CURRICULUM VITAE
SURNAME:
COLOMBO
NAME:
PAOLO
Department of Pharmacy
University of Parma
Viale G.P.Usberti 27/A
43100 PARMA (Italy)
phone 39+ O521 905007; fax 905006; E-mail:
[email protected]
Affiliation and official address:
Date and place of birth:
Education:
Career:
November 30, 1944 - Calco (CO), Italy
Nationality:
Italian
Pharm. D., 1968, University of Pavia (Italy)
University of Parma, Member of Evaluation Committee, 2009University of Parma, Head of Pharmaceutical Department, 1993- 1998; 2001University of Parma, Head Interuniversity Consortium TEFARCO Innova1996-2002
University of Parma, Delegate Rector of University of Parma,1989-2000; 2002-2009
University of Parma, Faculty of Pharmacy, SOCRATES coordinator 1987University of Parma, Faculty of Pharmacy, Full Professor 1986University of Pavia, Faculty of Pharmacy, Associate Professor, 1983-1986
University of Pavia, Faculty of Science, Charged Professor 1978-1983
University of Pavia, Faculty of Pharmacy, Assistant 1971-1983
University of Pavia, Faculty of Pharmacy, Fellowship holder, 1970-1971
Specialization:
(i) main field:
(ii) other fields:
(iii) current research interests:
(ii) Pharmaceutical technology
(i) Drug Delivery
(iii) Swellable matrices for oral delivery of drugs
(ii) Iontophoresis
(iii) Nasal and Pulmonary Administration of drugs
(ii) Disintegration of tablets
Honours, Awards, Fellowships, Membership of Professional Societies:
Fellowship "dott. Michele Berta", 1968
Fellowship "Guglielmina Brughera", 1968
Award for scientific production, University of Pavia, 1973
Foreign correspondent of Association Francaise des Enseignants de Pharmacie Galenique
Colorcon Award recipient, 1991
AAPS Fellow 1996
Outstanding paper Journal of Controlled Release / Jorge Heller Award, 1999
Nominated as Foreign Member of the Academy of Pharmacy of France
Professeur invité, Faculté de Pharmacie de Paris-Sud, France, 2001
FIP, member
Controlled Release Society, member and past-governor
ADRITELF (Italian Pharmaceutical Technology Teachers), member
SIFEB (Italian Society of Pharmacokinetics and Biopharmaceutics), member
AFI (Industrial Pharmacist Association), member
AAPS (American Association of Pharmaceutical Scientists), member and Fellow
EUFEPS (European Federation Pharmaceutical Scientists), member
APGI (Association Pharmacie Galenique Industrielle), Honorary Member
Ministery of Health, Expert for the evaluation of the european mutual recognition dossiers,
2002Member of Academie de Pharmacie Francaise, 2003Maurice-Marie Janot Award as highly recognized drug research scientist for
Pharmaceutical Sciences 2004
CRS Reiner Hofmann Award “Product through Science” 2007
Visitng Professor at Universiti Sains Malaysia, March 2009
Publications:
- number of papers in refereed journals:
221
- number of communications to scientific meetings:
- number invited lectures (since 1990): 100
- patents: 33
276
RESEARCH PAPERS PUBBLISHED BY PROF. PAOLO COLOMBO
1)
The effect of magnesium stearate and polytetrafluoroethylene as lubricants in
direct compression of acetylsalicylic acid. U. Conte, P. Colombo, C. Caramella,
A. La Manna. Il Farmaco, Ed. Prat., 27(8), 440-52 (1972) C.A. 77, 105577 m
2)
Tabletting properties of sulfamethoxydiazine formulation. U. Conte, C.
Caramella, P. Colombo, A. La Manna. Il Farmaco, Ed. Prat., 28(3), 161-74
(1973). C.A. 78, 140380 j
3)
The effect of fines on the physical properties of a starch-lactose granulation and
of corresponding tablets. P. Colombo, U. Conte, P.L. Catellani, C. Caramella,
A. La Manna Il Farmaco, Ed. Prat., 29(2), 102-9 (1974) C.A. 80, 124718 m
4)
Rheological analysis in the evaluation and prediction of the stability of
suspensions. C. Caramella, P. Colombo, U. Conte, A. La Manna. Il Farmaco,
Ed. Prat., 29(6), 318-32 (1974) C.A. 81 176099 a
5)
On the direct compression of sulfamethoxydiazine (SMD) polymorphic forms. I .
U. Conte, P. Colombo, C. Caramella, G.P. Bettinetti, F. Giordano, A. La Manna.
Il Farmaco, Ed. Prat., 30(4), 194-206 (1975) C.A. 83, 48154 u
6)
L' uso della microscopia a scansione nella determinazione dei fattori di forma
delle particelle. C. Caramella, P. Colombo, U. Conte, A. La Manna. Il Farmaco,
Ed. Prat., 30(6) 282-90 (1975)
7)
On the direct compression of sulfamethoxydiazine (SMD) polymorphic forms. II.
C. Caramella, P. Colombo, U.Conte, G.P.Bettinetti, F.Giordano, A. La Manna. Il
Farmaco, Ed. Prat., 30(10), 496-501 (1975) C.A. 84, 49764 a
8)
The effect of polytetrafluotoethylene (Fluon) on the stability of acetylsalycylic
acid (ASA) tablets. P. Colombo, G. A. Cocchi, C. Caramella, U. Conte, A. La
Manna. Il Farmaco, Ed. Prat., 31(4), 212-18 (1976) C.A. 84, 169616 a
9)
The effect of compression force on the characteristics of coated acetylsalycylic
acid tablets. U. Conte, P. Colombo, C. Caramella, G. P. Bettinetti, F. Giordano,
A. La Manna. Il Farmaco, Ed Prat. 31(11), 586-94 (1976) C.A. 86, 21765 u
10) On the characteristics of diluents for direct compression. P. Colombo, U. Conte,
C. Caramella, G. A. Cocchi, P. L. Catellani, A. La Manna Boll. Chim. Farm.,
115(8), 585-95 (1976) C.A. 86, 34227 v
11) The effect of some wetting agents on the characteristics of suspensions of
sulfamethoxypyridazine and its N-acetyl dereivative. C. Caramella, G. A.
Cocchi, P.L. Catellani, U. Conte, P. Colombo, A. La Manna Boll. Chim. Farm.,
115(9), 658-66 (1976) C.A. 86, 60484 w
12) Applicazione dell' analisi reologica allo studio della stabilità fisica di sospensioni
di antibiotici. C. Caramella, U. Conte, P. Colombo, G. A. Cocchi Boll. Chim.
Farm., 115(10), 702-13 (1976) C.A. 86, 111122 m
13) La mesure de la force radiale a l'aide d'une matrice divisee. Application aux
problemes pharmaceutiques. U. Conte, P. Colombo, A. La Manna, C.
Caramella. Il Farmaco, Ed. Prat., 32(11), 551-9 (1977) C.A.88, 41652 z
14) Force de compression et activitee antiacide in vitro, des comprimes d'hydroxide
d'aluminium et de glicinate d'aluminium. P. Colombo, C. Caramella, U. Conte,
P. L. Catellani. Il Farmaco, Ed. Prat., 32(11), 560-7 (1977) C.A. 88, 41625 t
15) Previsione della velocità di dissoluzione della sulfametossidiazina. C.
Caramella, G. P. Bettinetti, F. Giordano, P. Colombo. Boll. Chim. Farm.,
116(8), 484-92 (1977) C.A. 88, 141574 u
16) The influence of disgregants on the characteristics of coated acetylsalicylic acid
tablets. C. Caramella, P. Colombo, U. Conte, A. La Manna. Il Farmaco, Ed.
Prat., 33(11), 498-507 (1978) C.A. 90, 28971 z
17) The relevance of viscous behaviour to stress-displacement relationship in
pharmaceutical powder compression. P. Colombo, U. Conte, C. Caramella, A.
