Group Leader
Marina Marini, Associate Professor
Department of Histology, Embryology and Cell Biology
University of Bologna
Via Belmeloro, 8 - 40126 BOLOGNA, ITALY
tel (+39)051 2094 116 (office); 094 or 126 or 127 (lab);
100 (secretary)
fax (+39)051 2094 110
e-mail: [email protected]
Group members
Simona di Tullio
(post-doc fellow)
tel. (+39)051 2094 094
email: [email protected]
Provvidenza M. Abruzzo
(PhD student)
tel. (+39)051 2094 094
email: [email protected]
Cosetta Marchionni
(laboratory technician)
tel. (+39)051 2094 094
email: [email protected]
Key words (max 5)
Oxidative stress, aging, ADP-ribosylation, physical exercise, neuromuscolar diseases
Research projects
• Physical exercise, hypoxia and oxidative stress
To evaluate the biomolecular pathways activated by physical exercise and hypoxia,
in the view that the oxidative stress they induce may have hormetic effects, and
hence, at low doses, limit apoptosis and DNA damage.
• Oxidative stress in skeletal muscle denervation
To elucidate the pathogenetic role of oxidative stress in degenerative processes
occurring in denervated muscles and the role of physical exercise in contrasting
aging-related sarkopenia.
• Oxidative stress in mental disorders
A project under development.
Collaborations
Prof. Arsenio Veicsteinas and Prof. Michele Samaja
University of Milan, Italy
Prof. Rosanna Abbate
University of Florence, Italy
Prof. Luisa Gorza and Prof. Ugo Carraro
University of Padua, Italy
Prof. Giorgio Fanò
University of Chieti, Italy
Prof. M. Rosaria Faraone-Mennella
University of Naples, Italy
Dr. Alessandro Ghezzo
Fondazione Don Gnocchi, Ancona, Italy
Dr. Helmut Kern
Wilhelminenspital. Vienna, Austria
Publications (last 5 years)
1. Marini M., Lapalombella R., Canaider S., Farina A., Monti D., De Vescovi V., Morellini M., Bellizzi D., Dato
S., De Benedictis G., Passarino G., Moresi R., Tesei S., Franceschi C. Heat shock response by EBVimmortalized B-lymphocytes from centenarians and control subjects: A model to study the relevance of
stress response in longevity. Experimental Gerontology, 39, 83-90 (2004).
2. Fabbri F., Carloni S., Brigliadori G., Zoli W., Lapalombella R., Marini M. Sequential events of apoptosis
involving docetaxel, a microtubule-interfering agent : a cytometric study BMC Cell Biology, 7:6 (2006)
3. Marini M., Lapalombella R., Margonato V., Ronchi R., Samaja M, Scapin C., Gorza L., Maraldi T., Carinci
P.,Ventura C., Veicsteinas A. Mild exercise training, cardioprotection and stress gene profile.
European Journal of Applied Physiology 99:503-510 (2007)
4. Tavolari S, Bonafé M, Marini M, Ferreri C, Bartolini G, Brighenti E, Manara S, Tomasi V, Laufer S,
Guarnieri T. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells
through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade.
Carcinogenesis 29:371-380 (2008)
5. Marini M., Falcieri E., Margonato V., Treré D., Lapalombella R., di Tullio S., Marchionni C., Burattini S.,
Samaja M., Esposito F., Veicsteinas A. Partial persistance of exercise-induced myocardial angiogenesis
following 4-wk detraining in the rat. Histochem Cell Biol 129(4): 479-487 (2008)
6. Lapalombella R., Kern H., Adami N., Biral D., Zampieri S., Scordari A., di Tullio S., Marini M. Persistance
of regenerative myogenesis in spite of down-regulation of activity-dependent genes in long-term
denervated rat muscle. Neurological Research 30 (2): 197-206 (2008)
7. Malagolini N., Chiricolo M., Marini M., Dall'Olio F. Exposure of alpha-2,6-sialylated lactosaminic chains
marks apoptotic and necrotic death in different cell types. Glycobiology 19(2):172-181 (2009)
8. Romani R, De Medio GE, di Tullio S, Lapalombella R, Pirisinu I., Margonato V, Veicsteinas A, Marini M,
Rosi G. Modulation of paraoxonase 1 and 3 expression after moderate exercise training in the rat
Journal of Lipid Res (2009) e-pub 16 Dec 2008; PMID: 19091700.
9. Giusti B., Marini M. , Rossi L., Lapini I., Magi A., Capalbo A., Lapalombella R., di Tullio S., Samaja M.,
Esposito F., Margonato V., Boddi M., Abbate R., Veicsteinas A. Gene expression profiling in rat left
ventricle after 10-week mild exercise training Conditionally Accepted now under revision.
10. Esposito F, Ronchi R, Milano G, Margonato V, Paracchino E, Di Tullio S, Marini M, Veicsteinas A, Samaja
M. Long-term training in rats improves reversibly myocardial tolerance to ischemia- reperfusion via stress
protein signaling Submitted
11. Squecco R., Kern H., Carraro U., Pond A., Adami N., Biral D., Vindigni V., Boncompagni S., Pietrangelo
T., Bosco G., Fanò G., Marini M., Abruzzo P. M., Germinario E., Danieli-Betto D., Protasi F., Francini F.,
Zampieri S. Despite lost contractility, a sub-population of rat muscle fibers maintains an assessable
excitation-contraction coupling mechanism after long-standing denervation Submitted
12. Faraone-Mennella M.R., Marini M, Ferone A., Cacace A., Liguoro A., Margonato V., Farina B., Veicsteinas
A. Physical exercise activates the poly(ADP-ribosyl)ation system in rat testes Submitted