation BRCA Telomere and/or telomerase Embryonic development Topoisomerase Endocytosis Ubiquitin and/or ubiquitination Endoplasmic reticulum (ER) Wilms' Tumor Gene (WT1) Epigenetics Epithelial mesenchyme transition (EMT) FGF and/or receptor Glucocorticoids and/or receptors Glucose metabolism and/or Warburg effect Glycoproteins and/or glycosylation Golgi Heat shock proteins (HSP) High Mobility Group Proteins (HMG) Ion channels Lipid metabolism Liver development and/or regeneration MDM2 Membrane biology Myc Netrin receptors Nitric oxide Oncogenes p21 - activated kinases (PAK) Phosphatases Phospholipids KEYWORDS BY TOPIC Genetics Aneuploidy Pharmacogenetics/Pharmacogenomics Centrosome Polymorphisms/SNPs Chromatin remodeling Post-translational modification Cytogenetics and/or chromosome alterations RNA splicing DNA damage siRNA and/or non coding RNA DNA double strand break repair (DSBR) Synthetic lethality DNA methylation Transcription DNA recombination Transcription factors DNA repair Transformation assays DNA replication Translesion synthesis DNA single strand break repair (SSBR) Translocation Functional genomics Tumor suppressor genes Fusion genes Gene alteration/gain or loss Gene expression and/or profile Gene regulation Genetics Genome wide screening/GWAS Genomic imprinting Genomic/Genetic instability Genomics Hereditary DNA repair disorders Histone modifications Homologous recombination Loss of heterozygosity (LOH) microRNA Mitosis mRNA processing mRNA translation Mutation (somatic and/or germline) Nuclear structures KEYWORDS BY TOPIC Immunology Autoimmunity/Autoantibodies Tolerance B cells Toll-like receptors (TLR) Chemokines Treg cells Costimulatory molecules Tumor antigen COX2 Tumor dormancy CTL Vaccine Cytokines/Interleukins Dendritic cells Granulocytes Hematopoiesis HLA/Major Histocompatibility Complex (MHC) Immune escape Immunization Immuno-editing Immunosuppression and/or suppressor cells Immunotherapy Infection Inflammation and/or inflammatory cytokines Innate immunity Interferons Lymphocyte differentation Macrophages and/or monocytes Monoclonal antibodies (mAbs) and/or immunoconjugates NF-kB family NK and/or NKT cells Phagocytes and/or phagocytosis Prostaglandins T cells/TCR T helpers TNF and/or receptors KEYWORDS BY TOPIC Methods Animal models Proteomics Biochemistry Spheroids/3D cultures Bioinformatics Statistics Biomolecular modelling Systems biology Biophysics Tissue microarrays (TMA) C.elegans Transgenic mice Chemistry Xenopus Comparative genomics hybridization (CGH) Yeast Computational biology Zebrafish Crystallography Docking Drosophila Risk factors Epidemiology Aging Flow cytometry Biomarkers Fluorescence in situ hybridization (FISH) Body mass index (BMI) and/or obesity Fluorescence resonance energy transfer (FRET) Carcinogenesis Functional validation of target genes Diet Immunohistochemistry Genotoxicity In vitro imaging and/or live cell imaging Metabolism/Metabolomics In vivo imaging Organic compounds Mass spectrometry Oxidative stress and/or Reactive Oxygen Species (ROS) Mathematical modeling Precancerous lesions Microarrays Prevention and/or chemoprevention Microscopy Risk factors Mouse models Screening Nanotechnology/Nanoparticles Smoking Next generation sequencing NMR spectroscopy Phage display Protein microarrays KEYWORDS BY TOPIC Signaling and cell cycle Androgen and/or receptors Rb/Rb family Beta-catenin/Wnt pathway RET Cell cycle Retinoic acid and/or receptors Cell cycle checkpoint G1/S Rho GTPases family Cell cycle checkpoint G2/M Src family Cell differentiation and/or differentiation therapy TGF and/or receptors Cell signaling Thyroid hormone Crosstalk Tyrosine kinase receptors (TKR) and/or inhibitors Cyclic AMP Cyclins and/or inhibitors EGF and/or receptors Stem cells Estrogens and/or receptors Cancer stem cells Folate and/or receptor CD133/Stem cell markers G-proteins and/or GPCR Circulating tumor cells Growth factors and/or receptors Hematopoietic stem cells Growth induction and/or growth arrest Normal stem cells Hedgehog pathway HER1-2-3-4 Hippo pathway Hormones Insulin Insulin-like growth factor (IGF) and/or receptors Jak/Stat pathway Kinase/Kinome MAP Kinases MET/HGF Notch pathway Nuclear receptor PDGF and/or receptors Phosphorylation PI3K/Akt/PTEN/mTOR pathway RAS/RAS inhibitors KEYWORDS BY TOPIC Types of tumors ALL Solid tumors AML Testis ca. Bladder tumor Thymoma Bone disease Thyroid ca. Brain and/or nervous system tumors Triple negative breast ca. Breast ca. Burkitt lymphoma Cervix or endometrial ca. Therapies CLL Adjuvant therapy CML Anti-angiogenic therapy Colorectal and/or Intestinal ca. Antibody/mAb therapy Gastric ca. Aromatase and/or inhibitors Glioma and/or glioblastoma Chemotherapy and/or chemotherapic drugs Gynecological tumors Clinical practice guidelines Head and neck ca. Clinical trials Hematologic malignancies Combination therapy Hepatocellular carcinoma (HCC) Drug delivery Hereditary tumors Drug discovery and/or development Hodgkin's lymphoma Drug response and/or resistance Kidney ca. Drug screening Leukaemia Gene therapy Lung ca. Multidrug resistance (MDR) Lymphomas Peptides as drugs Medulloblastoma Pharmacokinetics Melanoma Pharmacology Mesothelioma Preclinical studies Myeloma Radionuclide therapy Neuroblastoma Radiosensitivity and/or resistance Non melanoma skin tumors Radiotherapy Osteosarcoma Radiotoxicity Ovarian ca. Response and/or resistance to therapy Pancreas ca. Signal transduction inhibitors Pediatric tumors Small molecule inhibitors Prostate ca. Surgery Sarcoma Target therapy Soft tissue tumors KEYWORDS BY TOPIC Viruses Adenovirus AIDS/HIV/Kaposi Epstein-Barr Virus (EBV) Hepatitis B virus (HBV) Hepatitis C virus (HCV) Herpes virus Human Papilloma Virus (HPV) Lentivirus Oncogenic virus/Viral oncology Virology