La Manna, J. C. Guyot, A. Delacourte, R. Devise, M. Traisnell, M. Boniface Il
Farmaco, Ed. Prat., 33(12), 531-42 (1978) C.A. 90, 76519 e
18) Drug content uniformity of directly compressed tablets in relations to the
physical characteristics of diluents. P. Colombo, U. Conte, C. Caramella, A. La
Manna, P. L. Catellani Boll. Chim. Farm., 117(12), 711-20 (1978) C.A. 91,
9453 m
19) A study on the electrokinetic properties of some chemotherapeutic drug
suspensions. C. Caramella, U. Conte, P. Colombo, A. La Manna Il Farmaco,
Ed. Prat., 34(7), 295-305 (1979) C.A. 91, 145918 u
20) Sustained release nitrofurantoin tablets by direct compression. U. Conte, P.
Colombo, C. Caramella, A. La Manna Il Farmaco, Ed. Prat., 34(7), 306-16
(1979) C.A. 91, 145919 v
21) Drug interactions and physical properties in trimethoprim-sulfamethoxazole
suspensions C. Caramella, F. Giordano, G.P. Bettinetti, P. Colombo, U. Conte,
A. La Manna Il Farmaco, Ed. Prat., 35(6), 277-85 (1980) C.A. 93, 101427 v
22) Effective dosage of antacid product. U. Conte, P. Colombo, C. Caramella, A. La
Manna, P. L. Catellani Il Farmaco, Ed. Prat., 35(7), 339-48 (1980) C.A. 93,
191970 u
23) Force de delitement des comprimes. P. Colombo, U. Conte, C. Caramella, A.
La Manna, A. M. Guyot-Hermann, J. Ringard Il Farmaco, Ed. Prat., 35(8), 391402 (1980) C.A. 93, 173672 u
24) Disintegrating force and tablet properties. P. Colombo, C. Caramella, U. Conte,
A. La Manna, A. M. Guyot-Hermann, J. Ringard. Drug Dev. Ind. Pharm., 7(2),
135-53 (1981) C.A. 94, 162666 v
25) In vitro absorption studies on trimethoprim and sulfamethoxazole. Note I. C.
Caramella, F. Giordano, G. P. Bettinetti, P. Colombo, U. Conte, A. La Manna
Pharm. Acta Helv., 57(5-6), 154-9 (1982) C.A. 97, 33100 p
26) In vitro absorption studies on trimethoprim and sulfamethoxazole. Note II. C.
Caramella, F. Giordano, G.P. Bettinetti, P. Colombo, U. Conte, La Manna, G.
Gastaldi, D. Casirola, G. Ferrari. Pharm. Acta Helv., 58(3), 85-7 (1983) C.A.
98, 172541 s
27) The effect of formulation factors on the solid state interaction between
Trimethoprim and Sulfamethoxazole in compressed tablets. G. P. Bettinetti, F.
Giordano, C. Caramella, P. Colombo, U. Conte, A. La Manna. Il Farmaco, Ed.
Prat., 38(7), 259-64 (1983) C.A. 99, 93607 k
28) Antacid tablets strength and neutralization rate. G. Dondi, M. L. Binda, C.
Caramella, P. Colombo, U. Conte, A. La Manna. Pharm. Acta Helv., 28, 259
(1983) ; Expo-Congr. Int. Technol. Pharm. 3rd 5, 58-65, (1983) C.A. 103,
76153 t
29) Poids, force et proprietes des comprimes. P. Colombo, U. Conte, C.
Caramella, A. La Manna, J. C. Guyot, M. Traisnel. Acta Pharm. Technol.,
29(4), 302-8 (1983) C.A. 100, 126778 m
30) Variation of the properties of tablets on a production machine equipped with
weight control systems. P. Colombo, U. Conte, C. Caramella, A. La Manna, J.
C. Guyot, M. Traisnel. Expo.-Congr. Int. Technol. Pharm., 3rd 3, 50-9 (1983)
C.A. 103, 200827 g
31) The compactability of polymers for drug delivery systems. U. Conte, P.
Colombo, C. Caramella, A. La Manna Il Farmaco, Ed. Prat., 38(10), 361-8
(1983) C.A. 99, 218527 t
32) Press-coated systems for drug release control. U. Conte, P. Colombo, C.
Caramella, A. La Manna. Polym. Sci. Technol.(Plenum) 23(Polym. Med.) 17986 (1983) C.A. 100, 56791 j
33) Disintegrating force as a new formulation parameter. P. Colombo, U. Conte, C.
Caramella, M. Geddo, A. La Manna. J. Pharm. Sci., 73(5) 701-5 (1984)
34) Swelling properties of disintegrants. Caramella, P. Colombo, G. P. Bettinetti, F.
Giordano, U. Conte, A. La Manna. Acta Pharm. Technol., 30(2) 132-9 (1984)
35) Press-coated, zero order drug delivery system. U. Conte, P. Colombo, C.
Caramella, A. La Manna. Il Farmaco, Ed. Prat., 39(3), 67-75 (1984) C.A. 100
180059 r
36) Swelling of disintegrant particles and disintegrating force of tablets. Caramella,
P. Colombo, U. Conte, A. La Manna. Labo-Pharma, Probl. Tech. 339, 115-9
(1984) C.A. 101, 60050 e
37) The role of swelling in disintegration process. Caramella, P. Colombo, U.
Conte, A.Gazzaniga, A. La Manna. Inter. J. Pharm. Technol. Prod. Manuf., 5
(2), 1-5 (1984) C.A. 103, 11330 d
38) Tablets weight and biopharmaceutical properties variations. P. Colombo, C.
Caramella, U. Conte, A. Gazzaniga, A. La Manna, M. Geddo. Acta Pharm.
Tech., 31 (2), 63 (1985). Biopharm. Pharmacokinet., Eur. Congr., 2nd 1, 51220 (1984) C.A. 102, 209345 k
39) Compressed polymeric minimatrices for drug release control. P. Colombo, U.
Conte, C. Caramella, A. Gazzaniga, A. La Manna. J. Controlled Release, 1(4),
283-9 (1985) C.A. 103, 92776 d
40) Effective surface area and activity of antacid preparations. P. L. Catellani, F.
Ronchini, C. Caramella, P. Colombo, U. Conte, A. Gazzaniga, F. Ferrari. Il
Farmaco, Ed. Prat., 40(7), 225-36 (1985) C.A. 103, 92778 f
41) Calibration of an equipped single stroke tablet press. P. Colombo, U. Conte, F.
Ferrari, A. La Manna, M. Geddo. Chimica oggi, (3), 49-53 (1986)
42) Relazioni tra forza di disgregazione e penetrazione dell'acqua nelle compresse:
un contributo alla valutazione delle proprietà disgreganti di una formula. C.
Caramella, A. Gazzaniga, F. Ferrari, P. Colombo, U. Conte, A. La Manna, H. V.
Van Kamp. Chimica oggi, (12), 11-13 (1986) C.A. 107, 12727 r
43) Bioavailability of Indomethacin from a modified release system containing
indomethacin as lysine salt. A. Marzo, A. Reiner, E. Arrigoni Martelli, U. Conte,
P. Colombo, A. La Manna. Eur. J. Clin. Pharmacol. 32(1), 85-7 (1987) C.A.
106, 201641r
44) Water uptake and disintegrating force measurements: towards a general
understanding of disintegration mechanisms. Caramella, P. Colombo, U.
Conte, F. Ferrari, A. La Manna, H. V. Van Kamp, G. K. Bolhuis. Drug Dev. Ind.
Pharm., 12(11-13), 1749-66 (1986).
C.A. 105, 214045 d. Also in
PHARMACEUTICAL TECHNOLOGY tableting technologu vol1, Ed. M.
Rubinstein; Ellis Horwood Books in The biological Sciences. Chapter 5, 51-61.
45) In vitro programmable zero order release drug delivery system. P. Colombo, A.
Gazzaniga, C. Caramella, U. Conte, A. La Manna. Acta Pharm. Technol., 33(1),
15-20 (1987). C.A. 106, 182536 s
46) A new indomethacin lysinate modified release system. P. Colombo, U. Conte,
A. Gazzaniga, C. Caramella, A. La Manna. Polym. Sci. Technol. (Plenum) 34
(Polym. Med. 2) 369-377 (1986)
C.A. 106, 201615 k
47) Tablet disintegration update: the dynamic approach. Caramella, P. Colombo,
U. Conte, A. La Manna. Drug Dev. Ind. Pharmacy, 13(12), 2111-45 (1987) C.A.
108, 43867 d
48) The mechanism of disintegration of compressed particulate system.
Caramella, P. Colombo, U. Conte, F. Ferrari, A. Gazzaniga, A. La Manna, N. A.
Peppas. Polym. Bull. 18(6), 541-4 (1987) C.A. 108, 95422 z
49) Solvent front movement and release kinetics in compressed swellable
matrices. P. Colombo, A. Gazzaniga, U. Conte, M.E. Sangalli, A. La Manna.
Proc. Int. Symp. Control. Rel. Bioact. Mater.14 (1987), 83-84.
50) Compressed matrices : formulation and drug release kinetics. P. L. Catellani,
G. Vaona, P. Plazzi, P. Colombo. Acta Pharm. Technol., 34(1), 38-41 (1988) .
C.A. 110, 29022 j
51) Influence of tablet weight control systems during production on
biopharmaceutical properties of the tablets. U. Conte, P. Colombo, C.
Caramella, F. Ferrari, A. Gazzaniga, J. C. Guyot, A. La Manna, M. Traisnel.
Acta Pharm. Technol., 34 (2), 63-7 (1988). C.A. 110, 63652
52) A physical analysis of the phenomenon of tablet disintegration. C. Caramella,
P. Colombo, U. Conte, F. Ferrari, A. Gazzaniga, A. La Manna, N. A. Peppas.
Intern. J. Pharm., 44(1-3), 177-86 (1988). C.A. 109, 43391 q
53) Modified release tablet formulations. P.L. Catellani, P. Colombo, T. Vitali, C.
Caramella. Prog. Biomed. Eng. 5 (Polym. Med. III)169-74 (1988). C.A. 109,
215932 k
54) A multiple unit modified release system. A.Gazzaniga, U.Conte, P.Colombo,
M.E. Sangalli, C.Caramella, A. La Manna. Prog. Biomed. Eng. 5 (Polym. Med.
III) 201-208 (1988)
55) Drug/polymer matrix swelling and dissolution. R.S.Harland, A.Gazzaniga,
M.E.Sangalli, P.Colombo, N.A.Peppas. Pharm. Res., 5(8), 488-94 (1988). C.A.
109, 176185 x
56) Simulation of disintegration process of pharmaceutical tablets. P. Colombo, F.
Ferrari, A. Gazzaniga, C. Caramella, U. Conte, A. La Manna, N. A. Peppas.
Pharma Acta Helv., 63(8) 221-3 (1988)
57) Swelling activated drug delivery system. U.Conte, P.Colombo, A.Gazzaniga,
M.E.Sangalli, A.La Manna. Biomaterials, 9(6), 489-93 (1988). C.A. 110, 63660
a
58) Experimental evidence of disintegration mechanism. C.Caramella, P.Colombo,
U.Conte, A.Gazzaniga, F.Ferrari, A.La Manna, Acta Pharm. Technol., 35 (1),
30-3 (1989). C.A. 113, 217945 Y
59) Tablet water uptake and disintegration force measurements. P.L. Catellani, P.
Predella, A. Bellotti, P. Colombo. Int. J. Pharm., 51(1), 63-6 (1989). C.A. 110,
218961 a
60) Energetics of tablet disintegration. N. A. Peppas, P. Colombo, U. Conte, A.
Gazzaniga, C. Caramella, F. Ferrari. Int. J. Pharm., 51(1), 77-83 (1989). C.A.
110, 218963 c
61) Alprenolol HCl compressed matrices: discontinuous barrier for zero-order
release rate. P. Santi, P.L. Catellani, A. Cassarà, P. Colombo. Chimica Oggi,
7(4), 21-4 (1989). C.A. 111, 120720 s
62) The role of compression force in floating tablet formula optimization. P.
Colombo, D. Provasi, M.G. Borazzo, L. Maggi, P.L. Catellani. Acta Pharm.
Technol., 35 (3), 168-70 (1989). C.A. 113, 218070 w
63) Validation of tablet formulation. P. Colombo. Drug Dev. Ind. Pharm., 15 (6-7),
1047-58, (1989)
64) Cross-linked sodium carboxymethylcellulose as a carrier for dissolution rate
improvement of drugs. M.E. Sangalli, P. Giunchedi, P. Colombo, U. Conte, A.
Gazzaniga, A. La Manna. Boll. Chim. Farm., 128(7-8), 242-7 (1989)
65) Rheological properties and diffusion dissolution behaviour of hydrophilic
polymers. C. Caramella, F. Ferrari, M.C. Bonferoni, M. Ronchi, P. Colombo.
Boll. Chim. Farm., 128(10), 298-302 (1989)
66) Development of disintegration force during water penetration in porous
pharmaceutical systems. N. Peppas and P.Colombo. J. Controlled
Release,10(3), 245-50 (1989). C.A. 112, 84012 x
67) A new Ibuprofen Pulsed Release Oral Dosage Form. U. Conte, P. Colombo, A.
La Manna, A. Gazzaniga, M.E. Sangalli, P. Giunchedi. Drug Dev. and Ind.
Pharm., 15(14-16), 2583-96 (1989)
68) Water uptake and disintegration force development in pharmaceutical tablets.
P. Colombo, P. Santi, P.L. Catellani, N.A. Peppas. Congr. Int. Technol. Pharm.,
5th 1989, 5, 427-31 (Fr). Assoc. Pharm. Galénique Ind.: Chatenay-Malabry, Fr..
C.A. 112, 125050 d
69) Stable sucralfate suspensions free of suspending agents. C. Caramella, U.
Conte, P. Colombo. Congr. Int. Technol. Pharm., 5th 1989, 1, 492-9 (Fr).
Assoc. Pharm. Galénique Ind.: Chatenay-Malabry, Fr. C.A. 112, 42473 t
70) Piroxicam/ß-cyclodextrin inclusion compound and its interaction with water.
P.L. Catellani, P. Santi, M.G. Borazzo, A. Bellotti, P. Colombo. Minutes Int.
Symp. Cyclodextrins, 5th Edited. by Duchêne Dominique, Ed. Santé, Paris
(F), pag. 445-9, (1990). C.A. 116, 46128 q
71) Disintegration of Tablets - Bond Weakening by Liquids, M. Luangtana-anan,
P.L. Catellani, P. Colombo, R. Dinarvand, J.T. Fell, P. Santi. 9th
Pharmaceutical Technology Conference, Vehldoven Holland, April 4th-6th
1990, 135-144 (Drug Dev. and Ind. Pharm.)
72) Drug release modulation by physical restrictions of matrix swelling, P.
Colombo, U. Conte, A. Gazzaniga, L. Maggi, M.E. Sangalli, N.A. Peppas
and A. La Manna, Int. J. of Pharmaceutics, 63 (1990) 43-48
73) A new approach to tabletting validation. G. Dondi, M. L. Binda, P. Colombo, U.
Conte, L. Maggi. Acta Pharm. Technol., 36 (4), 240-3 (1990). C.A. 114, 214345
74) Formulation and drug delivery systems, P. Colombo, International Conference
on Pharmaceutical Ingredients and Intermediates, Frankfurt, 8-9 October 1990,
96-107
75) Partition and transport of verapamil and nicotine through artificial membranes.
P. Santi, P.L. Catellani, P. Colombo, C. Ringard-Lefebvre, C. Barthélémy, A.M.
Guyot-Hermann. Int. J. Pharm., 68, 43-49 (1991). C.A. 114, 12895 1a
76) Use of sucralfate humid gel in beauty masks formulation. Provasi, P. Colombo,
G. Massimo, U. Conte, C. Caramella, P. Santi. Les Nouvelles Dermatologiques,
10 (1), 100-4 (1991)
77) Release mechanism of piroxicam from ß-cyclodextrin inclusion compound. P.
Colombo, P. Santi, D. Provasi, A. De Ascentiis, G. Massimo, P.L. Catellani.
Acta Technologiae et Legis Medicamenti, 2(1), 37-49 (1991)
78) Drug release kinetics in swellable delivery systems. P. Colombo, U. Conte, A.
La Manna. Proceedings of Synthetic Polymers as Drug Carriers. Interactions
with blood., Pallanza, April 21-24 (1991)
79) Physical restriction in swellable matrices as modulator of drug release. La
Manna, U. Conte, P. Colombo. Proceedings of Synthetic Polymers as Drug
Carriers. Interactions with blood., Pallanza, April 21-24 (1991)
80) Rheological study of sucralfate humid gel; a contribution to the comprehension
of its stability properties. S.Rossi, M.C.Bonferoni, C.Caramella, P.Colombo,
U.Conte. Eur. J. Pharm. Biopharm., 38 (2), 78-81 (1992)
81) A comparative study of the disintegrating efficiency of polysaccharides in a
directly tablettable formulation. Duru, P. Colombo, D. Gaudy, G. Massimo, P.
Santi, P.L. Catellani, P.Bartelemy. Pharm. Technol. Int., 4 (5), 15-23 (1992)
82) Nasal powders: an animal model for formulation studies. Provasi, A. Minutello,
A. De Ascentiis, P.L. Catellani, P. Colombo. MINUTES European Symposium
on Buccal and Nasal Administration as an Alternative to Parenteral
Administration, 282-286 (1992)
83) Mechanism and kinetics of some modified release theophilline drug products.
M.T. Peracchia, P. Colombo, P.L. Catellani, S. Negro Alvarez, R. Cadorniga
Carro. Boll. Chim. Farm., 4, 144-149 (1992)
84) Dimensionality in swelling of polymer carriers and its importance in drug
release. N.A. Peppas, P. Colombo, U. Conte, L. Maggi. SAFYBI, 32 (86), 2228 (1992)
85) Validation of a new rotary tablet machine equipped with a centrifugal feeding
device. . P.L. Catellani, P. Santi, E. Gasperini, S. Ciceri, G. Dondi, P. Colombo.
Proceed. 6th International Conference on Pharmaceutical Technology, Paris 34 June 1992.
86) Diffusional, electric and electro-osmotic contributions in iontophoretic transport
of verapamil through artificial membranes. P. Santi, P.L. Catellani, G. Massimo,
P. Colombo. Proceed. 6th International Conference on Pharmaceutical
Technology, Paris 3-4 June 1992.
87) Nasal powders for calcitonin administration. Provasi, A. Minutello, P.L.
Catellani, P. Santi, G. Massimo, P. Colombo. Proceed. Intern. Symp. Control.
Rel. Bioact. Mater., 19 (1992), Controlled Release Society, Inc.
88) Azione citoprotettiva sulla mucosa gastrica del sucralfato in due forme
farmaceutiche diverse. U. Conte, P. Colombo, G. Zagnoli, S. Contos, M. De
Bernardi, C. Caramella. Acta Toxicologica et Therapeutica, 13 (3), 187-203
(1992)
89) The role of bond weakening by liquids in the disintegration of tablets. M.
Luangtana-anan, P.L. Catellani, P. Colombo, R. Dinarvan, J.T. Fell, P. Santi.
Eur. J. Pharm. Biopharm., 38 (5) 169-171 (1992)
90) Measurement of the swelling force in ionic polymeric networks.I. Effect of pH
and ionic content. A.K. Khare, N.A. Peppas, G. Massimo, P. Colombo. J. Contr.
Rel., 22, 239-244 (1992).
91) Efficacy and mechanism of lubrication in tablet technology. A Delacourte, J.C.
Guyot, P. Colombo, P.L. Catellani, 11th Pharmaceutical Technology
Conference; Manchester, 6-8 Aprile 1992
92) Permeation of piroxicam and piroxicam-B-cyclodextrin through artificial
membranes. R. Bettini, P. Santi, P.L. Catellani, G. Massimo, A. Bellotti, P.
Colombo. Eur J. Pharm. Biopharm., 38 (6), 203-208 (1992)
93) Ibuprofen delayed release dosage forms: a proposal for the preparation of an in
vitro/in vivo pulsatile system. U. Conte, P. Giunchedi, L. Maggi, M.E. Sangalli,
A. Gazzaniga, P. Colombo, A. La Manna. Eur J. Pharm. Biopharm., 38 (6), 209212 (1992)
94) Swelling characteristics of matrices for controlled release: new dimensionless
number to describe the swelling and release behavior. P. Colombo, P.L.
Catellani, N.A. Peppas, L. Maggi, U. Conte. Int. J. of Pharm., 88, 99-109 (1992)
95) Centrifugal die filling system in a new rotary tablet machine. P.L. Catellani, P.
Santi, E. Gasperini, S. Ciceri, G. Dondi, P. Colombo. Int. J. of Pharm., 88, 285291 (1992)
96) Compressed barrier layers for constant drug release in swellable matrix tablet.
Conte U.; Colombo P.; Maggi L.; La Manna A.. Congr. Int. Technol.Pharm. 6th
1992, 2, 102-11
97) Iontophoretic transport of verapamil and melatonin. I. Cellophane membrane as
a barrier. P. Santi, P.L. Catellani, G. Massimo, G. Zanardi, P. Colombo. Int. J.
Pharm., 92, 23-28 (1993)
98) Multi-layered hydrophilic matrices as constant release device (Geomatrix®
Systems). U. Conte, L. Maggi, P. Colombo, A. La Manna. J. Contr. Release,
26, 39-47 (1993)
99) Relationship between swelling and drug release in hydrogel matrices. R.
Bettini, P. Santi, M.T. Peracchia, P.L. Catellani, P. Colombo. Proceed. Intern.
Symp. Control. Rel. Bioact. Mater., 20, 218-219 (1993), Controlled Release
Society, Inc.
100) A method for quantitative evaluation of the effectiveness of the lubricants used
in tablet technology. Delacourte, P. Predella, P. Leterme, D. Provasi, P.
Colombo, U. Conte, P.L. Catellani, J.C. Guyot. Drug Dev. Ind. Pharm., 19 (9),
1047 (1993)
101) Swelling-controlled release in hydrogel matrices for oral route. P. Colombo.
Adv. Drug Delivery Reviews, 11, 37-57 (1993)
102) New rotary tablet machine equipped with central die filling device. P.L.
Catellani, P. Santi, G. Massimo, P. Colombo. 2th Pharmaceutical Technology
Conference; Elsinore (DK), volume 1, 235-245, 1993.
103) Powder delivery from devices for nasal applications. D.Provasi, A.De Ascentiis,
P.Colombo. 12th Pharmaceutical Technology Conference; Elsinore (DK),
1993.
104) Swelling controlled-release systems for oral drug delivery. P. Colombo.
Proceedings 1st European Pharm. Tech. Conference, Dusseldorf, 373-380,
1993.
105) Efficacy and lubrication mechanism in tablet technology. Delacourte, J.C.
Guyot, P. Colombo, P.L. Catellani. in Pharmaceutical Technology: tableting
technology Volume 2 (Compression), ed. Wells and Rubinstein, Ellis Horwood,
London, 81-88 (1993).
106) On the release mechanism from coated swellable minimatrices. Gazzaniga,
M.E. Sangalli, U. Conte, C. Caramella, P. Colombo, A. La Manna. Int. J.
Pharmaceutics, 91, 167-171,1993
107) Gastric retention of sucralfate gel and suspension in upper gastrointestinal
deseases. Vaira, C. Corbelli, G. Brunetti, M. Menegatti, M. Levorato, P. Mulè,
P. Colombo, M. Migliori, L. Barbara. Aliment. Pharmacol. Ther, 7, 531-535,
1993
108) Press-coated tablets for the sequential pulsed administration of two different
drugs. L.Maggi, U.Conte, P.Giunchedi, P.Colombo. Int. J. Pharmaceutics, 99,
173-179, 1993
109) Iontophoretic transport of verapamil and melatonin through hairless mouse
skin. P. Santi, G. Massimo, P.L. Catellani, G. Morini, P. Colombo. Europ. J.
Pharm. Sciences, 1 (1994) 259-263.
110) A rheometric method for assessing the sucralfate mucin interaction. Rossi S.,
Bonferoni M.C., Caramella C., Colombo P.. Eur J. Pharm. Biopharm., 40 (3),
179-182 (1994).
111) Nasal powders of progesterone: manufacturing and bioavailability. Provasi D.,
De Ascentiis A., Minutello A., Colombo P., Catellani P.L.. Eur J. Pharm.
Biopharm, 40 (4), 223-227 (1994).
112) Swelling and drug release in hydrogel matrices: Polymer viscosity and matrix
porosity effects. Bettini R., Colombo P., Massimo G., Catellani P. L., Vitali T..
Europ.J. Pharm. Sci. 2 (1994) 213-219
113) Mathematical analysis of drug delivery from swellable systems with partial
physical restriction or impermeable coatings. Hariharan D., Peppas N.A.,
Colombo P., Bettini R.. International Journal of Pharmaceutics 112 (1994) 4754
114) Natural polymer hydrophilic matrix: influencing drug release factors.. S.Rizk,
C.Duru, D.Gaudy, M.Jacob, P.Colombo, G.Massimo. Drug Development
Industrial Pharmacy, 20(16), 2563-2574 (1994)
115) Mucoadhesion of Poly(2-hydroxyethyl Methacrylate) is Improved when Linear
Poly(ethylene oxide) Chains are Added to the Polymer Network. de Ascentiis,
J. deGrazia, C.N. Bowman, P. Colombo, N.A. Peppas.. J.Controlled Release
33, 197-201 (1995)
116) Measurement of the swelling force in ionic polymeric networks. II. Swelling
force and disintegration of controlled release dosage formulations using pHsensitive components. M.T. am Ende, C.L.Bell, N.A.Peppas, G.Massimo,
P.Colombo. Int. J. Pharm. 120 (1995) 33-40
117) Screening of Potentially Mucoadhesive Microparticles in Contact with Rat
Intestinal Mucosa. A.De Ascentiis, Paolo Colombo, N.A. Peppas. Eur. J.
Pharm. Biopharm 41,(1995) 229-234
118) Drug diffusion front is important in drug release from swellable controlled
release systems. P.Colombo, R.Bettini, G.Massimo, P.L. Catellani, P. Santi,
N.A. Peppas. J.Pharm Sciences, 84, 8 (1995) 991-997
119) Solubility Effects on Drug Transport through pH-sensitive, Swelling-Controlled
Release System: Transport of Theophylline and Metoclopramide
Monohydrochloride.. R.Bettini, P.Colombo, N.Peppas. J.Controlled Release37
(1995) 105-111
120) Effectiveness of lubricants and lubrication mechanism in tablet technology, A.
Delacourte, J.C. Guyot, P. Colombo, P.L. Catellani. Drug Development
Industrial Pharmacy, 21(19),2187-2199 (1995)
121) Modification of drug release profiles and swelling behavior in poly(vinyl acohol)
due to the presence of a crystalline phase. S.K.Mallapragada, N.A.Peppas,
P.Colombo. Polym.Mater.Sci.Eng.Proceed., 74, ACS (1996)
122) Iontophoresis Enhances the Transport of Acyclovir through Nude Mouse Skin
by Electro repulsion and Electroosmosis. N. Volpato, P. Santi, P. Colombo.
Pharmaceutical Research, Vol. 12,No.11,1623-1627,1995
123) In vitro characteristics of nicotine microspheres for transnasal delivery. A.-L.
Cornaz, A. De Ascentis, P. Colombo, P. Buri. Int. J. Pharm. 129, 4, 175-183,
(1996)
124) Analysis of the Swelling and Release Mechanism from Drug Delivery Systems
with Emphasis on Drug Solubility and Water Transport. P.Colombo, R.Bettini,
P. Santi, A. De Ascentiis, N.A. Peppas. J.Controlled Release, 39 (1996) 231237
125) The suitability of a small scale high-shear mixer for powder pelletization.
L.Maggi, A.Bonfanti, P.Santi, G.Massimo, P.L.Catellani, A.Bellotti, P.Colombo,
A.Zanchetta.. Pharm. Tech. Eur., 8 (9), 1996, 82-90.
126) Delivery of nasal powders of beta-cyclodextrin by insufflation. A.De Ascebtiis,
R.Bettini, G.Caponetti, P.L.Catellani, M.T.Peracchia, P.Santi, P.Colombo.
Pharmaceutical Research, Vol.13.No 5, 1996,734-738.
127) Analysis of drug release behavior from swellable polymer carriers using the
dimensionality index. N.A.Peppas, P.Colombo. J. Controlled Release 45
(1997) 35-40
128) Clean-in-Place System Evaluation of a Rotary Tabletting Machine. A.Bonfanti,
P.Colombo, R.Trebbi, F.Breviglieri,, P.Santi, G.Massimo, P.L.Catellani.
Pharmaceutical Technology Europe, april 1997, 31-38
129)
Transdermal Iontophoresis of Salmon Calcitonin can Reproduce the Hypocalcemic Effect of Intravenous
Administration. P.Santi, N.M.Volpato, R.Bettini, P.L.Catellani, G.Massimo, P.Colombo. Il Farmaco, 52 (67), 445-448 (1997)
130) Drug reservoir composition and transport of salmon calcitonin in transdermal
iontophoresis. P. Santi, P. Colombo, R. Bettini, P.L Catellani, A. Minutello, N.M.
Volpato. Pharm. Res., 14 (1), 63-66, 1997.
131) Crystal dissolution-controlled release systems. II. Metronidazole release from
semicrystalline poly(vinyl alcohol) systems. S.K.Mallapragada, N.A.Peppas,
P.Colombo, J.Biomed. Mater.Res., 36, 125-130, 1997
132) Assay of acyclovir in human skin layers by high-performance liquid
chromatography, N.M. Volpato, P. Santi, C. Laureri, P. Colombo, J. Pharm. and
Biomed. Analysis., 16, 515-520,1997.
133) Salmon calcitonin transdermal iontophoresis, P. Santi, N.M. Volpato, P.
Colombo, Minutes of Transdermal Administration, a case study, iontophoresis,
Ed. D. Duchêne, Editions de Santé, Paris (F), 338-342 (1997)
134) Skin distribution of acyclovir after transdermal iontophoresis, N.M. Volpato, P.
Santi, P. Colombo, Minutes of Transdermal Administration, a case study,
iontophoresis, Ed. D. Duchêne, Editions de Santé, Paris (F), 398-401 (1997)
135) Calcitonin transdermal iontophoresis in comparison with intravenous
administration, P. Colombo, N.M. Volpato, P. Santi, Proceed. Intern. Symp.
Control. Rel. Bioact. Mater., 24, 693-694, Controlled Release Society, Inc.,
(1997)
136) Khellin distribution into human skin after transdermal iontophoresis, B. Marconi,
F. Mancini, P. Colombo, F. Allegra, F. Giordano, P. Santi, Proceed. 2nd World
Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology,
825-826 (1998)
137) Interpretation of Drug Release Kinetics and Drug Concentration Profiles in
HPMC Gels, R.Bettini, P.L. Catellani, N.A. Peppas, P. Colombo, Proceed. 2nd
World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical
Technology, 327-328 (1998)
138) In vitro acyclovir distribution in human skin layers after transdermal
iontophoresis, N.M. Volpato, S. Nicoli, C. Laureri, P. Colombo, P. Santi, J.
Control. Rel., 50, 291-296, 1998.
139) Dried sucralfate gel mantaining the same colloidal properties of humid
sucralfate gel, L.Maggi, F.Cudazzo, F.Zani, A.Minutello, P.Colombo,
P.Mattaboni. BCF International , January-February 1998, 8-11.
140) Partial Permselective Coating Adds an Osmotic Contribution to Drug Release
from Swellable Matrices. P.L. Catellani, P. Colombo, N.A. Peppas, P. Santi, R.
Bettini. Journal of Pharmaceutical Sciences, Vol. 87, 6, 726-731, 1998.
141) Microparticles of Novel Branched Copolymers of Lactic Acid and Amino Acids:
Preparation and Characterization. G.Caponetti, J.F.Hrkach, B.Kriwet, M. Poh,
N. Lotan, P. Colombo, R. Langer. Journal of Pharmaceutical Sciences, Vol. 88,
No 1, January1999, 136-141.
142) Physico-chemical compatibility between Thiocolchicoside injection (MuscoRil®)
and products usually used for combined therapy. M.Artusi, L. Maggi, P.
Colombo, P. Pacifico. BCF International, November-December 1998, 10-13
143) Solid Dosage. How to maintain the colloidal properties of moist sucralfate gel in
solid dosage forms. P. Colombo, Pharmaceutical Technology Europe, June
1999, 44
144) Distribution of khellin in excised human skin following iontophoresis and
passive dermal transport. B. Marconi, F. Mancini, P. Colombo, F. Allegra, F.
Giordano, A. Gazzaniga, G. Orecchia, P. Santi. Journal of Controlled Release
60 (1999) 261-268
145) Observation of swelling process and diffusion front position during swelling in
hydroxypropyl methyl cellulose (HPMC) matrices containing a soluble drug.
Paolo Colombo, Ruggero Bettini, Nikolaos Peppas, Journal of Controlled
Release 61 (1999) 83-91
146) Drug volume fraction profile in the gel phase and drug release kinetics in
hydroxypropylmethyl cellulose matrices containing a soluble drug. P. Colombo,
R.Bettini,
P.L.Catellani,
P.Santi,N.A.Peppas,
European
Journal
of
Pharmaceutical Sciences 9 (1999) 33-40
147) Mucosal drug delivery: Nasal, P.Colombo, in Mathiowitz Ed., Encyclopedia of
Controlled Drug Delivery, Vol.2, 593-605, 1999. John Wiley and Sons, New
York, NY (USA).
148) Nicotine nasal powder: design and characterization. R. Bettini, C. d’Andria, P.L.
Catellani, P. Santi, G. Massimo, D. Cocconi, P. Colombo. S.T.P. Pharma
Sciences 9 (5) 457-462 1999
149) Influence of flow and packing properties on the pneumatic conveying of
powdered mixtures for direct compression. C. D’Andria, G. Massimo, P.L.
Catellani, P. Santi, R. Bettini, L. Bianco, P. Colombo, Pharmaceutical
Technology Europe, January 2000, 17-23
150) Controlled release dosage forms: from ground to space. P.Colombo,R.Bettini,
M.T.Peracchia, P.Santi. Eur.J.Drug Metab.Pharmacokinet. 1996,No.2, pp.87-91
151) Ionized prodrugs of Dehydroepiandrosterone for transdermal iontophoretic
delivery. S. Laneri, A.Sacchi, E. Abbignente di Frassello, E. Luraschi, P.
Colombo, P.Santi. Pharmaceutical Research. Vol. 16, No 12, 1999 1818-1824
152)
Response surface methodology applied to fluid bed granulation. P. Wehrlé, P.
Colombo, P. Santi, R.Bettini, A. Nora, C. Tenore, P.L. Catellani.
Pharmaceutical Technology Europe April 2000, 36-46
153)
Surface smoothing of lactose particles for dry powders inhalers. COLOMBO P.,
CATELLANI P.L., MASSIMO G., SANTI P., BETTINI R., COCCONI D.,
CAGNANI S., VENTURA P., Respiratory Drug Delivery VII, Palm Harbor,
May 14-18 2000, 629-632.
154) Disintegration Propensity of Tablets Evaluated by Means of Disintegrating
Force Kinetics, G.Massimo, P.L.Catellani, P.Santi, R.Bettini, G.Vaona,
A.Bonfanti, L.Maggi, P.Colombo. Pharmaceutical Development and
Technology, 5(2), 163-169 (2000).
155) Swellable matrices for controlled drug delivery: gel-layer behaviour,
mechanisms and optimal performance. P. Colombo, R.Bettini, P.Santi,
N.A.Peppas. PSTT Vol.3, No 6 June 2000,198-204.
156) Swelling force development as a result of hydrate formation in diclofenac
sodium or nitrofurantoin tablets. R.Bettini, F.Giordano, C.Donini,
G.Massimo, P.L.Catellani, P.Colombo. S.T.P. PHARMA SCIENCES 10 (4)
335-339, 2000. 09-11
157) Drug release from swelling-controlled system. P.Colombo, P.Santi, R.Bettini,
C.S.Brazel, N.A.Peppas. Handbook of Pharmaceutical Controlled Release
Technology, Ed D.L.Wise, Marcel Dekker, Inc. New York; Basel. Chapter
9. 2000
158)
Effect of drying methods on retention of moist sucralfate gel properties.
L.Maggi, P.L.Catellani, E.Fisicaro, F.Zani, G.Massimo, P.Colombo. AAPS
PharmSciTech,2000; 1 (3) article 28 (http://www.pharmscitech.com/)
159) Design of triptorelin nanospheres for transdermal iontophoretic
administration. S.Nicoli, P.Santi, P. Couvreur, G. Couarraze, P. Colombo,
E. Fattal. International Journal of Pharmaceutics, 214,31-35,2001
160) State of the art and new perspectives on dry powder inhalation. C.Terzano,
P.Colombo, European Review for Medical and Pharmacological Sciences,
1999;3: 247-254.
161) Translocation of drug particles in HPMC matrix gel layer: effect of drug
solubility and influence on release rate. R.Bettini, P.L.Catellani, P.Santi,
G.Massimo, N.A.Peppas, P.Colombo. Journal of Controlled Release 70
(2001) 383-391
162) Biopharmaceutical aspects of nasal and pulmonary drug delivery. P.
Colombo, D.Cocconi, P.Santi, R.Bettini, G.Massimo, P.L.Catellani,
C.Terzano, in Pharmacokinetics Optimization in Drug Research.
Biological, Physicochemical, and computational Strategies. Eds. B.Testa,
H.van de Waterbeemd, G. Folkers, R.Guy. VHCA, Verlag Helvetica
Chimica Acta, Zurich, Switzerland. Wiley-VCH, Weinheim, Germany, pp.
173-188, 2001
163) Controlled Delivery of biotechnological products. S. Conti, L. Polonelli, R.
Frazzi, M. Artusi, R. Bettini, D. Cocconi, P. Colombo, Current
Pharmaceutical Biotechnology, 2000, I , 313-323
164) Plasma and skin concentration of 5-methoxypsoralen in psoriatic patients
after oral administration, A.Zucchi, E.Raho, B.Marconi, S.Nicoli, M.Santini,
F.Allegra, P.Colombo, R.Bettini, P.Santi, The Journal of Investigative
Dermatology, VOL. 117, NO.2, AUGUST 2001, 379-382.
165) Liberation controlée des medicaments: voies et formes utilisées, S.Nicoli,
P.Colombo, Annales Pharmaceutiques Francaises, 59: 227-231, 2001
166) Hydrophilic polymers for matrix systems. P.Colombo, R.Bettini, P.Santi, New
Trends in Polymers for oral and parenteral administration: from design to
receptors. Paris, 12-13 march 2001. Editions Santé, Minutes pg 99-106.
167) Physical and chemical enhancement of transdermal delivery of triptorelin.
S.Nicoli, S. rimondi, P.Colombo, P.Santi, Pharmaceutical Research, Vol
18, No 11, November 2001, 1634-1637.
168) Influence of Layer Position on in Vitro and in Vivo Release of Levodopa
Methyl Ester and Carbidopa from Three-Layer Matrix Tablets", R. Bettini,
D. Acerbi, G. Caponetti, R. Musa, N. Magi, P. Colombo, D. Cocconi, P.
Santi, P.L. Catellani, P. Ventura. European Journal of Pharmaceutics and
Biopharmaceutics, 53, 2002, pp. 227-232.
169) Caffeine microparticles for nasal administration obtained by spray drying, C.
Sacchetti, M. Artusi, P. Santi and P. Colombo, International Journal of
Pharmaceutics, 242 (2002) 335-339.
170)
Preparation of poly(methacrylic acid-g-poly(ethylene glycol) nanospheres
from methacrylic monomers for pharmaceutical applications, C.Donini,
D.N.Robinson, P.Colombo, F.Giordano, N.A.Peppas;
International
Journal of Pharmaceutics 245 (2002) 83-91
171) Inhalation mixtures of antiasmathic drugs with smoothed lactose, D.COCCONI,
C.PENOTTI, R.BETTINI, P.YOUNG, R.PRICE, P.COLOMBO, C.MARRIOT.
Respiratory Drug Delivery VIII,2002, 739.
172)
Characterization of a surface modified dry powder inhalation carrier prepared
by “particle smoothing”, P.M. Young, D.Cocconi, P. Colombo, R. Bettini.
R. Price, D.F.Steele, M.J.Toby, Journal of Pharmacy and Pharmacology,
2002,54: 1339-1344
173) Distribution and quantification of polyethylenimine oligodeoxynucleotide
complexes in human skin after iontophoretic delivery using confocal
scanning laser microscopy. C.Brus, P.Santi, P. Colombo, T. Kissel,
Journal of Controlled Release 84 (2002) 171-181
174) Buccal delivery of thiocolchicoside: in vitro and in vivo permeation studies.
M.Artusi, P.Santi, P.Colombo, H.E.Junginger, International Journal of
Pharmaceutics 250 (2003) 203-213
175) Skin permeation of 5-mehtoxypsoralen from topical dosage forms,
G.Colombo, M.Artusi, P.Santi, P.Colombo, R.Bettini, A.Zucchi, S.Nicoli,
Drug Dev.Ind.Pharm. Vol 29,No 2,pp. 247-251,2003
176) In vitro and in vivo study of 5-mehtoxypsoralen skin concentration after
topical application, G. Colombo, A. Zucchi, F. Allegra, P.Colombo, F.Zani,
P.Santi, Skin Pharmacol. Appl.Skin Physio. 2003;16; 103-136
177) Disintegration force kinetics as formulation tool for pharmaceutical
development of spironolactone conventional release tablets G.Massimo,
R. Bettini, P: Santi, S. Nicoli, F. Zani, P. Colombo, AAPS Pharm Sci Tech
2003;4 (2) Article 17 (http://www.pharmscitech.org)
178) Characterization of the permselective properties of rabbit skin during
transdermal iontophoresis, S. Nicoli, M. Cappellazzi, P. Colombo, P. Santi,
Journal of Pharmaceutical Sciences, vOL.92, NO.7, July 2003, 1482-1488
179)
Innovations en matiere d’administration des medicaments: voie orale,
transdermique et par inhalation. Paolo Colombo, Ruggero Bettini, Gina
Massimo, Patrizia Santi, B.T: Gattefossé N° 96- Tome 2- 2003, pg 57-62.
180) Validation of a Clean-in-Place System on a Capsule Filling Machine. Sara
Nicoli, Roveno Bonora, Roberto Trebbi, Gina Massimo, Pier Luigi
Catellani, Paolo Colombo, Ruggero Bettini Pharmaceutical Technology
Europe October 2003 27-35
181) Post-iontophoresis transport of ibuprofen lysine across rabbit ear skin. P.
Santi, S. Nicoli, G. Colombo, R. Bettini, M. Artusi, S. Rimondi, C. Padula,
P. Rizzo, P. Colombo. International Journal of Pharmaceutics Volume
266, Issues 1-2, 6 November 2003, Pages 69-75
182) Bioadhesive transdermal film containing caffeine. S. NICOLI, V. AMORETTI,
P. COLOMBO, P. SANTI, Skin Pharmacology and Physiology 2004;17:
119-123
183) A novel spray dried formulation for pulmonary administration of insulin
CAGNANI.S., COLOMBO P., R.BETTINI, VENTURA P. Respiratory Drug
Delivery IX, April 25-29,2004, 813-816
184) Chimeral agglomerates of microparticles for nasal administration of analgesic
powders. RUSSO P., COLOMBO P., BETTINI R., SONVICO F., BUTTINI F.
Respiratory Drug Delivery IX, 2004, 817-820
185) Preparation and characterization of chitosan based micro networks:
Transposition to a prilling process. L. MARTINEZ, F. AGNELY, R. BETTINI,
M. BESNARD, J. L. PASTOL, P. COLOMBO, G. COUARRAZE. Journal of
applied polymer science, Vol 93, 2550-2558, 2004
186)
Drug-b-Cyclodextrin Containing Pellets Prepared with a High-Shear Mixer A.
GAINOTTI, R. BETTINI, A. GAZZANIGA, P. COLOMBO, F. GIORDANO.
Drug Development and Industrial Pharmacy. Vol. 30, No. 10, pp. 1061–
1068, 2004
187) Chimeral agglomerates of microparticles for the administration of caffeine
nasal powders. P.RUSSO, F.BUTTINI, F.SONVICO, R. BETTINI, G.
MASSIMO, C. SACCHETTI, P. COLOMBO, P. SANTI. Journal of Drug
Delivery Science and Technology 14, N° 6, 449-454, 2004
188)
The Surface Roughness of Lactose Particles Can Be Modulated by WetSmoothing Using a High-Shear Mixer, F. FERRARI, D. COCCONI, R.
BETTINI, F. GIORDANO, P. SANTI, M. TOBYN, R. PRICE, P. YOUNG, C.
CARAMELLA, P. COLOMBO. AAPS PharmSciTech 2004; 5 (4) Article 60
(2004). http://dx.doi.org/10.1007/BF02830541
189)
Effect of Chemical Enhancers and Iontophoresis on Thiocolchicoside
Permeation across Rabbit and Human Skin In Vitro M. ARTUSI, S. NICOLI,
P. COLOMBO, R. BETTINI, A. SACCHI, P. SANTI. Journal of
Pharmaceutical Sciences, vol. 93, no. 10, 2431-2438, 2005
190)
Mechanisms of formation and disintegration of alginate beads obtained by
prilling, P. DEL GAUDIO, P. COLOMBO, G. COLOMBO, P. RUSSO, F.
SONVICO International Journal of Pharmaceutics302 (2005) 1-9.
191) Establishment of an in vitro model expressing the folate receptor for the
investigation of targeted delivery systems F. SONVICO, C. DUBERNET, V.
MARSAUD, M. APPEL, H. CHACUN, B. STELLA, M. RENOIR, P.
COLOMBO, P. COUVREUR. J. Drug Del. Sci. Tech., 15 (1) 407-410 2005
192) Metallic colloid nanotechnology, applications in diagnosis and therapeutics. F.
SONVICO, C. DUBERNET, P. COLOMBO, P. COUVREUR. Curr Pharm
Des. 2005;11(16):2095-105.
193) Effect of residual water content on the physico-chemical properties of
sucralfate dried gel obtained by microwave drying. A.GAINOTTI, E.LOSI,
R.BETTINI, P.COLOMBO, F.SONVICO, D.BARONI, P.SANTI,
G.COLOMBO, Drug Development and Industrial Pharmacy, 31:645-652,
2005.
194) Release and Permeation Kinetics of Caffeine From Bioadhesive Transdermal
Films, S. NICOLI, P. COLOMBO, P. SANTI. The AAPS Journal, 7 (1),
article 20 (2005).
195) Pressurized metered dose inhalers. P. COLOMBO, F. BUTTINI. APGI
Gazzette (2006) Tome 21 n°3-4, 22-24.
196) Assemblage of novel release modules for the development of adaptable drug
delivery systems. E. LOSI, R. BETTINI, P. SANTI, F. SONVICO, G.
COLOMBO, K. LOFTHUS, P. COLOMBO, N. A. PEPPAS. Journal of
Controlled Release 111 (2006) 212–218
197) The Effect of Residual Water on Antacid Properties of Sucralfate Gel Driedby
Microwaves. A. GAINOTTI, E. LOSI, P. COLOMBO, P. SANTI, F.
SONVICO, D. BARONI, G. MASSIMO, G. COLOMBO, P. DEL GAUDIO.
AAPS
PharmSciTech
2006;
7
(1)
Article
9
(http://www.aapspharmscitech.org).
198) Bpps Folate-Conjugated Iron Oxide Nanoparticles for Solid Tumor Targeting
as Potential Specific Magnetic Hyperthermia Mediators: Synthesis,
Physicochemical Characterization and in Vitro Experiments" F.
SONVICO, S. MORNET, S. VASSEUR, C. DUBERNET, D. JAILLARD,
J. DEGROUARD, J. HOEBEKE, ETIENNE DUGUET, P. COLOMBO
AND P. COUVREUR Bioconjugate Chemistry, 16, 1181-1188 (2005)
199) Nasal powders of morphine microcrystal agglomerates. P.COLOMBO,
A.ROSSI, P. RUSSO, F. SONVICO, G. COLOMBO, F. BUTTINI.
RESPIRATORY DRUG DELIVERY X, ISBN: Book 3,1-930114-97-4.
2006, 885-887.
200) Primary microparticles and agglomerates of morphine for nasal insufflation.
P.RUSSO, C.SACCHETTI, I. PASQUALI, R.BETTINI, G.MASSIMO, P.
COLOMBO, A. ROSSI. Journal of Pharmaceutical Sciences 95,12,25532561, 2006.
201) Formation of self-organized nanoparticles by lecithin/chitosan ionic.
interaction”, F. SONVICO, A. CAGNANI, A. ROSSI, S. MOTTA, M.T. DI
BARI, F. CAVATORTA, M.J. ALONSO, A. DERIU, P. COLOMBO.
International Journal of Pharmaceutics, 324, 67-73 (2006).
202)
New transdermal bioadhesive film containing oxybutynin: In
vitro permeation across rabbit ear skin, S. NICOLI, E. PENNA, C.
PADULA, P. COLOMBO, P. SANTI. International Journal of
Pharmaceutics, 325, 2-7 (2006).
203)
Set-Up and Validation of a Clean-In-Place (CIP) System for a
Coating Pan”, S. UCCI, A. SPADONI, C. FUNARO, G. BERTUZZI, R.
TREBBI, G. CIARAMELLA, P. COLOMBO, R. BETTINI. Pharmaceutical
Engineering, 26, No. 6, 1-8, (2006).
204)
Biological In Vitro Models for Absorption by Nonoral Routes, P.
COLOMBO, S. CAGNANI, F. SONVICO, P. SANTI, P. RUSSO, G.
COLOMBO. COMPREHENSIVE MEDICINAL CHEMISTRY II, Ed.
J.B.Taylor& D.Triggle Vol 5,Vol Editors: B.Testa, H.Van de Waterbeend;
Elsevier, Oxford, UK. 2007, 279-299, ISBN-13: 978-0-08-044513-7;
ISBN-10: 0-08-044513-6
205)
Bioadhesive film for dermal and transdermal drug delivery”
Padula, S. Nicoli, V. Aversa, P. Colombo, F. Falson, F. Pirot, P. Santi.,
European Journal of Dermatology, 17 (4), 309-312 (2007).
206)
Soft
agglomerates
of
pantoprazole
gastro-resistant
microparticles for oral administration and intestinal release Raffin R.P.,
Colombo P., Sonvico F., Polleto F.S., Colombo G., Rossi A., Polhmann
A.R., Guterres S.S. J Drug Del Sci Tech, 17, 407-413 (2007)
207)
Single-layer transdermal film containing lidocaine: modulation
of drug release C.Padula, S. Nicoli, P. Colombo, P. Santi, European
Journal of Pharmaceutics and Biopharmaceutics, 66, 422-428 (2007)
208)
Multilayer PVA adsorption onto hydrophobic drug substrates to
engineer drug-rich microparticles. Buttini,F., Soltani, A., Colombo, P.,
Marriott, C., Jones, S.A.. Eur.J.Pharm.Sci., 33 (2008) 20-28.
209)
Back to Basic: The Development of a Simple,
Homogeneous,Two-Component Dry-Powder Inhaler Formulation for the
Delivery of Budesonide Using Miscible Vinyl Polymer. F. Buttini,
P.Colombo, M.P.E. Wenger, P. Mesquida, C. Marriot, Stuart A. Jones,
Journal of Pharmaceutical Sciences, Vol. 97, NO. 3, March 2008, 12571267
210)
Dynamics of lipid–saccharide nanoparticles by quasielastic
neutron scattering, M.T. Di Bari, Y. Gerelli , F. Sonvico , A. Deriu, F.
Cavatorta, G. Albanese, P. Colombo, F. Fernandez-Alonso, Chemical
Physics 345 (2008) 239–244
211)
Module assemblage technology for floating systems: invitro
flotation and in vivo gastro-retention, O.L:Strusi, F.Sonvico, R.Bettini,
P:Santi, G.Colombo, P.Barata, A.Oliveira, D.Santos, P.Colombo, Journal
of Controlled Release 129 (2008) 88-92
212)
Methacholine dry powder inhaler as a new tool for bronchial
challenge test. G. Colombo, C. Terzano, P. Colombo, A. Petroianni, A.
Ricci, F. Buttini., International Journal of Pharmaceutics, 352, 165-171
(2008).
213)
Structure and organization of phospholipid/polysaccharide
nanoparticles, Y. Gerelli, M.T. Di Bari, A. Deriu, L. Cantù, P. Colombo, C.
Como, S. Motta, F. Sonvico, R. May. Journal of Physics: Condensed
Matter, 20 (10), #104211 (8pp) (2008).
214)
Francesca Buttini, Chris Grainger, Stuart A. Jones, Paul G.
Royall, Gary P. Martin, Ben Forbes. Characterisation of particles emitted
from two formulations of beclomethasone dipropionate solution Metered
Dose Inhalers. RDD 2008, Respiratory Drug Delivery XI. 581-584, Book
2 (ISBN 1-933722-22-3), ed. Davis Healthcare International Publishing.
215)
Gaia Colombo, Claudio Terzano, Paolo Colombo, Angelo
Petroianni, Alberto Ricci, Francesca Buttini. A Clinical study of a
methacholine dry powder for the bronchial challenge test. RDD 2008,
Respiratory Drug Delivery XI. 831-836, Book 3 (ISBN 1-933722-23-1),
ed. Davis Healthcare International Publishing.
216)
Chiara Parlati, Handoko Adi, Francesca Buttini, Paolo
Colombo, Paul M.Young, Daniela Traini. In Vitro evaluation of coprocess antibiotic for inhalation. RDD 2008, Respiratory Drug Delivery
XI. 907-910, Book 3 (ISBN 1-933722-23-1), ed. Davis Healthcare
International Publishing.
217)
Y. Gerelli,† S. Barbieri,‡ M. T. Di Bari,† A. Deriu,†* L. Cantu ,§ P. Brocca,§ F.
Sonvico,‡ P. Colombo,‡ R. May, and S. Motta‡ Structure of SelfOrganized Multilayer Nanoparticles for Drug Deliver. ASAP Langmuir,
ASAP Article, 10.1021/la801992t Web Release Date: September 24,
2008y Novel platforms for oral drug delivery, P.COLOMBO,F. SONVICO,
G. COLOMBO, R. BETTINI Pharmaceutical Research: Volume 26,
Issue3 (2009), Page 601.
218) Pulmonary Spray Dried Powders of Tobramycin Containing Sodium
Stearate to Imptove Aerosolization Efficiency, C.PARLATI,
P.COLOMBO, F.BUTTINI, P.YOUNG, H.ADI, A.J.AMMIT,
D.TRAINI, Pharmaceutical Research, Vol.26, May 2009, 1084-1092
219)
Physical characteristics and aerosol performance of naringin dry powders for
pulmonary delivery prepared by spray drying. F.SANSONE,
R.P.AQUINO,
P.DEL
GAUDIO,
P.COLOMBO,
P.RUSSO,
Eur.J.Pharm.and Biopharm. Accepted
220)
Therapeutic Paint of Cidofovir/Sucralfate Gel Combination Topically
Administered
by
Spraying
for
Treatment
of
orf
virus
Infections.,F.SONVICO, G.COLOMBO, L. GALLINA, F.BORTOLOTTI,
A.ROSSI, G.MASSIMO, P.COLOMBO, A. SCAGLIARINI, The AAPS
Journal 2009 DOI:10.1208/s12248-009-9101-8
221)
Agglomerates Containing Pantoprazole Microparticles: Modulating the Drug
Release, R.RAFFIN, P.COLOMBO, F.SONVICO, A. ROSSI, D.S.
JORNADA, A.R. POHLMAN, S.S. UTIERRES, AAPS *harmSciTech
8”009, DOI: 10.1208/s12249-009-9214-5